{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:22:27Z","timestamp":1790018547273,"version":"4.0.1"},"reference-count":45,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NeuroSci"],"abstract":"<jats:p>Background: Lower limb (LL) and low back Radicular Syndromes (RSs) may result from discopathy of the lumbo-sacral spine. Consistent benefits are reported from Epidural Adhesiolysis (EA). Aim: To evaluate clinical and European Quality of Life items (EQ-5D) of Peri-Neural Release interventions (PNR, a modified approach and terminology for EA) among patients diagnosed with lumbo-sacral discopathy associated radicular syndromes. Methods: A retrospective study was conducted by retrieving records of patients e treated by PNR for low back and lower limbs pain between January 2018 and December 2024. Eligible patients were adults who were diagnosed with lumbo-sacral discopathy, stenosis, or Post Lumbar Surgery Syndrome (PLSS). Data on Patient-Reported Outcome Measures (PROMs) adopting the European Quality of Life five items (Euro-QoL 5D) that includes self-ratings of mobility, active daily living, self-care, pain and discomfort, anxiety and depression) was collected before the procedure and on subsequent follow-up visits. Other clinical outcomes included numerical pain rating scales (NRSs), sleep quality, time to pain during activity, and self-reported health scores. Results: A total of 221 patients were included in this analysis. Of these, 56.6% were female, with a mean age of 45.1 \u00b1 14.7 years. In total, 50.2% of patients underwent PNR alone, followed by 28.1% who underwent PNR balloon decompression neuroplasty. Of the remaining patients, 7.2% underwent epiduroscopic PNR, 6.3% PNR combined with annuloplasty (biacuplasty) and 8.1% underwent PNR combined with nucleoplasty. Significant improvements were observed across all EQ-5D and NRS (p &lt; 0.001) at follow-up assessments without major complications. The interventions were associated with a decrease in NRS from 7.9 to 3.1, and an increase in the duration of pain-free activity (walking, standing, sitting) (p &lt; 0.001). Self-reported overall health scores improved from 53.9 \u00b1 18.4 to 81.1 \u00b1 15.1. In terms of complications, two patients reported post-operative headache. The remaining side effects included coccydynia at the site of intervention, resolving with application of non-steroid anti-inflammatory topicals and self-resolving lower limb numbness in five cases. Conclusions: The presented data suggest that PNR\u2014whether performed alone or in combination with adjunctive intradiscal procedures\u2014is a safe intervention, and is associated, in the majority of patients, with substantial pain relief and improvement in EQ-5D both in the short- and long-term follow-up.<\/jats:p>","DOI":"10.3390\/neurosci7020033","type":"journal-article","created":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T13:00:02Z","timestamp":1772802002000},"page":"33","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Retrospective Cohort Study of 221 Cases of Epidural Per-Cutaneous Peri-Neural Release (Adhesiolysis)"],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7149-3768","authenticated-orcid":false,"given":"Yasin Said","family":"Almakadma","sequence":"first","affiliation":[{"name":"Aspetar Orthopedic and Sports Medicine Hospital, Doha 29222, Qatar"},{"name":"Weil-Cornell Medical College, Doha 24144, Qatar"},{"name":"College of Medicine, Qatar University, Doha P.O. Box 2713, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jouhara","family":"Jouhar","sequence":"additional","affiliation":[{"name":"Aspetar Orthopedic and Sports Medicine Hospital, Doha 29222, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9162-4948","authenticated-orcid":false,"given":"Abdulaziz","family":"Farooq","sequence":"additional","affiliation":[{"name":"Aspetar Orthopedic and Sports Medicine Hospital, Doha 29222, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8660-3227","authenticated-orcid":false,"given":"Tahani","family":"Albatarni","sequence":"additional","affiliation":[{"name":"Aspetar Orthopedic and Sports Medicine Hospital, Doha 29222, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"642","DOI":"10.4184\/asj.2017.11.4.642","article-title":"Neuropathic Pain after Spinal Surgery","volume":"11","author":"Cho","year":"2017","journal-title":"Asian Spine J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1111\/papr.13379","article-title":"Persistent spinal pain syndrome type 2","volume":"24","author":"Peene","year":"2024","journal-title":"Pain. 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