{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T09:05:16Z","timestamp":1773219916709,"version":"3.50.1"},"reference-count":12,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NeuroSci"],"abstract":"<jats:p>Creutzfeldt\u2013Jakob disease (CJD) is a rare, fatal prion disease of the central nervous system that develops due to the conversion of the normal cellular protein PrPc to the abnormal PrPSc molecule. The first clinical cases were described in the 1920s. The aim of this paper is to present the clinical progress of the disease and the diagnostic process, including some of the most common diagnostic traps. The paper highlights a range of symptoms that should serve as a potential warning signal for clinicians\u2014not just neurologists\u2014indicating the need to evaluate the patient more thoroughly.<\/jats:p>","DOI":"10.3390\/neurosci7020035","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T10:53:31Z","timestamp":1773140011000},"page":"35","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Creutzfeldt\u2013Jakob Disease: Spectrum of Symptoms, Clinical Progress and Diagnostics\u2014Report of Five Cases"],"prefix":"10.3390","volume":"7","author":[{"given":"Klaudia","family":"Rojewska","sequence":"first","affiliation":[{"name":"Department of Neurology with Stroke Unit, Independent Public Voivodeship Combined Hospital in Szczecin, ul. Arko\u0144ska 4, 71-455 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0172-7674","authenticated-orcid":false,"given":"Natalia","family":"Dynowska","sequence":"additional","affiliation":[{"name":"Department of Neurology with Stroke Unit, Independent Public Voivodeship Combined Hospital in Szczecin, ul. Arko\u0144ska 4, 71-455 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iwona","family":"Rotter","sequence":"additional","affiliation":[{"name":"Department of Medical Rehabilitation and Clinical Physiotherapy, Pomeranian Medical University in Szczecin, ul. \u017bo\u0142nierska 54, 71-210 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u0142gorzata","family":"Niekrasz","sequence":"additional","affiliation":[{"name":"Department of Neurology with Stroke Unit, Independent Public Voivodeship Combined Hospital in Szczecin, ul. Arko\u0144ska 4, 71-455 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1093\/brain\/awm063","article-title":"Creutzfeldt-Jakob disease in Germany: A prospective 12-year surveillance","volume":"130","author":"Heinemann","year":"2007","journal-title":"Brain"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Gao, L.-P., Tian, T.-T., Xiao, K., Chen, C., Zhou, W., Liang, D.-L., Cao, R.-D., Shi, Q., and Dong, X.-P. (2024). Updated global epidemiology atlas of human prion diseases. Front. Public Health, 12.","DOI":"10.3389\/fpubh.2024.1411489"},{"key":"ref_3","unstructured":"Liberski, P.P., and Mossakowski, M.J. (2003). Pasa\u017cowalne encefalopatie g\u0105bczaste-choroby wywo\u0142ane przez priony. Neurodegeneracje. T1, Biologia Molekularne, Podstawy Strukturalne, Choroby Neurodegeneracyjne, CUN PAN."},{"key":"ref_4","unstructured":"Pawe\u0142, P. (2003). Liberski Choroba Creutzfeldta-Jakoba i Inne Choroby Wywo\u0142ane Przez Priony-Pasa\u017cowalne Encefalopatie G\u0105bczaste, Czelej."},{"key":"ref_5","unstructured":"(2025, November 11). National Creutzfeldt-Jakob Disease Surveillance Diagnostic Criteria. National Creutzfeldt-Jakob Disease Surveillance 2010. Available online: http:\/\/www.cjd.ed.ac.uk."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1093\/brain\/awp191","article-title":"Updated clinical diagnostic criteria for sporadic Creutzfeldt-Jakob disease","volume":"132","author":"Zerr","year":"2009","journal-title":"Brain"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"150","DOI":"10.4161\/pri.5.3.16893","article-title":"Real-time quaking-induced conversion. A highly sensitive assay for prion detection","volume":"5","author":"Atarashi","year":"2011","journal-title":"Prion"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1099\/vir.0.033365-0","article-title":"Sensitive and specific detection of sporadic Creutzfeldt-Jakob disease brain prion protein using real-time quaking-induced conversion","volume":"93","author":"Peden","year":"2012","journal-title":"J. Gen. Virol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nm.2294","article-title":"Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced conversion","volume":"17","author":"Atarashi","year":"2011","journal-title":"Nat. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/ana.23589","article-title":"Real Time Quaking-Induced Conversion Analysis of Cerebrospinal Fluid in Sporadic Creutzfeldt-Jakob Disease","volume":"72","author":"McGuire","year":"2012","journal-title":"Am. Neurol. Assoc."},{"key":"ref_11","unstructured":"Louis, E.D., Mayer, S.A., and Noble, J.M. (2023). Neurologia Merrita, T.1-2., Edra Urban &Partner."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Ga\u0142ecki, P., and Szulc, A. (2023). Psychiatria, Tom 2, Edra Urban & Partner.","DOI":"10.53270\/2022.008"}],"container-title":["NeuroSci"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2673-4087\/7\/2\/35\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T11:13:59Z","timestamp":1773141239000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2673-4087\/7\/2\/35"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,10]]},"references-count":12,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["neurosci7020035"],"URL":"https:\/\/doi.org\/10.3390\/neurosci7020035","relation":{},"ISSN":["2673-4087"],"issn-type":[{"value":"2673-4087","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,10]]}}}