{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T16:24:56Z","timestamp":1783441496487,"version":"3.54.6"},"reference-count":17,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T00:00:00Z","timestamp":1781913600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Florence & George Heighway Endowment Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NeuroSci"],"abstract":"<jats:p>Background: Creating antibiograms solely for adults may overestimate resistance of antimicrobials for certain pathogens in children. The Canadian Paediatric Society comments that areas with no cephalosporin-resistant Streptococcus pneumoniae cases should consider ceftriaxone or cefotaxime monotherapy for meningitis, despite most experts recommending adding vancomycin. The present study created age-specific antibiograms using LifeLabs data to report incidences of resistant bacterial meningitis pathogens at the regional level to determine the need for duo-coverage. Methods: Data of common bacterial meningitis pathogen susceptibility was collected from 1 January 2023 to 31 December 2024, in the LifeLabs community laboratory on Vancouver Island. Results: Most Streptococcus pneumoniae isolates (78\/83) were susceptible to ceftriaxone using the meningitis breakpoint; the remaining five isolates showed intermediate susceptibility to ceftriaxone. There was a significant difference when comparing S. pneumoniae susceptibility using penicillin-meningitis and penicillin-non-meningitis breakpoints (82% vs. 99%, respectively; p &lt; 0.05). There was a significant difference between the three age groups (&lt;18 years, 18\u201350 years, &gt;50 years) when analyzing ciprofloxacin susceptibility of isolates [82% (n = 462), 77% (n = 2452), 75% (n = 8352), respectively, p &lt; 0.05]. Conclusions: Ceftriaxone should remain the drug of choice for community-acquired bacterial meningitis and might be sufficient as a monotherapy for pneumococcal meningitis on Vancouver Island. The age-specific differences in E. coli susceptibilities to ciprofloxacin showed the importance of age-specific antibiograms.<\/jats:p>","DOI":"10.3390\/neurosci7030073","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T15:02:56Z","timestamp":1783436576000},"page":"73","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Age-Specific Antibiograms for Bacterial Meningitis Pathogens Based on Isolates Collected in a Community Laboratory"],"prefix":"10.3390","volume":"7","author":[{"given":"Alexsa J.","family":"Zurowski","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Faculty of Science, University of British Columbia, Vancouver, BC V6T 1Z4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5183-1838","authenticated-orcid":false,"given":"Eugene Y. H.","family":"Yeung","sequence":"additional","affiliation":[{"name":"Continuing Pharmacy Professional Development, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC V6T 1Z3, Canada"},{"name":"Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC V5Z 1M9, Canada"},{"name":"Clinical Faculty, School of Medicine, Simon Fraser University, Surrey, BC V3T 0A3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1086\/425368","article-title":"Practice guidelines for the management of bacterial meningitis","volume":"39","author":"Tunkel","year":"2004","journal-title":"Clin. Infect. 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Child Health"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.1016\/j.cmi.2016.01.007","article-title":"ESCMID guideline: Diagnosis and treatment of acute bacterial meningitis","volume":"22","author":"Cabellos","year":"2016","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_6","unstructured":"NICE (2025, July 29). Meningitis (Bacterial) and Meningococcal Disease: Recognition, Diagnosis and Management. Available online: https:\/\/www.nice.org.uk\/guidance\/ng240\/chapter\/Recommendations."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1093\/pch\/19.3.141","article-title":"Guidelines for the management of suspected and confirmed bacterial meningitis in Canadian children older than one month of age","volume":"19","year":"2014","journal-title":"Paediatr. Child Health"},{"key":"ref_8","unstructured":"Clinical and Laboratory Standards Institute (2025, July 29). 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