{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:43:49Z","timestamp":1791485029358,"version":"4.3.4"},"reference-count":402,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NeuroSci"],"abstract":"<jats:p>Parkinson\u2019s disease (PD) is a neurodegenerative disorder caused by the loss of dopaminergic neurons. Its symptoms affect both motor functions\u2014such as bradykinesia, rigidity, resting tremor, and postural instability\u2014and non-motor functions, including neuropsychiatric issues, sleep disorders, and constipation. Drawing on the literature, the following topics were developed and presented: Pathophysiology; Treatment; Neuropsychiatric and Cognitive Function; Sleep Challenges; Exercise and Movement; Striving for Wellness; and Obstacles\/Paths Forward. These seven categories form the foundation of this review, which centers on four main areas related to PD: dopamine biology and pathophysiology; management of key motor and non-motor symptoms; strategies for achieving wellness; and unresolved issues in PD. The complexity of PD\u2019s clinical features is highlighted by describing patient\u2013healthcare provider interactions, elucidating disease mechanisms, managing motor and non-motor symptoms, highlighting the benefits of exercise, emphasizing the importance of sleep, addressing mental health challenges and cognitive changes, fostering a hopeful and resilient mindset, potentially slowing disease progression, treating comorbidities, and promoting overall wellness. Although there have been tremendous advances in the basic science and clinical management of PD in recent years, PD remains incurable. Thus, we describe several roadblocks that have hindered progress in understanding PD. Only by integrating historical insights with the latest PD advances can we acquire the knowledge needed to change the disease\u2019s trajectory. Finally, this review aims to provide a meaningful summary for healthcare professionals (and students) caring for patients with PD.<\/jats:p>","DOI":"10.3390\/neurosci7040093","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T15:51:05Z","timestamp":1787327465000},"page":"93","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Parkinson\u2019s Disease: Pathophysiology, Treatment Strategies, Wellness Approaches, and Obstacles\/Paths Forward"],"prefix":"10.3390","volume":"7","author":[{"given":"Frank C.","family":"Church","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill C.","family":"Rau","sequence":"additional","affiliation":[{"name":"Department of Neurology, Bob Bov\u00e9 Neuroscience Institute at HonorHealth, Scottsdale, AZ 85251, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Brotini","sequence":"additional","affiliation":[{"name":"Movement Disorders Center, Department of Neurosciences, AUSL Toscana Centro, San Giuseppe Hospital, 50053 Empoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2022.12.032","article-title":"Hallmarks of neurodegenerative diseases","volume":"186","author":"Wilson","year":"2023","journal-title":"Cell"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1242\/dmm.030205","article-title":"Neurodegenerative disease: Models, mechanisms, and a new hope","volume":"10","author":"Gitler","year":"2017","journal-title":"Dis. Models Mech."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"a028035","DOI":"10.1101\/cshperspect.a028035","article-title":"Pathology of neurodegenerative diseases","volume":"9","author":"Dugger","year":"2017","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1002\/mds.27115","article-title":"Past, present, and future of Parkinson\u2019s disease: A special essay on the 200th Anniversary of the Shaking Palsy","volume":"32","author":"Obeso","year":"2017","journal-title":"Mov. Disord."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1176\/jnp.14.2.223","article-title":"An essay on the shaking palsy","volume":"14","author":"Parkinson","year":"2002","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0140-6736(14)61393-3","article-title":"Parkinson\u2019s disease","volume":"386","author":"Kalia","year":"2015","journal-title":"Lancet"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"17013","DOI":"10.1038\/nrdp.2017.13","article-title":"Parkinson disease","volume":"3","author":"Poewe","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_8","unstructured":"Ahlskog, J.E. (2015). The New Parkinson\u2019s Disease Treatment Book: Partnering with Your Doctor to Get the Most from Your Medications, Oxford University Press."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0140-6736(23)01419-8","article-title":"The epidemiology of Parkinson\u2019s disease","volume":"403","author":"Darweesh","year":"2024","journal-title":"Lancet"},{"key":"ref_10","first-page":"129","article-title":"The pathophysiology of motor symptoms in Parkinson\u2019s disease","volume":"103","author":"Santens","year":"2003","journal-title":"Acta Neurol. Belg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1002\/mds.27372","article-title":"International Parkinson and movement disorder society evidence-based medicine review: Update on treatments for the motor symptoms of Parkinson\u2019s disease","volume":"33","author":"Fox","year":"2018","journal-title":"Mov. Disord."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1002\/mds.20458","article-title":"Motor fluctuations and dyskinesias in Parkinson\u2019s disease: Clinical manifestations","volume":"20","author":"Jankovic","year":"2005","journal-title":"Mov. Disord."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"101834","DOI":"10.1016\/j.arr.2022.101834","article-title":"Premotor, nonmotor and motor symptoms of Parkinson\u2019s disease: A new clinical state of the art","volume":"84","author":"Silva","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.neubiorev.2016.07.010","article-title":"Motor symptoms in Parkinson\u2019s disease: A unified framework","volume":"68","author":"Moustafa","year":"2016","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.nrl.2014.10.010","article-title":"Motor and non-motor symptoms of Parkinson\u2019s disease and their impact on quality of life and on different clinical subgroups","volume":"31","author":"Berganzo","year":"2016","journal-title":"Neurolog\u00eda"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/nrg1831","article-title":"Genetics of Parkinson disease: Paradigm shifts and future prospects","volume":"7","author":"Farrer","year":"2006","journal-title":"Nat. Rev. Genet."},{"key":"ref_17","unstructured":"Stoker, T.B., and Greenland, J.C. (2018). Parkinson\u2019s Disease: Etiology, Neuropathology, and Pathogenesis. Parkinson\u2019s Disease: Pathogenesis and Clinical Aspects, Codon Publications."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s40035-017-0099-z","article-title":"Current understanding of the molecular mechanisms in Parkinson\u2019s disease: Targets for potential treatments","volume":"6","author":"Maiti","year":"2017","journal-title":"Transl. Neurodegener."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/nrneurol.2015.249","article-title":"Evolving basic, pathological and clinical concepts in PD","volume":"12","author":"Kalia","year":"2016","journal-title":"Nat. Rev. Neurol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Church, F.C. (2021). Treatment Options for Motor and Non-Motor Symptoms of Parkinson\u2019s Disease. Biomolecules, 11.","DOI":"10.3390\/biom11040612"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Hribar, C.A., Cobbold, P.H., and Church, F.C. (2020). Potential Role of Vitamin D in the Elderly to Resist COVID-19 and to Slow Progression of Parkinson\u2019s Disease. Brain Sci., 10.","DOI":"10.3390\/brainsci10050284"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1097\/TGR.0000000000000278","article-title":"Integrative medicine and health therapy for Parkinson disease","volume":"36","author":"Hall","year":"2020","journal-title":"Top. Geriatr. Rehabil."},{"key":"ref_23","first-page":"495","article-title":"Parkinson matters","volume":"8","author":"Darweesh","year":"2018","journal-title":"J. Park. Dis."},{"key":"ref_24","first-page":"S3","article-title":"The emerging evidence of the Parkinson pandemic","volume":"8","author":"Dorsey","year":"2018","journal-title":"J. Park. Dis."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1002\/mds.29637","article-title":"What is the Parkinson pandemic?","volume":"38","author":"Albin","year":"2023","journal-title":"Mov. Disord. Off. J. Mov. Disord. Soc."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/S1474-4422(16)30230-7","article-title":"The epidemiology of Parkinson\u2019s disease: Risk factors and prevention","volume":"15","author":"Ascherio","year":"2016","journal-title":"Lancet Neurol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Morowitz, J.M., Pogson, K.B., Roque, D.A., and Church, F.C. (2022). Role of SARS-CoV-2 in Modifying Neurodegenerative Processes in Parkinson\u2019s Disease: A Narrative Review. Brain Sci., 12.","DOI":"10.3390\/brainsci12050536"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e095610","DOI":"10.1136\/bmjopen-2024-095610","article-title":"Global burden of Parkinson\u2019s disease from 1990 to 2021: A population-based study","volume":"15","author":"Li","year":"2025","journal-title":"BMJ Open"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Luo, Y., Qiao, L., Li, M., Wen, X., Zhang, W., and Li, X. (2025). Global, regional, national epidemiology and trends of Parkinson\u2019s disease from 1990 to 2021: Findings from the Global Burden of Disease Study 2021. Front. Aging Neurosci., 16.","DOI":"10.3389\/fnagi.2024.1498756"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e080952","DOI":"10.1136\/bmj-2024-080952","article-title":"Projections for prevalence of Parkinson\u2019s disease and its driving factors in 195 countries and territories to 2050: Modelling study of Global Burden of Disease Study 2021","volume":"388","author":"Su","year":"2025","journal-title":"BMJ"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/s41531-023-00523-y","article-title":"Care access and utilization among medicare beneficiaries living with Parkinson\u2019s disease","volume":"9","author":"Pearson","year":"2023","journal-title":"npj Park. Dis."},{"key":"ref_32","first-page":"135","article-title":"Delivering multidisciplinary rehabilitation Care in Parkinson\u2019s disease: An international consensus statement","volume":"14","author":"Goldman","year":"2024","journal-title":"J. Park. Dis."},{"key":"ref_33","first-page":"1087","article-title":"Recommendations for the Organization of Multidisciplinary Clinical Care Teams in Parkinson\u2019s Disease","volume":"10","author":"Radder","year":"2020","journal-title":"J. Park. Dis."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/BF02816113","article-title":"Biochemistry of Parkinson\u2019s disease with special reference to the dopaminergic systems","volume":"9","author":"Hirsch","year":"1994","journal-title":"Mol. Neurobiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.tins.2007.03.002","article-title":"Dopamine: 50 years in perspective","volume":"30","author":"Iversen","year":"2007","journal-title":"Trends Neurosci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4172\/2471-271X.1000120","article-title":"Dopamine: Receptors, functions, synthesis, pathways, locations and mental disorders: Review of literatures","volume":"2","author":"Ayano","year":"2016","journal-title":"J. Ment. Disord. Treat."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"S64","DOI":"10.1016\/S1471-1931(00)00019-7","article-title":"Molecular effects of dopamine on striatal-projection pathways","volume":"23","author":"Gerfen","year":"2000","journal-title":"Trends Neurosci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.neuroscience.2014.10.008","article-title":"The place of dopamine in the cortico-basal ganglia circuit","volume":"282","author":"Haber","year":"2014","journal-title":"Neuroscience"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s10571-018-0632-3","article-title":"Dopamine: Functions, signaling, and association with neurological diseases","volume":"39","author":"Klein","year":"2019","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1001\/archneur.61.5.641","article-title":"The neurobiology of dopamine signaling","volume":"61","author":"Girault","year":"2004","journal-title":"Arch. Neurol."},{"key":"ref_41","first-page":"17","article-title":"The nigrostriatal system in Parkinson\u2019s disease","volume":"53","author":"Graybiel","year":"1990","journal-title":"Adv. Neurol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/nrd.2017.178","article-title":"Trends in GPCR drug discovery: New agents, targets and indications","volume":"16","author":"Hauser","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"101760","DOI":"10.1016\/j.xcrm.2024.101760","article-title":"The penetration of therapeutics across the blood-brain barrier: Classic case studies and clinical implications","volume":"5","author":"Banks","year":"2024","journal-title":"Cell Rep. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"5692","DOI":"10.1038\/277093a0","article-title":"Multiple receptors for dopamine","volume":"277","author":"Kebabian","year":"1979","journal-title":"Nature"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1152\/physrev.1998.78.1.189","article-title":"Dopamine receptors: From structure to function","volume":"8","author":"Missale","year":"1998","journal-title":"Physiol. Rev."},{"key":"ref_46","unstructured":"Rubenstein, J.L.R., and Rakic, P. (2013). Chapter 23\u2014The Generation of Midbrain Dopaminergic Neurons. Patterning and Cell Type Specification in the Developing CNS and PNS, Academic Press."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/nature11466","article-title":"Dopaminergic neurons inhibit striatal output through non-canonical release of GABA","volume":"490","author":"Tritsch","year":"2012","journal-title":"Nature"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0166-2236(90)90106-K","article-title":"The neural network of the basal ganglia as revealed by the study of synaptic connections of identified neurones","volume":"13","year":"1990","journal-title":"Trends Neurosci."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Giovanni, G., Di Matteo, V., and Esposito, E. (2009). The Nigrostriatal Pathway: Axonal Collateralization and Compartmental Specificity. Birth, Life and Death of Dopaminergic Neurons in the Substantia Nigra, Springer.","DOI":"10.1007\/978-3-211-92660-4"},{"key":"ref_50","unstructured":"Young, C.B., Reddy, V., and Sonne, J. (2023). Neuroanatomy, basal ganglia. StatPearls [internet], StatPearls Publishing."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.neuron.2006.09.006","article-title":"Leptin regulation of the mesoaccumbens dopamine pathway","volume":"51","author":"Fulton","year":"2006","journal-title":"Neuron"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"S136","DOI":"10.1038\/sj.bjp.0706473","article-title":"Dopamine: The rewarding years","volume":"147","author":"Marsden","year":"2006","journal-title":"Br. J. Pharmacol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/ADM.0b013e31819a86f7","article-title":"Imaging of brain dopamine pathways: Implications for understanding obesity","volume":"3","author":"Wang","year":"2009","journal-title":"J. Addctn. Med."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"DeYoung, C.G. (2013). The neuromodulator of exploration: A unifying theory of the role of dopamine in personality. Front. Hum. Neurosci., 7.","DOI":"10.3389\/fnhum.2013.00762"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/0166-2236(86)90065-2","article-title":"Dopamine: A retinal neuromodulator?","volume":"9","author":"Dowling","year":"1986","journal-title":"Trends Neurosci."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Speranza, L., Di Porzio, U., Viggiano, D., de Donato, A., and Volpicelli, F. (2021). Dopamine: The neuromodulator of long-term synaptic plasticity, reward and movement control. Cells, 10.","DOI":"10.3390\/cells10040735"},{"key":"ref_57","unstructured":"Church, F.C. (2026, April 12). The Complex Role of Neurotransmitters in Parkinson\u2019s. Available online: https:\/\/journeywithparkinsons.com\/2022\/12\/22\/the-complex-role-of-neurotransmitters-in-parkinsons\/."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Chang, E.H. (2024). Bridging complexity through integrative systems neuroscience. Front. Syst. Biol., 4.","DOI":"10.3389\/fsysb.2024.1487298"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.conb.2015.04.003","article-title":"On simplicity and complexity in the brave new world of large-scale neuroscience","volume":"32","author":"Gao","year":"2015","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/nn.4502","article-title":"Network neuroscience","volume":"20","author":"Bassett","year":"2017","journal-title":"Nat. Neurosci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0165-0173(98)00019-8","article-title":"What is the role of dopamine in reward: Hedonic impact, reward learning, or incentive salience?","volume":"28","author":"Berridge","year":"1998","journal-title":"Brain Res. Rev."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.neuron.2010.11.022","article-title":"Dopamine in motivational control: Rewarding, aversive, and alerting","volume":"68","author":"Matsumoto","year":"2010","journal-title":"Neuron"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/nature18942","article-title":"Rapid signalling in distinct dopaminergic axons during locomotion and reward","volume":"535","author":"Howe","year":"2016","journal-title":"Nature"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.bandc.2009.10.013","article-title":"Developmental changes in dopamine neurotransmission in adolescence: Behavioral implications and issues in assessment","volume":"72","author":"Wahlstrom","year":"2010","journal-title":"Brain Cogn."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.tics.2013.04.001","article-title":"Aversive stimuli and loss in the mesocorticolimbic dopamine system","volume":"17","author":"Brooks","year":"2013","journal-title":"Trends Cogn. Sci."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1007\/s12035-012-8369-3","article-title":"The central theme of Parkinson\u2019s disease: \u03b1-synuclein","volume":"47","author":"Ozansoy","year":"2013","journal-title":"Mol. Neurobiol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/s41593-024-01866-2","article-title":"Propagation of pathologic \u03b1-synuclein from kidney to brain may contribute to Parkinson\u2019s disease","volume":"28","author":"Yuan","year":"2025","journal-title":"Nat. Neurosci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/s41582-024-01043-w","article-title":"\u03b1-Synuclein pathology as a target in neurodegenerative diseases","volume":"21","author":"Park","year":"2025","journal-title":"Nat. Rev. Neurol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"105760","DOI":"10.1016\/j.neuint.2024.105760","article-title":"The misfolding mystery: \u03b1-synuclein and the pathogenesis of Parkinson\u2019s disease","volume":"177","author":"Negi","year":"2024","journal-title":"Neurochem. Int."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1002\/mds.22956","article-title":"Who was the man who discovered the \u201cLewy bodies\u201d?","volume":"25","author":"Geldsetzer","year":"2010","journal-title":"Mov. Disord."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0140-6736(23)01478-2","article-title":"The pathogenesis of Parkinson\u2019s disease","volume":"403","author":"Morris","year":"2024","journal-title":"Lancet"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"127","DOI":"10.14802\/jmd.24075","article-title":"\u03b1-Synuclein: A promising biomarker for Parkinson\u2019s disease and related disorders","volume":"17","author":"Hatano","year":"2024","journal-title":"J. Mov. Disord."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/s41419-023-05672-9","article-title":"Alpha-synuclein in Parkinson\u2019s disease and other synucleinopathies: From overt neurodegeneration back to early synaptic dysfunction","volume":"14","author":"Calabresi","year":"2023","journal-title":"Cell Death Dis."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/s41531-022-00357-0","article-title":"Opportunities and challenges of alpha-synuclein as a potential biomarker for Parkinson\u2019s disease and other synucleinopathies","volume":"8","author":"Lashuel","year":"2022","journal-title":"npj Park. Dis."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1126\/science.276.5321.2045","article-title":"Mutation in the \u03b1-synuclein gene identified in families with Parkinson\u2019s disease","volume":"276","author":"Polymeropoulos","year":"1997","journal-title":"Science"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/42166","article-title":"\u03b1-Synuclein in Lewy bodies","volume":"388","author":"Spillantini","year":"1997","journal-title":"Nature"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1126\/science.1195227","article-title":"\u03b1-Synuclein promotes SNARE-complex assembly in vivo and in vitro","volume":"329","author":"Sharma","year":"2010","journal-title":"Science"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"11113","DOI":"10.1073\/pnas.1903049116","article-title":"Functional cooperation of \u03b1-synuclein and VAMP2 in synaptic vesicle recycling","volume":"116","author":"Sun","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"a024091","DOI":"10.1101\/cshperspect.a024091","article-title":"Cell biology and pathophysiology of \u03b1-synuclein","volume":"8","author":"Sharma","year":"2018","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nature10324","article-title":"\u03b1-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation","volume":"477","author":"Bartels","year":"2011","journal-title":"Nature"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/s41531-022-00423-7","article-title":"Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson\u2019s disease in midbrain dopaminergic neurons","volume":"8","author":"Virdi","year":"2022","journal-title":"npj Park. Dis."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/s00702-023-02730-6","article-title":"Toxic interactions between dopamine, \u03b1-synuclein, monoamine oxidase, and genes in mitochondria of Parkinson\u2019s disease","volume":"131","author":"Naoi","year":"2024","journal-title":"J. Neural Transm."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1002\/mds.27823","article-title":"Neuronal vulnerability in Parkinson disease: Should the focus be on axons and synaptic terminals?","volume":"34","author":"Wong","year":"2019","journal-title":"Mov. Disord."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"R183","DOI":"10.1093\/hmg\/ddm159","article-title":"Parkinson\u2019s disease","volume":"16","author":"Thomas","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.mcp.2016.11.001","article-title":"Genetics of Parkinson\u2019s disease","volume":"30","author":"Lill","year":"2016","journal-title":"Mol. Cell. Probes"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S1474-4422(19)30287-X","article-title":"The genetic architecture of Parkinson\u2019s disease","volume":"19","author":"Blauwendraat","year":"2020","journal-title":"Lancet Neurol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nrneurol.2013.132","article-title":"Advances in the genetics of Parkinson disease","volume":"9","author":"Trinh","year":"2013","journal-title":"Nat. Rev. Neurol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1002\/mds.25132","article-title":"Systematic review and UK-based study of PARK2 (parkin), PINK1, PARK7 (DJ-1) and LRRK2 in early-onset Parkinson\u2019s disease","volume":"27","author":"Kilarski","year":"2012","journal-title":"Mov. Disord."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.neuron.2014.12.007","article-title":"The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson\u2019s disease","volume":"85","author":"Pickrell","year":"2015","journal-title":"Neuron"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/ana.10675","article-title":"The role of pathogenic DJ-1 mutations in Parkinson\u2019s disease","volume":"54","author":"Healy","year":"2003","journal-title":"Ann. Neurol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/S1474-4422(19)30320-5","article-title":"Identification of novel risk loci, causal insights, and heritable risk for Parkinson\u2019s disease: A meta-analysis of genome-wide association studies","volume":"18","author":"Nalls","year":"2019","journal-title":"Lancet Neurol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1002\/mds.26071","article-title":"GBA-associated Parkinson\u2019s disease: Reduced survival and more rapid progression in a prospective longitudinal study","volume":"30","author":"Brockmann","year":"2015","journal-title":"Mov. Disord."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Smith, L., and Schapira, A.H. (2022). GBA variants and Parkinson disease: Mechanisms and treatments. Cells, 11.","DOI":"10.3390\/cells11081261"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.brainres.2018.01.010","article-title":"Parkinson\u2019s disease from the gut","volume":"1693","author":"Liddle","year":"2018","journal-title":"Brain Res."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/nrneurol.2015.197","article-title":"Pathogenesis of Parkinson disease\u2014The gut\u2013brain axis and environmental factors","volume":"11","author":"Klingelhoefer","year":"2015","journal-title":"Nat. Rev. Neurol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41531-016-0002-0","article-title":"The gut-brain axis: Is intestinal inflammation a silent driver of Parkinson\u2019s disease pathogenesis?","volume":"3","author":"Houser","year":"2017","journal-title":"npj Park. Dis."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.4103\/1673-5374.373673","article-title":"Gut-microbiome-brain axis: The crosstalk between the vagus nerve, alpha-synuclein and the brain in Parkinson\u2019s disease","volume":"18","author":"Oliveira","year":"2023","journal-title":"Neural Regen. Res."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1002\/mdc3.12840","article-title":"Gut vibes in Parkinson\u2019s Disease: The microbiota-gut-brain axis","volume":"6","author":"Bullich","year":"2019","journal-title":"Mov. Disord. Clin. Pract."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"e12760","DOI":"10.1111\/nan.12760","article-title":"Impaired brain insulin signalling in Parkinson\u2019s disease","volume":"48","author":"Bassil","year":"2022","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1007\/s00415-019-09321-0","article-title":"Is Parkinson\u2019s disease a chronic low-grade inflammatory bowel disease?","volume":"267","author":"Bourreille","year":"2020","journal-title":"J. Neurol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/s41531-022-00295-x","article-title":"Gastrointestinal involvement in Parkinson\u2019s disease: Pathophysiology, diagnosis, and management","volume":"8","author":"Warnecke","year":"2022","journal-title":"npj Park. Dis."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/s43587-025-00818-0","article-title":"Large-scale proteomic analyses of incident Parkinson\u2019s disease reveal new pathophysiological insights and potential biomarkers","volume":"5","author":"Gan","year":"2025","journal-title":"Nat. Aging"},{"key":"ref_103","first-page":"2695","article-title":"The mitochondrial foundations of Parkinson\u2019s disease: Therapeutic implications","volume":"16","author":"Soman","year":"2025","journal-title":"Aging Dis."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/s41531-025-01130-9","article-title":"Resting and action tremor in Parkinson\u2019s disease: Pathophysiological insights from long-term STN-DBS","volume":"11","author":"Zampogna","year":"2025","journal-title":"npj Park. Dis."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1021\/acschemneuro.5c00809","article-title":"Neurotransmitter Dysregulation in Parkinson\u2019s Disease: Pathophysiological Insights and Therapeutic Perspectives","volume":"17","author":"Aslan","year":"2026","journal-title":"ACS Chem. Neurosci."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s00415-025-13138-5","article-title":"The gut\u2013brain axis in early Parkinson\u2019s disease: From prodrome to prevention","volume":"272","author":"Oliver","year":"2025","journal-title":"J. Neurol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"101719","DOI":"10.1016\/j.gendis.2025.101719","article-title":"Unraveling Parkinson\u2019s disease: The mystery of mitochondria and the role of aging","volume":"13","author":"Liu","year":"2025","journal-title":"Genes Dis."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1007\/s10753-024-02139-7","article-title":"The neuroprotective effects of agmatine on Parkinson\u2019s disease: Focus on oxidative stress, inflammation and molecular mechanisms","volume":"48","author":"Zamanian","year":"2025","journal-title":"Inflammation"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"a041774","DOI":"10.1101\/cshperspect.a041774","article-title":"Genetics of Parkinson\u2019s disease: From causes to treatment","volume":"15","author":"Westenberger","year":"2025","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/S1474-4422(25)00287-X","article-title":"Environmental toxicants and Parkinson\u2019s disease: Recent evidence, risks, and prevention opportunities","volume":"24","author":"Dorsey","year":"2025","journal-title":"Lancet Neurol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/s41582-025-01142-2","article-title":"Parkinson disease is a fatty acidopathy","volume":"21","author":"Fanning","year":"2025","journal-title":"Nat. Rev. Neurol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"4321","DOI":"10.1021\/jacsau.5c00694","article-title":"Stabilizing a Native Fold of Alpha-Synuclein with Short Helix-Constrained Peptides","volume":"5","author":"Meade","year":"2025","journal-title":"JACS Au"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"393","DOI":"10.7861\/clinmed.2020-0220","article-title":"Update on the diagnosis and management of Parkinson\u2019s disease","volume":"20","author":"Kobylecki","year":"2020","journal-title":"Clin. Med."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1503\/cmaj.151179","article-title":"An update on the diagnosis and treatment of Parkinson disease","volume":"188","author":"Rizek","year":"2016","journal-title":"Can. Med. Assoc. J."},{"key":"ref_115","first-page":"58","article-title":"Which clinical sign of Parkinson\u2019s disease best reflects the nigrostriatal lesion?","volume":"41","author":"Vingerhoets","year":"1997","journal-title":"Ann. Neurol. Off. J. Am. Neurol. Assoc. Child Neurol. Soc."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1002\/mds.23135","article-title":"Parkinson\u2019s disease symptoms: The patient\u2019s perspective","volume":"25","author":"Politis","year":"2010","journal-title":"Mov. Disord."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"21171","DOI":"10.1038\/s41598-024-71555-4","article-title":"Understanding what aspects of Parkinson\u2019s disease matter most to patients and families","volume":"14","author":"Mammen","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_118","first-page":"715","article-title":"People with Parkinson\u2019s disease: What symptoms do they most want to improve and how does this change with disease duration?","volume":"11","author":"Port","year":"2021","journal-title":"J. Park. Dis."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1002\/mds.20213","article-title":"Movement Disorder Society Task Force report on the Hoehn and Yahr staging scale: Status and recommendations the Movement Disorder Society Task Force on rating scales for Parkinson\u2019s disease","volume":"19","author":"Goetz","year":"2004","journal-title":"Mov. Disord."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1002\/mds.22340","article-title":"Movement Disorder Society-sponsored revision of the Unified Parkinson\u2019s Disease Rating Scale (MDS-UPDRS): Scale presentation and clinimetric testing results","volume":"23","author":"Goetz","year":"2008","journal-title":"Mov. Disord."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/S1474-4422(23)00405-2","article-title":"A biological definition of neuronal \u03b1-synuclein disease: Towards an integrated staging system for research","volume":"23","author":"Simuni","year":"2024","journal-title":"Lancet Neurol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S1474-4422(05)70285-4","article-title":"The diagnosis of Parkinson\u2019s disease","volume":"5","author":"Tolosa","year":"2006","journal-title":"Lancet Neurol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/ene.13412","article-title":"Atypical parkinsonian syndromes: A general neurologist\u2019s perspective","volume":"25","author":"Ross","year":"2018","journal-title":"Eur. J. Neurol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S1474-4422(21)00030-2","article-title":"Challenges in the diagnosis of Parkinson\u2019s disease","volume":"20","author":"Tolosa","year":"2021","journal-title":"Lancet Neurol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1097\/WCO.0b013e3283632da6","article-title":"Atypical parkinsonism: An update","volume":"26","author":"Stamelou","year":"2013","journal-title":"Curr. Opin. Neurol."},{"key":"ref_126","first-page":"61","article-title":"The differential diagnosis and treatment of atypical parkinsonism","volume":"113","author":"Levin","year":"2016","journal-title":"Dtsch. \u00c4rztebl. Int."},{"key":"ref_127","unstructured":"Curtin, S.C., Tejada-Vera, B., and Bastian, B.A. (2026, April 04). Deaths: Leading Causes for 2022. NCHS National Vital Statistics Reports, Available online: https:\/\/stacks.cdc.gov\/view\/cdc\/164020."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.4065\/mcp.2011.0443","article-title":"Cheaper, simpler, and better: Tips for treating seniors with Parkinson disease","volume":"86","author":"Ahlskog","year":"2011","journal-title":"Mayo Clin. Proc."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1016\/j.mayocp.2020.02.006","article-title":"Common Myths and Misconceptions That Sidetrack Parkinson Disease Treatment, to the Detriment of Patients","volume":"95","author":"Ahlskog","year":"2020","journal-title":"Mayo Clin. Proc."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.tem.2024.07.005","article-title":"Dopamine","volume":"36","author":"Zhou","year":"2025","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1056\/NEJM196902132800701","article-title":"Modification of Parkinsonism\u2014Chronic treatment with L-dopa","volume":"280","author":"Cotzias","year":"1969","journal-title":"N. Engl. J. Med."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/mds.26120","article-title":"Four pioneers of L-dopa treatment: Arvid Carlsson, Oleh Hornykiewicz, George Cotzias, and Melvin Yahr","volume":"30","author":"Lees","year":"2015","journal-title":"Mov. Disord."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1001\/jama.2014.3654","article-title":"Pharmacological treatment of Parkinson disease: A review","volume":"311","author":"Connolly","year":"2014","journal-title":"JAMA"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/mds.26016","article-title":"Clinical spectrum of impulse control disorders in Parkinson\u2019s disease","volume":"30","author":"Weintraub","year":"2015","journal-title":"Mov. Disord."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/S1471-1931(00)00031-8","article-title":"Levodopa motor complications in Parkinson\u2019s disease","volume":"23","author":"Obeso","year":"2000","journal-title":"Trends Neurosci."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1007\/s00702-025-02893-4","article-title":"Levodopa treatment: Impacts and mechanisms throughout Parkinson\u2019s disease progression","volume":"132","author":"Riederer","year":"2025","journal-title":"J. Neural Transm."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.pneurobio.2015.07.002","article-title":"Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson\u2019s disease","volume":"132","author":"Bastide","year":"2015","journal-title":"Prog. Neurobiol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/nrn2471","article-title":"Molecular mechanisms of L-DOPA-induced dyskinesia","volume":"9","author":"Jenner","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.nbd.2003.07.003","article-title":"Levodopa-induced motor complications are associated with alterations of glutamate receptors in Parkinson\u2019s disease","volume":"14","author":"Calon","year":"2003","journal-title":"Neurobiol. Dis."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1002\/mds.29415","article-title":"Adaptive deep brain stimulation: From experimental evidence toward practical implementation","volume":"38","author":"Neumann","year":"2023","journal-title":"Mov. Disord."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/bs.irn.2017.01.002","article-title":"Treatment strategies in early Parkinson\u2019s disease","volume":"132","author":"Marsili","year":"2017","journal-title":"Int. Rev. Neurobiol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.ncl.2024.12.010","article-title":"Treatment of Motor Symptoms of Parkinson\u2019s Disease","volume":"43","author":"Marsili","year":"2025","journal-title":"Neurol. Clin."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1007\/s00702-018-1869-1","article-title":"Efficacy and safety of amantadine for the treatment of L-DOPA-induced dyskinesia","volume":"125","author":"Rascol","year":"2018","journal-title":"J. Neural Transm."},{"key":"ref_144","first-page":"282","article-title":"Docosahexaenoic acid reduces levodopa-induced dyskinesias in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine monkeys","volume":"59","author":"Samadi","year":"2006","journal-title":"Ann. Neurol. Off. J. Am. Neurol. Assoc. Child Neurol. Soc."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.arr.2011.03.001","article-title":"Impact of omega-3 fatty acids in Parkinson\u2019s disease","volume":"10","author":"Bousquet","year":"2011","journal-title":"Ageing Res. Rev."},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Conde, C.I., Lang, C., Baumann, C.R., Easthope, C.A., Taylor, W.R., and Ravi, D.K. (2023). Triggers for freezing of gait in individuals with Parkinson\u2019s disease: A systematic review. Front. Neurol., 14.","DOI":"10.3389\/fneur.2023.1326300"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.neubiorev.2016.01.002","article-title":"Gait in Parkinson\u2019s disease: A visuo-cognitive challenge","volume":"62","author":"Stuart","year":"2016","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_148","first-page":"282","article-title":"A possible pathway to freezing of gait in Parkinson\u2019s disease","volume":"15","author":"Factor","year":"2025","journal-title":"J. Park. Dis."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"105068","DOI":"10.1016\/j.neubiorev.2023.105068","article-title":"Cognition and freezing of gait in Parkinson\u2019s disease: A systematic review and meta-analysis","volume":"147","author":"Monaghan","year":"2023","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_150","first-page":"2","article-title":"Neuropathology of Autonomic Nervous System in","volume":"38","year":"1997","journal-title":"Eur. Neurol."},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Xu, H., Zheng, X., Xing, X., Bi, Z., Wang, D., Zhang, C., Wei, L., Jin, Y., and Xu, S. (2025). Advances in autonomic dysfunction research in Parkinson\u2019s disease. Front. Aging Neurosci., 17.","DOI":"10.3389\/fnagi.2025.1468895"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"s32","DOI":"10.1007\/s100720300035","article-title":"Autonomic dysfunction in Parkinson\u2019s disease","volume":"24","author":"Micieli","year":"2003","journal-title":"Neurol. Sci."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"106249","DOI":"10.1016\/j.clineuro.2020.106249","article-title":"Effectiveness of expiratory flow acceleration in patients with Parkinson\u2019s disease and swallowing deficiency: A preliminary study","volume":"199","author":"Riboldazzi","year":"2020","journal-title":"Clin. Neurol. Neurosurg."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"153","DOI":"10.4103\/AOMD.AOMD_9_22","article-title":"Treatment of sialorrhea in Parkinson\u2019s disease","volume":"5","author":"Mehta","year":"2022","journal-title":"Ann. Mov. Disord."},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Skj\u00e6rb\u00e6k, C., Knudsen, K., Horsager, J., and Borghammer, P. (2021). Gastrointestinal Dysfunction in Parkinson\u2019s Disease. J. Clin. Med., 10.","DOI":"10.3390\/jcm10030493"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1093\/ajh\/hpaa131","article-title":"Neurogenic Orthostatic Hypotension. Lessons From Synucleinopathies","volume":"34","author":"Idiaquez","year":"2021","journal-title":"Am. J. Hypertens."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s11255-011-9969-y","article-title":"Urinary tract dysfunction in Parkinson\u2019s disease: A review","volume":"44","author":"Yeo","year":"2012","journal-title":"Int. Urol. Nephrol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1111\/ene.12260","article-title":"How pain arises in Parkinson\u2019s disease?","volume":"20","author":"Defazio","year":"2013","journal-title":"Eur. J. Neurol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1146\/annurev.med.49.1.123","article-title":"Chronic pain","volume":"49","author":"Russo","year":"1998","journal-title":"Annu. Rev. Med."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.pneurobio.2008.09.018","article-title":"Towards a theory of chronic pain","volume":"87","author":"Apkarian","year":"2009","journal-title":"Prog. Neurobiol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.pnpbp.2017.10.010","article-title":"Chronic pain and pain processing in Parkinson\u2019s disease","volume":"87","author":"Blanchet","year":"2018","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1002\/mds.23959","article-title":"Pain in Parkinson\u2019s disease","volume":"27","author":"Ha","year":"2012","journal-title":"Mov. Disord."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"S98","DOI":"10.1002\/mds.22716","article-title":"Pain in Parkinson\u2019s disease","volume":"25","author":"Ford","year":"2010","journal-title":"Mov. Disord."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S1474-4422(25)00033-X","article-title":"Advances in diagnosis, classification, and management of pain in Parkinson\u2019s disease","volume":"24","author":"Tinazzi","year":"2025","journal-title":"Lancet Neurol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3390\/neurolint12030014","article-title":"Chronic pain treatment strategies in Parkinson\u2019s disease","volume":"12","author":"Edinoff","year":"2020","journal-title":"Neurol. Int."},{"key":"ref_166","first-page":"1","article-title":"An overview of pain in Parkinson\u2019s disease","volume":"2","author":"Tai","year":"2020","journal-title":"Clin. Park. Relat. Disord."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1111\/ene.13323","article-title":"Relationship between pain and motor and non-motor symptoms in Parkinson\u2019s disease","volume":"24","author":"Defazio","year":"2017","journal-title":"Eur. J. Neurol."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1517\/14728214.2012.677949","article-title":"Emerging analgesic drugs for Parkinson\u2019s disease","volume":"17","author":"Rey","year":"2012","journal-title":"Expert Opin. Emerg. Drugs"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s11910-016-0628-7","article-title":"Integrated approach for pain management in Parkinson disease","volume":"16","author":"Geroin","year":"2016","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.jpainsymman.2006.05.020","article-title":"A survey of pain in idiopathic Parkinson\u2019s disease","volume":"32","author":"Lee","year":"2006","journal-title":"J. Pain Symptom Manag."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.parkreldis.2013.03.002","article-title":"Musculoskeletal problems in Parkinson\u2019s disease: Neglected issues","volume":"19","author":"Kim","year":"2013","journal-title":"Park. Relat. Disord."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.pain.2008.12.004","article-title":"Pain in Parkinson\u2019s disease: Prevalence and characteristics","volume":"141","author":"Beiske","year":"2009","journal-title":"Pain"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.ncl.2024.12.008","article-title":"Non-motor symptoms and treatments in Parkinson\u2019s disease","volume":"43","author":"Goldman","year":"2025","journal-title":"Neurol. Clin."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s00702-025-02963-7","article-title":"Parkinson\u2019s Disease Multidisciplinary Complex Therapy (PD-MCT): Appreciation of its current function for the treatment of people with Parkinson\u2019s disease in Germany and the needs of future development","volume":"133","author":"Scherbaum","year":"2026","journal-title":"J. Neural Transm."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1016\/j.ymthe.2025.03.030","article-title":"Recent developments in gene therapy for Parkinson\u2019s disease","volume":"33","author":"Szunyogh","year":"2025","journal-title":"Mol. Ther."},{"key":"ref_176","doi-asserted-by":"crossref","unstructured":"W\u00f3jcik, R., D\u0119bska, A., Zaczkowski, K., Szmyd, B., Podstawka, M., Bobeff, E.J., Piotrowski, M., Ratajczyk, P., Jask\u00f3lski, D.J., and Wi\u015bniewski, K. (2025). Deep brain stimulation for Parkinson\u2019s disease\u2014A narrative review. Biomedicines, 13.","DOI":"10.3390\/biomedicines13102430"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s00702-025-02990-4","article-title":"Motor and non-motor fluctuations in Parkinson\u2019s disease: The knowns and unknowns of current therapeutic approaches","volume":"133","author":"Regensburger","year":"2026","journal-title":"J. Neural Transm."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1007\/s40120-025-00800-3","article-title":"Update on the Present and Future Pharmacologic Treatment of Parkinson\u2019s Disease","volume":"14","year":"2025","journal-title":"Neurol. Ther."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s00702-025-03059-y","article-title":"Lifestyle medicine in Parkinson\u2019s disease","volume":"133","author":"Regensburger","year":"2026","journal-title":"J. Neural Transm."},{"key":"ref_180","first-page":"899","article-title":"Parkinson\u2019s Disease Drug Therapies in the Clinical Trial Pipeline: 2024 Update","volume":"14","author":"McFarthing","year":"2024","journal-title":"J. Park. Dis."},{"key":"ref_181","doi-asserted-by":"crossref","unstructured":"Bougea, A. (2024). Some Novel Therapies in Parkinson\u2019s Disease: A Promising Path Forward or Not Yet? A Systematic Review of the Literature. Biomedicines, 12.","DOI":"10.3390\/biomedicines12030549"},{"key":"ref_182","first-page":"e87309","article-title":"Innovations in Parkinson\u2019s Disease: Strategies and Novel Technologies","volume":"17","author":"Sha","year":"2025","journal-title":"Cureus"},{"key":"ref_183","first-page":"001","article-title":"Assisted technology in Parkinson\u2019s disease gait: What\u2019s up?","volume":"82","author":"Capato","year":"2024","journal-title":"Arq. de. Neuro-Psiquiatr."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1002\/mdc3.70144","article-title":"Management of Anxiety in Parkinson\u2019s Disease","volume":"12","author":"Berry","year":"2025","journal-title":"Mov. Disord. Clin. Pract."},{"key":"ref_185","first-page":"42","article-title":"Anxiety disorders in Parkinson\u2019s disease","volume":"96","author":"Richard","year":"2005","journal-title":"Behav. Neurol. Mov. Disord."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1136\/pmj.77.904.89","article-title":"Parkinson\u2019s disease and anxiety","volume":"77","author":"Walsh","year":"2001","journal-title":"Postgrad. Med. J."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/nrn.2017.62","article-title":"Non-motor features of Parkinson disease","volume":"18","author":"Schapira","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1093\/brain\/awh445","article-title":"Depression in Parkinson\u2019s disease: Loss of dopamine and noradrenaline innervation in the limbic system","volume":"128","author":"Remy","year":"2005","journal-title":"Brain"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jad.2011.07.002","article-title":"Is depression in Parkinson\u2019s disease (PD) a specific entity?","volume":"139","author":"Even","year":"2012","journal-title":"J. Affect. Disord."},{"key":"ref_190","doi-asserted-by":"crossref","unstructured":"Liu, J., Dong, J., Wang, L., Su, Y., Yan, P., and Sun, S. (2013). Comparative efficacy and acceptability of antidepressants in Parkinson\u2019s disease: A network meta-analysis. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0076651"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/mds.27602","article-title":"Update on treatments for nonmotor symptoms of Parkinson\u2019s disease\u2014An evidence-based medicine review","volume":"34","author":"Seppi","year":"2019","journal-title":"Mov. Disord."},{"key":"ref_192","first-page":"395","article-title":"Antidepressants in Parkinson\u2019s disease. Recommendations by the movement disorder study group of the Neurological Association of Madrid","volume":"33","author":"Mata","year":"2018","journal-title":"Neurolog\u00eda"},{"key":"ref_193","doi-asserted-by":"crossref","unstructured":"B\u00e9reau, M., Van Waes, V., Servant, M., Magnin, E., Tatu, L., and Anheim, M. (2023). Apathy in Parkinson\u2019s Disease: Clinical Patterns and Neurobiological Basis. Cells, 12.","DOI":"10.3390\/cells12121599"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"e209699","DOI":"10.1212\/WNL.0000000000209699","article-title":"Long-Term Dementia Risk in Parkinson Disease","volume":"103","author":"Gallagher","year":"2024","journal-title":"Neurology"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/s41582-023-00918-8","article-title":"Parkinson disease psychosis: From phenomenology to neurobiological mechanisms","volume":"20","author":"Pagonabarraga","year":"2024","journal-title":"Nat. Rev. Neurol."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.5498\/wjp.v12.i9.1127","article-title":"Emerging role of psychosis in Parkinson\u2019s disease: From clinical relevance to molecular mechanisms","volume":"12","author":"Zhang","year":"2022","journal-title":"World J. Psychiatry"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1007\/s40266-016-0416-8","article-title":"Psychosis in Parkinson Disease: A Review of Etiology, Phenomenology, and Management","volume":"33","author":"Samudra","year":"2016","journal-title":"Drugs Aging"},{"key":"ref_198","doi-asserted-by":"crossref","unstructured":"Zhang, J.-F., Wang, X.-X., Feng, Y., Fekete, R., Jankovic, J., and Wu, Y.-C. (2021). Impulse Control Disorders in Parkinson\u2019s Disease: Epidemiology, Pathogenesis and Therapeutic Strategies. Front. Psychiatry, 12.","DOI":"10.3389\/fpsyt.2021.635494"},{"key":"ref_199","first-page":"625","article-title":"Apathy and impulse control disorders: Yin & yang of dopamine dependent behaviors","volume":"5","author":"Sierra","year":"2015","journal-title":"J. Park. Dis."},{"key":"ref_200","doi-asserted-by":"crossref","unstructured":"Augustine, A., Winstanley, C.A., and Krishnan, V. (2021). Impulse Control Disorders in Parkinson\u2019s Disease: From Bench to Bedside. Front. Neurosci., 15.","DOI":"10.3389\/fnins.2021.654238"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/s40266-013-0090-z","article-title":"Dopamine agonist withdrawal syndrome: Implications for patient care","volume":"30","author":"Nirenberg","year":"2013","journal-title":"Drugs Aging"},{"key":"ref_202","first-page":"889","article-title":"The Last Straw: How Stress Can Unmask Parkinson\u2019s Disease","volume":"14","author":"Trenkwalder","year":"2024","journal-title":"J. Park. Dis."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/jnp.12028","article-title":"Executive dysfunction in Parkinson\u2019s disease: A review","volume":"7","author":"Dirnberger","year":"2013","journal-title":"J. Neuropsychol."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41572-021-00280-3","article-title":"Parkinson disease-associated cognitive impairment","volume":"7","author":"Aarsland","year":"2021","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_205","first-page":"2076942","article-title":"Cognition Deficits in Parkinson\u2019s Disease: Mechanisms and Treatment","volume":"2020","author":"Fang","year":"2020","journal-title":"Park. Dis."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/PL00007725","article-title":"Cognitive deficits in Parkinson\u2019s disease","volume":"244","author":"Dubois","year":"1996","journal-title":"J. Neurol."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1212\/WNL.43.10.2016","article-title":"Fatigue in Parkinson\u2019s disease","volume":"43","author":"Friedman","year":"1993","journal-title":"Neurology"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/mds.26077","article-title":"The Onset of Nonmotor Symptoms in Parkinson\u2019s Disease (The ONSET PD Study)","volume":"30","author":"Hotter","year":"2015","journal-title":"Mov. Disord."},{"key":"ref_209","first-page":"100288","article-title":"Exploring the layers of fatigue in Parkinson\u2019s Disease: A comprehensive analysis of its prevalence and contributing factors","volume":"11","author":"Sarmento","year":"2024","journal-title":"Clin. Park. Relat. Disord."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/mdc3.12343","article-title":"The pathophysiology of fatigue in Parkinson\u2019s disease and its pragmatic management","volume":"3","year":"2016","journal-title":"Mov. Disord. Clin. Pract."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"157","DOI":"10.4103\/aomd.aomd_99_24","article-title":"Fatigue in Parkinson\u2019s disease\u2014A narrative review","volume":"7","author":"Panigrahi","year":"2024","journal-title":"Ann. Mov. Disord."},{"key":"ref_212","first-page":"659","article-title":"Physical exercise as a potential treatment for fatigue in Parkinson\u2019s disease? A systematic review and meta-analysis of pharmacological and non-pharmacological interventions","volume":"13","author":"Folkerts","year":"2023","journal-title":"J. Park. Dis."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/ene.12205","article-title":"Benefits of treatment with rasagiline for fatigue symptoms in patients with early P arkinson\u2019s disease","volume":"21","author":"Stocchi","year":"2014","journal-title":"Eur. J. Neurol."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1002\/mds.10505","article-title":"Levodopa improves physical fatigue in Parkinson\u2019s disease: A double-blind, placebo-controlled, crossover study","volume":"18","author":"Lou","year":"2003","journal-title":"Mov. Disord."},{"key":"ref_215","first-page":"CD010925","article-title":"Interventions for fatigue in Parkinson\u2019s disease","volume":"10","author":"Elbers","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_216","doi-asserted-by":"crossref","unstructured":"Barnish, M., Sheikh, M., and Scholey, A. (2023). Nutrient therapy for the improvement of fatigue symptoms. Nutrients, 15.","DOI":"10.3390\/nu15092154"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"e209609","DOI":"10.1212\/WNL.0000000000209609","article-title":"The Parkinson\u2019s Disease Composite of Executive Functioning: A Measure for Detecting Cognitive Decline in Clinical Trials","volume":"103","author":"Young","year":"2024","journal-title":"Neurology"},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"102207","DOI":"10.1016\/j.arr.2024.102207","article-title":"Neural alterations underlying executive dysfunction in Parkinson\u2019s disease: A systematic review and coordinate-based meta-analysis of functional neuroimaging studies","volume":"95","author":"Arrigoni","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"ref_219","unstructured":"Brown, B.B., and Prinstein, M.J. (2011). Executive Function. Encyclopedia of Adolescence, Academic Press."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1146\/annurev-psych-113011-143750","article-title":"Executive functions","volume":"64","author":"Diamond","year":"2013","journal-title":"Annu. Rev. Psychol."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1177\/0891988709358590","article-title":"Contemporary review 2009: Cognitive aging","volume":"23","author":"Drag","year":"2010","journal-title":"J. Geriatr. Psychiatry Neurol."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1111\/j.1532-5415.2012.04209.x","article-title":"Gait and Cognition: A Complementary Approach to Understanding Brain Function and the Risk of Falling","volume":"60","author":"Verghese","year":"2012","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.pbb.2013.08.007","article-title":"The neural and genetic basis of executive function: Attention, cognitive flexibility, and response inhibition","volume":"123","author":"Logue","year":"2014","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.4103\/1673-5374.389631","article-title":"Dopamine in the prefrontal cortex plays multiple roles in the executive function of patients with Parkinson\u2019s disease","volume":"19","author":"Zhou","year":"2024","journal-title":"Neural Regen. Res."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/s41582-025-01163-x","article-title":"Characteristics and mechanisms of cognitive impairment in Parkinson disease","volume":"22","author":"Oikonomou","year":"2026","journal-title":"Nat. Rev. Neurol."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"afag063","DOI":"10.1093\/ageing\/afag063","article-title":"Best practice guidelines for the diagnosis, evaluation, and management of cognitive disorders in Parkinson\u2019s disease","volume":"55","author":"Pourzinal","year":"2026","journal-title":"Age Ageing"},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"17562864251336903","DOI":"10.1177\/17562864251336903","article-title":"Approaches for treating neuropsychiatric symptoms in Parkinson\u2019s disease: A narrative review","volume":"18","author":"Pagonabarraga","year":"2025","journal-title":"Ther. Adv. Neurol. Disord."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"17562864251356062","DOI":"10.1177\/17562864251356062","article-title":"Neuropsychiatric disorders in Parkinson\u2019s disease","volume":"18","author":"Heim","year":"2025","journal-title":"Ther. Adv. Neurol. Disord."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"13535","DOI":"10.1038\/s41598-025-98508-9","article-title":"Association between cognitive and autonomic dysfunctions in patients with de novo Parkinson\u2019s disease","volume":"15","author":"Joo","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_230","doi-asserted-by":"crossref","unstructured":"Falup-Pecurariu, C., Murasan, I., Monescu, V., Kakucs, C., and Diaconu, S. (2026). The Association of Anxiety and Depression with Sleep Disturbances in Parkinson\u2019s Disease. Brain Sci., 16.","DOI":"10.3390\/brainsci16020172"},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/S1474-4422(24)00170-4","article-title":"Sleep and sleep disorders in people with Parkinson\u2019s disease","volume":"23","author":"Iranzo","year":"2024","journal-title":"Lancet Neurol."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.2147\/NSS.S478860","article-title":"Sleep Disturbance in Parkinson\u2019s Disease: Consequences for the Brain and Disease Progression\u2013A Narrative Review","volume":"17","author":"Anderson","year":"2025","journal-title":"Nat. Sci. Sleep"},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1212\/WNL.0000000000003540","article-title":"Changes in insomnia subtypes in early Parkinson disease","volume":"88","author":"Tholfsen","year":"2017","journal-title":"Neurology"},{"key":"ref_234","doi-asserted-by":"crossref","unstructured":"Ma, H., Yan, J., Sun, W., Jiang, M., and Zhang, Y. (2022). Melatonin Treatment for Sleep Disorders in Parkinson\u2019s Disease: A Meta-Analysis and Systematic Review. Front. Aging Neurosci., 14.","DOI":"10.3389\/fnagi.2022.784314"},{"key":"ref_235","doi-asserted-by":"crossref","unstructured":"Trotti, L.M. (2019). Treatment of daytime sleepiness in Parkinson\u2019s disease. Therapy of Movement Disorders: A Case-Based Approach, Springer.","DOI":"10.1007\/978-3-319-97897-0_21"},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/s41531-020-00126-x","article-title":"Multiple comorbid sleep disorders adversely affect quality of life in Parkinson\u2019s disease patients","volume":"6","author":"Zhang","year":"2020","journal-title":"npj Park. Dis."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0140-6736(22)01018-2","article-title":"Understanding and approaching excessive daytime sleepiness","volume":"400","author":"Mignot","year":"2022","journal-title":"Lancet"},{"key":"ref_238","first-page":"2029","article-title":"Management of sleep disturbances in Parkinson\u2019s disease","volume":"12","author":"Hermann","year":"2022","journal-title":"J. Park. Dis."},{"key":"ref_239","first-page":"1","article-title":"Fighting against the clock: Circadian disruption and Parkinson\u2019s disease","volume":"17","author":"Chen","year":"2023","journal-title":"J. Mov. Disord."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.sleep.2021.06.023","article-title":"Circadian activity rhythm in Parkinson\u2019s disease: Findings from the PHASE study","volume":"85","author":"Obayashi","year":"2021","journal-title":"Sleep Med."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1056\/NEJMcp021288","article-title":"Restless legs syndrome","volume":"348","author":"Earley","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S1474-4422(05)70139-3","article-title":"The restless legs syndrome","volume":"4","author":"Trenkwalder","year":"2005","journal-title":"Lancet Neurol."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/s41572-021-00311-z","article-title":"Restless legs syndrome","volume":"7","author":"Manconi","year":"2021","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1212\/CON.0000000000000488","article-title":"Restless legs syndrome and sleep-related movement disorders","volume":"23","author":"Trotti","year":"2017","journal-title":"Continuum"},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1080\/00207454.2019.1608200","article-title":"Decreased serum ferritin may be associated with increased restless legs syndrome in Parkinson\u2019s disease (PD): A meta-analysis for the diagnosis of RLS in PD patients","volume":"129","author":"Li","year":"2019","journal-title":"Int. J. Neurosci."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/s41386-019-0448-y","article-title":"Sleep in Parkinson\u2019s disease","volume":"45","author":"Stefani","year":"2020","journal-title":"Neuropsychopharmacology"},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1002\/mds.28412","article-title":"Impact of obstructive sleep apnea on cognitive and motor functions in Parkinson\u2019s disease","volume":"36","author":"Elfil","year":"2021","journal-title":"Mov. Disord."},{"key":"ref_248","first-page":"zsx197","article-title":"Prevalence and determinants of rapid eye movement sleep behavior disorder in the general population","volume":"41","author":"Frauscher","year":"2018","journal-title":"Sleep"},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/S1474-4422(06)70441-0","article-title":"Rapid-eye-movement sleep behaviour disorder and neurodegenerative diseases","volume":"5","author":"Gagnon","year":"2006","journal-title":"Lancet Neurol."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"104996","DOI":"10.1016\/j.nbd.2020.104996","article-title":"REM sleep behavior disorder (RBD)","volume":"143","author":"Hu","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s10072-016-2744-1","article-title":"Prevalence of rapid eye movement sleep behavior disorder (RBD) in Parkinson\u2019s disease: A meta and meta-regression analysis","volume":"38","author":"Zhang","year":"2017","journal-title":"Neurol. Sci."},{"key":"ref_252","doi-asserted-by":"crossref","unstructured":"V\u00e1radi, C. (2020). Clinical features of Parkinson\u2019s disease: The evolution of critical symptoms. Biology, 9.","DOI":"10.3390\/biology9050103"},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1002\/mds.25086","article-title":"Rapid eye movement sleep behavior disorder and subtypes of Parkinson\u2019s disease","volume":"27","author":"Romenets","year":"2012","journal-title":"Mov. Disord."},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1136\/jnnp-2013-306104","article-title":"REM sleep behaviour disorder is associated with worse quality of life and other non-motor features in early Parkinson\u2019s disease","volume":"85","author":"Rolinski","year":"2014","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_255","doi-asserted-by":"crossref","unstructured":"Standards of Practice Committee, Aurora, R.N., Zak, R.S., Maganti, R.K., Auerbach, S.H., Casey, K.R., Chowdhuri, S., Karippot, A., Ramar, K., and Kristo, D.A. (2010). Best practice guide for the treatment of REM sleep behavior disorder (RBD). J. Clin. Sleep Med., 6, 85\u201395.","DOI":"10.5664\/jcsm.27717"},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/mdc3.14254","article-title":"Intersection of sleep disorders and Parkinson disease: Unveiling the bidirectional relationship","volume":"12","author":"Antelmi","year":"2025","journal-title":"Mov. Disord. Clin. Pract."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"132","DOI":"10.2174\/0118715273314675240820191447","article-title":"Sleep-related disorders in Parkinson\u2019s disease: Mechanisms, diagnosis, and therapeutic approaches","volume":"24","author":"Hamid","year":"2025","journal-title":"CNS Neurol. Disord.-Drug Targets"},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"zsae251","DOI":"10.1093\/sleep\/zsae251","article-title":"Glymphatic system, sleep, and Parkinson\u2019s disease: Interconnections, research opportunities, and potential for disease modification","volume":"48","author":"Nepozitek","year":"2025","journal-title":"Sleep"},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/s41591-020-01198-1","article-title":"Impaired meningeal lymphatic drainage in patients with idiopathic Parkinson\u2019s disease","volume":"27","author":"Ding","year":"2021","journal-title":"Nat. Med."},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/nrneurol.2017.157","article-title":"Idiopathic REM sleep behaviour disorder and neurodegeneration\u2014An update","volume":"14","author":"Stefani","year":"2018","journal-title":"Nat. Rev. Neurol."},{"key":"ref_261","doi-asserted-by":"crossref","unstructured":"Postuma, R.B., Gagnon, J.-F., and Montplaisir, J.Y. (2013). REM sleep behavior disorder and prodromal neurodegeneration\u2013where are we headed?. Tremor Other Hyperkinetic Mov., 3.","DOI":"10.5334\/tohm.171"},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1093\/sleep\/32.5.589","article-title":"Review of the relationship of restless legs syndrome and periodic limb movements in sleep to hypertension, heart disease, and stroke","volume":"32","author":"Walters","year":"2009","journal-title":"Sleep"},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jns.2018.08.007","article-title":"Restless legs syndrome, leg motor restlessness and their variants in patients with Parkinson\u2019s disease and related disorders","volume":"393","author":"Matsubara","year":"2018","journal-title":"J. Neurol. Sci."},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1001\/jamaneurol.2025.4691","article-title":"Obstructive Sleep Apnea, Positive Airway Pressure, and Implications of Early Treatment in Parkinson Disease","volume":"83","author":"Neilson","year":"2026","journal-title":"JAMA Neurol."},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"e70193","DOI":"10.1111\/jsr.70193","article-title":"The Effect of Deep Brain Stimulation on Sleep and Cognition in Patients With Parkinson\u2019s Disease","volume":"35","author":"Geurtsen","year":"2026","journal-title":"J. Sleep Res."},{"key":"ref_266","first-page":"1308","article-title":"Effects of physical activity on aging processes in elderly persons","volume":"19","author":"Andrieieva","year":"2019","journal-title":"J. Phys. Educ. Sport"},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s10522-016-9641-0","article-title":"Physical activity in older age: Perspectives for healthy ageing and frailty","volume":"17","author":"McPhee","year":"2016","journal-title":"Biogerontology"},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1742-1241.2008.01957.x","article-title":"Health benefits of physical activity in older patients: A review","volume":"63","author":"Vogel","year":"2009","journal-title":"Int. J. Clin. Pract."},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/gerona\/56.suppl_2.13","article-title":"Physical activity in aging: Changes in patterns and their relationship to health and function","volume":"56","author":"DiPietro","year":"2001","journal-title":"J. Gerontol. Ser. A Biol. Sci. Med. Sci."},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1001\/jama.2018.14854","article-title":"The physical activity guidelines for Americans","volume":"320","author":"Piercy","year":"2018","journal-title":"JAMA"},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1038\/s41374-019-0232-y","article-title":"The beneficial effects of physical exercise in the brain and related pathophysiological mechanisms in neurodegenerative diseases","volume":"99","author":"Liu","year":"2019","journal-title":"Lab. Investig."},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1089\/ars.2020.8075","article-title":"Preventive and therapeutic potential of physical exercise in neurodegenerative diseases","volume":"34","author":"Beleza","year":"2021","journal-title":"Antioxid. Redox Signal."},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"165778","DOI":"10.1016\/j.bbadis.2020.165778","article-title":"Exercise, redox system and neurodegenerative diseases","volume":"1866","author":"Quan","year":"2020","journal-title":"Biochim. Biophys. Acta (BBA) -Mol. Basis Dis."},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"104859","DOI":"10.1016\/j.nbd.2020.104859","article-title":"Effects of exercise on sleep in neurodegenerative disease","volume":"140","author":"Memon","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"ref_275","doi-asserted-by":"crossref","unstructured":"Far\u00ec, G., Lunetti, P., Pignatelli, G., Raele, M.V., Cera, A., Mintrone, G., Ranieri, M., Megna, M., and Capobianco, L. (2021). The effect of physical exercise on cognitive impairment in neurodegenerative disease: From pathophysiology to clinical and rehabilitative aspects. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222111632"},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.physio.2019.04.003","article-title":"The effect of exercise on high-level mobility in individuals with neurodegenerative disease: A systematic literature review","volume":"106","author":"Smith","year":"2020","journal-title":"Physiotherapy"},{"key":"ref_277","doi-asserted-by":"crossref","unstructured":"Lee, B., Shin, M., Park, Y., Won, S.-Y., and Cho, K.S. (2021). Physical exercise-induced myokines in neurodegenerative diseases. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22115795"},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"101108","DOI":"10.1016\/j.arr.2020.101108","article-title":"Exercise benefits on Alzheimer\u2019s disease: State-of-the-science","volume":"62","author":"Valenzuela","year":"2020","journal-title":"Ageing Res. Rev."},{"key":"ref_279","doi-asserted-by":"crossref","unstructured":"Gupta, R., Khan, R., and Cortes, C.J. (2021). Forgot to Exercise? Exercise Derived Circulating Myokines in Alzheimer\u2019s Disease: A Perspective. Front. Neurol., 12.","DOI":"10.3389\/fneur.2021.649452"},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s12974-023-02753-6","article-title":"Exercise suppresses neuroinflammation for alleviating Alzheimer\u2019s disease","volume":"20","author":"Wang","year":"2023","journal-title":"J. Neuroinflamm."},{"key":"ref_281","doi-asserted-by":"crossref","unstructured":"Rody, T., De Amorim, J.A., and De Felice, F.G. (2022). The emerging neuroprotective roles of exerkines in Alzheimer\u2019s disease. Front. Aging Neurosci., 14.","DOI":"10.3389\/fnagi.2022.965190"},{"key":"ref_282","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.cmet.2012.08.012","article-title":"Energy intake and exercise as determinants of brain health and vulnerability to injury and disease","volume":"16","author":"Mattson","year":"2012","journal-title":"Cell Metab."},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0166-2236(02)02143-4","article-title":"Exercise: A behavioral intervention to enhance brain health and plasticity","volume":"25","author":"Cotman","year":"2002","journal-title":"Trends Neurosci."},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nrendo.2016.76","article-title":"The potential of endurance exercise-derived exosomes to treat metabolic diseases","volume":"12","author":"Safdar","year":"2016","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_285","doi-asserted-by":"crossref","unstructured":"Loprinzi, P.D., Moore, D., and Loenneke, J.P. (2020). Does Aerobic and Resistance Exercise Influence Episodic Memory through Unique Mechanisms?. Brain Sci., 10.","DOI":"10.3390\/brainsci10120913"},{"key":"ref_286","doi-asserted-by":"crossref","unstructured":"Mitchell, A.K., Bliss, R.R., and Church, F.C. (2024). Exercise, Neuroprotective Exerkines, and Parkinson\u2019s Disease: A Narrative Review. Biomolecules, 14.","DOI":"10.3390\/biom14101241"},{"key":"ref_287","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1152\/japplphysiol.00210.2011","article-title":"Exercise, brain, and cognition across the life span","volume":"111","author":"Voss","year":"2011","journal-title":"J. Appl. Physiol."},{"key":"ref_288","first-page":"533","article-title":"The effect of physical activity on the brain derived neurotrophic factor: From animal to human studies","volume":"61","author":"Pilc","year":"2010","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_289","doi-asserted-by":"crossref","unstructured":"Hou, L., Chen, W., Liu, X., Qiao, D., and Zhou, F.-M. (2017). Exercise-induced neuroprotection of the nigrostriatal dopamine system in Parkinson\u2019s disease. Front. Aging Neurosci., 9.","DOI":"10.3389\/fnagi.2017.00358"},{"key":"ref_290","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3233\/BPL-150021","article-title":"The effects of exercise on dopamine neurotransmission in Parkinson\u2019s disease: Targeting neuroplasticity to modulate basal ganglia circuitry","volume":"1","author":"Petzinger","year":"2015","journal-title":"Brain Plast."},{"key":"ref_291","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1111\/j.1460-9568.2003.03041.x","article-title":"VEGF is necessary for exercise-induced adult hippocampal neurogenesis","volume":"18","author":"Fabel","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"ref_292","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/S1474-4422(13)70123-6","article-title":"Exercise-enhanced Neuroplasticity Targeting Motor and Cognitive Circuitry in Parkinson\u2019s Disease","volume":"12","author":"Petzinger","year":"2013","journal-title":"Lancet Neurol."},{"key":"ref_293","doi-asserted-by":"crossref","first-page":"5291","DOI":"10.1523\/JNEUROSCI.1069-07.2007","article-title":"Effects of treadmill exercise on dopaminergic transmission in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse model of basal ganglia injury","volume":"27","author":"Petzinger","year":"2007","journal-title":"J. Neurosci."},{"key":"ref_294","doi-asserted-by":"crossref","first-page":"eadh1403","DOI":"10.1126\/sciadv.adh1403","article-title":"Intensive exercise ameliorates motor and cognitive symptoms in experimental Parkinson\u2019s disease restoring striatal synaptic plasticity","volume":"9","author":"Marino","year":"2023","journal-title":"Sci. Adv."},{"key":"ref_295","doi-asserted-by":"crossref","unstructured":"Tyler, J., Podaras, M., Richardson, B., Roeder, N., Hammond, N., Hamilton, J., Blum, K., Gold, M., Baron, D.A., and Thanos, P.K. (2023). High intensity interval training exercise increases dopamine D2 levels and modulates brain dopamine signaling. Front. Public Health, 11.","DOI":"10.3389\/fpubh.2023.1257629"},{"key":"ref_296","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/s41531-024-00641-1","article-title":"Intense exercise increases dopamine transporter and neuromelanin concentrations in the substantia nigra in Parkinson\u2019s disease","volume":"10","author":"Hoye","year":"2024","journal-title":"npj Park. Dis."},{"key":"ref_297","doi-asserted-by":"crossref","first-page":"261809","DOI":"10.1155\/2015\/261809","article-title":"Physical training regulates mitochondrial parameters and neuroinflammatory mechanisms in an experimental model of Parkinson\u2019s disease","volume":"2015","author":"Tuon","year":"2015","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_298","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1089\/ars.2011.4498","article-title":"Oxygen consumption and usage during physical exercise: The balance between oxidative stress and ROS-dependent adaptive signaling","volume":"18","author":"Radak","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"ref_299","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.redox.2017.02.015","article-title":"Exercise, oxidants, and antioxidants change the shape of the bell-shaped hormesis curve","volume":"12","author":"Radak","year":"2017","journal-title":"Redox Biol."},{"key":"ref_300","doi-asserted-by":"crossref","unstructured":"Gleeson, M. (2013). Anti-inflammatory effects of exercise. Obesity, Inflammation and Cancer, Springer.","DOI":"10.1007\/978-1-4614-6819-6_16"},{"key":"ref_301","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1177\/1545968314562108","article-title":"Effects of physical exercise on neuroinflammation, neuroplasticity, neurodegeneration, and behavior: What we can learn from animal models in clinical settings","volume":"29","author":"Svensson","year":"2015","journal-title":"Neurorehabilit. Neural Repair"},{"key":"ref_302","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1152\/japplphysiol.00343.2011","article-title":"Exercise training increases mitochondrial biogenesis in the brain","volume":"111","author":"Steiner","year":"2011","journal-title":"J. Appl. Physiol."},{"key":"ref_303","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/j.exger.2013.08.004","article-title":"Exercise training attenuates aging-associated mitochondrial dysfunction in rat skeletal muscle: Role of PGC-1\u03b1","volume":"48","author":"Kang","year":"2013","journal-title":"Exp. Gerontol."},{"key":"ref_304","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.exger.2017.01.001","article-title":"Treadmill exercise alleviates motor deficits and improves mitochondrial import machinery in an MPTP-induced mouse model of Parkinson\u2019s disease","volume":"89","author":"Koo","year":"2017","journal-title":"Exp. Gerontol."},{"key":"ref_305","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1073\/pnas.1015950108","article-title":"Exercise training increases size of hippocampus and improves memory","volume":"108","author":"Erickson","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_306","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1007\/s11064-015-1581-6","article-title":"The glymphatic system: A beginner\u2019s guide","volume":"40","author":"Jessen","year":"2015","journal-title":"Neurochem. Res."},{"key":"ref_307","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/978-981-15-1792-1_27","article-title":"Exercise regulates the immune system","volume":"Volume 1228","author":"Xiao","year":"2020","journal-title":"Physical Exercise for Human Health;Advances in Experimental Medicine and Biology"},{"key":"ref_308","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s10865-015-9617-6","article-title":"The effects of physical activity on sleep: A meta-analytic review","volume":"38","author":"Kredlow","year":"2015","journal-title":"J. Behav. Med."},{"key":"ref_309","unstructured":"American College of Sports Medicine (2026, April 11). Parkinson\u2019s Disease Exercise Recommendations Updated. Available online: https:\/\/acsm.org\/parkinsons-disease-exercise-recommendations-updated-2026\/."},{"key":"ref_310","unstructured":"Parkinson\u2019s Foundation (2026, April 11). Exercise. Available online: https:\/\/www.parkinson.org\/living-with-parkinsons\/treatment\/exercise."},{"key":"ref_311","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1002\/mdc3.70444","article-title":"The Relation between Exercise and Non-Motor Symptoms in Parkinson\u2019s Disease","volume":"13","author":"Kinger","year":"2026","journal-title":"Mov. Disord. Clin. Pract."},{"key":"ref_312","doi-asserted-by":"crossref","first-page":"116251","DOI":"10.1016\/j.bbr.2026.116251","article-title":"Effects of Tai Chi on core motor symptoms in patients with Parkinson\u2019s disease: A three\u2212armed randomized controlled trial","volume":"510","author":"Zhang","year":"2026","journal-title":"Behav. Brain Res."},{"key":"ref_313","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.soard.2017.01.046","article-title":"Health is a state of complete physical, mental and social well-being and not merely absence of disease or infirmity","volume":"13","author":"Rieger","year":"2017","journal-title":"Surg. Obes. Relat. Dis."},{"key":"ref_314","doi-asserted-by":"crossref","first-page":"41","DOI":"10.18848\/2156-8960\/CGP\/v09i01\/41-56","article-title":"Health to wellness: A review of wellness models and transitioning back to health","volume":"9","author":"Oliver","year":"2018","journal-title":"Int. J. Health Wellness Soc."},{"key":"ref_315","first-page":"13","article-title":"Wellness: Encouraging a lifetime pursuit of excellence","volume":"8","author":"Hettler","year":"1984","journal-title":"Health Values"},{"key":"ref_316","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.1111\/jocn.12819","article-title":"How do people live life successfully with Parkinson\u2019s disease?","volume":"24","author":"Kang","year":"2015","journal-title":"J. Clin. Nurs."},{"key":"ref_317","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1097\/01376517-199110000-00010","article-title":"The experience of living with Parkinson\u2019s disease","volume":"23","author":"Marr","year":"1991","journal-title":"J. Neurosci. Nurs."},{"key":"ref_318","first-page":"4598651","article-title":"The impact of living with Parkinson\u2019s disease: Balancing within a web of needs and demands","volume":"2018","author":"Westergren","year":"2018","journal-title":"Park. Dis."},{"key":"ref_319","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1177\/1049732319851485","article-title":"Living with Parkinson\u2019s: The process of finding optimism","volume":"29","author":"Gardenhire","year":"2019","journal-title":"Qual. Health Res."},{"key":"ref_320","doi-asserted-by":"crossref","first-page":"103923","DOI":"10.1016\/j.ijnurstu.2021.103923","article-title":"\u2018Striving for normality\u2019when coping with Parkinson\u2019s disease in everyday life: A metasynthesis","volume":"118","author":"Haahr","year":"2021","journal-title":"Int. J. Nurs. Stud."},{"key":"ref_321","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1007\/s00702-022-02509-1","article-title":"Life style and Parkinson\u2019s disease","volume":"129","author":"Reichmann","year":"2022","journal-title":"J. Neural Transm."},{"key":"ref_322","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/mds.27577","article-title":"The association between lifestyle factors and Parkinson\u2019s disease progression and mortality","volume":"34","author":"Paul","year":"2019","journal-title":"Mov. Disord."},{"key":"ref_323","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1002\/mds.27720","article-title":"Environment, lifestyle, and Parkinson\u2019s disease: Implications for prevention in the next decade","volume":"34","author":"Marras","year":"2019","journal-title":"Mov. Disord."},{"key":"ref_324","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1034\/j.1600-0404.2003.00128.x","article-title":"Lifestyle-related risk factors for Parkinson\u2019s disease: A population-based study","volume":"108","author":"Baldereschi","year":"2003","journal-title":"Acta Neurol. Scand."},{"key":"ref_325","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/j.1440-1630.2006.00610.x","article-title":"Living with Parkinson\u2019s disease: Elderly patients\u2019 and relatives\u2019 perspective on daily living","volume":"54","author":"Wressle","year":"2007","journal-title":"Aust. Occup. Ther. J."},{"key":"ref_326","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1590\/0034-7167-2016-0577","article-title":"The daily lives of people with Parkinson\u2019s disease","volume":"71","author":"Valcarenghi","year":"2018","journal-title":"Rev. Bras. Enferm."},{"key":"ref_327","doi-asserted-by":"crossref","first-page":"8","DOI":"10.17925\/USN.2023.19.1.8","article-title":"Wellness in Parkinson\u2019s Disease: A Framework for Management Using a Holistic Culturally Sensitive Approach","volume":"19","author":"Subramanian","year":"2023","journal-title":"touchREVIEWS Neurol."},{"key":"ref_328","doi-asserted-by":"crossref","first-page":"6405278","DOI":"10.1155\/2017\/6405278","article-title":"Role of Diet and Nutritional Supplements in Parkinson\u2019s Disease Progression","volume":"2017","author":"Mischley","year":"2017","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_329","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/advances\/nmy071","article-title":"Perspective: The Dietary Inflammatory Index (DII)\u2014Lessons learned, improvements made, and future directions","volume":"10","author":"Shivappa","year":"2019","journal-title":"Adv. Nutr."},{"key":"ref_330","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1093\/epirev\/mxz005","article-title":"Dietary inflammatory potential and the risk of neurodegenerative diseases in adults","volume":"41","author":"Kheirouri","year":"2019","journal-title":"Epidemiol. Rev."},{"key":"ref_331","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/s41398-025-03297-4","article-title":"Dietary inflammatory index and brain disorders: A Large Prospective Cohort study","volume":"15","author":"Fu","year":"2025","journal-title":"Transl. Psychiatry"},{"key":"ref_332","doi-asserted-by":"crossref","first-page":"705","DOI":"10.2174\/1871527316666170321124949","article-title":"Ultra-micronized palmitoylethanolamide: An efficacious adjuvant therapy for Parkinson\u2019s disease","volume":"16","author":"Brotini","year":"2017","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"ref_333","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1007\/s11940-014-0314-5","article-title":"A review of the clinical evidence for complementary and alternative therapies in Parkinson\u2019s disease","volume":"16","author":"Bega","year":"2014","journal-title":"Curr. Treat. Options Neurol."},{"key":"ref_334","doi-asserted-by":"crossref","first-page":"57","DOI":"10.14802\/jmd.14009","article-title":"Complementary & alternative management of Parkinson\u2019s disease: An evidence-based review of eastern influenced practices","volume":"7","author":"Bega","year":"2014","journal-title":"J. Mov. Disord."},{"key":"ref_335","first-page":"1720621","article-title":"Alpha-Synuclein in Parkinson\u2019s Disease: From Pathogenetic Dysfunction to Potential Clinical Application","volume":"2016","author":"Xu","year":"2016","journal-title":"Park. Dis."},{"key":"ref_336","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jep.2016.08.020","article-title":"Management of Parkinson\u2019s disease in Ayurveda: Medicinal plants and adjuvant measures","volume":"197","author":"Vaidya","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"ref_337","doi-asserted-by":"crossref","first-page":"e092315","DOI":"10.1136\/bmjopen-2024-092315","article-title":"Pranayama (yogic breathing practices) in Parkinson\u2019s disease: Protocol for a scoping review of literature","volume":"14","author":"Rao","year":"2024","journal-title":"BMJ Open"},{"key":"ref_338","doi-asserted-by":"crossref","unstructured":"Cho, K.-H., Kim, T.-H., Kwon, S., Jung, W.-S., Moon, S.-K., Ko, C.-N., Cho, S.-Y., Jeon, C.-Y., Lee, S.-H., and Choi, T.Y. (2018). Complementary and alternative medicine for idiopathic Parkinson\u2019s disease: An evidence-based clinical practice guideline. Front. Aging Neurosci., 10.","DOI":"10.3389\/fnagi.2018.00323"},{"key":"ref_339","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41531-020-00152-9","article-title":"Stress and mindfulness in Parkinson\u2019s disease\u2014A survey in 5000 patients","volume":"7","author":"Speckens","year":"2021","journal-title":"npj Park. Dis."},{"key":"ref_340","doi-asserted-by":"crossref","first-page":"105908","DOI":"10.1016\/j.parkreldis.2023.105908","article-title":"Effects of physical exercise interventions on cognitive function in Parkinson\u2019s disease: An updated systematic review and meta-analysis of randomized controlled trials","volume":"117","author":"Kim","year":"2023","journal-title":"Park. Relat. Disord."},{"key":"ref_341","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.parkreldis.2011.09.021","article-title":"What determines resilience in patients with Parkinson\u2019s disease?","volume":"18","author":"Robottom","year":"2012","journal-title":"Park. Relat. Disord."},{"key":"ref_342","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/s41531-024-00699-x","article-title":"Structural underpinnings and long-term effects of resilience in Parkinson\u2019s disease","volume":"10","author":"Dzialas","year":"2024","journal-title":"npj Park. Dis."},{"key":"ref_343","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1097\/01376517-199704000-00004","article-title":"Hope and a health-promoting lifestyle in persons with Parkinson\u2019s disease","volume":"29","author":"Fowler","year":"1997","journal-title":"J. Neurosci. Nurs."},{"key":"ref_344","doi-asserted-by":"crossref","first-page":"613592","DOI":"10.1155\/2014\/613592","article-title":"The experience of Parkinson\u2019s disease: A systematic review and meta-ethnography","volume":"2014","author":"Soundy","year":"2014","journal-title":"Sci. World J."},{"key":"ref_345","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1037\/0022-3514.84.2.377","article-title":"Counting blessings versus burdens: An experimental investigation of gratitude and subjective well-being in daily life","volume":"84","author":"Emmons","year":"2003","journal-title":"J. Pers. Soc. Psychol."},{"key":"ref_346","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/bjhp.12043","article-title":"Thinking positively about chronic illness: An exploration of optimism, illness perceptions and well-being in patients with P arkinson\u2019s disease","volume":"19","author":"Hurt","year":"2014","journal-title":"Br. J. Health Psychol."},{"key":"ref_347","doi-asserted-by":"crossref","unstructured":"Aldbyani, A., Wang, G., Qi, Y., Chuanxia, Z., Li, J., Leng, J., and Alhimaidi, A. (2025). Positive psychological traits and psychological well-being: Investigating roles of positive coping strategies and life stressors. BMC Psychol., 13.","DOI":"10.1186\/s40359-025-02807-9"},{"key":"ref_348","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41531-022-00283-1","article-title":"The silver linings of Parkinson\u2019s disease","volume":"8","author":"Voeten","year":"2022","journal-title":"npj Park. Dis."},{"key":"ref_349","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/mdc3.70381","article-title":"A Holistic Wellness Prescription for Parkinson\u2019s Disease: Evidence-Based Perspectives and Unmet Needs","volume":"13","author":"Subramanian","year":"2026","journal-title":"Mov. Disord. Clin. Pract."},{"key":"ref_350","doi-asserted-by":"crossref","first-page":"107573","DOI":"10.1016\/j.parkreldis.2025.107573","article-title":"Building University-based Wellness & Exercise Programs for Individuals with Parkinson\u2019s Disease","volume":"134","author":"Salem","year":"2025","journal-title":"Park. Relat. Disord."},{"key":"ref_351","unstructured":"Cush, K., Pascal, M.R., Montanye, G., McCoy, A., Mallon, J., and Hayward, M. (2026, May 04). The Impact of a Wellness Program Consisting of Meditation and Dietary Education on the Symptoms of Parkinson\u2019s Disease: A Protocol. Available online: https:\/\/digitalcommons.misericordia.edu\/research_posters2026\/18\/."},{"key":"ref_352","doi-asserted-by":"crossref","first-page":"e182","DOI":"10.1016\/j.apmr.2026.02.446","article-title":"Impact of an 8-week Occupation-based Holistic Wellness Program on Parkinson\u2019s Disease Symptoms: A Case Series","volume":"107","year":"2026","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_353","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1002\/ana.26897","article-title":"Role of the exposome in neurodegenerative disease: Recent insights and future directions","volume":"95","author":"Sakowski","year":"2024","journal-title":"Ann. Neurol."},{"key":"ref_354","doi-asserted-by":"crossref","first-page":"e213785","DOI":"10.1212\/WNL.0000000000213785","article-title":"An ounce of prevention: The growing need for preventive neurologists","volume":"105","author":"Sabayan","year":"2025","journal-title":"Neurology"},{"key":"ref_355","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1212\/WNL.0000000000012554","article-title":"Opinion & special article: Preventive neurology: An emerging field toward brain health","volume":"97","author":"Sabayan","year":"2021","journal-title":"Neurology"},{"key":"ref_356","doi-asserted-by":"crossref","first-page":"e210226","DOI":"10.1212\/WNL.0000000000210226","article-title":"The neurologist\u2019s role in promoting brain health: Emerging issues in neurology","volume":"104","author":"Selwa","year":"2025","journal-title":"Neurology"},{"key":"ref_357","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1001\/jamaneurol.2025.4445","article-title":"Preventive Neurology Isn\u2019t a Pill; It\u2019s a Plan","volume":"83","author":"Sheth","year":"2026","journal-title":"JAMA Neurol."},{"key":"ref_358","doi-asserted-by":"crossref","first-page":"107208","DOI":"10.1016\/j.parkreldis.2024.107208","article-title":"Parkinson\u2019s disease subtypes: Approaches and clinical implications","volume":"130","author":"Deng","year":"2025","journal-title":"Park. Relat. Disord."},{"key":"ref_359","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/s41582-024-01034-x","article-title":"Parkinson disease therapy: Current strategies and future research priorities","volume":"20","author":"Stocchi","year":"2024","journal-title":"Nat. Rev. Neurol."},{"key":"ref_360","doi-asserted-by":"crossref","unstructured":"Hassanzadeh, K., and Mouradian, M.M. (2025). Advances in Disease Modifying Therapies for Parkinson\u2019s Disease. Trends CNS Drug Discovery, John Wiley & Sons, Inc.","DOI":"10.1002\/9783527844678.ch2"},{"key":"ref_361","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1002\/mds.30307","article-title":"Anti-Neuroinflammatory and Anti-Inflammatory Effects of the NLRP3 Inhibitor NT-0796 in Subjects with Parkinson\u2019s Disease","volume":"40","author":"Clarke","year":"2025","journal-title":"Mov. Disord."},{"key":"ref_362","unstructured":"Chia-Hui Yu, L. (2026). Chapter 14\u2014Intestinal epithelial cells: Gatekeepers of the gut\u2013brain axis, microbiome, and beyond. Mucosal Barriers and Host-Microbiota Interplay, Academic Press."},{"key":"ref_363","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/s41579-020-00460-0","article-title":"The gut microbiota\u2013brain axis in behaviour and brain disorders","volume":"19","author":"Morais","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_364","doi-asserted-by":"crossref","first-page":"e143775","DOI":"10.1172\/JCI143775","article-title":"Neurodegenerative disorders and gut-brain interactions","volume":"131","author":"Singh","year":"2021","journal-title":"J. Clin. Investig."},{"key":"ref_365","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1172\/JCI78361","article-title":"Neuroepithelial circuit formed by innervation of sensory enteroendocrine cells","volume":"125","author":"Shahid","year":"2015","journal-title":"J. Clin. Investig."},{"key":"ref_366","doi-asserted-by":"crossref","first-page":"eaat5236","DOI":"10.1126\/science.aat5236","article-title":"A gut-brain neural circuit for nutrient sensory transduction","volume":"361","author":"Kaelberer","year":"2018","journal-title":"Science"},{"key":"ref_367","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/s41586-025-09301-7","article-title":"A gut sense for a microbial pattern regulates feeding","volume":"645","author":"Liu","year":"2025","journal-title":"Nature"},{"key":"ref_368","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/B978-0-12-800100-4.00003-9","article-title":"The role of short-chain fatty acids in health and disease","volume":"121","author":"Tan","year":"2014","journal-title":"Adv. Immunol."},{"key":"ref_369","doi-asserted-by":"crossref","first-page":"e70137","DOI":"10.1002\/cph4.70137","article-title":"The Brain-Gut Axis in Parkinson\u2019s Disease Pathology","volume":"16","author":"Ozkaya","year":"2026","journal-title":"Compr. Physiol."},{"key":"ref_370","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1002\/mds.27842","article-title":"The gut-brain axis in Parkinson\u2019s disease: A focus on the transport of \u03b1-Synuclein","volume":"34","author":"Sundaram","year":"2019","journal-title":"Mov. Disord."},{"key":"ref_371","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1080\/10408398.2017.1399860","article-title":"Psychobiotics: A new approach for treating mental illness?","volume":"59","author":"Misra","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_372","doi-asserted-by":"crossref","unstructured":"Chen, Y., Xu, J., and Chen, Y. (2021). Regulation of neurotransmitters by the gut microbiota and effects on cognition in neurological disorders. Nutrients, 13.","DOI":"10.3390\/nu13062099"},{"key":"ref_373","doi-asserted-by":"crossref","first-page":"3465","DOI":"10.1038\/s41467-025-58459-1","article-title":"Relationships between brain activity, tryptophan-related gut metabolites, and autism symptomatology","volume":"16","author":"Ringold","year":"2025","journal-title":"Nat. Commun."},{"key":"ref_374","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1002\/mds.20987","article-title":"\u201cParadoxical kinesis\u201d is not a hallmark of Parkinson\u2019s disease but a general property of the motor system","volume":"21","author":"Ballanger","year":"2006","journal-title":"Mov. Disord. Off. J. Mov. Disord. Soc."},{"key":"ref_375","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1002\/mds.28550","article-title":"Parkinson\u2019s kinesia paradoxa is not a paradox","volume":"36","author":"Duysens","year":"2021","journal-title":"Mov. Disord."},{"key":"ref_376","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1093\/ptj\/80.6.578","article-title":"Movement disorders in people with Parkinson disease: A model for physical therapy","volume":"80","author":"Morris","year":"2000","journal-title":"Phys. Ther."},{"key":"ref_377","doi-asserted-by":"crossref","first-page":"57","DOI":"10.4103\/NRR.NRR-D-24-01063","article-title":"Hidden face of Parkinson\u2019s disease: Is it a new autoimmune disease?","volume":"21","author":"Jo","year":"2026","journal-title":"Neural Regen. Res."},{"key":"ref_378","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.neuroscience.2026.04.007","article-title":"Neuronal vulnerability in Parkinson\u2019s disease: Insights from murine \u03b1-synuclein pathology models","volume":"605","author":"Asadpoordezaki","year":"2026","journal-title":"Neuroscience"},{"key":"ref_379","doi-asserted-by":"crossref","unstructured":"Lucchesi, M., Biso, L., Bonaso, M., Longoni, B., Buchignani, B., Battini, R., Santorelli, F.M., Doccini, S., and Scarselli, M. (2025). Mitochondrial dysfunction in genetic and non-genetic Parkinson\u2019s disease. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26094451"},{"key":"ref_380","doi-asserted-by":"crossref","first-page":"102482","DOI":"10.1016\/j.ceb.2025.102482","article-title":"LRRK2, lysosome damage, and Parkinson\u2019s disease","volume":"93","author":"Clegg","year":"2025","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_381","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41531-019-0103-7","article-title":"Parkinson\u2019s disease: Proteinopathy or lipidopathy?","volume":"6","author":"Fanning","year":"2020","journal-title":"npj Park. Dis."},{"key":"ref_382","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/j.neuron.2019.03.004","article-title":"Circuit mechanisms of Parkinson\u2019s disease","volume":"101","author":"McGregor","year":"2019","journal-title":"Neuron"},{"key":"ref_383","first-page":"35","article-title":"Alpha-synuclein aggregation in Parkinson\u2019s disease","volume":"146","author":"Leite","year":"2025","journal-title":"Adv. Protein Chem. Struct. Biol."},{"key":"ref_384","doi-asserted-by":"crossref","unstructured":"Arias-Carri\u00f3n, O., Guerra-Crespo, M., Padilla-God\u00ednez, F.J., Soto-Rojas, L.O., and Manjarrez, E. (2025). \u03b1-Synuclein pathology in synucleinopathies: Mechanisms, biomarkers, and therapeutic challenges. Int. J. Mol. Sci., 26.","DOI":"10.20944\/preprints202504.2181.v1"},{"key":"ref_385","doi-asserted-by":"crossref","first-page":"109602","DOI":"10.1016\/j.mehy.2020.109602","article-title":"Synergy between plasminogen activator inhibitor-1, \u03b1-synuclein, and neuroinflammation in Parkinson\u2019s disease","volume":"138","author":"Reuland","year":"2020","journal-title":"Med. Hypotheses"},{"key":"ref_386","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.neuron.2006.09.026","article-title":"Mechanisms of Parkinson\u2019s disease linked to pathological \u03b1-synuclein: New targets for drug discovery","volume":"52","author":"Lee","year":"2006","journal-title":"Neuron"},{"key":"ref_387","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/s41531-021-00203-9","article-title":"Alpha-synuclein research: Defining strategic moves in the battle against Parkinson\u2019s disease","volume":"7","author":"Oliveira","year":"2021","journal-title":"npj Park. Dis."},{"key":"ref_388","doi-asserted-by":"crossref","unstructured":"Pitton Rissardo, J., McGarry, A., Shi, Y., Fornari Caprara, A.L., and Kannarkat, G.T. (2025). Alpha-Synuclein Neurobiology in Parkinson\u2019s Disease: A Comprehensive Review of Its Role, Mechanisms, and Therapeutic Perspectives. Brain Sci., 15.","DOI":"10.3390\/brainsci15121260"},{"key":"ref_389","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/s41582-018-0107-7","article-title":"Dementia with Lewy bodies\u2014from scientific knowledge to clinical insights","volume":"15","author":"Arnaoutoglou","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"ref_390","doi-asserted-by":"crossref","first-page":"243142","DOI":"10.1063\/1.4936910","article-title":"Transient \u03b2-hairpin formation in \u03b1-synuclein monomer revealed by coarse-grained molecular dynamics simulation","volume":"143","author":"Yu","year":"2015","journal-title":"J. Chem. Phys."},{"key":"ref_391","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.bbrc.2011.06.133","article-title":"A partially folded structure of amyloid-beta(1-40) in an aqueous environment","volume":"411","author":"Vivekanandan","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_392","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1016\/j.str.2019.09.003","article-title":"Insight into the Structure of the \u201cUnstructured\u201d Tau Protein","volume":"27","author":"Popov","year":"2019","journal-title":"Structure"},{"key":"ref_393","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1097\/CM9.0000000000003802","article-title":"Protein aggregation in neurodegenerative diseases","volume":"138","author":"Wang","year":"2025","journal-title":"Chin. Med. J."},{"key":"ref_394","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1038\/s41593-018-0221-2","article-title":"Selective vulnerability in neurodegenerative diseases","volume":"21","author":"Fu","year":"2018","journal-title":"Nat. Neurosci."},{"key":"ref_395","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/B978-0-323-85538-9.00012-2","article-title":"Mixed pathology as a rule, not exception: Time to reconsider disease nosology","volume":"192","author":"Chu","year":"2023","journal-title":"Handb. Clin. Neurol."},{"key":"ref_396","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1515\/revneuro-2026-0041","article-title":"Psychiatric and behavioral disorders in Parkinson\u2019s disease: Co-pathogenic mechanisms of tau, A\u03b2, and \u03b1-synuclein proteins (narrative review)","volume":"37","author":"Chai","year":"2026","journal-title":"Rev. Neurosci."},{"key":"ref_397","doi-asserted-by":"crossref","first-page":"7281","DOI":"10.1523\/JNEUROSCI.0490-10.2010","article-title":"Synergistic interactions between A\u03b2, tau, and \u03b1-synuclein: Acceleration of neuropathology and cognitive decline","volume":"30","author":"Clinton","year":"2010","journal-title":"J. Neurosci."},{"key":"ref_398","first-page":"35","article-title":"Prevalence of concomitant pathologies in Parkinson\u2019s disease: Implications for prognosis, diagnosis, and insights into common pathogenic mechanisms","volume":"14","author":"Walker","year":"2024","journal-title":"J. Park. Dis."},{"key":"ref_399","doi-asserted-by":"crossref","unstructured":"Matarazzo, M., Borghammer, P., Elsayed, I., Goldman, J.G., Huang, Y., Lohmann, K., Svenningsson, P., Kalia, L.V., Berg, D., and Kordower, J.H. (2026). Co-and Multi-Pathologies in Parkinson\u2019s Disease: An International Parkinson and Movement Disorder Society Scientific Issues Committee Review. Mov. Disord.","DOI":"10.1002\/mds.70324"},{"key":"ref_400","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/nrn3549","article-title":"Parkinson\u2019s disease dementia: Convergence of \u03b1-synuclein, tau and amyloid-\u03b2 pathologies","volume":"14","author":"Irwin","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_401","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s11910-026-01488-0","article-title":"Amyloid and Tau Co-pathology in Parkinson Disease and Atypical Parkinsonism","volume":"26","author":"Dorman","year":"2026","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"ref_402","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/s41582-026-01185-z","article-title":"Towards biomarker-based diagnosis of Parkinson disease","volume":"22","author":"Tolosa","year":"2026","journal-title":"Nat. Rev. Neurol."}],"container-title":["NeuroSci"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2673-4087\/7\/4\/93\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T04:25:03Z","timestamp":1787631903000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2673-4087\/7\/4\/93"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,21]]},"references-count":402,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["neurosci7040093"],"URL":"https:\/\/doi.org\/10.3390\/neurosci7040093","relation":{},"ISSN":["2673-4087"],"issn-type":[{"value":"2673-4087","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,21]]}}}