{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T16:11:11Z","timestamp":1792253471395,"version":"4.4.0"},"reference-count":41,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2018,1,13]],"date-time":"2018-01-13T00:00:00Z","timestamp":1515801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008247","name":"University of Otago","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008247","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Healthcare Otago Charitable Trust"},{"name":"HEHA (Healthy Eating, Healthy Action)"},{"name":"Fisher and Paykel"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Vitamin D status and associated metabolism during pregnancy and lactation have been assessed in only a limited number of longitudinal studies, all from the northern hemisphere, with no infant data concurrently reported. Therefore, we aimed to describe longitudinal maternal and infant 25-hydroxy vitamin D (25OHD) and parathyroid hormone (PTH) status during pregnancy and up to 5 months postnatal age, in New Zealand women and their infants living at 45\u00b0 S latitude. Between September 2011 and June 2013, 126 pregnant women intending to exclusively breastfeed for at least 20 weeks were recruited. Longitudinal data were collected at three time-points spanning pregnancy, and following birth and at 20 weeks postpartum. Vitamin D deficiency (25OHD &lt; 50 nmol\/L) was common, found at one or more time-points in 65% and 76% of mothers and their infants, respectively. Mean cord 25OHD was 41 nmol\/L, and three infants exhibited secondary hyperparathyroidism by postnatal week 20. Maternal late pregnancy 25OHD (gestation 32\u201338 weeks) was closely correlated with infant cord 25OHD, r2 = 0.87 (95% CI (Confidence interval) 0.8\u20130.91), while no correlation was seen between early pregnancy (&lt;20 weeks gestation) maternal and cord 25OHD, r2 = 0.06 (95% CI \u22120.16\u20130.28). Among other variables, pregnancy 25OHD status, and therefore infant status at birth, were influenced by season of conception. In conclusion, vitamin D deficiency in women and their infants is very common during pregnancy and lactation in New Zealand at 45\u00b0 S. These data raise questions regarding the applicability of current pregnancy and lactation policy at this latitude, particularly recommendations relating to first trimester maternal vitamin D screening and targeted supplementation for those \u201cat risk\u201d.<\/jats:p>","DOI":"10.3390\/nu10010086","type":"journal-article","created":{"date-parts":[[2018,1,15]],"date-time":"2018-01-15T12:30:36Z","timestamp":1516019436000},"page":"86","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["A Longitudinal Study of 25-Hydroxy Vitamin D and Parathyroid Hormone Status throughout Pregnancy and Exclusive Lactation in New Zealand Mothers and Their Infants at 45\u00b0 S"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3348-5238","authenticated-orcid":false,"given":"Benjamin","family":"Wheeler","sequence":"first","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health, Dunedin School of Medicine, University of Otago, Dunedin 9054, New Zealand"},{"name":"Paediatric Endocrinology, Southern District Health Board, Dunedin 9010, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6450-8677","authenticated-orcid":false,"given":"Barry","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health, Dunedin School of Medicine, University of Otago, Dunedin 9054, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"De Lange","sequence":"additional","affiliation":[{"name":"Department Preventative and Social Medicine, University of Otago, Dunedin 9054, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Harper","sequence":"additional","affiliation":[{"name":"Department of Human Nutrition, University of Otago, Dunedin 9054, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirley","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health, Dunedin School of Medicine, University of Otago, Dunedin 9054, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adel","family":"Mekhail","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health, Dunedin School of Medicine, University of Otago, Dunedin 9054, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Houghton","sequence":"additional","affiliation":[{"name":"Department of Human Nutrition, University of Otago, Dunedin 9054, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,1,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ar.1091790102","article-title":"Sequential changes in weight, density, and percentage ash weight of human skeletons from an early fetal period through old age","volume":"179","author":"Trotter","year":"1974","journal-title":"Anat. 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