{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T23:08:48Z","timestamp":1767827328847,"version":"3.49.0"},"reference-count":42,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2018,2,13]],"date-time":"2018-02-13T00:00:00Z","timestamp":1518480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Oxidative stress has been associated with adverse neonatal outcomes, and many carotenoids, including lycopene, potentially have antioxidant properties. The objective of this analysis was to explore the associations between serum lycopene concentrations, including lycopene isomers, and maternal-newborn outcomes. Maternal and cord blood samples were collected in 180 mother-infant pairs. Serum of total lycopene as well as the cis- and trans-isomers concentrations were measured using HPLC (High Performance Liquid Chromatography). Descriptive statistics were calculated; Spearman coefficients were used to assess correlations between maternal and cord concentrations. The relationship between lycopene concentration and outcomes were evaluated with linear and logistic regression models, with adjustment for relevant confounders. A p \u2264 0.05 was considered statistically significant. Maternal and cord serum lycopene concentrations were positively correlated for total lycopene (r = 0.30, p &lt; 0.0001), cis-lycopene (r = 0.29, p = 0.0002); and trans-lycopene (r = 0.32, p &lt; 0.0001). Maternal concentrations of cis-lycopene were significantly lower in mothers whose infants developed respiratory distress syndrome compared to those who did not (0.336 \u00b1 0.171 vs. 0.445 \u00b1 0.238 \u00b5mol\/L, p = 0.04) and also in mothers whose babies were admitted to the newborn intensive care unit compared to those who were not (0.380 \u00b1 0.202 vs. 0.458 \u00b1 0.244 \u00b5mol\/L, p = 0.04). Conversely, cord concentrations of trans-lycopene were significantly higher in infants who developed RDS (Respiratory Distress Syndrome) (0.023 \u00b1 0.012 vs. 0.016 \u00b1 0.012, p = 0.007 for RDS vs. no RDS), and a similar pattern was seen NICU admission (0.023 \u00b1 0.016 vs. 0.015 \u00b1 0.009 \u00b5mol\/L for NICU (Newborn Intensive Care Unit) admission vs. no NICU admission, p = 0.007). Maternal concentrations of total and cis-lycopene were positively associated with infant birth weight, length and head circumference after adjustment for relevant confounders. As serum carotenoids, including lycopene, are modifiable by diet, future research determining the clinical impact of these compounds is warranted.<\/jats:p>","DOI":"10.3390\/nu10020204","type":"journal-article","created":{"date-parts":[[2018,2,13]],"date-time":"2018-02-13T05:32:19Z","timestamp":1518499939000},"page":"204","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Serum Lycopene Concentrations and Associations with Clinical Outcomes in a Cohort of Maternal-Infant Dyads"],"prefix":"10.3390","volume":"10","author":[{"given":"Corrine","family":"Hanson","sequence":"first","affiliation":[{"name":"College of Allied Health Professions Medical Nutrition Education, University of Nebraska Medical Center, Omaha, NE 68198-4045, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Lyden","sequence":"additional","affiliation":[{"name":"College of Public Health, University of Nebraska Medical Center, Omaha, NE 68198-4375, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5258-1869","authenticated-orcid":false,"given":"Jeremy","family":"Furtado","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Harvard School of Public Health, Boston, MA 02215, USA <email>jfurtado@hsph.harvard.edu<\/email>"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1541-0155","authenticated-orcid":false,"given":"Matthew","family":"Van Ormer","sequence":"additional","affiliation":[{"name":"College of Medicine Pediatrics, University of Nebraska Medical Center, Omaha, NE 68198-1205, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly","family":"White","sequence":"additional","affiliation":[{"name":"College of Medicine Pediatrics, University of Nebraska Medical Center, Omaha, NE 68198-1205, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1871-041X","authenticated-orcid":false,"given":"Nina","family":"Overby","sequence":"additional","affiliation":[{"name":"Department of Public Health, Sport and Nutrition, University of Agder, P.O. 422, 4606 Kristiansand, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Anderson-Berry","sequence":"additional","affiliation":[{"name":"College of Medicine Pediatrics, University of Nebraska Medical Center, Omaha, NE 68198-1205, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,2,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1093\/ajcn\/81.6.1390","article-title":"Oxidative stress, diet, and the etiology of preeclampsia","volume":"81","author":"Scholl","year":"2005","journal-title":"Am. 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