{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:59:39Z","timestamp":1787029179374,"version":"build-2736575974"},"reference-count":62,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2018,3,8]],"date-time":"2018-03-08T00:00:00Z","timestamp":1520467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sooft Italia SpA","award":["not available"],"award-info":[{"award-number":["not available"]}]},{"name":"Italian Ministry of Health","award":["RF-201102351158"],"award-info":[{"award-number":["RF-201102351158"]}]}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Nutrients"],"abstract":"<jats:p>Optic neuritis is an acute inflammatory demyelinating disorder of the optic nerve (ON) and is an initial symptom of multiple sclerosis (MS). Optic neuritis is characterized by ON degeneration and retinal ganglion cell (RGC) loss that contributes to permanent visual disability and lacks a reliable treatment. Here, we used the experimental autoimmune encephalomyelitis (EAE) mouse model of MS, a well-established model also for optic neuritis. In this model, C57BL6 mice, intraperitoneally injected with a fragment of the myelin oligodendrocyte glycoprotein (MOG), were found to develop inflammation, M\u00fcller cell gliosis, and infiltration of macrophages with increased production of oncomodulin (OCM), a calcium binding protein that acts as an atypical trophic factor for neurons enabling RGC axon regeneration. Immunolabeling of retinal whole mounts with a Brn3a antibody demonstrated drastic RGC loss. Dietary supplementation with Neuro-FAG (nFAG\u00ae), a balanced mixture of fatty acids (FAs), counteracted inflammatory and gliotic processes in the retina. In contrast, infiltration of macrophages and their production of OCM remained at elevated levels thus eventually preserving OCM trophic activity. In addition, the diet supplement with nFAG exerted a neuroprotective effect preventing MOG-induced RGC death. In conclusion, these data suggest that the balanced mixture of FAs may represent a useful form of diet supplementation to limit inflammatory events and death of RGCs associated to optic neuritis. This would occur without affecting macrophage infiltration and the release of OCM thus favoring the maintenance of OCM neuroprotective role.<\/jats:p>","DOI":"10.3390\/nu10030325","type":"journal-article","created":{"date-parts":[[2018,3,8]],"date-time":"2018-03-08T12:07:33Z","timestamp":1520510853000},"page":"325","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["RETRACTED: Fatty Acids Dietary Supplements Exert Anti-Inflammatory Action and Limit Ganglion Cell Degeneration in the Retina of the EAE Mouse Model of Multiple Sclerosis"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5181-4456","authenticated-orcid":false,"given":"Massimo","family":"Dal Monte","sequence":"first","affiliation":[{"name":"Department of Biology, University of Pisa, via San Zeno 31, 56127 Pisa, Italy"},{"name":"Interdepartmental Research Center Nutrafood \u201cNutraceuticals and Food for Health\u201d, University of Pisa, via del Borghetto 80, 56124 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8934-5838","authenticated-orcid":false,"given":"Maurizio","family":"Cammalleri","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Pisa, via San Zeno 31, 56127 Pisa, Italy"},{"name":"Interdepartmental Research Center Nutrafood \u201cNutraceuticals and Food for Health\u201d, University of Pisa, via del Borghetto 80, 56124 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Locri","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Pisa, via San Zeno 31, 56127 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario","family":"Amato","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Pisa, via San Zeno 31, 56127 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Marsili","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Pisa, via San Zeno 31, 56127 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Rusciano","sequence":"additional","affiliation":[{"name":"Sooft Italia SpA, Contrada Molino 17, 63833 Montegiorgio (F.M.), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Bagnoli","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Pisa, via San Zeno 31, 56127 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,3,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/bpa.12454","article-title":"Multiple sclerosis animal models: A clinical and histopathological perspective","volume":"27","author":"Kipp","year":"2017","journal-title":"Brain Pathol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.preteyeres.2013.03.001","article-title":"Optic neuritis in neuromyelitis optica","volume":"36","author":"Levin","year":"2013","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/ceo.12751","article-title":"Afferent visual pathways in multiple sclerosis: A review","volume":"45","author":"Graham","year":"2017","journal-title":"Clin. Exp. Ophthalmol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"19587","DOI":"10.1073\/pnas.0907085106","article-title":"Oncomodulin links inflammation to optic nerve regeneration","volume":"106","author":"Yin","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"195","DOI":"10.2147\/EB.S54131","article-title":"Optic neuritis as an early sign of multiple sclerosis","volume":"8","author":"Kale","year":"2016","journal-title":"Eye Brain"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1001\/archopht.126.7.994","article-title":"Treatment of acute optic neuritis: A summary of findings from the optic neuritis treatment trial","volume":"126","author":"Beck","year":"2008","journal-title":"Arch. Ophthalmol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"7180632","DOI":"10.1155\/2017\/7180632","article-title":"Mitochondrial Uncoupler Prodrug of 2,4-Dinitrophenol, MP201, Prevents Neuronal Damage and Preserves Vision in Experimental Optic Neuritis","volume":"2017","author":"Khan","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"13","DOI":"10.2147\/EB.S140481","article-title":"Visual consequences of medications for multiple sclerosis: The good, the bad, the ugly, and the unknown","volume":"9","author":"Moss","year":"2017","journal-title":"Eye Brain"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Abu-Amero, K.K., Kondkar, A.A., and Chalam, K.V. (2016). Resveratrol and Ophthalmic Diseases. Nutrients, 8.","DOI":"10.3390\/nu8040200"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.brainres.2007.12.015","article-title":"Orally administered epigallocatechin gallate attenuates retinal neuronal death in vivo and light-induced apoptosis in vitro","volume":"1198","author":"Zhang","year":"2008","journal-title":"Brain Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"89","DOI":"10.4103\/2225-4110.130374","article-title":"Omega-3 Fatty acids could alleviate the risks of traumatic brain injury\u2014A mini review","volume":"4","author":"Kumar","year":"2014","journal-title":"J. Tradit. Complement. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.tins.2013.10.005","article-title":"Omega-3 fatty acids and traumatic neurological injury: From neuroprotection to neuroplasticity?","volume":"37","author":"Priestley","year":"2014","journal-title":"Trends Neurosci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.expneurol.2012.09.015","article-title":"Improved outcome after spinal cord compression injury in mice treated with docosahexaenoic acid","volume":"239","author":"Lim","year":"2013","journal-title":"Exp. Neurol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.immuni.2015.09.007","article-title":"Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestine","volume":"43","author":"Haghikia","year":"2015","journal-title":"Immunity"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jneuroim.2010.12.002","article-title":"Lipoic acid decreases inflammation and confers neuroprotection in experimental autoimmune optic neuritis","volume":"233","author":"Chaudhary","year":"2011","journal-title":"J. Neuroimmunol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3945\/ajcn.117.153825","article-title":"\u03c9-3 and \u03c9-6 long-chain PUFAs and their enzymatic metabolites in neovascular eye diseases","volume":"106","author":"Gong","year":"2017","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1159\/000441359","article-title":"Omega-3 Fatty Acids and Age-Related Macular Degeneration","volume":"55","author":"Souied","year":"2015","journal-title":"Ophthalmic Res."},{"key":"ref_18","first-page":"901686","article-title":"Do nutritional supplements have a role in age macular degeneration prevention?","volume":"2014","author":"Arias","year":"2014","journal-title":"J. Ophthalmol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Age-Related Eye Disease Study 2 Research Group (2013). Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: The Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial. JAMA, 309, 2005\u20132015.","DOI":"10.1001\/jama.2013.4997"},{"key":"ref_20","first-page":"3","article-title":"Effectiveness test: Anti-inflammatory action of the F.A.G. (Fatty Acid Groups)","volume":"1","author":"Facchini","year":"2016","journal-title":"J. Res. Ther."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Cammalleri, M., Dal Monte, M., Locri, F., Lardner, E., Kvanta, A., Rusciano, D., Andr\u00e9, H., and Bagnoli, P. (2017). Efficacy of a Fatty Acids Dietary Supplement in a Polyethylene Glycol-Induced Mouse Model of Retinal Degeneration. Nutrients, 9.","DOI":"10.3390\/nu9101079"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jneuroim.2016.06.008","article-title":"Microglia response in retina and optic nerve in chronic experimental autoimmune encephalomyelitis","volume":"298","author":"Horstmann","year":"2016","journal-title":"J. Neuroimmunol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1177\/107385840100700310","article-title":"Sex hormones in experimental autoimmune encephalomyelitis: Implications for multiple sclerosis","volume":"7","author":"Voskuhl","year":"2001","journal-title":"Neuroscientist"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/1742-2094-10-120","article-title":"Inflammatory demyelination induces glia alterations and ganglion cell loss in the retina of an experimental autoimmune encephalomyelitis model","volume":"10","author":"Horstmann","year":"2013","journal-title":"J. Neuroinflamm."},{"key":"ref_25","unstructured":"(2018, February 05). Google Patents. Available online: https:\/\/encrypted.google.com\/patents\/WO2014135529A1?cl=ar."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","article-title":"Dose translation from animal to human studies revisited","volume":"22","author":"Nihal","year":"2008","journal-title":"FASEB J."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/labinvest.2016.116","article-title":"CD68\/macrosialin: Not just a histochemical marker","volume":"97","author":"Chistiakov","year":"2017","journal-title":"Lab. Investig."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.it.2005.07.008","article-title":"A function for the macrophage F4\/80 molecule in tolerance induction","volume":"26","author":"Kraal","year":"2005","journal-title":"Trends Immunol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"463","DOI":"10.3945\/an.116.014191","article-title":"Influence of Diet in Multiple Sclerosis: A Systematic Review","volume":"8","author":"Bagur","year":"2017","journal-title":"Adv. Nutr."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s13760-012-0166-2","article-title":"Preventive effect of vitamin D3 supplementation on conversion of optic neuritis to clinically definite multiple sclerosis: A double blind, randomized, placebo-controlled pilot clinical trial","volume":"113","author":"Derakhshandi","year":"2013","journal-title":"Acta Neurol. Belg."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.neulet.2016.12.057","article-title":"Valproic acid and ASK1 deficiency ameliorate optic neuritis and neurodegeneration in an animal model of multiple sclerosis","volume":"639","author":"Azuchi","year":"2017","journal-title":"Neurosci. Lett."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.exer.2016.06.001","article-title":"Increased production of omega-3 fatty acids protects retinal ganglion cells after optic nerve injury in mice","volume":"148","author":"Peng","year":"2016","journal-title":"Exp. Eye Res."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Parry, D.A., Oeppen, R.S., Amin, M., and Brennan, P.A. (2017). Can dietary supplements improve a clinician\u2019s well-being and health?. Br. J. Oral Maxillofac. Surg.","DOI":"10.1016\/j.bjoms.2017.12.002"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.neuroscience.2008.07.036","article-title":"The role of macrophages in optic nerve regeneration","volume":"158","author":"Cui","year":"2009","journal-title":"Neuroscience"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1684\/ecn.2013.0334","article-title":"Contribution of TNF-\u03b1 to the development of retinal neurodegenerative disorders","volume":"24","author":"Elsherbiny","year":"2013","journal-title":"Eur. Cytokine Netw."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"6524","DOI":"10.1523\/JNEUROSCI.3838-12.2013","article-title":"Tumor necrosis factor-alpha is produced by dying retinal neurons and is required for Muller glia proliferation during zebrafish retinal regeneration","volume":"33","author":"Nelson","year":"2013","journal-title":"J. Neurosci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1007\/s11481-006-9020-8","article-title":"Up-regulation of BDNF in astrocytes by TNF-alpha: A case for the neuroprotective role of cytokine","volume":"1","author":"Saha","year":"2006","journal-title":"J. Neuroimmune Pharmacol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"126","DOI":"10.3389\/fnagi.2016.00126","article-title":"Chronic Inflammation Links Cancer and Parkinson\u2019s Disease","volume":"8","author":"Li","year":"2016","journal-title":"Front. Aging Neurosci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.yexcr.2014.08.040","article-title":"IL-1\u03b2 induces IL-6 production in retinal M\u00fcller cells predominantly through the activation of p38 MAPK\/NF-\u03baB signaling pathway","volume":"331","author":"Liu","year":"2015","journal-title":"Exp. Cell Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.preteyeres.2011.05.002","article-title":"Inflammation in diabetic retinopathy","volume":"30","author":"Tang","year":"2011","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_41","first-page":"908","article-title":"Anti-vascular endothelial growth factor acts on retinal microglia\/macrophage activation in a rat model of ocular inflammation","volume":"20","author":"Couturier","year":"2014","journal-title":"Mol. Vis."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"214","DOI":"10.3389\/fnagi.2017.00214","article-title":"The Role of Microglia in Retinal Neurodegeneration: Alzheimer\u2019s Disease, Parkinson, and Glaucoma","volume":"9","author":"Ramirez","year":"2017","journal-title":"Front. Aging Neurosci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.lfs.2016.08.001","article-title":"The importance of glial cells in the homeostasis of the retinal microenvironment and their pivotal role in the course of diabetic retinopathy","volume":"162","author":"Sorrentino","year":"2016","journal-title":"Life Sci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.bpa.2010.11.001","article-title":"Neuronal injury in chronic CNS inflammation","volume":"24","author":"Zindler","year":"2010","journal-title":"Best Pract. Res. Clin. Anaesthesiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1136\/jnnp-2016-313300","article-title":"Neurodegeneration in multiple sclerosis and neuromyelitis optica","volume":"88","author":"Kawachi","year":"2017","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/nrneurol.2014.141","article-title":"Treatment of neuromyelitis optica: State-of-the-art and emerging therapies","volume":"10","author":"Papadopoulos","year":"2014","journal-title":"Nat. Rev. Neurol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Ad\u00e1n, A., Sol\u00e9, M., Corcostegui, B., Navarro, R., and Bur\u00e9s, A. (2009). Cytological vitreous findings in a patient with infantile neurological cutaneous and articular (CINCA) syndrome. BMJ Case Rep.","DOI":"10.1136\/bcr.09.2008.0992"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.expneurol.2015.12.015","article-title":"Reaching the brain: Advances in optic nerve regeneration","volume":"287","author":"Benowitz","year":"2017","journal-title":"Exp. Neurol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1742-2094-10-35","article-title":"Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation status","volume":"10","author":"Vogel","year":"2013","journal-title":"J. Neuroinflamm."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"5744","DOI":"10.1167\/iovs.14-14672","article-title":"HE3286 reduces axonal loss and preserves retinal ganglion cell function in experimental opticneuritis","volume":"55","author":"Khan","year":"2014","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.neulet.2009.07.028","article-title":"Effect of geranylgeranylacetone on optic neuritis in experimental autoimmune encephalomyelitis","volume":"462","author":"Guo","year":"2009","journal-title":"Neurosci. Lett."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.exer.2008.05.017","article-title":"Inflammatory demyelination induces axonal injury and retinal ganglion cell apoptosis in experimental optic neuritis","volume":"87","author":"Shindler","year":"2008","journal-title":"Exp. Eye Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jneuroim.2006.05.019","article-title":"Retinal ganglion cell damage induced by spontaneous autoimmune optic neuritis in MOG-specific TCR transgenic mice","volume":"178","author":"Guan","year":"2006","journal-title":"J. Neuroimmunol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"5585","DOI":"10.1523\/JNEUROSCI.5705-11.2012","article-title":"Preclinical retinal neurodegeneration in a model of multiple sclerosis","volume":"32","author":"Fairless","year":"2012","journal-title":"J. Neurosci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1111\/j.1750-3639.2004.tb00047.x","article-title":"Mechanisms and time course of neuronal degeneration in experimental autoimmune encephalomyelitis","volume":"14","author":"Hobom","year":"2004","journal-title":"Brain Pathol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1056\/NEJMcp053247","article-title":"Clinical practice. Optic neuritis","volume":"354","author":"Balcer","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jneuroim.2017.07.005","article-title":"Resolution of inflammation, n-3 fatty acid supplementation and Alzheimer disease: A narrative review","volume":"310","author":"Fraga","year":"2017","journal-title":"J. Neuroimmunol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nrneurol.2014.207","article-title":"Microglial and macrophage polarization\u2014New prospects for brain repair","volume":"11","author":"Hu","year":"2015","journal-title":"Nat. Rev. Neurol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1167\/iovs.16-20979","article-title":"Neuroprotective Effects of Omega-3 Polyunsaturated Fatty Acids in a Rat Model of Anterior Ischemic Optic Neuropathy","volume":"58","author":"Georgiou","year":"2017","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0074-7696(03)30005-1","article-title":"Up-regulation of glial fibrillary acidic protein in response to retinal injury: Its potential role in glial remodeling and a comparison to vimentin expression","volume":"230","author":"Lewis","year":"2003","journal-title":"Int. Rev. Cytol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1007\/s12010-015-1878-6","article-title":"Amyloid \u03b2 Peptide Induces Apoptosis Through P2X7 Cell Death Receptor in Retinal Cells: Modulation by Marine Omega-3 Fatty Acid DHA and EPA","volume":"178","author":"Wakx","year":"2016","journal-title":"Appl. Biochem. Biotechnol."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Lidster, K., Jackson, S.J., Ahmed, Z., Munro, P., Coffey, P., Giovannoni, G., Baker, M.D., and Baker, D. (2013). Neuroprotection in a novel mouse model of multiple sclerosis. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0079188"}],"updated-by":[{"DOI":"10.3390\/nu18132171","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2018,3,8]],"date-time":"2018-03-08T00:00:00Z","timestamp":1520467200000}}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/10\/3\/325\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T16:20:38Z","timestamp":1783095638000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/10\/3\/325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,8]]},"references-count":62,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018,3]]}},"alternative-id":["nu10030325"],"URL":"https:\/\/doi.org\/10.3390\/nu10030325","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,8]]}}}