{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T05:14:02Z","timestamp":1788498842425,"version":"build-2803163510"},"reference-count":79,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2018,3,13]],"date-time":"2018-03-13T00:00:00Z","timestamp":1520899200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Vitamin D deficiency is highly prevalent in newly settled refugees in Western Australia (WA). If adherence to daily vitamin D therapy is problematic, depot therapy is a therapeutic alternative. The aim of this study was to compare daily versus depot treatment and factors influencing the therapeutic outcome. Newly settled refugees (n = 151) with 25(OH)D levels less than 78 nmol\/L were randomised to receive daily or depot vitamin D therapy with eight weekly interval follow up to 40 weeks. Biochemical and clinical parameters were collected at each visit. Generalized Linear Mixed Models (GLMM) examined the longitudinal changes over time controlling for confounders including age, gender, treatment arm, season, country of refuge\/origin and sun exposure score. Participants were aged 5.5 months to 16.0 years (75 males, 83 females). Both treatment groups achieved vitamin D sufficiency. The daily treatment group had significantly higher 25(OH)D levels at each visit post baseline and a higher proportion of participants with levels above 50 nmol\/L at all time points. Time, treatment group, calcium and sun exposure score were significant predictors of 25(OH)D serum levels. Depot vitamin D therapy is an alternative to daily treatment in this at-risk group of children and adolescents in whom treatment adherence is problematic.<\/jats:p>","DOI":"10.3390\/nu10030348","type":"journal-article","created":{"date-parts":[[2018,3,13]],"date-time":"2018-03-13T13:37:21Z","timestamp":1520948241000},"page":"348","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Randomised Controlled Trial Comparing Daily Versus Depot Vitamin D3 Therapy in 0\u201316-Year-Old Newly Settled Refugees in Western Australia Over a Period of 40 Weeks"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8097-5072","authenticated-orcid":false,"given":"Ushma","family":"Wadia","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Metabolic Medicine, Princess Margaret Hospital for Children, Perth, WA 6008, Australia"},{"name":"Department of Infectious Diseases, Princess Margaret Hospital for Children, Perth, WA 6008, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne","family":"Soon","sequence":"additional","affiliation":[{"name":"Division of Paediatrics, School of Medicine, Faculty of Health and Medical Sciences, The University of Western Australia, Perth, WA 6008, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2278-4857","authenticated-orcid":false,"given":"Paola","family":"Chivers","sequence":"additional","affiliation":[{"name":"Institute for Health Research, The University of Notre Dame Australia, Fremantle, WA 6160, Australia"},{"name":"School of Medical and Health Sciences &amp; Exercise Medicine Research Institute, Edith Cowan University, Perth, WA 6027, Australia"},{"name":"Western Australian Bone Research Collaboration, Perth, WA 6008, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aesen","family":"Thambiran","sequence":"additional","affiliation":[{"name":"Humanitarian Entrant Health Service, North Metropolitan Health Service, Perth, WA 6000, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Burgner","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, The University of Melbourne, Melbourne, VIC 3052, Australia"},{"name":"Department of Paediatrics, Monash University, Melbourne, VIC 3168, Australia"},{"name":"Murdoch Children\u2019s Research Institute, Royal Children\u2019s Hospital Melbourne, Melbourne, VIC 3052, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Cherian","sequence":"additional","affiliation":[{"name":"Division of Paediatrics, School of Medicine, Faculty of Health and Medical Sciences, The University of Western Australia, Perth, WA 6008, Australia"},{"name":"Refugee Health Service, Department of Paediatrics, Princess Margaret Hospital for Children, Perth, WA 6008, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aris","family":"Siafarikas","sequence":"additional","affiliation":[{"name":"Division of Paediatrics, School of Medicine, Faculty of Health and Medical Sciences, The University of Western Australia, Perth, WA 6008, Australia"},{"name":"Institute for Health Research, The University of Notre Dame Australia, Fremantle, WA 6160, Australia"},{"name":"School of Medical and Health Sciences &amp; Exercise Medicine Research Institute, Edith Cowan University, Perth, WA 6027, Australia"},{"name":"Western Australian Bone Research Collaboration, Perth, WA 6008, Australia"},{"name":"Department of Endocrinology and Diabetes, PrincessMargaret Hospital for Children, Perth,WA 6008, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,3,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1056\/NEJMra070553","article-title":"Vitamin D deficiency","volume":"357","author":"Holick","year":"2007","journal-title":"N. 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