{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:23:38Z","timestamp":1791912218977,"version":"4.3.4"},"reference-count":102,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2018,3,17]],"date-time":"2018-03-17T00:00:00Z","timestamp":1521244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Increased oxidative stress contributes to development and progression of several human chronic inflammatory diseases. Cherries are a rich source of polyphenols and vitamin C which have anti-oxidant and anti-inflammatory properties. Our aim is to summarize results from human studies regarding health benefits of both sweet and tart cherries, including products made from them (juice, powder, concentrate, capsules); all referred to as cherries here. We found 29 (tart 20, sweet 7, unspecified 2) published human studies which examined health benefits of consuming cherries. Most of these studies were less than 2 weeks of duration (range 5 h to 3 months) and served the equivalent of 45 to 270 cherries\/day (anthocyanins 55\u2013720 mg\/day) in single or split doses. Two-thirds of these studies were randomized and placebo controlled. Consumption of cherries decreased markers for oxidative stress in 8\/10 studies; inflammation in 11\/16; exercise-induced muscle soreness and loss of strength in 8\/9; blood pressure in 5\/7; arthritis in 5\/5, and improved sleep in 4\/4. Cherries also decreased hemoglobin A1C (HbA1C), Very-low-density lipoprotein (VLDL) and triglycerides\/high-density lipoprotein (TG\/HDL) in diabetic women, and VLDL and TG\/HDL in obese participants. These results suggest that consumption of sweet or tart cherries can promote health by preventing or decreasing oxidative stress and inflammation.<\/jats:p>","DOI":"10.3390\/nu10030368","type":"journal-article","created":{"date-parts":[[2018,3,20]],"date-time":"2018-03-20T06:57:11Z","timestamp":1521529031000},"page":"368","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":193,"title":["A Review of the Health Benefits of Cherries"],"prefix":"10.3390","volume":"10","author":[{"given":"Darshan","family":"Kelley","sequence":"first","affiliation":[{"name":"US Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center, Davis, CA 95616, USA"},{"name":"Department of Nutrition, University of California, Davis, CV 95616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuriko","family":"Adkins","sequence":"additional","affiliation":[{"name":"US Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center, Davis, CA 95616, USA"},{"name":"Department of Nutrition, University of California, Davis, CV 95616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Laugero","sequence":"additional","affiliation":[{"name":"US Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center, Davis, CA 95616, USA"},{"name":"Department of Nutrition, University of California, Davis, CV 95616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,3,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.7326\/0003-4819-134-12-200106190-00010","article-title":"The effect of fruit and vegetable intake on risk for coronary heart disease","volume":"134","author":"Joshipura","year":"2001","journal-title":"Ann. Intern. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ije\/26.1.1","article-title":"Fruit and vegetables, and cardiovascular disease: A review","volume":"26","author":"Ness","year":"1997","journal-title":"Int. J. Epidemiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1038\/ejcn.2012.85","article-title":"Fruit and vegetable intake and type 2 diabetes: EPIC-InterAct prospective study and meta-analysis","volume":"66","author":"Cooper","year":"2012","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.1093\/jn\/136.10.2588","article-title":"Fruit and vegetable consumption and risk of coronary heart disease: A meta-analysis of cohort studies","volume":"136","author":"Dauchet","year":"2006","journal-title":"J. Nutr."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1080\/03009740600704155","article-title":"Anti-inflammatory and anti-oxidative effects of cherries on Freund\u2019s adjuvant-induced arthritis in rats","volume":"35","author":"He","year":"2006","journal-title":"Scand. J. Rheumatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1002\/ijc.28024","article-title":"Intake of fruit and vegetables and risk of esophageal squamous cell carcinoma: A meta-analysis of observational studies","volume":"133","author":"Liu","year":"2013","journal-title":"Int. J. Cancer"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/0140-6736(93)92876-U","article-title":"Dietary antioxidant flavonoids and risk of coronary heart disease: The Zutphen Elderly Study","volume":"342","author":"Hertog","year":"1993","journal-title":"Lancet"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"71S","DOI":"10.1016\/S0002-9343(01)00995-0","article-title":"Bioactive compounds in foods: Their role in the prevention of cardiovascular disease and cancer","volume":"113","author":"Hecker","year":"2002","journal-title":"Am. J. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1093\/ajcn\/79.5.727","article-title":"Polyphenols: Food sources and bioavailability","volume":"79","author":"Manach","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"5812401","DOI":"10.1155\/2017\/5812401","article-title":"Effects of Polyphenol Intake on Metabolic Syndrome: Current Evidences from Human Trials","volume":"2017","author":"Badimon","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1017\/jns.2013.33","article-title":"Acute effects of raisin consumption on glucose and insulin reponses in healthy individuals","volume":"3","author":"Esfahani","year":"2014","journal-title":"J. Nutr. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1017\/S0007114517001805","article-title":"Dietary polyphenol intake and risk of type 2 diabetes in the Polish arm of the Health, Alcohol and Psychosocial factors in Eastern Europe (HAPIEE) study","volume":"118","author":"Grosso","year":"2017","journal-title":"Br. J. Nutr."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Grosso, G., Stepaniak, U., Micek, A., Kozela, M., Stefler, D., Bobak, M., and Pajak, A. (2017). Dietary polyphenol intake and risk of hypertension in the Polish arm of the HAPIEE study. Eur. J. Nutr.","DOI":"10.1007\/s00394-017-1438-7"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"7432797","DOI":"10.1155\/2016\/7432797","article-title":"Oxidative Stress and Inflammation: What Polyphenols Can Do for Us?","volume":"2016","author":"Hussain","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.numecd.2014.09.001","article-title":"Effects of total dietary polyphenols on plasma nitric oxide and blood pressure in a high cardiovascular risk cohort. The PREDIMED randomized trial","volume":"25","author":"Pons","year":"2015","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Miranda, A.M., Steluti, J., Fisberg, R.M., and Marchioni, D.M. (2016). Association between Polyphenol Intake and Hypertension in Adults and Older Adults: A Population-Based Study in Brazil. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0165791"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1038\/ejcn.2016.227","article-title":"Do grape polyphenols improve metabolic syndrome components? A systematic review","volume":"71","author":"Woerdeman","year":"2017","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10408390903001719","article-title":"Cherries and health: A review","volume":"51","author":"McCune","year":"2011","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"9","DOI":"10.4137\/IJTR.S9394","article-title":"A jerte valley cherry-based product as a supply of tryptophan","volume":"5","author":"Garrido","year":"2012","journal-title":"Int. J. Tryptophan Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s12161-009-9084-1","article-title":"Assays of the Amino Acid Tryptophan in Cherries by HPLC-Fluorescence","volume":"3","author":"Cubero","year":"2010","journal-title":"Food Anal. Methods"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"6993","DOI":"10.3390\/molecules15106993","article-title":"Cherry antioxidants: From farm to table","volume":"15","author":"Ferretti","year":"2010","journal-title":"Molecules"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Commisso, M., Bianconi, M., di Carlo, F., Poletti, S., Bulgarini, A., Munari, F., Negri, S., Stocchero, M., Ceoldo, S., and Avesani, L. (2017). Multi-approach metabolomics analysis and artificial simplified phytocomplexes reveal cultivar-dependent synergy between polyphenols and ascorbic acid in fruits of the sweet cherry (Prunus avium L.). PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0180889"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1093\/jn\/136.4.981","article-title":"Consumption of Bing sweet cherries lowers circulating concentrations of inflammation markers in healthy men and women","volume":"136","author":"Kelley","year":"2006","journal-title":"J. Nutr."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"12332","DOI":"10.1021\/jf504023z","article-title":"Evaluation of sour cherry (Prunus cerasus L.) fruits for their polyphenol content, antioxidant properties, and nutritional components","volume":"62","author":"Wojdylo","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"C67","DOI":"10.1111\/j.1365-2621.2004.tb17858.x","article-title":"Total anthocyanins and total phenolics of fresh and processed cherries and their antioxidant properties","volume":"69","author":"Chaovanalikit","year":"2004","journal-title":"J. Food Sci."},{"key":"ref_26","first-page":"C73","article-title":"Anthocyanin and polyphenolic composition of fresh and processed cherries","volume":"69","author":"Chaovanalikit","year":"2004","journal-title":"J. Food Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1021\/jf8032039","article-title":"Anthocyanin content, lipid peroxidation and cyclooxygenase enzyme inhibitory activities of sweet and sour cherries","volume":"57","author":"Mulabagal","year":"2009","journal-title":"J. Agric. Food Chem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.foodres.2017.03.030","article-title":"Phenolic compounds profile and antioxidant properties of six sweet cherry (Prunus avium) cultivars","volume":"97","author":"Martini","year":"2017","journal-title":"Food Res. Int."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/jpi.12044","article-title":"Melatonin and its potential biological functions in the fruits of sweet cherry","volume":"55","author":"Zhao","year":"2013","journal-title":"J. Pineal Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"4898","DOI":"10.1021\/jf010321+","article-title":"Detection and quantification of the antioxidant melatonin in Montmorency and Balaton tart cherries (Prunus cerasus)","volume":"49","author":"Burkhardt","year":"2001","journal-title":"J. Agric. Food Chem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1007\/s00394-015-0988-9","article-title":"Phytochemical uptake following human consumption of Montmorency tart cherry (L. Prunus cerasus) and influence of phenolic acids on vascular smooth muscle cells in vitro","volume":"55","author":"Keane","year":"2016","journal-title":"Eur. J. Nutr."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"230S","DOI":"10.1093\/ajcn\/81.1.230S","article-title":"Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies","volume":"81","author":"Manach","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"995","DOI":"10.3945\/ajcn.112.049247","article-title":"Human metabolism and elimination of the anthocyanin, cyanidin-3-glucoside: A (13)C-tracer study","volume":"97","author":"Czank","year":"2013","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1111\/sms.12085","article-title":"The role of cherries in exercise and health","volume":"24","author":"Bell","year":"2014","journal-title":"Scand. J. Med. Sci. Sports"},{"key":"ref_35","first-page":"1885","article-title":"Consumption of cherries as a strategy to attenuate exercise-induced muscle damage and inflammation in humans","volume":"32","author":"Prestes","year":"2015","journal-title":"Nutr. Hosp."},{"key":"ref_36","first-page":"1","article-title":"Tart Cherries and Health: Current Knowledge and Need for a Better Understanding of the Fate of Phytochemicals in Human Gastrointenstinal Tract","volume":"28","author":"Marasini","year":"2017","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1249\/MSS.0b013e31820e5adc","article-title":"Montmorency cherry juice reduces muscle damage caused by intensive strength exercise","volume":"43","author":"Bowtell","year":"2011","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e321","DOI":"10.1016\/j.eclnm.2009.09.003","article-title":"A Nutraceutical Product Based on Jerte Valley Cherries Improves Sleep and Augments the Antioxidant Status in Humans","volume":"4","author":"Garrido","year":"2009","journal-title":"e-SPEN Eur. e-J. Clin. Nutr. Metab."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1111\/j.1600-0838.2009.01005.x","article-title":"Influence of tart cherry juice on indices of recovery following marathon running","volume":"20","author":"Howatson","year":"2010","journal-title":"Scand. J. Med. Sci. Sports"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1093\/jn\/133.6.1826","article-title":"Consumption of cherries lowers plasma urate in healthy women","volume":"133","author":"Jacob","year":"2003","journal-title":"J. Nutr."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s12970-016-0133-z","article-title":"Effects of powdered Montmorency tart cherry supplementation on acute endurance exercise performance in aerobically trained individuals","volume":"13","author":"Levers","year":"2016","journal-title":"J. Int. Soc. Sports Nutr."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1007\/s11130-014-0409-x","article-title":"Effect of a tart cherry juice supplement on arterial stiffness and inflammation in healthy adults: A randomised controlled trial","volume":"69","author":"Lynn","year":"2014","journal-title":"Plant Foods Hum. Nutr."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.3945\/jn.109.111716","article-title":"Tart cherry juice decreases oxidative stress in healthy older men and women","volume":"139","author":"Traustadottir","year":"2009","journal-title":"J. Nutr."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"829","DOI":"10.3390\/nu6020829","article-title":"Montmorency cherries reduce the oxidative stress and inflammatory responses to repeated days high-intensity stochastic cycling","volume":"6","author":"Bell","year":"2014","journal-title":"Nutrients"},{"key":"ref_45","first-page":"90","article-title":"Characterization and Trials of a Jerte Valley Cherry Product as a Natural Antioxidant-Enriched Supplement","volume":"25","author":"Garrido","year":"2013","journal-title":"Ital. J. Food Sci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12970-015-0102-y","article-title":"Effects of powdered Montmorency tart cherry supplementation on an acute bout of intense lower body strength exercise in resistance trained males","volume":"12","author":"Levers","year":"2015","journal-title":"J. Int. Soc. Sports Nutr."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12970-016-0151-x","article-title":"Effect of tart cherry juice on recovery and next day performance in well-trained Water Polo players","volume":"13","author":"McCormick","year":"2016","journal-title":"J. Int. Soc. Sports Nutr."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jff.2014.09.004","article-title":"Montmorency tart cherry (Prunus cerasus L.) concentrate lowers uric acid, independent of plasma cyanidin-3-O-glucosiderutinoside","volume":"11","author":"Bell","year":"2014","journal-title":"J. Funct. Foods"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Bell, P.G., Stevenson, E., Davison, G.W., and Howatson, G. (2016). The Effects of Montmorency Tart Cherry Concentrate Supplementation on Recovery Following Prolonged, Intermittent Exercise. Nutrients, 8.","DOI":"10.3390\/nu8070441"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s12970-015-0085-8","article-title":"Influence of a montmorency cherry juice blend on indices of exercise-induced stress and upper respiratory tract symptoms following marathon running--a pilot investigation","volume":"12","author":"Dimitriou","year":"2015","journal-title":"J. Int. Soc. Sports Nutr."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"340","DOI":"10.3945\/jn.112.171371","article-title":"Sweet bing cherries lower circulating concentrations of markers for chronic inflammatory diseases in healthy humans","volume":"143","author":"Kelley","year":"2013","journal-title":"J. Nutr."},{"key":"ref_52","unstructured":"Martin, K.R., Bopp, J., Burrell, L., and Hook, G. (2011). The effect of 100% tart cherry juice on serum uric acid levels, biomarkers of inflammation and cardiovascular disease risk factors. FASEB J., 25."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s12603-013-0029-4","article-title":"A Jerte valley cherry product provides beneficial effects on sleep quality. Influence on aging","volume":"17","author":"Garrido","year":"2013","journal-title":"J. Nutr. Health Aging"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s00394-015-1083-y","article-title":"Consumption of anthocyanin-rich cherry juice for 12 weeks improves memory and cognition in older adults with mild-to-moderate dementia","volume":"56","author":"Kent","year":"2017","journal-title":"Eur. J. Nutr."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.joca.2013.05.009","article-title":"Randomized double-blind crossover study of the efficacy of a tart cherry juice blend in treatment of osteoarthritis (OA) of the knee","volume":"21","author":"Schumacher","year":"2013","journal-title":"Osteoarthr. Cartil."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1080\/01635581.2014.949801","article-title":"Dietary polyamine intake and polyamines measured in urine","volume":"66","author":"Vargas","year":"2014","journal-title":"Nutr. Cancer"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1136\/bjsm.2005.025429","article-title":"Efficacy of a tart cherry juice blend in preventing the symptoms of muscle damage","volume":"40","author":"Connolly","year":"2006","journal-title":"Br. J. Sports Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1550-2783-7-17","article-title":"Efficacy of tart cherry juice in reducing muscle pain during running: A randomized controlled trial","volume":"7","author":"Kuehl","year":"2010","journal-title":"J. Int. Soc. Sports Nutr."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1108\/00346650810891414","article-title":"Effects of Sour Cherry Juic on Blood Glucose and Some Cardiovascular Risk Factors Improvements in Diabetic Women","volume":"38","author":"Hosseini","year":"2008","journal-title":"Nutr. Food Sci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.3945\/ajcn.115.123869","article-title":"Effects of Montmorency tart cherry (Prunus cerasus L.) consumption on vascular function in men with early hypertension","volume":"103","author":"Keane","year":"2016","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1017\/S0007114516004177","article-title":"Montmorency Tart cherries (Prunus cerasus L.) modulate vascular function acutely, in the absence of improvement in cognitive performance","volume":"116","author":"Keane","year":"2016","journal-title":"Br. J. Nutr."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3109\/09637486.2015.1121472","article-title":"Acute reduction in blood pressure following consumption of anthocyanin-rich cherry juice may be dose-interval dependant: A pilot cross-over study","volume":"67","author":"Kent","year":"2016","journal-title":"Int. J. Food Sci. Nutr."},{"key":"ref_63","first-page":"309","article-title":"Cherry diet control for gout and arthritis","volume":"8","author":"Blau","year":"1950","journal-title":"Tex. Rep. Biol. Med."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"4004","DOI":"10.1002\/art.34677","article-title":"Cherry consumption and decreased risk of recurrent gout attacks","volume":"64","author":"Zhang","year":"2012","journal-title":"Arthritis Rheum."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1089\/jmf.2009.0096","article-title":"Effects of a tart cherry juice beverage on the sleep of older adults with insomnia: A pilot study","volume":"13","author":"Pigeon","year":"2010","journal-title":"J. Med. Food"},{"key":"ref_66","unstructured":"Rodriguez Moratinos, A.B., Terron Sanchez, M.P., Fernandez Gonzalez, M.D.C., Pariente Llanos, J.A., Cubero Juanez, J., Gonzalez Gomez, D., Garrido Alvarez, M., Hernandez Mendez, T., Barriga Ibars, C., and Paredes Royano, S.D. (2011). Composicion Nutraceutica Contra Trastornos del Estado Animico y el Insomnia. (ES2342141), Spanish Patent."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1080\/1040869059096","article-title":"Dietary polyphenols and the prevention of diseases","volume":"45","author":"Scalbert","year":"2005","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1089\/jmf.2011.0336","article-title":"Tart cherry juice induces differential dose-dependent effects on apoptosis, but not cellular proliferation, in MCF-7 human breast cancer cells","volume":"15","author":"Martin","year":"2012","journal-title":"J. Med. Food"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jsmc.2007.03.003","article-title":"Sleep and Cytokines","volume":"2","author":"Krueger","year":"2007","journal-title":"Sleep Med. Clin."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1078\/0944-7113-00053","article-title":"Cyclooxygenase inhibitory and antioxidant cyanidin glycosides in cherries and berries","volume":"8","author":"Seeram","year":"2001","journal-title":"Phytomedicine"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1385\/ENDO:27:2:189","article-title":"A review of the multiple actions of melatonin on the immune system","volume":"27","author":"Guerrero","year":"2005","journal-title":"Endocrine"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"67","DOI":"10.2174\/1872214808666140121151334","article-title":"Effect of antioxidant extract from cherries on diabetes","volume":"8","author":"Lachin","year":"2014","journal-title":"Recent Pat. Endocr. Metab. Immune Drug Discov."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.biopha.2017.01.155","article-title":"Hypoglycemic effects of Prunus cerasus L. pulp and seed extracts on Alloxan-Induced Diabetic Mice with histopathological evaluation","volume":"88","author":"Saleh","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1021\/jf0520342","article-title":"Amelioration of obesity and glucose intolerance in high-fat-fed C57BL\/6 mice by anthocyanins and ursolic acid in Cornelian cherry (Cornus mas)","volume":"54","author":"Jayaprakasam","year":"2006","journal-title":"J. Agric. Food Chem."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1089\/jmf.2007.658","article-title":"Altered hyperlipidemia, hepatic steatosis, and hepatic peroxisome proliferator-activated receptors in rats with intake of tart cherry","volume":"11","author":"Seymour","year":"2008","journal-title":"J. Med. Food"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.3945\/jn.115.228817","article-title":"Consumption of Quercetin and Quercetin-Containing Apple and Cherry Extracts Affects Blood Glucose Concentration, Hepatic Metabolism, and Gene Expression Patterns in Obese C57BL\/6J High Fat-Fed Mice","volume":"146","author":"Snyder","year":"2016","journal-title":"J. Nutr."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s11517-014-1223-1","article-title":"Effective identification and localization of immature precursors in bone marrow biopsy","volume":"53","author":"Cao","year":"2015","journal-title":"Med. Biol. Eng. Comput."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.foodres.2017.02.023","article-title":"Sweet cherries from Fundao possess antidiabetic potential and protect human erythrocytes against oxidative damage","volume":"95","author":"Goncalves","year":"2017","journal-title":"Food Res. Int."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"4675","DOI":"10.1039\/C6FO01295G","article-title":"Bioactive and functional properties of sour cherry juice (Prunus cerasus)","volume":"7","author":"Casedas","year":"2016","journal-title":"Food Funct."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1007\/BF03346357","article-title":"Dipeptidyl peptidase 4 (DPP-4) inhibitors and their role in Type 2 diabetes management","volume":"30","author":"Crepaldi","year":"2007","journal-title":"J. Endocrinol. Investig."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.foodchem.2015.07.130","article-title":"Anthocyanin composition, antioxidant efficiency, and alpha-amylase inhibitor activity of different Hungarian sour cherry varieties (Prunus cerasus L.)","volume":"194","author":"Homoki","year":"2016","journal-title":"Food Chem."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1021\/jf049018+","article-title":"Insulin secretion by bioactive anthocyanins and anthocyanidins present in fruits","volume":"53","author":"Jayaprakasam","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1021\/jf5041993","article-title":"Phenolic metabolites of anthocyanins modulate mechanisms of endothelial function","volume":"63","author":"Edwards","year":"2015","journal-title":"J. Agric. Food Chem."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"5423","DOI":"10.1210\/jc.2003-032223","article-title":"Increased plasma S100A12 (EN-RAGE) levels in patients with type 2 diabetes","volume":"89","author":"Kosaki","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.2741\/2285","article-title":"Plasminogen activator inhibitor (PAI)-1 in vascular inflammation and thrombosis","volume":"12","author":"Aso","year":"2007","journal-title":"Front. Biosci."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3945\/an.110.000042","article-title":"Anthocyanins in cardiovascular disease","volume":"2","author":"Wallace","year":"2011","journal-title":"Adv. Nutr."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"6896","DOI":"10.2174\/138161281939131127120517","article-title":"Cardioprotective effects of sour cherry seed extract (SCSE) on the hypercholesterolemic rabbit heart","volume":"19","author":"Juhasz","year":"2013","journal-title":"Curr. Pharm. Des."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"663","DOI":"10.3390\/nu5030663","article-title":"Extracts, anthocyanins and procyanidins from Aronia melanocarpa as radical scavengers and enzyme inhibitors","volume":"5","author":"Braunlich","year":"2013","journal-title":"Nutrients"},{"key":"ref_89","first-page":"53","article-title":"Inhibitory Effects of Tart Cherry (Prunus cerasus) Juice on Xanthine Oxidoreductase Activity and its Hypouricemic and Antioxidant Effects on Rats","volume":"15","author":"Haidari","year":"2009","journal-title":"Malays. J. Nutr."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.bbr.2003.11.011","article-title":"Tart cherry anthocyanins suppress inflammation-induced pain behavior in rat","volume":"153","author":"Tall","year":"2004","journal-title":"Behav. Brain Res."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1016\/j.bcp.2013.06.010","article-title":"Malvidin-3-O-beta glucoside, major grape anthocyanin, inhibits human macrophage-derived inflammatory mediators and decreases clinical scores in arthritic rats","volume":"86","author":"Decendit","year":"2013","journal-title":"Biochem. Pharmacol."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Min, H.K., Kim, S.M., Baek, S.Y., Woo, J.W., Park, J.S., Cho, M.L., Lee, J., Kwok, S.K., Kim, S.W., and Park, S.H. (2015). Anthocyanin Extracted from Black Soybean Seed Coats Prevents Autoimmune Arthritis by Suppressing the Development of Th17 Cells and Synthesis of Proinflammatory Cytokines by Such Cells, via Inhibition of NF-kappaB. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0138201"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1007\/s00394-011-0263-7","article-title":"Effect of tart cherry juice (Prunus cerasus) on melatonin levels and enhanced sleep quality","volume":"51","author":"Howatson","year":"2012","journal-title":"Eur. J. Nutr."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.exger.2012.05.003","article-title":"The consumption of a Jerte Valley cherry product in humans enhances mood, and increases 5-hydroxyindoleacetic acid but reduces cortisol levels in urine","volume":"47","author":"Garrido","year":"2012","journal-title":"Exp. Gerontol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1179\/1476830515Y.0000000005","article-title":"Anthocyanin-rich cherry juice does not improve acute cognitive performance on RAVLT","volume":"19","author":"Caldwell","year":"2016","journal-title":"Nutr. Neurosci."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1111\/nure.12149","article-title":"Fruits, vegetables, 100% juices, and cognitive function","volume":"72","author":"Lamport","year":"2014","journal-title":"Nutr. Rev."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s11357-016-9945-7","article-title":"Tart cherry supplementation improves working memory, hippocampal inflammation, and autophagy in aged rats","volume":"38","author":"Thangthaeng","year":"2016","journal-title":"Age"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"9921","DOI":"10.1021\/jf0518599","article-title":"Sweet and sour cherry phenolics and their protective effects on neuronal cells","volume":"53","author":"Kim","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"ref_99","first-page":"186","article-title":"Cyanidin-3-O-galactoside and blueberry extracts supplementation improves spatial memory and regulates hippocampal ERK expression in senescence-accelerated mice","volume":"27","author":"Tan","year":"2014","journal-title":"Biomed. Environ. Sci."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1097\/MJT.0b013e3182589188","article-title":"Effects of anthocyanins on active avoidance test of rats exposed to disruption of diurnal rhythm","volume":"20","author":"Varadinova","year":"2013","journal-title":"Am. J. Ther."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.neulet.2012.12.023","article-title":"Protective effect of cyanidin 3-O-glucoside on beta-amyloid peptide-induced cognitive impairment in rats","volume":"534","author":"Qin","year":"2013","journal-title":"Neurosci. Lett."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1179\/1476830515Y.0000000042","article-title":"Anthocyanin suppresses the toxicity of AB deposits through diversion of molecular forms in in vitro and in vivo models of Alzheimer\u2019s diesease","volume":"19","author":"Yoshida","year":"2016","journal-title":"Nutr. Neurosci."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/10\/3\/368\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T14:57:29Z","timestamp":1760194649000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/10\/3\/368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,17]]},"references-count":102,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018,3]]}},"alternative-id":["nu10030368"],"URL":"https:\/\/doi.org\/10.3390\/nu10030368","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,17]]}}}