{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T06:46:47Z","timestamp":1767854807763,"version":"3.49.0"},"reference-count":37,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2018,4,3]],"date-time":"2018-04-03T00:00:00Z","timestamp":1522713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The purpose of this study was to evaluate the effect of the administration of two egg white hydrolysates on glucose metabolism complications related to Metabolic Syndrome (MS) in Zucker fatty rats (ZFR). ZFR were given 750 mg\/kg\/day of egg white hydrolyzed with pepsin (HEW1) or with aminopeptidase (HEW2) for 12 weeks in their drinking water or just water. Zucker lean rats (ZLR), which received water, were used as a control. The presence of tactile allodynia, which is a sign of peripheral neuropathy, was assessed. Blood samples and pancreas were collected to determine the effect of the hydrolysates on glucose metabolism. The intake of HEW1 significantly lowered plasma insulin levels and improved the quantitative indexes of insulin resistance, insulin sensitivity, and pancreatic \u03b2-cell functionality (HOMA-IR, HOMA-\u03b2, and QUICKI, respectively), but non-significant changes were observed in group treated with HEW2. Compared to ZLR, ZFR showed tactile allodynia, but the consumption of both hydrolysates significantly increased mechanical sensitivity in ZFR. In conclusion, HEW1 pepsin could improve the glucose metabolism abnormalities associated with MS in obese Zucker rats.<\/jats:p>","DOI":"10.3390\/nu10040441","type":"journal-article","created":{"date-parts":[[2018,4,3]],"date-time":"2018-04-03T13:31:51Z","timestamp":1522762311000},"page":"441","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Pepsin Egg White Hydrolysate Improves Glucose Metabolism Complications Related to Metabolic Syndrome in Zucker Fatty Rats"],"prefix":"10.3390","volume":"10","author":[{"given":"Marta","family":"Garc\u00e9s-Rim\u00f3n","sequence":"first","affiliation":[{"name":"Instituto de Investigaci\u00f3n en Ciencias de Alimentaci\u00f3n (CIAL, CSIC-UAM), Madrid 28049, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n en Nutrici\u00f3n y Farmacolog\u00eda (URJC), Unidad Asociada al Instituto de Investigaci\u00f3n en Ciencias de la Alimentaci\u00f3n (CSIC), Madrid 28049, Spain"},{"name":"Departamento de Ciencias B\u00e1sicas de la Salud, Universidad Rey Juan Carlos, Alcorc\u00f3n, Madrid 28922, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gema","family":"Vera","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n en Nutrici\u00f3n y Farmacolog\u00eda (URJC), Unidad Asociada al Instituto de Investigaci\u00f3n en Ciencias de la Alimentaci\u00f3n (CSIC), Madrid 28049, Spain"},{"name":"Departamento de Ciencias B\u00e1sicas de la Salud, Universidad Rey Juan Carlos, Alcorc\u00f3n, Madrid 28922, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9-A.","family":"Uranga","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n en Nutrici\u00f3n y Farmacolog\u00eda (URJC), Unidad Asociada al Instituto de Investigaci\u00f3n en Ciencias de la Alimentaci\u00f3n (CSIC), Madrid 28049, Spain"},{"name":"Departamento de Ciencias B\u00e1sicas de la Salud, Universidad Rey Juan Carlos, Alcorc\u00f3n, Madrid 28922, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosina","family":"L\u00f3pez-Fandi\u00f1o","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n en Ciencias de Alimentaci\u00f3n (CIAL, CSIC-UAM), Madrid 28049, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Visitaci\u00f3n","family":"L\u00f3pez-Miranda","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n en Nutrici\u00f3n y Farmacolog\u00eda (URJC), Unidad Asociada al Instituto de Investigaci\u00f3n en Ciencias de la Alimentaci\u00f3n (CSIC), Madrid 28049, Spain"},{"name":"Departamento de Ciencias B\u00e1sicas de la Salud, Universidad Rey Juan Carlos, Alcorc\u00f3n, Madrid 28922, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5525-1056","authenticated-orcid":false,"given":"Marta","family":"Miguel","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n en Ciencias de Alimentaci\u00f3n (CIAL, CSIC-UAM), Madrid 28049, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,4,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.arcmed.2004.12.003","article-title":"The metabolic syndrome: A concept hard to define","volume":"36","author":"Rojas","year":"2005","journal-title":"Arch. 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