{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T12:09:40Z","timestamp":1790338180262,"version":"4.1.0"},"reference-count":43,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2018,4,13]],"date-time":"2018-04-13T00:00:00Z","timestamp":1523577600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Spanish Ministry of Science &amp; Technology","award":["CEN-20091006"],"award-info":[{"award-number":["CEN-20091006"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: we have evaluated the antihypertensive effect of several flavonoid extracts in a rat model of arterial hypertension caused by chronic administration (6 weeks) of the nitric oxide synthesis inhibitor, L-NAME. Methods: Sprague Dawley rats received L-NAME alone or L-NAME plus flavonoid-rich vegetal extracts (Lemon, Grapefruit + Bitter Orange, and Cocoa) or purified flavonoids (Apigenin and Diosmin) for 6 weeks. Results: L-NAME treatment resulted in a marked elevation of blood pressure, and treatment with Apigenin, Lemon Extract, and Grapefruit + Bitter Orange extracts significantly reduced the elevated blood pressure of these animals. Apigenin and some of these flavonoids also ameliorated nitric oxide-dependent and -independent aortic vasodilation and elevated nitrite urinary excretion. End-organ abnormalities such as cardiac infarcts, hyaline arteriopathy and fibrinoid necrosis in coronary arteries and aorta were improved by these treatments, reducing the end-organ vascular damage. Conclusions: the flavonoids included in this study, specially apigenin, may be used as functional food ingredients with potential therapeutic benefit in arterial hypertension.<\/jats:p>","DOI":"10.3390\/nu10040484","type":"journal-article","created":{"date-parts":[[2018,4,13]],"date-time":"2018-04-13T14:38:14Z","timestamp":1523630294000},"page":"484","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Beneficial Effects of Different Flavonoids on Vascular and Renal Function in L-NAME Hypertensive Rats"],"prefix":"10.3390","volume":"10","author":[{"given":"M.","family":"Paredes","sequence":"first","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Facultad de Medicina & Instituto Murciano de Investigaciones Biosanitarias, Universidad de Murcia, 30120 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Romec\u00edn","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Facultad de Medicina & Instituto Murciano de Investigaciones Biosanitarias, Universidad de Murcia, 30120 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4667-3270","authenticated-orcid":false,"given":"Noem\u00ed","family":"Atucha","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Facultad de Medicina & Instituto Murciano de Investigaciones Biosanitarias, Universidad de Murcia, 30120 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9207-2287","authenticated-orcid":false,"given":"Francisco","family":"O\u2019Valle","sequence":"additional","affiliation":[{"name":"Departamento de Anatom\u00eda Patol\u00f3gica, Facultad de Medicina, IBIMER, ibs.Granada, Universidad de Granada, 18011 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juli\u00e1n","family":"Castillo","sequence":"additional","affiliation":[{"name":"Instituto Universitario de Envejecimiento & Research and Development Department, Nutrafur SA-FRUTAROM Group, 30820 Alcantarilla (Murcia), Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ortiz","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Facultad de Medicina & Instituto Murciano de Investigaciones Biosanitarias, Universidad de Murcia, 30120 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7243-0240","authenticated-orcid":false,"given":"Joaqu\u00edn","family":"Garc\u00eda-Esta\u00f1","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Facultad de Medicina & Instituto Murciano de Investigaciones Biosanitarias, Universidad de Murcia, 30120 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,4,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1039\/C4FO00144C","article-title":"Modulation of nitric oxide by flavonoids","volume":"5","author":"Duarte","year":"2014","journal-title":"Food Funct."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Miranda, A.M., Steluti, J., Fisberg, R.M., and Marchioni, D.M. 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