{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T15:35:58Z","timestamp":1790523358093,"version":"4.1.0"},"reference-count":60,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2018,4,20]],"date-time":"2018-04-20T00:00:00Z","timestamp":1524182400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Our objective was to quantify to what extent the association between adherence to the French nutritional recommendations at midlife, measured by the Programme National Nutrition Sant\u00e9-Guideline Score (PNNS-GS), and healthy aging (HA) is mediated by body mass index (BMI) status. Methods: We analyzed data from 2249 participants of the French \u2018Supplementation with Vitamins and Mineral Antioxidants\u2019 (SU.VI.MAX-\u2018SUppl\u00e9mentation en VItamines et Min\u00e9raux AntioXydants\u2019) cohort. At baseline (1994\u20131995), data on BMI status (&lt;25 vs. \u226525 and &lt;30 vs. \u226530) and diet were collected. At follow-up (2007\u20132009), HA status (yes\/no) was evaluated via a multidimensional concept focusing on chronic disease incidence, physical and cognitive functioning, mental and social health, pain, and perceived health. Relative risks (RR) were estimated by extensively adjusted robust-error-variance Poisson regression, and counterfactual-based mediation analysis was performed. Results: Our HA criteria were met by 39% of participants. We identified a positive direct relation of a greater adherence to the French nutritional recommendations, with the probability of HA (RRQuartile 4 vs. quartile 1 = 1.31 (95% confidence interval (CI) = 1.13, 1.53)), and an indirect relation mediated by BMI status (1.01 (95% CI: 1.01, 1.02)), accounting for 5% of the total relation. Conclusion: These results indicate that high dietary quality may contribute to the preservation of overall health during aging, partly via obesity prevention and partly via other mechanisms.<\/jats:p>","DOI":"10.3390\/nu10040515","type":"journal-article","created":{"date-parts":[[2018,4,23]],"date-time":"2018-04-23T04:29:17Z","timestamp":1524457757000},"page":"515","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["The Mediating Role of Overweight and Obesity in the Prospective Association between Overall Dietary Quality and Healthy Aging"],"prefix":"10.3390","volume":"10","author":[{"given":"Karen E.","family":"Assmann","sequence":"first","affiliation":[{"name":"Nutritional Epidemiology Research Team (EREN), Centre of Research in Epidemiology and Statistics Sorbonne Paris Cit\u00e9, Inserm (U1153), Inra (U1125), Cnam, Paris 13 University, COMUE Sorbonne Paris Cit\u00e9, 93017 Bobigny, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indunil","family":"Ruhunuhewa","sequence":"additional","affiliation":[{"name":"Nutritional Epidemiology Research Team (EREN), Centre of Research in Epidemiology and Statistics Sorbonne Paris Cit\u00e9, Inserm (U1153), Inra (U1125), Cnam, Paris 13 University, COMUE Sorbonne Paris Cit\u00e9, 93017 Bobigny, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moufidath","family":"Adjibade","sequence":"additional","affiliation":[{"name":"Nutritional Epidemiology Research Team (EREN), Centre of Research in Epidemiology and Statistics Sorbonne Paris Cit\u00e9, Inserm (U1153), Inra (U1125), Cnam, Paris 13 University, COMUE Sorbonne Paris Cit\u00e9, 93017 Bobigny, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Li","sequence":"additional","affiliation":[{"name":"INSERM, U1168, VIMA: Aging and Chronic Diseases, Epidemiological and Public Health Approaches, F-94807 Villejuif, France"},{"name":"Universit\u00e9 Versailles St-Quentin-en-Yvelines, UMR-S 1168, F-78180 Montigny le Bretonneux, France"},{"name":"School of Public Health, Faculty of Medicine, Universit\u00e9 Paris-Sud, 94276 Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rapha\u00eblle","family":"Varraso","sequence":"additional","affiliation":[{"name":"INSERM, U1168, VIMA: Aging and Chronic Diseases, Epidemiological and Public Health Approaches, F-94807 Villejuif, France"},{"name":"Universit\u00e9 Versailles St-Quentin-en-Yvelines, UMR-S 1168, F-78180 Montigny le Bretonneux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Hercberg","sequence":"additional","affiliation":[{"name":"Nutritional Epidemiology Research Team (EREN), Centre of Research in Epidemiology and Statistics Sorbonne Paris Cit\u00e9, Inserm (U1153), Inra (U1125), Cnam, Paris 13 University, COMUE Sorbonne Paris Cit\u00e9, 93017 Bobigny, France"},{"name":"Public Health Department, Avicenne Hospital, 93017 Bobigny, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Galan","sequence":"additional","affiliation":[{"name":"Nutritional Epidemiology Research Team (EREN), Centre of Research in Epidemiology and Statistics Sorbonne Paris Cit\u00e9, Inserm (U1153), Inra (U1125), Cnam, Paris 13 University, COMUE Sorbonne Paris Cit\u00e9, 93017 Bobigny, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9715-3534","authenticated-orcid":false,"given":"Emmanuelle","family":"Kesse-Guyot","sequence":"additional","affiliation":[{"name":"Nutritional Epidemiology Research Team (EREN), Centre of Research in Epidemiology and Statistics Sorbonne Paris Cit\u00e9, Inserm (U1153), Inra (U1125), Cnam, Paris 13 University, COMUE Sorbonne Paris Cit\u00e9, 93017 Bobigny, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,4,20]]},"reference":[{"key":"ref_1","unstructured":"United Nations, Department of Economic and Social Affairs, Population Division (2009). 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