{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:20:00Z","timestamp":1790792400053,"version":"4.1.0"},"reference-count":40,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2018,5,4]],"date-time":"2018-05-04T00:00:00Z","timestamp":1525392000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The quantity and quality of dietary lipids in infant formulae have a significant impact on health outcomes, especially when fat storing and\/or absorption are limited (e.g., preterm birth and short bowel disease) or when fat byproducts may help to prevent some pathologies (e.g., atopy). The lipid composition of infant formulae varies according to the different fat sources used, and the potential biological effects are related to the variety of saturated and unsaturated fatty acids. For example, since lipids are the main source of energy when the normal absorptive capacity of the digestive tract is compromised, medium-chain saturated fatty acids might cover this requirement. Instead, ruminant-derived trans fatty acids and metabolites of n-3 long-chain polyunsaturated fatty acids with their anti-inflammatory properties can modulate immune function. Furthermore, dietary fats may influence the nutrient profile of formulae, improving the acceptance of these products and the compliance with dietary schedules.<\/jats:p>","DOI":"10.3390\/nu10050567","type":"journal-article","created":{"date-parts":[[2018,5,7]],"date-time":"2018-05-07T03:12:21Z","timestamp":1525662741000},"page":"567","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["The Role of Lipids in Human Milk and Infant Formulae"],"prefix":"10.3390","volume":"10","author":[{"given":"Alessandra","family":"Mazzocchi","sequence":"first","affiliation":[{"name":"Pediatric Intermediate Care Unit, Fondazione IRCCS Ospedale Ca\u2019 Granda-Ospedale Maggiore Policlinico, Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"D\u2019Oria","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit, Fondazione IRCCS Ca\u2019 Granda, Ospedale Maggiore Policlinico, Department of Anesthesia and Intensive Care and Emergency, 20122 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina De","family":"Cosmi","sequence":"additional","affiliation":[{"name":"Pediatric Intermediate Care Unit, Fondazione IRCCS Ospedale Ca\u2019 Granda-Ospedale Maggiore Policlinico, Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy"},{"name":"Department of Clinical Sciences and Community Health, University of Milan, Branch of Medical Statistics, Biometry, and Epidemiology \u201cG. A. Maccacaro\u201d, 20122 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Bettocchi","sequence":"additional","affiliation":[{"name":"Institute of Microbiology Catholic University of the Sacred Heart, 29100 Piacenza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3829-4254","authenticated-orcid":false,"given":"Gregorio Paolo","family":"Milani","sequence":"additional","affiliation":[{"name":"Pediatric Unit, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7051-3405","authenticated-orcid":false,"given":"Marco","family":"Silano","sequence":"additional","affiliation":[{"name":"Department of Food Safety, Unit of Human Nutrition and Health, Nutrition and Veterinary Public Health, Istituto Superiore di Sanit\u00e0, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5006-0832","authenticated-orcid":false,"given":"Carlo","family":"Agostoni","sequence":"additional","affiliation":[{"name":"Pediatric Intermediate Care Unit, Fondazione IRCCS Ospedale Ca\u2019 Granda-Ospedale Maggiore Policlinico, Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy"},{"name":"SIGENP (Italian Society of Pediatric Gastroenterology, Hepatology, and Nutrition), via Libero Temolo 4 (Torre U8), 20126 Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,5,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1111\/j.1651-2227.2011.02343.x","article-title":"Physiological aspects of human milk lipids and implications for infant feeding: A workshop report","volume":"100","author":"Koletzko","year":"2011","journal-title":"Acta Paediatr."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"275","DOI":"10.3945\/an.111.000448","article-title":"Dietary triacylglycerol structure and its role in infant nutrition","volume":"2","author":"Innis","year":"2011","journal-title":"Adv. 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