{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T15:56:41Z","timestamp":1785254201409,"version":"3.55.0"},"reference-count":55,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2018,5,7]],"date-time":"2018-05-07T00:00:00Z","timestamp":1525651200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The Gilles de la Tourette syndrome (GTS) and Non-Coeliac Gluten Sensitivity (NCGS) may be associated. We analyse the efficacy of a gluten-free diet (GFD) in 29 patients with GTS (23 children; six adults) in a prospective pilot study. All of them followed a GFD for one year. The Yale Global Tics Severity Scale (YGTSS), the Yale-Brown Obsessive-Compulsive Scale\u2014Self Report (Y-BOCS) or the Children\u2019s Yale-Brown Obsessive-Compulsive Scale\u2014Self Report (CY-BOCS), and the Cavanna\u2019s Quality of Life Questionnaire applied to GTS (GTS-QOL) were compared before and after the GFD; 74% of children and 50% of adults were males, not significant (NS). At the beginning of the study, 69% of children and 100% of adults had associated obsessive-compulsive disorder (OCD) (NS). At baseline, the YGTSS scores were 55.0 \u00b1 17.5 (children) and 55.8 \u00b1 19.8 (adults) (NS), the Y-BOCS\/CY-BOCS scores were 15.3, (standard deviation (SD) = 12.3) (children) and 26.8 (9.2) (adults) (p = 0.043), and the GTS-QOL scores were 42.8 \u00b1 18.5 (children) and 64 \u00b1 7.9 (adults) (p = 0.000). NCGS was frequent in both groups, with headaches reported by 47.0% of children and 83.6% of adults (p = 0.001). After one year on a GFD there was a marked reduction in measures of tics (YGTSS) (p = 0.001), and the intensity and frequency of OCD (Y-BOCS\/CY-BOCS) (p = 0.001), along with improved generic quality of life (p = 0.001) in children and adults. In conclusion, a GFD maintained for one year in GTS patients led to a marked reduction in tics and OCD both in children and adults.<\/jats:p>","DOI":"10.3390\/nu10050573","type":"journal-article","created":{"date-parts":[[2018,5,8]],"date-time":"2018-05-08T02:48:08Z","timestamp":1525747688000},"page":"573","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Efficacy of a Gluten-Free Diet in the Gilles de la Tourette Syndrome: A Pilot Study"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1717-9345","authenticated-orcid":false,"given":"Luis","family":"Rodrigo","sequence":"first","affiliation":[{"name":"Gastroenterology Unit, Hospital Universitario Central de Asturias (HUCA), Avda. de Roma s\/n, 33011 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Hospital Universitario Central de Asturias (HUCA), Avda. de Roma s\/n, 33011 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Fern\u00e1ndez-Bustillo","sequence":"additional","affiliation":[{"name":"Technical Department, Hospital Universitario Central de Asturias (HUCA), Avda. de Roma s\/n, 33011 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Salas-Puig","sequence":"additional","affiliation":[{"name":"Neurology Service, Hospital del Valle de Hebr\u00f3n, Paseo del Valle de Hebr\u00f3n 119, 08035 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos","family":"Huerta","sequence":"additional","affiliation":[{"name":"Psychiatry Service, Mental Health Center, Pedro Pablo 42, 33209 Gij\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Hern\u00e1ndez-Lahoz","sequence":"additional","affiliation":[{"name":"Neurology Service, Hospital Universitario Central de Asturias (HUCA), Avda. de Roma s\/n, 33011 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,5,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association (2013). 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