{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:59:09Z","timestamp":1760241549318,"version":"build-2065373602"},"reference-count":36,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T00:00:00Z","timestamp":1526342400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The regulation of growth hormone (GH) release during prenatal development and during early postnatal life is not entirely clarified. In this study plasma GH concentrations in pigs with inherited pseudo vitamin D deficiency type I (PDDR-I), which regularly show growth retardation, were compared during ontogeny with unaffected pigs of the same breed (German Landrace, DL) as control. Plasma GH concentrations were measured in plasma of chronically catheterized fetuses (beginning on day 101 after mating or after artificial insemination) and in piglets (day 37 postpartum (p.p.)\u2014day 42 p.p.) of both lines. A growth curve beginning at day 7 p.p. was recorded for both lines. The relative amount of GH receptor (GHR) mRNA in liver was quantified by competitive reverse transcription polymerase chain reaction in piglets at day 42 p.p. A trend for higher GH concentrations was observed in PDDR-I fetuses (p &lt; 0.1). In PDDR-I piglets compared to DL piglets higher plasma GH values (p &lt; 0.01), were observed despite lower body weight. The relative quantity of GHR mRNA in liver was not significantly different between the two lines. Piglets with an inherited defect of vitamin D synthesis showed higher GH concentrations. A hormonal imprinting by low 1,25(OH)2D3 could be one reason for our observations and should be analysed in detail in future.<\/jats:p>","DOI":"10.3390\/nu10050617","type":"journal-article","created":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T03:29:34Z","timestamp":1526354974000},"page":"617","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Growth Hormone Secretion Patterns in German Landrace (DL) Fetuses and Piglets Compared to DL Piglets with Inherited 1,25-Dihydroxyvitamin D3 Deficiency"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5465-5817","authenticated-orcid":false,"given":"Manfred","family":"Mielenz","sequence":"first","affiliation":[{"name":"Department of Functional Genomics and Bioregulation, Institute of Farm Animal Genetics, Friedrich-Loeffler-Institut (FLI), Mariensee, 31535 Neustadt a. Rbge., Germany"},{"name":"Institute of Nutritional Physiology \u201cOskar Kellner\u201d, Leibniz Institute for Farm Animal Biology (FBN), Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3192-1019","authenticated-orcid":false,"given":"Michael","family":"Pfaffl","sequence":"additional","affiliation":[{"name":"Department of Animal Physiology and Immunology, Technical University Munich, Weihenstephaner Berg 3, 85354 Freising, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Schlumbohm","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Veterinary Medicine Hannover, Foundation, Bischofsholer Damm 15, 30173 Hannover, Germany"},{"name":"Neu Encepharm GmbH, Hans-Adolf-Krebs Weg 9, 37077 G\u00f6ttingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johein","family":"Harmeyer","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Veterinary Medicine Hannover, Foundation, Bischofsholer Damm 15, 30173 Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nahid","family":"Parvizi","sequence":"additional","affiliation":[{"name":"Department of Functional Genomics and Bioregulation, Institute of Farm Animal Genetics, Friedrich-Loeffler-Institut (FLI), Mariensee, 31535 Neustadt a. Rbge., Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,5,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"353","DOI":"10.4065\/81.3.353","article-title":"High prevalence of vitamin D inadequacy and implications for health","volume":"81","author":"Holick","year":"2006","journal-title":"Mayo Clin. Proc."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Sowah, D., Fan, X., Dennett, L., Hagtvedt, R., and Straube, S. (2017). Vitamin D levels and deficiency with different occupations: A systematic review. 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