{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:57:47Z","timestamp":1791874667446,"version":"4.3.4"},"reference-count":134,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2018,6,13]],"date-time":"2018-06-13T00:00:00Z","timestamp":1528848000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Cholesterol is an essential molecule that exerts pleiotropic actions. Although its presence is vital to the cell, its excess can be harmful and, therefore, sustaining cholesterol homeostasis is crucial to maintaining proper cellular functioning. It is well documented that high plasma cholesterol concentration increases the risk of atherosclerotic heart disease. In the last decades, several studies have investigated the association of plasma cholesterol concentrations and the risk of cardiovascular diseases as well as the signaling pathways involved in cholesterol homeostasis. Here, we present an overview of several mechanisms involved in intestinal cholesterol absorption, the regulation of cholesterol synthesis and uptake. We also discuss the importance of reverse cholesterol transport and transintestinal cholesterol transport to maintain cholesterol homeostasis and prevent atherosclerosis development. Additionally, we discuss the influence of dietary cholesterol on plasma cholesterol concentration and the new recommendations for cholesterol intake in a context of a healthy dietary pattern.<\/jats:p>","DOI":"10.3390\/nu10060760","type":"journal-article","created":{"date-parts":[[2018,6,13]],"date-time":"2018-06-13T10:45:35Z","timestamp":1528886735000},"page":"760","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":138,"title":["Molecular Pathways Underlying Cholesterol Homeostasis"],"prefix":"10.3390","volume":"10","author":[{"given":"Milessa Silva","family":"Afonso","sequence":"first","affiliation":[{"name":"Marc and Ruti Bell Vascular Biology and Disease Program, Leon H. Charney Division of Cardiology, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta Marcondes","family":"Machado","sequence":"additional","affiliation":[{"name":"Laboratorio de Lipides (LIM 10), Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP 05403-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Lavrador","sequence":"additional","affiliation":[{"name":"Laboratorio de Lipides (LIM 10), Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP 05403-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eder Carlos Rocha","family":"Quintao","sequence":"additional","affiliation":[{"name":"Laboratorio de Lipides (LIM 10), Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP 05403-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Moore","sequence":"additional","affiliation":[{"name":"Marc and Ruti Bell Vascular Biology and Disease Program, Leon H. Charney Division of Cardiology, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA"},{"name":"Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Lottenberg","sequence":"additional","affiliation":[{"name":"Laboratorio de Lipides (LIM 10), Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP 05403-000, Brazil"},{"name":"Faculdade Israelita de Ci\u00eancias da Sa\u00fade, Albert Einstein, S\u00e3o Paulo, SP 05403-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,6,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/nrm2336","article-title":"Cellular cholesterol trafficking and compartmentalization","volume":"9","author":"Ikonen","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1126\/science.1174621","article-title":"Lipid rafts as a membrane-organizing principle","volume":"327","author":"Lingwood","year":"2010","journal-title":"Science"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.ceb.2010.05.004","article-title":"Cholesterol, the central lipid of mammalian cells","volume":"22","author":"Maxfield","year":"2010","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"3179201","DOI":"10.1155\/2018\/3179201","article-title":"Cardiovascular Outcomes of PCSK9 Inhibitors: With Special Emphasis on Its Effect beyond LDL-Cholesterol Lowering","volume":"2018","author":"Bandyopadhyay","year":"2018","journal-title":"J. Lipids"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e67","DOI":"10.1161\/CIR.0000000000000558","article-title":"Heart Disease and Stroke Statistics-2018 Update: A Report from the American Heart Association","volume":"137","author":"Benjamin","year":"2018","journal-title":"Circulation"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0022-2275(20)40622-4","article-title":"Effects of continuous and intermittent feeding on biliary lipid outputs in man: Application for measurements of intestinal absorption of cholesterol and bile acids","volume":"20","author":"Mok","year":"1979","journal-title":"J. Lipid Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"9","DOI":"10.5650\/jos.ess14221","article-title":"Factors affecting intestinal absorption of cholesterol and plant sterols and stanols","volume":"64","author":"Ikeda","year":"2015","journal-title":"J. Oleo Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1126\/science.1093131","article-title":"Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption","volume":"303","author":"Altmann","year":"2004","journal-title":"Science"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1194\/jlr.M018820","article-title":"Cholesterol esterification by ACAT2 is essential for efficient intestinal cholesterol absorption: Evidence from thoracic lymph duct cannulation","volume":"53","author":"Nguyen","year":"2012","journal-title":"J. Lipid Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"E1183","DOI":"10.1152\/ajpendo.90899.2008","article-title":"Intestinal lipid absorption","volume":"296","author":"Iqbal","year":"2009","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"16237","DOI":"10.1073\/pnas.252582399","article-title":"Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion","volume":"99","author":"Yu","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.1210\/en.2013-2143","article-title":"The Niemann-Pick C1 like 1 (NPC1L1) inhibitor ezetimibe improves metabolic disease via decreased liver X receptor (LXR) activity in liver of obese male mice","volume":"155","author":"Sugizaki","year":"2014","journal-title":"Endocrinology"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"15565","DOI":"10.1074\/jbc.M301311200","article-title":"Stimulation of cholesterol excretion by the liver X receptor agonist requires ATP-binding cassette transporters G5 and G8","volume":"278","author":"Yu","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1111\/j.1365-2796.2012.02529.x","article-title":"LXR\u03b2 activation increases intestinal cholesterol absorption, leading to an atherogenic lipoprotein profile","volume":"272","author":"Hu","year":"2012","journal-title":"J. Intern. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1194\/jlr.C079715","article-title":"The good side of cholesterol: A requirement for maintenance of intestinal integrity","volume":"58","author":"Hui","year":"2017","journal-title":"J. Lipid Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"52772","DOI":"10.1074\/jbc.M410302200","article-title":"Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and Insigs","volume":"279","author":"Adams","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1.1","DOI":"10.1146\/annurev-biochem-062917-011852","article-title":"Retrospective on Cholesterol Homeostasis: The Central Role of Scap","volume":"87","author":"Brown","year":"2018","journal-title":"Annu. Rev. Biochem."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cmet.2005.11.014","article-title":"Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake","volume":"3","author":"Gong","year":"2006","journal-title":"Cell Metab."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"26483","DOI":"10.1074\/jbc.M504041200","article-title":"Insig required for sterol-mediated inhibition of Scap\/SREBP binding to COPII proteins in vitro","volume":"280","author":"Sun","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1093\/jb\/mvh184","article-title":"COPII coat assembly and selective export from the endoplasmic reticulum","volume":"136","author":"Sato","year":"2004","journal-title":"J. Biochem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"6519","DOI":"10.1073\/pnas.0700907104","article-title":"Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins","volume":"104","author":"Sun","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S1097-2765(02)00591-9","article-title":"Cholesterol addition to ER membranes alters conformation of SCAP, the SREBP escort protein that regulates cholesterol metabolism","volume":"10","author":"Brown","year":"2002","journal-title":"Mol. Cell"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.cell.2005.12.022","article-title":"Protein sensors for membrane sterols","volume":"124","author":"Goldstein","year":"2006","journal-title":"Cell"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"48801","DOI":"10.1074\/jbc.M407817200","article-title":"Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: A novel role of SREBP in regulating cholesterol metabolism","volume":"279","author":"Zeng","year":"2004","journal-title":"J. Biol Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1172\/JCI57275","article-title":"Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis","volume":"121","author":"Rayner","year":"2011","journal-title":"J. Clin. Investig."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1126\/science.1189862","article-title":"MiR-33 contributes to the regulation of cholesterol homeostasis","volume":"328","author":"Rayner","year":"2010","journal-title":"Science"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3242","DOI":"10.1073\/pnas.0500206102","article-title":"Intramembrane aspartic acid in SCAP protein governs cholesterol-induced conformational change","volume":"102","author":"Feramisco","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Cook, E.C., Nelson, J.K., Sorrentino, V., Koenis, D., Moeton, M., Scheij, S., Ottenhoff, R., Bleijlevens, B., Loregger, A., and Zelcer, N. (2017). Identification of the ER-resident E3 ubiquitin ligase RNF145 as a novel LXR-regulated gene. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0172721"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e28766","DOI":"10.7554\/eLife.28766","article-title":"Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP","volume":"6","author":"Zhang","year":"2017","journal-title":"eLife"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s11745-015-4096-7","article-title":"Revisiting Human Cholesterol Synthesis and Absorption: The Reciprocity Paradigm and its Key Regulators","volume":"51","author":"Alphonse","year":"2016","journal-title":"Lipids"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.atherosclerosis.2008.05.021","article-title":"Molecular basis of statin-associated myopathy","volume":"202","author":"Vaklavas","year":"2009","journal-title":"Atherosclerosis"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"276","DOI":"10.3945\/ajcn.114.100305","article-title":"Dietary cholesterol and cardiovascular disease: A systematic review and meta-analysis","volume":"102","author":"Berger","year":"2015","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1194\/jlr.R800054-JLR200","article-title":"Cholesterol feedback: From Schoenheimer\u2019s bottle to Scap\u2019s MELADL","volume":"50","author":"Brown","year":"2009","journal-title":"J. Lipid Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"52479","DOI":"10.1074\/jbc.M310053200","article-title":"Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols andgeranylgeraniol","volume":"278","author":"Sever","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"20503","DOI":"10.1073\/pnas.1112831108","article-title":"Sterol-induced degradation of HMG-CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8","volume":"108","author":"Jo","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.molcel.2005.08.009","article-title":"Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase","volume":"19","author":"Song","year":"2005","journal-title":"Mol. Cell"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"19288","DOI":"10.1074\/jbc.M110.134213","article-title":"Sterol-induced dislocation of 3-hydroxy-3-methylglutaryl coenzyme A reductase from endoplasmic reticulum membranes into the cytosol through a subcellular compartment resembling lipid droplets","volume":"285","author":"Hartman","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3300","DOI":"10.1091\/mbc.e13-03-0157","article-title":"Sterol-induced dislocation of 3-hydroxy-3-methylglutaryl coenzyme A reductase from membranes of permeabilized cells","volume":"24","author":"Elsabrouty","year":"2013","journal-title":"Mol. Biol. Cell"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/cr.2008.61","article-title":"Feedback regulation of cholesterol synthesis: Sterol-accelerated ubiquitination and degradation of HMG CoA reductase","volume":"18","year":"2008","journal-title":"Cell Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"6511","DOI":"10.1073\/pnas.0700899104","article-title":"Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Oxysterols block transport by binding to Insig","volume":"104","author":"Radhakrishnan","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.cmet.2005.01.001","article-title":"Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol","volume":"1","author":"Song","year":"2005","journal-title":"Cell Metab."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1074\/jbc.M706967200","article-title":"Effectors of rapid homeostatic responses of endoplasmic reticulum cholesterol and 3-hydroxy-3-methylglutaryl-CoA reductase","volume":"283","author":"Lange","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"18707","DOI":"10.1074\/jbc.R113.479808","article-title":"Controlling cholesterol synthesis beyond 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR)","volume":"288","author":"Sharpe","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.phrs.2014.03.002","article-title":"The pharmacology of statins","volume":"88","author":"Sirtori","year":"2014","journal-title":"Pharmacol. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1097\/MOL.0b013e3283613b8b","article-title":"Statins and lipid metabolism: An update","volume":"24","year":"2013","journal-title":"Curr. Opin. Lipidol."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Scandinavian Simvastatin Study Group (1994). Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4S). Lancet, 344, 1383\u20131389.","DOI":"10.1016\/S0140-6736(94)90566-5"},{"key":"ref_47","first-page":"CD004816","article-title":"Statins for the primary prevention of cardiovascular disease","volume":"1","author":"Taylor","year":"2013","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"27533","DOI":"10.1074\/jbc.M115.675181","article-title":"The Regulatory Domain of Squalene Monooxygenase Contains a Re-entrant Loop and Senses Cholesterol via a Conformational Change","volume":"290","author":"Howe","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.cmet.2011.01.015","article-title":"Cholesterol-dependent degradation of squalene monooxygenase, a control point in cholesterol synthesis beyond HMG-CoA reductase","volume":"13","author":"Gill","year":"2011","journal-title":"Cell Metab."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1128\/MCB.01140-13","article-title":"The E3 ubiquitin ligase MARCH6 degrades squalene monooxygenase and affects 3-hydroxy-3-methyl-glutaryl coenzyme A reductase and the cholesterol synthesis pathway","volume":"34","author":"Zelcer","year":"2014","journal-title":"Mol. Cell. Biol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1194\/jlr.M011080","article-title":"Atorvastatin increases intestinal expression of NPC1L1 in hyperlipidemic men","volume":"52","author":"Tremblay","year":"2011","journal-title":"J. Lipid Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0022-2275(20)39534-1","article-title":"Effects of dietary cholesterol on the regulation of total body cholesterol in man","volume":"12","author":"Grundy","year":"1971","journal-title":"J. Lipid Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0022-2275(20)38010-X","article-title":"Long term steroid metabolism balance studies in subjects on cholesterol-free and cholesterol-rich diets: Comparison between normal and hypercholesterolemic individuals","volume":"24","year":"1983","journal-title":"J. Lipid Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1172\/JCI116666","article-title":"Effects of lovastatin and dietary cholesterol on sterol homeostasis in healthy human subjects","volume":"92","author":"Duane","year":"1993","journal-title":"J. Clin. Investig."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/0026-0495(76)90112-8","article-title":"Changes in cholesterol synthesis and excretion when cholesterol intake is increased","volume":"25","author":"Nestel","year":"1976","journal-title":"Metabolism"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1172\/JCI113013","article-title":"Heterogeneity of cholesterol homeostasis in man. Response to changes in dietary fat quality and cholesterol quantity","volume":"79","author":"McNamara","year":"1987","journal-title":"J. Clin. Investig."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1146\/annurev.physiol.69.031905.160725","article-title":"Regulation of intestinal cholesterol absorption","volume":"69","author":"Wang","year":"2007","journal-title":"Annu. Rev. Physiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1002\/cphy.c120023","article-title":"Bile acid metabolism and signaling","volume":"3","author":"Chiang","year":"2013","journal-title":"Compr. Physiol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/B978-0-12-152811-9.50011-0","article-title":"The LDL pathway in human fibroblasts: A Receptor-mediated mechanism for the regulation of cholesterol metabolism","volume":"11","author":"Goldstein","year":"1976","journal-title":"Curr. Top. Cell. Regul."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1161\/ATVBAHA.108.179564","article-title":"The LDL receptor","volume":"29","author":"Goldstein","year":"2009","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"28856","DOI":"10.1074\/jbc.M109.037085","article-title":"Dissection of the endogenous cellular pathways of PCSK9-induced low density lipoprotein receptor degradation: Evidence for an intracellular route","volume":"284","author":"Poirier","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/ng1161","article-title":"Mutations in PCSK9 cause autosomal dominant hypercholesterolemia","volume":"34","author":"Abifadel","year":"2003","journal-title":"Nat. Genet."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1126\/science.1168974","article-title":"LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor","volume":"325","author":"Zelcer","year":"2009","journal-title":"Science"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"19720","DOI":"10.1074\/jbc.M110.123729","article-title":"The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2","volume":"285","author":"Hong","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1084\/jem.182.6.1959","article-title":"On the pathogenesis of atherosclerosis: Enzymatic transformation of human low density lipoprotein to an atherogenic moiety","volume":"182","author":"Bhakdi","year":"1995","journal-title":"J. Exp. Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/978-1-60327-029-8_24","article-title":"Oxidized low-density lipoprotein","volume":"610","author":"Parthasarathy","year":"2010","journal-title":"Methods Mol. Biol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.biocel.2017.08.013","article-title":"LOX-1: A potential target for therapy in atherosclerosis; an in vitro study","volume":"91","author":"Arjuman","year":"2017","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1161\/ATVBAHA.117.307025","article-title":"From High-Density Lipoprotein Cholesterol to Measurements of Function: Prospects for the Development of Tests for High-Density Lipoprotein Functionality in Cardiovascular Disease","volume":"38","author":"Sacks","year":"2018","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0022-2275(20)43114-1","article-title":"The plasma lecithins:cholesterol acyltransferase reaction","volume":"9","author":"Glomset","year":"1968","journal-title":"J. Lipid Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1373\/clinchem.2016.257725","article-title":"The Changing Face of HDL and the Best Way to Measure It","volume":"63","author":"Karathanasis","year":"2017","journal-title":"Clin. Chem."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1161\/ATVBAHA.108.181206","article-title":"Reverse cholesterol transport revisited: Contribution of biliary versus intestinal cholesterol excretion","volume":"31","author":"Brufau","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1097\/MOL.0b013e328356dba0","article-title":"Macrophage oxysterols and their binding proteins: Roles in atherosclerosis","volume":"23","author":"Olkkonen","year":"2012","journal-title":"Curr. Opin. Lipidol."},{"key":"ref_73","first-page":"2032","article-title":"Protein Kinase C is Involved in the Induction of ATP-Binding Cassette Transporter A1 Expression by Liver X Receptor\/Retinoid X Receptor Agonist in Human Macrophages","volume":"116","author":"Huwait","year":"2015","journal-title":"J. Cell. Physiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.bcp.2017.08.008","article-title":"Doxorubicin enhances oxysterol levels resulting in a LXR-mediated upregulation of cardiac cholesterol transporters","volume":"144","author":"Monzel","year":"2017","journal-title":"Biochem. Pharmacol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1097\/00041433-200006000-00005","article-title":"ABCA1-mediated transport of cellular cholesterol and phospholipids to HDL apolipoproteins","volume":"11","author":"Oram","year":"2000","journal-title":"Curr. Opin. Lipidol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"28240","DOI":"10.1074\/jbc.M003337200","article-title":"Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor\/retinoid X receptor","volume":"275","author":"Costet","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1016\/j.cell.2017.05.020","article-title":"Structure of the Human Lipid Exporter ABCA1","volume":"169","author":"Qian","year":"2017","journal-title":"Cell"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1194\/jlr.M300355-JLR200","article-title":"ABCA1 and amphipathic apolipoproteins form high-affinity molecular complexes required for cholesterol efflux","volume":"45","author":"Fitzgerald","year":"2004","journal-title":"J. Lipid Res."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"47890","DOI":"10.1074\/jbc.M306258200","article-title":"Apolipoprotein A-I activates protein kinase C alpha signaling to phosphorylate and stabilize ATP binding cassette transporter A1 for the high density lipoprotein assembly","volume":"278","author":"Yamauchi","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1194\/jlr.M082685","article-title":"Interaction of lecithin:cholesterol acyltransferase with lipid surfaces and apolipoprotein A-I-derived peptides","volume":"59","author":"Casteleijn","year":"2018","journal-title":"J. Lipid Res."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S1388-1981(00)00153-0","article-title":"Lecithin cholesterol acyltransferase","volume":"1529","author":"Jonas","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1074\/jbc.M115.672790","article-title":"Agonistic Human Antibodies Binding to Lecithin-Cholesterol Acyltransferase Modulate High Density Lipoprotein Metabolism","volume":"291","author":"Gunawardane","year":"2016","journal-title":"J. Biol. Chem."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0022-2275(20)33339-3","article-title":"Effects of natural mutations in lecithin:cholesterol acyltransferase on the enzyme structure and activity","volume":"40","author":"Peelman","year":"1999","journal-title":"J. Lipid Res."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1194\/jlr.M059873","article-title":"The high-resolution crystal structure of human LCAT","volume":"56","author":"Piper","year":"2015","journal-title":"J. Lipid Res."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"15093","DOI":"10.1073\/pnas.0704602104","article-title":"High-density lipoprotein protects macrophages from oxidized low-density lipoprotein-induced apoptosis by promoting efflux of 7-ketocholesterol via ABCG1","volume":"104","author":"Terasaka","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1161\/ATVBAHA.110.204230","article-title":"Adenosine monophosphate activated protein kinase regulates ABCG1-mediated oxysterol efflux from endothelial cells and protects against hypercholesterolemia-induced endothelial dysfunction","volume":"30","author":"Li","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.lfs.2017.03.024","article-title":"The lipid moiety 7-ketocholesteryl-9-carboxynonanoate mediates binding interaction of oxLDL to LOX-1 and upregulates ABCA1 expression through PPAR\u03b3","volume":"177","author":"Li","year":"2017","journal-title":"Life Sci."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.biocel.2017.07.022","article-title":"The \u03c9-carboxyl group of 7-ketocholesteryl-9-carboxynonanoate mediates the binding of oxLDL to CD36 receptor and enhances caveolin-1 expression in macrophages","volume":"90","author":"Li","year":"2017","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"7316","DOI":"10.1016\/S0021-9258(18)50321-5","article-title":"Relative contributions by liver and intestine to individual plasma apolipoproteins in the rat","volume":"254","author":"Wu","year":"1979","journal-title":"J. Biol. Chem."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.1073\/pnas.0510345103","article-title":"TNF-alpha induces ABCA1 through NF-kappaB in macrophages and in phagocytes ingesting apoptotic cells","volume":"103","author":"Li","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Shavva, V.S., Mogilenko, D.A., Nekrasova, E.V., Trulioff, A.S., Kudriavtsev, I.V., Larionova, E.E., Babina, A.V., Dizhe, E.B., Missyul, B.V., and Orlov, S.V. (2018). Tumor necrosis factor \u03b1 stimulates endogenous apolipoprotein A-I expression and secretion by human monocytes and macrophages: Role of MAP-kinases, NF-\u03baB, and nuclear receptors PPAR\u03b1 and LXRs. Mol. Cell. Biochem.","DOI":"10.1007\/s11010-018-3327-7"},{"key":"ref_92","first-page":"436","article-title":"Impact of TLR 2, TLR 4-activation on the Expression of ABCA1 and ABCG1 in Raw Cells","volume":"47","author":"Suzuki","year":"2017","journal-title":"Ann. Clin. Lab. Sci."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Takiguchi, S., Ayaori, M., Yakushiji, E., Nishida, T., Nakaya, K., Sasaki, M., Iizuka, M., Uto-Kondo, H., Terao, Y., and Yogo, M. (2018). Hepatic Overexpression of Endothelial Lipase Lowers HDL (High-Density Lipoprotein) but Maintains Reverse Cholesterol Transport in Mice: Role of SR-BI (Scavenger Receptor Class B Type I)\/ABCA1 (ATP-Binding Cassette Transporter A1)-Dependent Pathways. Arterioscler. Thromb. Vasc. Biol.","DOI":"10.1161\/ATVBAHA.118.311056"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1194\/jlr.R082735","article-title":"Cholesteryl ester transfer protein and its inhibitors","volume":"59","author":"Shrestha","year":"2018","journal-title":"J. Lipid Res."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"S201","DOI":"10.1194\/jlr.R800061-JLR200","article-title":"The role of plasma lipid transfer proteins in lipoprotein metabolism and atherogenesis","volume":"50","author":"Masson","year":"2009","journal-title":"J. Lipid Res."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1126\/science.276.5320.1861","article-title":"Crystal structure of human BPI and two bound phospholipids at 2.4 angstrom resolution","volume":"276","author":"Beamer","year":"1997","journal-title":"Science"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1172\/JCI115993","article-title":"Dietary cholesterol increases transcription of the human cholesteryl ester transfer protein gene in transgenic mice. Dependence on natural flanking sequences","volume":"90","author":"Jiang","year":"1992","journal-title":"J. Clin. Investig."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0022-2275(20)40735-7","article-title":"Cholesteryl ester transfer protein and high density lipoprotein responses to cholesterol feeding in men: Relationship to apolipoprotein E genotype","volume":"34","author":"Martin","year":"1993","journal-title":"J. Lipid Res."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/nsmb1197","article-title":"Crystal structure of cholesteryl ester transfer protein reveals a long tunnel and four bound lipid molecules","volume":"14","author":"Qiu","year":"2007","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1097\/MOG.0000000000000156","article-title":"Bile acids as metabolic regulators","volume":"31","author":"Li","year":"2015","journal-title":"Curr. Opin. Gastroenterol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1146\/annurev.biochem.72.121801.161712","article-title":"The enzymes, regulation, and genetics of bile acid synthesis","volume":"72","author":"Russell","year":"2003","journal-title":"Annu. Rev. Biochem."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1172\/JCI0216309","article-title":"Cholic acid mediates negative feedback regulation of bile acid synthesis in mice","volume":"110","author":"Olin","year":"2002","journal-title":"J. Clin. Investig."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1194\/jlr.R900010-JLR200","article-title":"Bile acids: Regulation of synthesis","volume":"50","author":"Chiang","year":"2009","journal-title":"J. Lipid Res."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/S0006-291X(02)00229-2","article-title":"LXR alpha is the dominant regulator of CYP7A1 transcription","volume":"293","author":"Gupta","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0022-2275(20)31482-6","article-title":"Regulation of cholesterol-7alpha-hydroxylase: BAREly missing a SHP","volume":"43","author":"Davis","year":"2002","journal-title":"J. Lipid Res."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"3741","DOI":"10.1172\/JCI94029","article-title":"RNA-binding protein ZFP36L1 maintains posttranscriptional regulation of bile acid metabolism","volume":"127","author":"Tarling","year":"2017","journal-title":"J. Clin. Investig."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S1097-2765(00)00051-4","article-title":"A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis","volume":"6","author":"Goodwin","year":"2000","journal-title":"Mol. Cell"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1097\/MOL.0000000000000473","article-title":"Transintestinal cholesterol excretion in humans","volume":"29","author":"Reeskamp","year":"2018","journal-title":"Curr. Opin. Lipidol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1161\/ATVBAHA.112.300263","article-title":"Transintestinal cholesterol excretion is an active metabolic process modulated by PCSK9 and statin involving ABCB1","volume":"33","author":"Berger","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1194\/jlr.M022194","article-title":"Trans-intestinal cholesterol efflux is not mediated through high density lipoprotein","volume":"53","author":"Vrins","year":"2012","journal-title":"J. Lipid Res."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"G203","DOI":"10.1152\/ajpgi.90231.2008","article-title":"Regulation of direct transintestinal cholesterol excretion in mice","volume":"295","author":"Vrins","year":"2008","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.plipres.2017.12.001","article-title":"Determinants of cholesterol efflux capacity in humans","volume":"69","author":"Talbot","year":"2018","journal-title":"Prog. Lipid Res."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1161\/CIRCULATIONAHA.108.810721","article-title":"Inflammation impairs reverse cholesterol transport in vivo","volume":"119","author":"McGillicuddy","year":"2009","journal-title":"Circulation"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1161\/CIRCULATIONAHA.115.020278","article-title":"High-Density Lipoprotein Proteomic Composition, and not Efflux Capacity, Reflects Differential Modulation of Reverse Cholesterol Transport by Saturated and Monounsaturated Fat Diets","volume":"133","author":"Dillon","year":"2016","journal-title":"Circulation"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.biocel.2012.03.016","article-title":"ER stress is associated with reduced ABCA-1 protein levels in macrophages treated with advanced glycated albumin\u2014Reversal by a chemical chaperone","volume":"44","author":"Castilho","year":"2012","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s11745-011-3647-9","article-title":"Inhibition of macrophage oxidative stress prevents the reduction of ABCA-1 transporter induced by advanced glycated albumin","volume":"47","author":"Castilho","year":"2012","journal-title":"Lipids"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"4847812","DOI":"10.1155\/2016\/4847812","article-title":"Metformin Inhibits Advanced Glycation End Products-Induced Inflammatory Response in Murine Macrophages Partly through AMPK Activation and RAGE\/NF\u03baB Pathway Suppression","volume":"2016","author":"Zhou","year":"2016","journal-title":"J. Diabetes Res."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jdiacomp.2017.09.012","article-title":"AGE-albumin enhances ABCA1 degradation by ubiquitin-proteasome and lysosomal pathways in macrophages","volume":"32","author":"Iborra","year":"2018","journal-title":"J. Diabetes Complicat."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"4046","DOI":"10.2337\/db15-0575","article-title":"RAGE Suppresses ABCG1-Mediated Macrophage Cholesterol Efflux in Diabetes","volume":"64","author":"Daffu","year":"2015","journal-title":"Diabetes"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"24604","DOI":"10.1074\/jbc.M115.675579","article-title":"The E3 ubiquitin ligases, HUWE1 and NEDD4-1, are involved in the post-translational regulation of the ABCG1 and ABCG4 lipid transporters","volume":"290","author":"Aleidi","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.bbalip.2017.12.011","article-title":"The E3 ubiquitin ligase, HECTD1, is involved in ABCA1-mediated cholesterol export from macrophages","volume":"1863","author":"Aleidi","year":"2018","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.nut.2016.12.014","article-title":"Egg consumption and heart health: A review","volume":"37","author":"Clayton","year":"2017","journal-title":"Nutrition"},{"key":"ref_123","unstructured":"US Department of Health and Human Services, and US Department of Agriculture (2018, May 20). 2015\u20132020 Dietary Guidelines for Americans, Available online: http:\/\/www.health.gov\/DietaryGuidelines."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"895","DOI":"10.3945\/ajcn.115.122317","article-title":"Associations of egg and cholesterol intakes with carotid intima-media thickness and risk of incident coronary artery disease according to apolipoprotein E phenotype in men: The Kuopio Ischaemic Heart Disease Risk Factor Study","volume":"103","author":"Virtanen","year":"2016","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.atherosclerosis.2014.04.019","article-title":"Egg consumption and carotid atherosclerosis in the Northern Manhattan study","volume":"235","author":"Goldberg","year":"2014","journal-title":"Atherosclerosis"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.jacl.2017.01.021","article-title":"The association between dietary cholesterol intake and subclinical atherosclerosis in Korean adults: The Kangbuk Samsung Health Study","volume":"11","author":"Rhee","year":"2017","journal-title":"J. Clin. Lipidol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.atherosclerosis.2015.05.036","article-title":"Egg consumption and coronary artery calcification in asymptomatic men and women","volume":"241","author":"Choi","year":"2015","journal-title":"Atherosclerosis"},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Blesso, C.N., and Fernandez, M.L. (2018). Dietary Cholesterol, Serum Lipids, and Heart Disease: Are Eggs Working for or Against You?. Nutrients, 10.","DOI":"10.3390\/nu10040426"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"146","DOI":"10.3945\/ajcn.112.051318","article-title":"Egg consumption in relation to risk of cardiovascular disease and diabetes: A systematic review and meta-analysis","volume":"98","author":"Shin","year":"2013","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1539-6924.2008.01149.x","article-title":"A comparison of egg consumption with other modifiable coronary heart disease lifestyle risk factors: A relative risk apportionment study","volume":"29","author":"Barraj","year":"2009","journal-title":"Risk Anal."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1093\/jn\/133.4.1036","article-title":"Men classified as hypo- or hyperresponders to dietary cholesterol feeding exhibit differences in lipoprotein metabolism","volume":"133","author":"Herron","year":"2003","journal-title":"J. Nutr."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"3667","DOI":"10.1210\/jc.2006-2567","article-title":"Increased intestinal cholesterol absorption in autosomal dominant hypercholesterolemia and no mutations in the low-density lipoprotein receptor or apolipoprotein B genes","volume":"92","author":"Junyent","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s11883-016-0615-0","article-title":"Does Dietary Cholesterol Matter?","volume":"18","author":"Grundy","year":"2016","journal-title":"Curr. Atheroscler. Rep."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Ravera, A., Carubelli, V., Sciatti, E., Bonadei, I., Gorga, E., Cani, D., Vizzardi, E., Metra, M., and Lombardi, C. (2016). Nutrition and Cardiovascular Disease: Finding the Perfect Recipe for Cardiovascular Health. Nutrients, 8.","DOI":"10.3390\/nu8060363"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/10\/6\/760\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T15:08:28Z","timestamp":1760195308000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/10\/6\/760"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,13]]},"references-count":134,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2018,6]]}},"alternative-id":["nu10060760"],"URL":"https:\/\/doi.org\/10.3390\/nu10060760","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,13]]}}}