{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T09:28:59Z","timestamp":1760866139840,"version":"build-2065373602"},"reference-count":53,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2018,7,17]],"date-time":"2018-07-17T00:00:00Z","timestamp":1531785600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Seventh Framework Programme","award":["613977"],"award-info":[{"award-number":["613977"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Adverse effects of low vitamin D status and calcium intakes in pregnancy may be mediated through functional effects on the calcium metabolic system. Little explored in pregnancy, we aimed to examine the relative importance of serum 25-hydroxyvitamin D (25(OH)D) and calcium intake on parathyroid hormone (PTH) concentrations in healthy white-skinned pregnant women. This cross-sectional analysis included 142 participants (14 \u00b1 2 weeks\u2019 gestation) at baseline of a vitamin D intervention trial at 51.9 \u00b0N. Serum 25(OH)D, PTH, and albumin-corrected calcium were quantified biochemically. Total vitamin D and calcium intakes (diet and supplements) were estimated using a validated food frequency questionnaire. The mean \u00b1 SD vitamin D intake was 10.7 \u00b1 5.2 \u03bcg\/day. With a mean \u00b1 SD serum 25(OH)D of 54.9 \u00b1 22.6 nmol\/L, 44% of women were &lt;50 nmol\/L and 13% &lt;30 nmol\/L. Calcium intakes (mean \u00b1 SD) were 1182 \u00b1 488 mg\/day and 23% of participants consumed &lt;800 mg\/day. The mean \u00b1 SD serum albumin-adjusted calcium was 2.2 \u00b1 0.1 mmol\/L and geometric mean (95% CI) PTH was 9.2 (8.4, 10.2) pg\/mL. PTH was inversely correlated with serum 25(OH)D (r = \u22120.311, p &lt; 0.001), but not with calcium intake or serum calcium (r = \u22120.087 and 0.057, respectively, both p &gt; 0.05). Analysis of variance showed that while serum 25(OH)D (dichotomised at 50 nmol\/L) had a significant effect on PTH (p = 0.025), calcium intake (&lt;800, 800\u20131000, \u22651000 mg\/day) had no effect (p = 0.822). There was no 25(OH)D-calcium intake interaction effect on PTH (p = 0.941). In this group of white-skinned women with largely sufficient calcium intakes, serum 25(OH)D was important for maintaining normal PTH concentration.<\/jats:p>","DOI":"10.3390\/nu10070916","type":"journal-article","created":{"date-parts":[[2018,7,18]],"date-time":"2018-07-18T08:45:42Z","timestamp":1531903542000},"page":"916","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Interactions between Vitamin D Status, Calcium Intake and Parathyroid Hormone Concentrations in Healthy White-Skinned Pregnant Women at Northern Latitude"],"prefix":"10.3390","volume":"10","author":[{"given":"Andrea","family":"Hemmingway","sequence":"first","affiliation":[{"name":"Cork Centre for Vitamin D and Nutrition Research, School of Food and Nutritional Sciences, University College Cork, T12 Y337 Cork, Ireland"},{"name":"The Irish Centre for Fetal and Neonatal Translational Research (INFANT), University College Cork, T12 Y337 Cork, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen M.","family":"O\u2019Callaghan","sequence":"additional","affiliation":[{"name":"Cork Centre for Vitamin D and Nutrition Research, School of Food and Nutritional Sciences, University College Cork, T12 Y337 Cork, Ireland"},{"name":"The Irish Centre for Fetal and Neonatal Translational Research (INFANT), University College Cork, T12 Y337 Cork, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1ine","family":"Hennessy","sequence":"additional","affiliation":[{"name":"Cork Centre for Vitamin D and Nutrition Research, School of Food and Nutritional Sciences, University College Cork, T12 Y337 Cork, Ireland"},{"name":"The Irish Centre for Fetal and Neonatal Translational Research (INFANT), University College Cork, T12 Y337 Cork, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George L. J.","family":"Hull","sequence":"additional","affiliation":[{"name":"Cork Centre for Vitamin D and Nutrition Research, School of Food and Nutritional Sciences, University College Cork, T12 Y337 Cork, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8185-1039","authenticated-orcid":false,"given":"Kevin D.","family":"Cashman","sequence":"additional","affiliation":[{"name":"Cork Centre for Vitamin D and Nutrition Research, School of Food and Nutritional Sciences, University College Cork, T12 Y337 Cork, Ireland"},{"name":"Department of Medicine, University College Cork, T12 Y337 Cork, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0973-808X","authenticated-orcid":false,"given":"Mairead E.","family":"Kiely","sequence":"additional","affiliation":[{"name":"Cork Centre for Vitamin D and Nutrition Research, School of Food and Nutritional Sciences, University College Cork, T12 Y337 Cork, Ireland"},{"name":"The Irish Centre for Fetal and Neonatal Translational Research (INFANT), University College Cork, T12 Y337 Cork, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,7,17]]},"reference":[{"key":"ref_1","first-page":"CD004905","article-title":"Multiple-micronutrient supplementation for women during pregnancy","volume":"4","author":"Haider","year":"2017","journal-title":"Cochrane Database Syst. 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Soc."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/10\/7\/916\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T15:12:39Z","timestamp":1760195559000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/10\/7\/916"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,17]]},"references-count":53,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2018,7]]}},"alternative-id":["nu10070916"],"URL":"https:\/\/doi.org\/10.3390\/nu10070916","relation":{},"ISSN":["2072-6643"],"issn-type":[{"type":"electronic","value":"2072-6643"}],"subject":[],"published":{"date-parts":[[2018,7,17]]}}}