{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T02:18:20Z","timestamp":1783477100498,"version":"3.55.0"},"reference-count":47,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2018,9,9]],"date-time":"2018-09-09T00:00:00Z","timestamp":1536451200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Research Council of Norway","award":["196156"],"award-info":[{"award-number":["196156"]}]},{"name":"the Norwegian Seafood Research Fund","award":["900842.FINS"],"award-info":[{"award-number":["900842.FINS"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Inadequate iodine status affects the synthesis of the thyroid hormones and may impair brain development in fetal life. The aim of this study was to explore the association between maternal iodine status in pregnancy measured by urinary iodine concentration (UIC) and child neurodevelopment at age 6, 12 and 18 months in a population-based cohort. In total, 1036 families from nine locations in Norway were enrolled in the little in Norway cohort. The present study includes n = 851 mother-child pairs with singleton pregnancies, no use of thyroid medication in pregnancy, no severe genetic disorder, data on exposure (UIC) in pregnancy and developmental outcomes (Bayley Scales of Infant and Toddler Development, third edition). Data collection also included general information from questionnaires. We examined associations between UIC (and use of iodine-containing supplements) and repeated measures of developmental outcomes using multivariable mixed models. The median UIC in pregnancy was 78 \u00b5g\/L (IQR 46\u2013130), classified as insufficient iodine intake according to the WHO. Eighteen percent reported use of iodine-containing multisupplements. A UIC below ~100 was associated with reduced receptive (p = 0.025) and expressive language skills (p = 0.002), but not with reduced cognitive or fine- and gross motor skills. Maternal use of iodine-containing supplements was associated with lower gross motor skills (b = \u22120.18, 95% CI = \u22120.33, \u22120.03, p = 0.02), but not with the other outcome measures. In conclusion, an insufficient iodine intake in pregnancy, reflected in a UIC below ~100 \u00b5g\/L, was associated with lower infant language skills up to 18 months. The use of iodine-containing supplements was not associated with beneficial effects.<\/jats:p>","DOI":"10.3390\/nu10091270","type":"journal-article","created":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T10:28:57Z","timestamp":1536575337000},"page":"1270","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Maternal Iodine Status is Associated with Offspring Language Skills in Infancy and Toddlerhood"],"prefix":"10.3390","volume":"10","author":[{"given":"Maria","family":"Markhus","sequence":"first","affiliation":[{"name":"Institute of Marine Research, P.O box 1870 Nordnes, 5817 Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9453-9821","authenticated-orcid":false,"given":"Lisbeth","family":"Dahl","sequence":"additional","affiliation":[{"name":"Institute of Marine Research, P.O box 1870 Nordnes, 5817 Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vibeke","family":"Moe","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Oslo, 0316 Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6519-2064","authenticated-orcid":false,"given":"Marianne","family":"Abel","sequence":"additional","affiliation":[{"name":"Division of Infection Control and Environmental Health, Norwegian Institute of Public Health, 0456 Oslo, Norway"},{"name":"Department of Nutrition, TINE SA, 0902 Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6315-7134","authenticated-orcid":false,"given":"Anne","family":"Brants\u00e6ter","sequence":"additional","affiliation":[{"name":"Division of Infection Control and Environmental Health, Norwegian Institute of Public Health, 0456 Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5590-5136","authenticated-orcid":false,"given":"Jannike","family":"\u00d8yen","sequence":"additional","affiliation":[{"name":"Institute of Marine Research, P.O box 1870 Nordnes, 5817 Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3591-7017","authenticated-orcid":false,"given":"Helle","family":"Meltzer","sequence":"additional","affiliation":[{"name":"Division of Infection Control and Environmental Health, Norwegian Institute of Public Health, 0456 Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kjell","family":"Stormark","sequence":"additional","affiliation":[{"name":"Regional Centre for Child and Youth Mental Health and Child Welfare, Uni Research Health, Uni Research, P.O box 7810, 5020 Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingvild","family":"Graff","sequence":"additional","affiliation":[{"name":"Institute of Marine Research, P.O box 1870 Nordnes, 5817 Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1334-2582","authenticated-orcid":false,"given":"Lars","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Oslo, 0316 Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7070-5784","authenticated-orcid":false,"given":"Marian","family":"Kjellevold","sequence":"additional","affiliation":[{"name":"Institute of Marine Research, P.O box 1870 Nordnes, 5817 Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,9,9]]},"reference":[{"key":"ref_1","unstructured":"WHO, UNICEF, and ICCIDD (2007). Assessment of Iodine Deficiency Disorders and Monitoring Their Elimination, World Health Organization."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Ma, Z.F., and Skeaff, S.A. (2017). Assessment of Population Iodine Status. Iodine Deficiency Disorders and Their Elimination, Springer.","DOI":"10.1007\/978-3-319-49505-7_2"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.semcdb.2011.07.009","article-title":"The role of iodine in human growth and development","volume":"22","author":"Zimmermann","year":"2011","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"668S","DOI":"10.3945\/ajcn.2008.26811C","article-title":"Iodine deficiency in pregnancy and the effects of maternal iodine supplementation on the offspring: A review","volume":"89","author":"Zimmermann","year":"2009","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1017\/S0007114507842292","article-title":"Reliability of studies of iodine intake and recommendations for number of samples in groups and in individuals","volume":"99","author":"Andersen","year":"2008","journal-title":"Br. J. Nutr."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1111\/j.1753-4887.2012.00528.x","article-title":"Assessment of iodine nutrition in populations: Past, present, and future","volume":"70","author":"Zimmermann","year":"2012","journal-title":"Nutr. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1469-8749.1985.tb04542.x","article-title":"Nerological signs in congenital iodine deficiency disorder (endemic cretinism)","volume":"27","author":"DeLong","year":"1985","journal-title":"Dev. Med. Child Neurol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/S0140-6736(71)91040-3","article-title":"Neurological damage to the fetus resulting from severe iodine deficiency during pregnancy","volume":"297","author":"Pharoah","year":"1971","journal-title":"Lancet"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/S0140-6736(83)90636-0","article-title":"Iodine deficiency disorders (idd) and their eradication","volume":"322","author":"Hetzel","year":"1983","journal-title":"Lancet"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1089\/thy.1994.4.107","article-title":"The disorders induced by iodine deficiency","volume":"4","author":"Delange","year":"1994","journal-title":"Thyroid"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1089\/thy.2007.0108","article-title":"The adverse effects of mild-to-moderate iodine deficiency during pregnancy and childhood: A review","volume":"17","author":"Zimmermann","year":"2007","journal-title":"Thyroid"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0140-6736(13)60436-5","article-title":"Effect of inadequate iodine status in UK pregnant women on cognitive outcomes in their children: Results from the avon longitudinal study of parents and children (alspac)","volume":"382","author":"Bath","year":"2013","journal-title":"Lancet"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.3390\/nu5041384","article-title":"Iodine and mental development of children 5 years old and under: A systematic review and meta-analysis","volume":"5","author":"Bougma","year":"2013","journal-title":"Nutrients"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1093\/jn\/nxy054","article-title":"Preconception maternal iodine status is positively associated with iq but not with measures of executive function in childhood","volume":"148","author":"Robinson","year":"2018","journal-title":"J. Nutr."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/S2213-8587(15)00263-6","article-title":"Iodine deficiency in pregnant women in europe","volume":"3","author":"Zimmermann","year":"2015","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Dahl, L., and Meltzer, H.M. (2009). The Iodine Content of Foods and Diets. Norwegian perspectives, Elsevier Inc.","DOI":"10.1016\/B978-0-12-374135-6.00037-6"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Brantsaeter, A.L., Knutsen, H.K., Johansen, N.C., Nyheim, K.A., Erlund, I., Meltzer, H.M., and Henjum, S. (2018). Inadequate iodine intake in population groups defined by age, life stage and vegetarian dietary practice in a norwegian convenience sample. Nutrients, 10.","DOI":"10.3390\/nu10020230"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"31969","DOI":"10.3402\/fnr.v60.31969","article-title":"Iodine status in the nordic countries\u2014Past and present","volume":"60","author":"Nystrom","year":"2016","journal-title":"Food Nutr. Res."},{"key":"ref_19","unstructured":"The Norwegian Directorate of Health (2018, January 20). Norwegian Recommendations for Nutrition and Physical Activity (in Norwegian). Available online: https:\/\/helsedirektoratet.no\/publikasjoner\/anbefalinger-om-kosthold-ernering-og-fysisk-aktivitet."},{"key":"ref_20","unstructured":"World Health Organization, Unicef (2007). Reaching Optimal Iodine Nutrition in Pregnant and Lactating Women and Young Children, World Health Organization."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1017\/S1368980007705360","article-title":"Reaching optimal iodine nutrition in pregnant and lactating women and young children: Programmatic recommendations","volume":"10","author":"Untoro","year":"2007","journal-title":"Public Health Nutr."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"424","DOI":"10.3390\/nu5020424","article-title":"Risk of suboptimal iodine intake in pregnant norwegian women","volume":"5","author":"Brantsaeter","year":"2013","journal-title":"Nutrients"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Henjum, S., Aakre, I., Lilleengen, A.M., Garnweidner-Holme, L., Borthne, S., Pajalic, Z., Blix, E., Gjengedal, E.L.F., and Brantsaeter, A.L. (2018). Suboptimal iodine status among pregnant women in the oslo area, norway. Nutrients, 10.","DOI":"10.3390\/nu10030280"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1038\/ejcn.2017.83","article-title":"Thyroid homeostasis in mother\u2013child pairs in relation to maternal iodine status: The misa study","volume":"71","author":"Berg","year":"2017","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Dahl, L., Wik Markhus, M., Sanchez, P.V.R., Moe, V., Smith, L., Meltzer, H.M., and Kjellevold, M. (2018). Iodine deficiency in a study population of norwegian pregnant women-results from the little in norway study (lin). Nutrients, 10.","DOI":"10.3390\/nu10040513"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1037\/abn0000246","article-title":"Patterns of pregnancy and postpartum depressive symptoms: Latent class trajectories and predictors","volume":"126","author":"Fredriksen","year":"2017","journal-title":"J. Abnorm. Psychol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Fredriksen, E., von Soest, T., Smith, L., and Moe, V. (2018). Parenting stress plays a mediating role in the prediction of early child development from both parents\u2019 perinatal depressive symptoms. J. Abnorm. Child. Psychol., 1\u201316.","DOI":"10.1007\/s10802-018-0428-4"},{"key":"ref_28","unstructured":"Bayley, N. (2017, January 20). Bayley Scales of Infant and Toddler Development\u00ae (bayley-iii\u00ae). Available online: https:\/\/www.pearsonclinical.com\/childhood\/products\/100000108\/bayley-scales-of-infant-and-toddler-development-third-edition-bayley-iii-screening-test.html."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1111\/j.1442-200X.2009.02844.x","article-title":"Predictive validity of bayley scale in language development of children at 6\u201336 months","volume":"51","author":"Lung","year":"2009","journal-title":"Pediatr. Int."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1177\/0734282906297199","article-title":"Bayley scales of infant and toddler development, third edition","volume":"25","author":"Albers","year":"2007","journal-title":"J Psychoeduc. Assess"},{"key":"ref_31","unstructured":"ERBA Diagnostics France (2018, September 08). Maxmat Creatinine Pap Reag. Available online: file:\/\/\/C:\/Users\/mwi\/AppData\/Local\/Microsoft\/Windows\/INetCache\/IE\/MMZGL9RY\/PI-e-CREA_PAP-18.pdf."},{"key":"ref_32","unstructured":"Buis, M. (2017, November 01). Postrcspline:Stata Module Containing Post-Estimation Commands for Models Using a Restricted Cubic Spline. Available online: https:\/\/ideas.repec.org\/c\/boc\/bocode\/s456928.html."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1089\/thy.2009.0094","article-title":"Estimation of iodine intake from various urinary iodine measurements in population studies","volume":"19","author":"Vejbjerg","year":"2009","journal-title":"Thyroid"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1210\/jc.2012-4249","article-title":"Mild iodine deficiency during pregnancy is associated with reduced educational outcomes in the offspring: 9-year follow-up of the gestational iodine cohort","volume":"98","author":"Hynes","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.3945\/jn.112.161950","article-title":"Low urinary iodine excretion during early pregnancy is associated with alterations in executive functioning in children","volume":"142","author":"Tiemeier","year":"2012","journal-title":"J. Nutr."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.3945\/jn.117.250456","article-title":"Suboptimal maternal iodine intake is associated with impaired child neurodevelopment at 3 years of age in the norwegian mother and child cohort study","volume":"147","author":"Abel","year":"2017","journal-title":"J. Nutr."},{"key":"ref_37","unstructured":"(2018, September 08). Interrelations of Language and Cognitive Development. Available online: https:\/\/www.researchgate.net\/publication\/265905729_Interrelations_of_language_and_cognitive_development."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Hynes, K.L., Otahal, P., Burgess, J.R., Oddy, W.H., and Hay, I. (2017). Reduced educational outcomes persist into adolescence following mild iodine deficiency in utero, despite adequacy in childhood: 15-year follow-up of the gestational iodine cohort investigating auditory processing speed and working memory. Nutrients, 9.","DOI":"10.3390\/nu9121354"},{"key":"ref_39","first-page":"CD011761","article-title":"Iodine supplementation for women during the preconception, pregnancy and postpartum period","volume":"3","author":"Harding","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Abel, M., Ystrom, E., Caspersen, I., Meltzer, H., Aase, H., Torheim, L., Askeland, R., Reichborn-Kjennerud, T., and Brants\u00e6ter, A. (2017). Maternal iodine intake and offspring attention-deficit\/hyperactivity disorder: Results from a large prospective cohort study. Nutrients, 9.","DOI":"10.3390\/nu9111239"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/S2213-8587(17)30332-7","article-title":"Effect of iodine supplementation in pregnant women on child neurodevelopment: A randomised, double-blind, placebo-controlled trial","volume":"5","author":"Gowachirapant","year":"2017","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"898S","DOI":"10.3945\/ajcn.115.110395","article-title":"Urinary iodine, thyroid function, and thyroglobulin as biomarkers of iodine status","volume":"104","author":"Pearce","year":"2016","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.3945\/jn.111.144071","article-title":"Ten repeat collections for urinary iodine from spot samples or 24-hour samples are needed to reliably estimate individual iodine status in women","volume":"141","author":"Konig","year":"2011","journal-title":"J. Nutr."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1007\/s00394-017-1410-6","article-title":"The sensitivity and specificity of thyroglobulin concentration using repeated measures of urinary iodine excretion","volume":"57","author":"Ma","year":"2018","journal-title":"Eur. J. Nutr."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1111\/j.1365-3016.2009.01062.x","article-title":"Self-selection and bias in a large prospective pregnancy cohort in norway","volume":"23","author":"Nilsen","year":"2009","journal-title":"Paediatr. Perinat. Epidemiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1037\/0012-1649.42.4.643","article-title":"Infants\u2019 early ability to segment the conversational speech signal predicts later language development: A retrospective analysis","volume":"42","author":"Newman","year":"2006","journal-title":"Dev. Psychol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Sun, D., Codling, K., Chang, S., Zhang, S., Shen, H., Su, X., Chen, Z., Scherpbier, R.W., and Yan, J. (2017). Eliminating iodine deficiency in china: Achievements, challenges and global implications. Nutrients, 9.","DOI":"10.3390\/nu9040361"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/10\/9\/1270\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T15:19:34Z","timestamp":1760195974000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/10\/9\/1270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,9]]},"references-count":47,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2018,9]]}},"alternative-id":["nu10091270"],"URL":"https:\/\/doi.org\/10.3390\/nu10091270","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,9]]}}}