{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T11:42:27Z","timestamp":1791891747615,"version":"4.3.4"},"reference-count":44,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2018,9,15]],"date-time":"2018-09-15T00:00:00Z","timestamp":1536969600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Tomato consumption has been recently associated with a reduced incidence of cardiovascular disease (CVD). The aim of this study was to test whether a seven-day period of tomato paste pur\u00e8e (tomato paste, TP) supplementation could improve some haemodynamic parameters in healthy volunteers before and after a standardized fat meal (FM). Methods and results: Nineteen healthy male volunteers participated in a randomized, single-blind (operator) crossover study. Participants maintained low fiber diets (LFD) during the study periods. They were randomized either to a LFD and TP arm (80 g of TP\/day) for seven-days, or to a control arm (LFD-only) with a two-week washout period. Flow Mediated Dilatation and other morpho-functional vascular indices were measured by ultrasound. Stiffness Index and Reflection Index were estimated by digital photo-plethysmography. All these parameters were measured one h before and two and 3.5 h after the FM. The difference in Stiffness Index was increased in the LFD and TP + FM-arm, as compared to the LFD-only + FM arm at both two and 3.5 h points. After the FM, in both arms, at two h, we observed a reduction in the Reflection Index and an increase in heart rate. Interestingly, only in the LFD and TP + FM-arm, some haemodynamic changes were detectable at two h; notably, there was an increase in brachial artery diameter and a reduction in diastolic blood pressure (BP). Conclusions: TP has no effect on Flow Mediated Dilatation but acutely modifies some haemodynamic parameters triggered by FM, suggesting possible haemodynamic beneficial effects in people consuming tomatoes.<\/jats:p>","DOI":"10.3390\/nu10091310","type":"journal-article","created":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T10:42:20Z","timestamp":1537180940000},"page":"1310","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Positive Effects of Tomato Paste on Vascular Function After a Fat Meal in Male Healthy Subjects"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0402-4176","authenticated-orcid":false,"given":"Andrea","family":"Dalbeni","sequence":"first","affiliation":[{"name":"Department of Medicine, General Medicine &amp; Hypertension Unit, University of Verona, Piazzale LA Scuro 10, 37134 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Treggiari","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, University of Verona, 37134 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Tagetti","sequence":"additional","affiliation":[{"name":"Department of Medicine, General Medicine &amp; Hypertension Unit, University of Verona, Piazzale LA Scuro 10, 37134 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Bevilaqua","sequence":"additional","affiliation":[{"name":"Department of Medicine, General Medicine &amp; Hypertension Unit, University of Verona, Piazzale LA Scuro 10, 37134 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Bonafini","sequence":"additional","affiliation":[{"name":"Department of Medicine, General Medicine &amp; Hypertension Unit, University of Verona, Piazzale LA Scuro 10, 37134 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8999-0001","authenticated-orcid":false,"given":"Martina","family":"Montagnana","sequence":"additional","affiliation":[{"name":"Department of Neurological, Biomedical and Movement Sciences, Laboratory of Clinical Biochemistry, University of Verona, 37134 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliana","family":"Scaturro","sequence":"additional","affiliation":[{"name":"Department of Medicine, General Medicine &amp; Hypertension Unit, University of Verona, Piazzale LA Scuro 10, 37134 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Minuz","sequence":"additional","affiliation":[{"name":"Department of Medicine, General Medicine &amp; Hypertension Unit, University of Verona, Piazzale LA Scuro 10, 37134 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8910-7378","authenticated-orcid":false,"given":"Cristiano","family":"Fava","sequence":"additional","affiliation":[{"name":"Department of Medicine, General Medicine &amp; Hypertension Unit, University of Verona, Piazzale LA Scuro 10, 37134 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,9,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1056\/NEJMoa1200303","article-title":"Primary Prevention of Cardiovascular Disease with a Mediterranean Diet","volume":"368","author":"Estruch","year":"2013","journal-title":"N. 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