{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T21:01:18Z","timestamp":1778274078102,"version":"3.51.4"},"reference-count":68,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2018,9,23]],"date-time":"2018-09-23T00:00:00Z","timestamp":1537660800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institutes of Health, National Center for Advancing Translational Sciences","award":["UL1TR001108"],"award-info":[{"award-number":["UL1TR001108"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Chronic kidney disease (CKD) affects approximately 10% of adults worldwide. Dysregulation of phosphorus homeostasis which occurs in CKD leads to development of CKD-Mineral Bone Disorder (CKD-MBD) and contributes to increased morbidity and mortality in these patients. Phosphorus is regulated by multiple hormones (parathyroid hormone (PTH), 1,25-dihyxdroxyvitamin D (1,25D), and fibroblast growth factor 23 (FGF23)) and tissues (kidney, intestine, parathyroid glands, and bone) to maintain homeostasis. In health, the kidneys are the major site of regulation for phosphorus homeostasis. However, as kidney function declines, the ability of the kidneys to adequately excrete phosphorus is reduced. The hormonal changes that occur with CKD would suggest that the intestine should compensate for impaired renal phosphorus excretion by reducing fractional intestinal phosphorus absorption. However, limited studies in CKD animal models and patients with CKD suggest that there may be a break in this homeostatic response where the intestine fails to compensate. As many existing therapies for phosphate management in CKD are aimed at reducing absolute intestinal phosphorus absorption, better understanding of the factors that influence fractional and absolute absorption, the mechanism by which intestinal phosphate absorption occurs, and how CKD modifies these is a much-needed area of study.<\/jats:p>","DOI":"10.3390\/nu10101364","type":"journal-article","created":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T10:38:49Z","timestamp":1537785529000},"page":"1364","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Intestinal Phosphorus Absorption in Chronic Kidney Disease"],"prefix":"10.3390","volume":"10","author":[{"given":"Elizabeth R.","family":"Stremke","sequence":"first","affiliation":[{"name":"Department of Nutrition Science, Purdue University, West Lafayette, IN 47907, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen M.","family":"Hill Gallant","sequence":"additional","affiliation":[{"name":"Department of Nutrition Science, Purdue University, West Lafayette, IN 47907, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,9,23]]},"reference":[{"key":"ref_1","first-page":"S12","article-title":"K\/DOQI clinical practice guidelines for chronic kidney disease: Evaluation, classification, and stratification","volume":"39","author":"Andrew","year":"2002","journal-title":"Am. J. Kidney Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1038\/ki.2011.47","article-title":"Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease","volume":"79","author":"Isakova","year":"2011","journal-title":"Kidney Int."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1038\/sj.ki.5000414","article-title":"Definition, evaluation, and classification of renal osteodystrophy: A position statement from kidney disease: Improving global outcomes (KDIGO)","volume":"69","author":"Moe","year":"2006","journal-title":"Kidney Int."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Bernasconi, R., Aeschbacher, S., Blum, S., Mongiat, M., Girod, M., Todd, J., Estis, J., Nolan, N., Renz, H., and Risch, L. (2018). Fibroblast growth factor 23 and renal function among young and healthy individuals. Clin. Chem. Lab. Med.","DOI":"10.1515\/cclm-2017-1183"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1056\/NEJMoa0706130","article-title":"Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis","volume":"359","author":"Gutierrez","year":"2008","journal-title":"New Engl. J. Med."},{"key":"ref_6","unstructured":"National Kidney Foundation (2018, August 01). K\/DOQI Clinical Practice Guidelines for Bone Metabolism and Disease in Chronic Kidney Disease. Available online: http:\/\/www2.kidney.org\/professionals\/KDOQI\/guidelines_bone\/."},{"key":"ref_7","first-page":"F432","article-title":"Phosphorus restriction reverses hyperparathyroidism in uremia independent of changes in calcium and calcitriol","volume":"28","author":"Martin","year":"1990","journal-title":"Ren. Fluid. Electrol. Physiol."},{"key":"ref_8","unstructured":"Medicine, I.O. (1997). Dietary Reference Intakes For Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride, National Academy Press."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"S1168","DOI":"10.1093\/jn\/126.suppl_4.1168S","article-title":"Changing phosphorus content of the us diet: Potential adverse effects on bone","volume":"126","author":"Calvo","year":"1996","journal-title":"J. Nutr."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/sdi.12042","article-title":"Contributions to total phosphorus intake: All sources considered","volume":"26","author":"Calvo","year":"2013","journal-title":"Seminars Dial."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1681\/ASN.2014050465","article-title":"Klotho and phosphate are modulators of pathologic uremic cardiac remodeling","volume":"26","author":"Hu","year":"2015","journal-title":"JASN"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1053\/j.ajkd.2011.08.009","article-title":"CKD-mineral and bone disorder: Core curriculum 2011","volume":"58","author":"Moorthi","year":"2011","journal-title":"Am. J. Kidney Dis."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1525-139X.2007.00309.x","article-title":"Phosphorus homeostasis in normal health and in chronic kidney disease patients with special emphasis on dietary phosphorus intake","volume":"20","author":"Uribarri","year":"2007","journal-title":"Seminars Dial."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.bbrc.2009.11.046","article-title":"Decreased expression of klotho gene in uremic atherosclerosis in apolipoprotein E-deficient mice","volume":"391","author":"Yu","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1053\/j.ajkd.2013.03.042","article-title":"Phosphate homeostasis in CKD report of a scientific symposium sponsored by the national kidney foundation","volume":"62","author":"Block","year":"2013","journal-title":"Am. J. Kidney Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1152\/physiol.00034.2008","article-title":"Novel mechanisms in the regulation of phosphorus homeostasis","volume":"24","author":"Berndt","year":"2009","journal-title":"Physiology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1146\/annurev.med.051308.111339","article-title":"Regulation of phosphate homeostasis by PHD, vitamin D, and FGF23","volume":"61","author":"Bergwitz","year":"2010","journal-title":"Annu. Rev. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"F1577","DOI":"10.1152\/ajprenal.00463.2006","article-title":"Fibroblast growth factor 23 impairs phosphorus and vitamin D metabolism in vivo and suppresses 25-hydroxyvitamin d-1alpha-hydroxylase expression in vitro","volume":"293","author":"Perwad","year":"2007","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1038\/ki.2008.642","article-title":"Phosphate and the parathyroid","volume":"75","author":"Silver","year":"2009","journal-title":"Kidney Int."},{"key":"ref_20","first-page":"E488","article-title":"Intestinal Ca and phosphate transport differential responses to vitamin D3 metabolites","volume":"2","author":"Walling","year":"1977","journal-title":"Am. J. Physiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1172\/JCI108815","article-title":"Role of 1,25-dihydroxyvitamin D3 on intestinal phosphate absorption in rats with a normal vitamin D supply","volume":"60","author":"Rizzoli","year":"1977","journal-title":"J. Clin. Investig."},{"key":"ref_22","first-page":"E1917","article-title":"Characterization of intestinal phosphate absorption using a novel in vivo method","volume":"292","author":"Williams","year":"2007","journal-title":"AJP: Endocrinol. Metab."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1359\/jbmr.090406","article-title":"Effects of hPTH(1\u201334) infusion on circulating serum phosphate, 1,25-dihydroxyvitamin D, and FGF23 levels in healthy men","volume":"24","author":"Henao","year":"2009","journal-title":"J. Bone Miner. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1002\/jbmr.340","article-title":"A clinician\u2019s guide to X-linked hypophosphatemia","volume":"26","author":"Carpenter","year":"2011","journal-title":"J. Bone Miner. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.2215\/CJN.11901115","article-title":"Phosphate toxicity in CKD: The killer among us","volume":"11","author":"Ritter","year":"2016","journal-title":"CJASN"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1053\/j.ackd.2010.11.007","article-title":"Molecular regulation of phosphate metabolism by fibroblast growth factor-23-klotho system","volume":"18","author":"Cheng","year":"2011","journal-title":"Adv. Chronic Kidney Dis."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1042\/BJ20041799","article-title":"Role of the vitamin D receptor in FGF23 action on phosphate metabolism","volume":"390","author":"Inoue","year":"2005","journal-title":"Biochem. J."},{"key":"ref_28","first-page":"549","article-title":"Sulphate and phosphate transport in the renal proximal tubule","volume":"299","author":"Ullrich","year":"1982","journal-title":"Philos. Trans. R. Soc. B Biol. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.mam.2012.07.007","article-title":"Phosphate transporters of the SLC20 and SLC 34 families","volume":"34","author":"Forster","year":"2013","journal-title":"Mol. Asp. Medicine"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1002\/cphy.c170024","article-title":"Mechanisms and regulation of intestinal phosphate absorption","volume":"8","author":"Hernando","year":"2018","journal-title":"Compr. Physiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1681\/ASN.2009050559","article-title":"Intestinal npt2b plays a major role in phosphate absorption and homeostasis","volume":"20","author":"Sabbagh","year":"2009","journal-title":"JASN"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/s00424-011-0948-z","article-title":"Voltage- and substrate-dependent interactions between sites in putative re-entrant domains of a Na(+)-coupled phosphate cotransporter","volume":"461","author":"Ghezzi","year":"2011","journal-title":"Eur. J. Physiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/0016-5085(83)90443-2","article-title":"Absorption of phosphate in the jejunum of patients with chronic renal failure before and after correction of vitamin D deficiency","volume":"85","author":"Davis","year":"1983","journal-title":"Gastroenterology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1042\/bj3430705","article-title":"Regulation of intestinal Na+-dependent phosphate co-transporters by a low-phosphate diet and 1,25-dyhydroxyvitamin D3","volume":"343","author":"Katai","year":"1999","journal-title":"Biochem. J."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"C487","DOI":"10.1152\/ajpcell.00412.2001","article-title":"Age-dependent regulation of rat intestinal type iib sodium-phosphate cotransporter by 1,25-(OH)(2) vitamin D(3)","volume":"282","author":"Xu","year":"2002","journal-title":"Am. J. Physiol. Cell. Physiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1210\/en.2011-1850","article-title":"Intestinal cell phosphate uptake and the targeted knockout of the 1,25D3-MARRS receptor\/PDIA3\/ERp57","volume":"153","author":"Nemere","year":"2012","journal-title":"Endocrinology"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"C429","DOI":"10.1152\/ajpcell.00331.2004","article-title":"Intestinal and renal adaptation to a low-Pi diet of type II NaPi cotransporters in vitamin D receptor- and 1alphaOHase-deficient mice","volume":"288","author":"Capuano","year":"2004","journal-title":"J. Physiol. Cell. Physiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"G369","DOI":"10.1152\/ajpgi.1986.250.3.G369","article-title":"Intestinal phosphate absorption: Influence of vitamin D and non vitamin D factors","volume":"205","author":"Lee","year":"1986","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"F1466","DOI":"10.1152\/ajprenal.00279.2009","article-title":"Regulation of rat intestinal na-dependent phosphate transporters by dietary phosphate","volume":"297","author":"Giral","year":"2009","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"731","DOI":"10.3945\/jn.109.110080","article-title":"Sodium-dependent phosphate uptake in the jejunum is post-transcriptionally regulated in pigs fed a low-phosphorus diet and is independent of dietary calcium concentration","volume":"140","author":"Saddoris","year":"2010","journal-title":"J. Nutr."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/sj.ki.5002292","article-title":"Intestinal phosphate absorption in a model of chronic renal failure","volume":"72","author":"Marks","year":"2007","journal-title":"Kidney Int."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1093\/ndt\/gfq419","article-title":"Pilot study of dietary phosphorus restriction and phosphorus binders to target fibroblast growth factor 23 in patients with chronic kidney disease","volume":"26","author":"Isakova","year":"2011","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"F39","DOI":"10.1152\/ajprenal.00375.2003","article-title":"Intestinal Na-P(i) cotransporter adaptation to dietary P(i) content in vitamin D receptor null mice","volume":"287","author":"Segawa","year":"2003","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/ki.2010.313","article-title":"Direct evidence for a causative role of FGF23 in the abnormal renal phosphate handling and vitamin D metabolism in rats with early-stage chronic kidney disease","volume":"78","author":"Hasegawa","year":"2010","journal-title":"Kidney Int."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.2215\/CJN.04430415","article-title":"Mineral (mal)adaptation to kidney disease\u2014Young investigator award address: American society of nephrology kidney week 2014","volume":"10","author":"Wolf","year":"2015","journal-title":"CJASN"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1006\/bbrc.2000.4226","article-title":"Severely reduced production of klotho in human chronic renal failure kidney","volume":"280","author":"Koh","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"4393","DOI":"10.1172\/JCI46122","article-title":"FGF23 induces left ventricular hypertrophy","volume":"121","author":"Faul","year":"2011","journal-title":"J. Clin. Investig."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1001\/archinte.167.9.879","article-title":"Relations of serum phosphorus and calcium levels to the incidence of cardiovascular disease in the community","volume":"167","author":"Dhingra","year":"2007","journal-title":"Arch. Int. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1053\/j.jrn.2011.04.004","article-title":"Differences among total and in vitro digestible phosphorus content of plant foods and beverages","volume":"22","author":"Karp","year":"2012","journal-title":"J. Ren. Nutr."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.1093\/ndt\/gft244","article-title":"Phosphate control in end-stage renal disease: Barriers and opportunities","volume":"28","author":"Waheed","year":"2013","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1093\/ndt\/gfr367","article-title":"Dietary phosphorus intake and mortality in moderate chronic kidney disease: Nhanes iii","volume":"27","author":"Murtaugh","year":"2012","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"544","DOI":"10.3945\/an.115.011189","article-title":"Nutrition in cardioskeletal health","volume":"7","author":"Weaver","year":"2016","journal-title":"Adv. Nutr."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3945\/an.113.004861","article-title":"Assessing the health impact of phosphorus in the food supply: Issues and considerations","volume":"5","author":"Calvo","year":"2014","journal-title":"Adv. Nutr."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1001\/jama.2009.96","article-title":"Effect of food additives on hyperphosphatemia among patients with end-stage renal disease: A randomized controlled trial","volume":"301","author":"Sullivan","year":"2009","journal-title":"JAMA"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1053\/j.jrn.2016.08.009","article-title":"Replacing phosphorus-containing food additives with foods without additives reduces phosphatemia in end-stage renal disease patients: A randomized clinical trial","volume":"27","year":"2017","journal-title":"J. Ren. Nutr."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1681\/ASN.2017121254","article-title":"A controlled increase in dietary phosphate elevates BP in healthy human subjects","volume":"29","author":"Mohammad","year":"2018","journal-title":"JASN"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1159\/000371498","article-title":"The effect of a diet containing 70% protein from plants on mineral metabolism and musculoskeletal health in chronic kidney disease","volume":"40","author":"Moorthi","year":"2014","journal-title":"Am. J. Nephrol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1053\/j.jrn.2015.12.004","article-title":"Reexamining the phosphorus-protein dilemma: Does phosphorus restriction compromise protein status?","volume":"26","author":"Woolf","year":"2016","journal-title":"J. Ren. Nutr."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"697","DOI":"10.2215\/CJN.00560206","article-title":"The case against calcium-based phosphate binders","volume":"1","author":"Moe","year":"2006","journal-title":"CJASN"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"704","DOI":"10.2215\/CJN.01831105","article-title":"Calcium-based phosphate binders are appropriate in chronic renal failure","volume":"1","author":"Friedman","year":"2006","journal-title":"CJASN"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/ki.2012.403","article-title":"Oral calcium carbonate affects calcium but not phosphorus balance in stage 3\u20134 chronic kidney disease","volume":"83","author":"Hill","year":"2013","journal-title":"Kidney Int."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1038\/ki.2011.490","article-title":"Calcium balance in normal individuals and in patients with chronic kidney disease on low- and high-calcium diets","volume":"81","author":"Spiegel","year":"2012","journal-title":"Kidney Int."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1681\/ASN.2012030223","article-title":"Effects of phosphate binders in moderate CKD","volume":"23","author":"Block","year":"2012","journal-title":"JASN"},{"key":"ref_64","unstructured":"SM, M. (2018). Current diagnosis & treatment. Nephrology & hypertension. Current Diagnosis & Treatment. Nephrology & Hypertension, Lerma, E.V. McGraw-Hill Medical."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1053\/j.jrn.2016.01.009","article-title":"An update on phosphate binders: A dietitian\u2019s perspective","volume":"26","author":"Gutekunst","year":"2016","journal-title":"J. Ren. Nutr."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1042\/cs0600055","article-title":"Comparison of radioisotope methods for the measurement of phosphate absorption in normal subjects and in patients with chronic renal failure","volume":"60","author":"Farrington","year":"1979","journal-title":"Clin. Sci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1681\/ASN.V3121930","article-title":"Renal and intestinal pi transport adaptation to low phosphorus diet in uremic rats","volume":"3","year":"1993","journal-title":"JASN"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.2215\/CJN.00390118","article-title":"Twenty-four-hour urine phosphorus as a biomarker of dietary phosphorus intake and absorption in ckd: A secondary analysis from a controlled diet balance study","volume":"13","author":"Stremke","year":"2018","journal-title":"CJASN"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/10\/10\/1364\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T15:22:07Z","timestamp":1760196127000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/10\/10\/1364"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,23]]},"references-count":68,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2018,10]]}},"alternative-id":["nu10101364"],"URL":"https:\/\/doi.org\/10.3390\/nu10101364","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,23]]}}}