{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:30:55Z","timestamp":1791811855048,"version":"4.3.4"},"reference-count":261,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:00:00Z","timestamp":1539043200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministerul Educa\u021biei \u0219i Cercet\u0103rii \u0218tiin\u021bifice","award":["Project PN.18.22.01.01"],"award-info":[{"award-number":["Project PN.18.22.01.01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Selenium is essential for humans and the deficit of Se requires supplementation. In addition to traditional forms such as Se salts, amino acids, or selenium-enriched yeast supplements, next-generation selenium supplements, with lower risk for excess supplementation, are emerging. These are based on selenium forms with lower toxicity, higher bioavailability, and controlled release, such as zerovalent selenium nanoparticles (SeNPs) and selenized polysaccharides (SPs). This article aims to focus on the existing analytical systems for the next-generation Se dietary supplement, providing, at the same time, an overview of the analytical methods available for the traditional forms. The next-generation dietary supplements are evaluated in comparison with the conventional\/traditional ones, as well as the analysis and speciation methods that are suitable to reveal which Se forms and species are present in a dietary supplement. Knowledge gaps and further research potential in this field are highlighted. The review indicates that the methods of analysis of next-generation selenium supplements should include a step related to chemical species separation. Such a step would allow a proper characterization of the selenium forms\/species, including molecular mass\/dimension, and substantiates the marketing claims related to the main advantages of these new selenium ingredients.<\/jats:p>","DOI":"10.3390\/nu10101466","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T11:10:44Z","timestamp":1539083444000},"page":"1466","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":108,"title":["Selenium Analysis and Speciation in Dietary Supplements Based on Next-Generation Selenium Ingredients"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3548-8443","authenticated-orcid":false,"given":"Diana","family":"Constantinescu-Aruxandei","sequence":"first","affiliation":[{"name":"National Research &amp; Development Institute for Chemistry and Petrochemistry ICECHIM, 202 Splaiul Independentei, 060021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3528-0327","authenticated-orcid":false,"given":"Rodica Mihaela","family":"Fr\u00eencu","sequence":"additional","affiliation":[{"name":"INCDCP-ICECHIM Calarasi Subsidiary, 7A Nicolae Titulescu St., 915300 Lehliu Gara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9501-3028","authenticated-orcid":false,"given":"Luiza","family":"Capr\u0103","sequence":"additional","affiliation":[{"name":"National Research &amp; Development Institute for Chemistry and Petrochemistry ICECHIM, 202 Splaiul Independentei, 060021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7723-1814","authenticated-orcid":false,"given":"Florin","family":"Oancea","sequence":"additional","affiliation":[{"name":"National Research &amp; Development Institute for Chemistry and Petrochemistry ICECHIM, 202 Splaiul Independentei, 060021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,10,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1093\/jn\/117.12.2002","article-title":"The two faces of selenium","volume":"117","author":"Oldfield","year":"1987","journal-title":"J. Nutr."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1007\/s12020-014-0477-6","article-title":"Selenium: An element for life","volume":"48","author":"Duntas","year":"2015","journal-title":"Endocrine"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1080\/10590501.2015.1055163","article-title":"Selenium and human health: Witnessing a copernican revolution?","volume":"33","author":"Jablonska","year":"2015","journal-title":"J. Environ. Sci. Health C Environ. Carcinog. Ecotoxicol. Rev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1152\/physrev.00039.2013","article-title":"Selenoproteins: Molecular pathways and physiological roles","volume":"94","author":"Labunskyy","year":"2014","journal-title":"Physiol. Rev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.3390\/nu5041349","article-title":"Selenium supranutrition: Are the potential benefits of chemoprevention outweighed by the promotion of diabetes and insulin resistance?","volume":"5","author":"Rocourt","year":"2013","journal-title":"Nutrients"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Vinceti, M., Filippini, T., Del Giovane, C., Dennert, G., Zwahlen, M., Brinkman, M., Zeegers, M.P.A., Horneber, M., D\u2019Amico, R., and Crespi, C.M. (2018). Selenium for preventing cancer. Cochrane Database Syst. Rev.","DOI":"10.1002\/14651858.CD005195.pub4"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1089\/ars.2013.5246","article-title":"Toward understanding success and failures in the use of selenium for cancer prevention","volume":"19","author":"Steinbrenner","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1007\/s00204-010-0595-8","article-title":"Selenium: A double-edged sword for defense and offence in cancer","volume":"84","author":"Chovanec","year":"2010","journal-title":"Arch. Toxicol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.tibs.2013.12.007","article-title":"Selenium and selenocysteine: Roles in cancer, health, and development","volume":"39","author":"Hatfield","year":"2014","journal-title":"Trends Biochem. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1080\/17474124.2017.1320219","article-title":"The missing link? The potential role of selenium in the development of liver cancer and significance for the general population","volume":"11","author":"Schomburg","year":"2017","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.2337\/dc11-2136","article-title":"Toenail selenium and incidence of type 2 diabetes in U.S. Men and women","volume":"35","author":"Park","year":"2012","journal-title":"Diabetes Care"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1016\/j.freeradbiomed.2013.04.003","article-title":"Epidemiology of selenium and type 2 diabetes: Can we make sense of it?","volume":"65","author":"Rayman","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jinorgbio.2015.09.003","article-title":"Importance of selenium and selenoprotein for brain function: From antioxidant protection to neuronal signalling","volume":"153","author":"Solovyev","year":"2015","journal-title":"J. Inorg. Biochem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1039\/c5mt00075k","article-title":"Selenium, selenoproteins and neurodegenerative diseases","volume":"7","author":"Cardoso","year":"2015","journal-title":"Metallomics"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/iub.1262","article-title":"Selenium and selenoprotein function in brain disorders","volume":"66","author":"Pillai","year":"2014","journal-title":"IUBMB Life"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Solovyev, N., Drobyshev, E., Bj\u00f8rklund, G., Dubrovskii, Y., Lysiuk, R., and Rayman, M.P. (2018). Selenium, selenoprotein p, and alzheimer\u2019s disease: Is there a link?. Free Radic. Biol. Med.","DOI":"10.1016\/j.freeradbiomed.2018.02.030"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1007\/s10534-016-9959-8","article-title":"Treatment strategies in alzheimer\u2019s disease: A review with focus on selenium supplementation","volume":"29","author":"Aaseth","year":"2016","journal-title":"BioMetals"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.toxlet.2013.11.016","article-title":"Selenium neurotoxicity in humans: Bridging laboratory and epidemiologic studies","volume":"230","author":"Vinceti","year":"2014","journal-title":"Toxicol. Lett."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s13195-017-0323-1","article-title":"A selenium species in cerebrospinal fluid predicts conversion to alzheimer\u2019s dementia in persons with mild cognitive impairment","volume":"9","author":"Vinceti","year":"2017","journal-title":"Alzheimers Res. Ther."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.3390\/nu7031494","article-title":"A review of dietary selenium intake and selenium status in Europe and the Middle East","volume":"7","author":"Stoffaneller","year":"2015","journal-title":"Nutrients"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1079\/BJN20041110","article-title":"Selenium and iodine intakes and status in New Zealand and Australia","volume":"91","author":"Thomson","year":"2004","journal-title":"Br. J. Nutr."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.scitotenv.2017.11.169","article-title":"Roles and potential mechanisms of selenium in countering thyrotoxicity of dehp","volume":"619\u2013620","author":"Zhang","year":"2018","journal-title":"Sci. Total Environ."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/S0140-6736(11)61452-9","article-title":"Selenium and human health","volume":"379","author":"Rayman","year":"2012","journal-title":"Lancet"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.aca.2012.10.029","article-title":"Selenium metabolomics in yeast using complementary reversed-phase\/hydrophilic ion interaction (hilic) liquid chromatography\u2013electrospray hybrid quadrupole trap\/orbitrap mass spectrometry","volume":"757","author":"Arnaudguilhem","year":"2012","journal-title":"Anal. Chim. Acta"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s12011-015-0242-6","article-title":"Biochemical comparison of commercial selenium yeast preparations","volume":"166","author":"Fagan","year":"2015","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Hatfield, D.L., Berry, M.J., and Gladyshev, V.N. (2006). Update of human dietary standards for selenium. Selenium: Its Molecular Biology and Role in Human Health, Springer.","DOI":"10.1007\/0-387-33827-6"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jtemb.2015.07.005","article-title":"Revised reference values for selenium intake","volume":"32","author":"Kipp","year":"2015","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_28","unstructured":"Institute of Medicine (US) Panel on Dietary Antioxidants and Related Compounds (2000). Institute of Medicine, Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.freeradbiomed.2018.02.015","article-title":"Effect of long-term selenium supplementation on mortality: Results from a multiple-dose, randomised controlled trial","volume":"127","author":"Rayman","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1001\/jama.2008.864","article-title":"Effect of selenium and vitamin e on risk of prostate cancer and other cancers: The selenium and vitamin e cancer prevention trial (select)","volume":"301","author":"Lippman","year":"2009","journal-title":"JAMA"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1080\/15592294.2015.1013792","article-title":"Epigenetic effects of selenium and their implications for health","volume":"10","author":"Speckmann","year":"2015","journal-title":"Epigenetics"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.freeradbiomed.2018.06.002","article-title":"Selenium at the redox interface of the genome, metabolome and exposome","volume":"127","author":"Fernandes","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"3094","DOI":"10.3390\/nu7053094","article-title":"Selenium and its supplementation in cardiovascular disease\u2014What do we know?","volume":"7","author":"Benstoem","year":"2015","journal-title":"Nutrients"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s12011-017-1013-3","article-title":"Effects of selenium supplementation on the diabetic condition depend on the baseline selenium status in kkay mice","volume":"181","author":"Febiyanto","year":"2018","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1093\/jnci\/djt456","article-title":"Baseline selenium status and effects of selenium and vitamin e supplementation on prostate cancer risk","volume":"106","author":"Kristal","year":"2014","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"100","DOI":"10.3945\/ajcn.115.114231","article-title":"Genetic polymorphisms that affect selenium status and response to selenium supplementation in United Kingdom pregnant women","volume":"103","author":"Mao","year":"2015","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.nut.2016.05.001","article-title":"Selenium nanoparticles as a nutritional supplement","volume":"33","author":"Skalickova","year":"2017","journal-title":"Nutrition"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1016\/j.carbpol.2017.12.007","article-title":"Characterization, antioxidation, anti-inflammation and renoprotection effects of selenized mycelia polysaccharides from oudemansiella radicata","volume":"181","author":"Gao","year":"2018","journal-title":"Carbohydr. Polym."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1039\/C7JA00378A","article-title":"Detection and characterization of biogenic selenium nanoparticles in selenium-rich yeast by single particle icpms","volume":"33","author":"Bierla","year":"2018","journal-title":"J. Anal. At. Spectrom."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.foodchem.2013.02.054","article-title":"Selenium bioaccessibility and speciation in biofortified Pleurotus mushrooms grown on selenium-rich agricultural residues","volume":"140","author":"Bhatia","year":"2013","journal-title":"Food chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.2147\/IJN.S157541","article-title":"Nano-selenium and its nanomedicine applications: A critical review","volume":"13","author":"Hosnedlova","year":"2018","journal-title":"Int. J. Nanomed."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Liu, M., Jing, H., Zhang, J., Che, G., Zhou, M., Gao, Z., Li, S., Ren, Z., Hao, L., and Liu, Y. (2016). Optimization of mycelia selenium polysaccharide extraction from agrocybe cylindracea sl-02 and assessment of their antioxidant and anti-ageing activities. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0160799"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s12937-016-0169-6","article-title":"Association between serum selenium level and type 2 diabetes mellitus: A non-linear dose\u2013response meta-analysis of observational studies","volume":"15","author":"Wang","year":"2016","journal-title":"Nutr. J."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"3621","DOI":"10.3390\/nu7053621","article-title":"Selenium and chronic diseases: A nutritional genomics perspective","volume":"7","year":"2015","journal-title":"Nutrients"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"19213","DOI":"10.1038\/srep19213","article-title":"Selenium exposure and cancer risk: An updated meta-analysis and meta-regression","volume":"6","author":"Cai","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1039\/C3MT00185G","article-title":"Selenium biochemistry and its role for human health","volume":"6","author":"Roman","year":"2014","journal-title":"Metallomics"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/ejcn.2015.78","article-title":"Selenium status and cardiovascular diseases: Meta-analysis of prospective observational studies and randomized controlled trials","volume":"70","author":"Zhang","year":"2015","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_48","first-page":"1670","article-title":"Acute selenium intoxication in the United-States","volume":"44","author":"Helzlsouer","year":"1985","journal-title":"Fed. Proc."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1001\/jama.1996.03530380029025","article-title":"Selenium poisoning from a nutritional supplement","volume":"275","author":"Clark","year":"1996","journal-title":"JAMA"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1001\/archinternmed.2009.495","article-title":"Acute selenium toxicity associated with a dietary supplement","volume":"170","author":"MacFarquhar","year":"2010","journal-title":"Arch. Intern. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.3390\/nu5041024","article-title":"Selenium toxicity from a misformulated dietary supplement, adverse health effects, and the temporal response in the nail biologic monitor","volume":"5","author":"Morris","year":"2013","journal-title":"Nutrients"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.talanta.2016.09.060","article-title":"Analysis of whole human blood for Pb, Cd, Hg, Se, and Mn by ICP-DRC-MS for biomonitoring and acute exposures","volume":"162","author":"Jones","year":"2017","journal-title":"Talanta"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Michalke, B., Willkommen, D., Drobyshev, E., and Solovyev, N. (2017). The importance of speciation analysis in neurodegeneration research. Trends Anal. Chem.","DOI":"10.1016\/j.trac.2017.08.008"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.microc.2018.03.009","article-title":"Bioavailability of hg and se from seafood after culinary treatments","volume":"139","author":"Schmidt","year":"2018","journal-title":"Microchem. J."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1515\/bmc-2017-0007","article-title":"Recent advances in the mechanism of selenoamino acids toxicity in eukaryotic cells","volume":"8","author":"Lazard","year":"2017","journal-title":"Biomol. Concepts"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"44761","DOI":"10.1038\/srep44761","article-title":"Exposure to selenomethionine causes selenocysteine misincorporation and protein aggregation in saccharomyces cerevisiae","volume":"7","author":"Plateau","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1002\/pros.20329","article-title":"Monomethylated selenium inhibits growth of lncap human prostate cancer xenograft accompanied by a decrease in the expression of androgen receptor and prostate-specific antigen (PSA)","volume":"66","author":"Lee","year":"2006","journal-title":"Prostate"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jtemb.2005.09.003","article-title":"Chemical forms of selenium for cancer prevention","volume":"19","author":"Abdulah","year":"2005","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.lwt.2016.02.016","article-title":"Evaluation of candidate reference material obtained from selenium-enriched sprouts for the purpose of selenium speciation analysis","volume":"70","author":"Bodnar","year":"2016","journal-title":"LWT-Food Sci. Technol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S1369-5266(03)00030-X","article-title":"Plants, selenium and human health","volume":"6","author":"Ellis","year":"2003","journal-title":"Curr. Opin. Plant Biol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"3536","DOI":"10.3390\/nu7053536","article-title":"Redox-active selenium compounds\u2014From toxicity and cell death to cancer treatment","volume":"7","author":"Misra","year":"2015","journal-title":"Nutrients"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"77R","DOI":"10.1039\/AN996210077R","article-title":"Speciation analysis of some organic selenium compounds. A review","volume":"121","year":"1996","journal-title":"Analyst"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1039\/b307508g","article-title":"Element selective characterization of stability and reactivity of selenium species in selenized yeast","volume":"19","author":"Uden","year":"2004","journal-title":"J. Anal. At. Spectrom."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.aca.2009.08.013","article-title":"Speciation of selenium dietary supplements; formation of S-(methylseleno)cysteine and other selenium compounds","volume":"652","author":"Amoako","year":"2009","journal-title":"Anal. Chim. Acta"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/07315724.2001.10719007","article-title":"Nutritional selenium supplements: Product types, quality, and safety","volume":"20","author":"Schrauzer","year":"2001","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"952","DOI":"10.2903\/j.efsa.2009.952","article-title":"Inability to assess the safety of selenium amino acid chelate added for nutritional purposes as a source of selenium in food supplements and the bioavailability of selenium from this source based on the supporting dossier\u2014Scientific statement of the panel on food additives and nutrient sources added to food (ANS)","volume":"7","author":"Aguilar","year":"2009","journal-title":"EFSA J."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1001\/jama.1996.03540240035027","article-title":"Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin: A randomized controlled trial","volume":"276","author":"Clark","year":"1996","journal-title":"JAMA"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.envpol.2013.01.032","article-title":"Relating selenium concentrations in a planktivore to selenium speciation in lakewater","volume":"176","author":"Ponton","year":"2013","journal-title":"Environ. Pollut."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.chroma.2017.11.026","article-title":"Application of enzymatic probe sonication for selenium speciation in animal feeds","volume":"1530","author":"Xiao","year":"2017","journal-title":"J. Chromatogr. A"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.envpol.2017.12.019","article-title":"A critical review of selenium biogeochemical behavior in soil-plant system with an inference to human health","volume":"234","author":"Natasha","year":"2018","journal-title":"Environ. Pollut."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1016\/j.foodchem.2007.04.072","article-title":"Speciation of selenium in diet supplements by hplc\u2013ms\/ms methods","volume":"105","author":"Gosetti","year":"2007","journal-title":"Food Chem."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.foodchem.2016.08.086","article-title":"Evaluation of selenium in dietary supplements using elemental speciation","volume":"218","author":"Kubachka","year":"2017","journal-title":"Food Chem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.trac.2017.10.008","article-title":"Advances in electrospray mass spectrometry for the selenium speciation: Focus on Se-rich yeast","volume":"104","author":"Bierla","year":"2018","journal-title":"Trends Anal. Chem."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jddst.2018.05.023","article-title":"Selenium nanomaterials in biomedicine\u2014An overview of new opportunities in nanomedicine of selenium","volume":"46","author":"Sakr","year":"2018","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"835","DOI":"10.2174\/1568026615666150827094936","article-title":"Potential roles of selenium and selenoproteins in the prevention of Alzheimer\u2019s disease","volume":"16","author":"Du","year":"2015","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ajog.2011.07.034","article-title":"Selenium in reproductive health","volume":"206","author":"Mistry","year":"2012","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.lwt.2015.03.086","article-title":"Antimicrobial and antibiofilm effects of selenium nanoparticles on some foodborne pathogens","volume":"63","author":"Khiralla","year":"2015","journal-title":"LWT-Food Sci. Technol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1007\/s00253-017-8688-4","article-title":"Selenium nanoparticles in poultry feed modify gut microbiota and increase abundance of Faecalibacterium prausnitzii","volume":"102","author":"Gangadoo","year":"2018","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.phytochem.2018.05.008","article-title":"Selenylated plant polysaccharides: A survey of their chemical and pharmacological properties","volume":"153","author":"Fiorito","year":"2018","journal-title":"Phytochemistry"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.chroma.2006.01.088","article-title":"Selenium bioaccessibility assessment in selenized yeast after \u201cin vitro\u201d gastrointestinal digestion using two-dimensional chromatography and mass spectrometry","volume":"1110","author":"Reyes","year":"2006","journal-title":"J. Chromatogr. A"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1039\/a707292i","article-title":"Selenium speciation in human body fluids","volume":"123","author":"Thomson","year":"1998","journal-title":"Analyst"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1177\/104063870601800108","article-title":"Comparative toxicosis of sodium selenite and selenomethionine in lambs","volume":"18","author":"Tiwary","year":"2006","journal-title":"J. Vet. Diagn. Investig."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.aquatox.2017.09.014","article-title":"Sensitivity and toxic mode of action of dietary organic and inorganic selenium in atlantic salmon (Salmo salar)","volume":"192","author":"Berntssen","year":"2017","journal-title":"Aquat. Toxicol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.aca.2013.09.054","article-title":"Solid phase extraction for the speciation and preconcentration of inorganic selenium in water samples: A review","volume":"804","year":"2013","journal-title":"Anal. Chim. Acta"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1021\/es702579w","article-title":"Immobilization of selenite on Fe3O4 and Fe\/Fe3c ultrasmall particles","volume":"42","author":"Nikitenko","year":"2008","journal-title":"Environ. Sci. Technol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.foodchem.2015.05.125","article-title":"Selenium species in selenium fortified dietary supplements","volume":"190","author":"Niedzielski","year":"2016","journal-title":"Food chem."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/j.foodchem.2017.06.042","article-title":"Identification and determination of selenohomolanthionine \u2013 the major selenium compound in torula yeast","volume":"237","author":"Suzuki","year":"2017","journal-title":"Food chem."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"e12467","DOI":"10.1111\/jfbc.12467","article-title":"Selenium biofortification of pleurotus species and its effect on yield, phytochemical profiles, and protein chemistry of fruiting bodies","volume":"42","author":"Gagandeep","year":"2018","journal-title":"J. Food Biochem."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.foodchem.2011.09.023","article-title":"Enrichment of pleurotus ostreatus mushrooms with selenium in coffee husks","volume":"131","author":"Naozuka","year":"2012","journal-title":"Food Chem."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"3681","DOI":"10.1016\/j.foodchem.2013.06.027","article-title":"Chemical characterisation and speciation of organic selenium in cultivated selenium-enriched Agaricus bisporus","volume":"141","author":"Maseko","year":"2013","journal-title":"Food Chem."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1080\/03601234.2012.716733","article-title":"Accumulation of elements by edible mushroom species: Part i. Problem of trace element toxicity in mushrooms","volume":"48","author":"Mleczek","year":"2013","journal-title":"J. Environ. Sci. Health B"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s00253-012-4552-8","article-title":"Macro and trace mineral constituents and radionuclides in mushrooms: Health benefits and risks","volume":"97","author":"Falandysz","year":"2013","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jtemb.2016.12.003","article-title":"Bioaccumulation and distribution of selenium in Enterococcus durans","volume":"40","author":"Pieniz","year":"2017","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1111\/jpn.12326","article-title":"Effects of dietary supplementation of selenium-enriched probiotics on production performance and intestinal microbiota of weanling piglets raised under high ambient temperature","volume":"99","author":"Lv","year":"2015","journal-title":"J. Anim. Physiol. Anim. Nutr. (Berl.)"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"4502","DOI":"10.1021\/jf501065d","article-title":"Selenium-enriched probiotics improve antioxidant status, immune function, and selenoprotein gene expression of piglets raised under high ambient temperature","volume":"62","author":"Gan","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/2008-2231-22-48","article-title":"The antimicrobial effects of selenium nanoparticle-enriched probiotics and their fermented broth against candida albicans","volume":"22","author":"Kheradmand","year":"2014","journal-title":"Daru"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s12011-015-0552-8","article-title":"Effects of selenium-enriched probiotics on lipid metabolism, antioxidative status, histopathological lesions, and related gene expression in mice fed a high-fat diet","volume":"171","author":"Nido","year":"2016","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1007\/s12011-011-9241-4","article-title":"The effects of oral consumption of selenium nanoparticles on chemotactic and respiratory burst activities of neutrophils in comparison with sodium selenite in sheep","volume":"146","author":"Kojouri","year":"2012","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/biof.5520150103","article-title":"Biological effects of a nano red elemental selenium","volume":"15","author":"Zhang","year":"2001","journal-title":"Biofactors"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3109\/13880209.2012.710241","article-title":"Acute and subacute toxicity of novel biogenic selenium nanoparticles in mice","volume":"51","author":"Shakibaie","year":"2013","journal-title":"Pharm. Biol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1016\/j.lfs.2004.09.026","article-title":"A subchronic toxicity study of elemental nano-Se in sprague-dawley rats","volume":"76","author":"Jia","year":"2005","journal-title":"Life Sci."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"5207","DOI":"10.1002\/adma.201002607","article-title":"Selenium-carbon bifunctional nanoparticles for the treatment of malignant mesothelioma","volume":"22","author":"Sarin","year":"2010","journal-title":"Adv. Mater."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.carbpol.2015.06.064","article-title":"Synthesis and antioxidant properties of chitosan and carboxymethyl chitosan-stabilized selenium nanoparticles","volume":"132","author":"Chen","year":"2015","journal-title":"Carbohydr. Polym."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.carbpol.2015.07.065","article-title":"Synthesis, characterization, and controlled release of selenium nanoparticles stabilized by chitosan of different molecular weights","volume":"134","author":"Zhang","year":"2015","journal-title":"Carbohydr. Polym."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s12951-017-0324-z","article-title":"Selenium nanoparticles-loaded chitosan\/citrate complex and its protection against oxidative stress in d-galactose-induced aging mice","volume":"15","author":"Bai","year":"2017","journal-title":"J. Nanobiotechnol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.colsurfb.2014.06.062","article-title":"Effects of chitosan-stabilized selenium nanoparticles on cell proliferation, apoptosis and cell cycle pattern in hepg2 cells: Comparison with other selenospecies","volume":"122","author":"Estevez","year":"2014","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"3775","DOI":"10.1007\/s12274-017-1590-7","article-title":"Construction of highly stable selenium nanoparticles embedded in hollow nanofibers of polysaccharide and their antitumor activities","volume":"10","author":"Ping","year":"2017","journal-title":"Nano Res."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"18629","DOI":"10.1038\/srep18629","article-title":"Biofunctionalization of selenium nanoparticle with dictyophora indusiata polysaccharide and its antiproliferative activity through death-receptor and mitochondria-mediated apoptotic pathways","volume":"5","author":"Liao","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.ijbiomac.2018.03.161","article-title":"Synthesis and antidiabetic activity of selenium nanoparticles in the presence of polysaccharides from Catathelasma ventricosum","volume":"114","author":"Liu","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Zhang, W., Zhang, J., Ding, D., Zhang, L., Muehlmann, L.A., Deng, S.E., Wang, X., Li, W., and Zhang, W. (2017). Synthesis and antioxidant properties of lycium barbarum polysaccharides capped selenium nanoparticles using tea extract. Artif. Cells Nanomed. Biotechnol., 1\u20138.","DOI":"10.1080\/21691401.2017.1373657"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s12951-017-0252-y","article-title":"Selenium nanoparticles decorated with ulva lactuca polysaccharide potentially attenuate colitis by inhibiting NF-\u03baB mediated hyper inflammation","volume":"15","author":"Zhu","year":"2017","journal-title":"J. Nanobiotechnol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1166\/nnl.2017.2524","article-title":"Biomacromolecule-directed synthesis and characterization of selenium nanoparticles and their compatibility with bacterial and eukaryotic cells","volume":"9","author":"Sun","year":"2017","journal-title":"Nanosci. Nanotechnol. Lett."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"4405","DOI":"10.1021\/acs.jafc.7b00896","article-title":"Phycocyanin-functionalized selenium nanoparticles reverse palmitic acid-induced pancreatic \u03b2 cell apoptosis by enhancing cellular uptake and blocking reactive oxygen species (ROS)-mediated mitochondria dysfunction","volume":"65","author":"Liu","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"4766","DOI":"10.1038\/s41598-018-23295-5","article-title":"Proteins enriched in charged amino acids control the formation and stabilization of selenium nanoparticles in comamonas testosteroni s44","volume":"8","author":"Xu","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_115","first-page":"4819","article-title":"Chitosan-decorated selenium nanoparticles as protein carriers to improve the in vivo half-life of the peptide therapeutic bay 55-9837 for type 2 diabetes mellitus","volume":"9","author":"Rao","year":"2014","journal-title":"Int. J. Nanomed."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"9602","DOI":"10.1039\/c2jm16828f","article-title":"Surface decoration of selenium nanoparticles by mushroom polysaccharides-protein complexes to achieve enhanced cellular uptake and antiproliferative activity","volume":"22","author":"Wu","year":"2012","journal-title":"J. Mater. Chem."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"9859","DOI":"10.1021\/jf403564s","article-title":"Induction of apoptosis and cell cycle arrest in a549 human lung adenocarcinoma cells by surface-capping selenium nanoparticles: An effect enhanced by polysaccharide\u2013protein complexes from Polyporus rhinocerus","volume":"61","author":"Wu","year":"2013","journal-title":"J. Agric. Food Chem."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3389\/fcimb.2017.00093","article-title":"Scaffold of selenium nanovectors and honey phytochemicals for inhibition of pseudomonas aeruginosa quorum sensing and biofilm formation","volume":"7","author":"Prateeksha","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1021\/acs.cgd.5b01647","article-title":"Modulation of calcium oxalate crystallization by colloidal selenium nanoparticles\u2013polyphenol complex","volume":"16","author":"Chen","year":"2016","journal-title":"Cryst. Growth Des."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.jcis.2014.06.030","article-title":"Quercetin and gallic acid mediated synthesis of bimetallic (silver and selenium) nanoparticles and their antitumor and antimicrobial potential","volume":"431","author":"Mittal","year":"2014","journal-title":"J. Colloid Interface Sci."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.msec.2018.04.048","article-title":"Synthesis, characterization and antitumor properties of selenium nanoparticles coupling with ferulic acid","volume":"90","author":"Cui","year":"2018","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.actbio.2015.06.035","article-title":"Sialic acid (SA)-modified selenium nanoparticles coated with a high blood\u2013brain barrier permeability peptide-b6 peptide for potential use in Alzheimer\u2019s disease","volume":"25","author":"Yin","year":"2015","journal-title":"Acta Biomater."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.colsurfb.2010.11.023","article-title":"Sialic acid surface decoration enhances cellular uptake and apoptosis-inducing activity of selenium nanoparticles","volume":"83","author":"Zheng","year":"2011","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"5409","DOI":"10.1039\/C4TB00399C","article-title":"Ph-responsive cancer-targeted selenium nanoparticles: A transformable drug carrier with enhanced theranostic effects","volume":"2","author":"Yu","year":"2014","journal-title":"J. Mater. Chem. B"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.carbpol.2017.11.068","article-title":"Ph-responsive selenium nanoparticles stabilized by folate-chitosan delivering doxorubicin for overcoming drug-resistant cancer cells","volume":"181","author":"Luesakul","year":"2018","journal-title":"Carbohydr. Polym."},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Shahverdi, A.R., Shahverdi, F., Faghfuri, E., Reza khoshayand, M., Mavandadnejad, F., Yazdi, M.H., and Amini, M. (2018). Characterization of folic acid surface-coated selenium nanoparticles and corresponding in vitro and in vivo effects against breast cancer. Arch. Med. Res.","DOI":"10.1016\/j.arcmed.2018.04.007"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"885","DOI":"10.3748\/wjg.v23.i5.885","article-title":"Impact of humic acids on the colonic microbiome in healthy volunteers","volume":"23","author":"Swidsinski","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1089\/jmf.2009.0178","article-title":"Glucan and humic acid: Synergistic effects on the immune system","volume":"13","author":"Vetvicka","year":"2010","journal-title":"J. Med. Food"},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Steinb\u00fcchel, A. (2005). Humic substances, medical aspects and applications of. Biopolymers Online, Wiley-VCH Verlag GmbH & Co. KGaA.","DOI":"10.1002\/3527600035"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1002\/tox.21819","article-title":"Mechanism of the toxicity induced by natural humic acid on human vascular endothelial cells","volume":"29","author":"Yusuke","year":"2014","journal-title":"Environ. Toxicol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1006\/enrs.2002.4359","article-title":"The effects of humic acid\u2013arsenate complexes on human red blood cells","volume":"89","author":"Hseu","year":"2002","journal-title":"Environ. Res."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1177\/153537020322800412","article-title":"Humic acid induces oxidative DNA damage, growth retardation, and apoptosis in human primary fibroblasts","volume":"228","author":"Cheng","year":"2003","journal-title":"Exp. Biol. Med."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0048-9697(87)90124-0","article-title":"The effects of humic acid on the chemical and biological properties of selenium in the environment","volume":"64","author":"An","year":"1987","journal-title":"Sci. Total Environ."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1080\/17435390.2016.1275866","article-title":"A comparison of fate and toxicity of selenite, biogenically, and chemically synthesized selenium nanoparticles to zebrafish (Danio rerio) embryogenesis","volume":"11","author":"Mal","year":"2017","journal-title":"Nanotoxicology"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ecoenv.2018.02.073","article-title":"Maternal dietary exposure to selenium nanoparticle led to malformation in offspring","volume":"156","author":"Shi","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1186\/s11671-015-1073-2","article-title":"Selenium nanoparticles for stress-resilient fish and livestock","volume":"10","author":"Sarkar","year":"2015","journal-title":"Nanoscale Res. Lett."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.chemosphere.2017.04.142","article-title":"Toxicological implications of selenium nanoparticles with different coatings along with Se4+ on Lemna minor","volume":"181","author":"Tarrahi","year":"2017","journal-title":"Chemosphere"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.chemosphere.2017.08.130","article-title":"Assessment of toxicity of selenium and cadmium selenium quantum dots: A review","volume":"188","author":"Sharma","year":"2017","journal-title":"Chemosphere"},{"key":"ref_139","first-page":"1","article-title":"Chromium(iii)-, iron(ii)- and selenium-humic acid\/fulvic acid chelate and supplemented humifulvate added for nutritional purposes to food supplements Scientific opinion of the panel on food additives and nutrient sources added to food","volume":"1147","author":"Aguilar","year":"2009","journal-title":"EFSA J."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"035028","DOI":"10.1088\/2057-1976\/aab524","article-title":"Selenized saccharomyces cerevisiae cells are a green dispenser of nanoparticles","volume":"4","year":"2018","journal-title":"Biomed. Phys. Eng. Express"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"J226","DOI":"10.1016\/j.jaut.2009.11.006","article-title":"Origin and fate of dietary nanoparticles and microparticles in the gastrointestinal tract","volume":"34","author":"Powell","year":"2010","journal-title":"J. Autoimmun."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1080\/10408398.2011.559558","article-title":"Food-grade nanoemulsions: Formulation, fabrication, properties, performance, biological fate, and potential toxicity","volume":"51","author":"McClements","year":"2011","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.tox.2011.11.004","article-title":"Models for oral uptake of nanoparticles in consumer products","volume":"291","author":"Roblegg","year":"2012","journal-title":"Toxicology"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1007\/s11051-012-1236-3","article-title":"Biosynthesis of selenium nanoparticles by Pantoea agglomerans and their antioxidant activity","volume":"14","author":"Torres","year":"2012","journal-title":"J. Nanopart. Res."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/j.jinorgbio.2007.06.021","article-title":"Size effect of elemental selenium nanoparticles (nano-se) at supranutritional levels on selenium accumulation and glutathione s-transferase activity","volume":"101","author":"Peng","year":"2007","journal-title":"J. Inorg. Biochem."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/S0891-5849(03)00428-3","article-title":"Free radical scavenging efficiency of nano-se in vitro","volume":"35","author":"Huang","year":"2003","journal-title":"Free Radic. Biol. Med."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.carbpol.2013.03.063","article-title":"Bioactivity of selenium-enriched exopolysaccharides produced by Enterobacter cloacae z0206 in broilers","volume":"96","author":"Lu","year":"2013","journal-title":"Carbohydr. Polym."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.carbpol.2016.01.058","article-title":"Biosynthesis of selenium rich exopolysaccharide (Se-EPS) by Pseudomonas pt-8 and characterization of its antioxidant activities","volume":"142","author":"Ye","year":"2016","journal-title":"Carbohydr. Polym."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.ijbiomac.2016.09.076","article-title":"Synthesis, characterization and antioxidant activity of selenium polysaccharide from Cordyceps militaris","volume":"93","author":"Zhu","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.ijbiomac.2012.08.011","article-title":"Synthesis of selenium-containing polysaccharides and evaluation of antioxidant activity in vitro","volume":"51","author":"Wang","year":"2012","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1016\/j.carbpol.2011.07.007","article-title":"Extraction optimization and antioxidant activity of intracellular selenium polysaccharide by Cordyceps sinensis SU-02","volume":"86","author":"Wang","year":"2011","journal-title":"Carbohydr. Polym."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1039\/C7FO01725A","article-title":"The neuroprotective and antioxidant profiles of selenium-containing polysaccharides from the fruit of Rosa laevigata","volume":"9","author":"Liu","year":"2018","journal-title":"Food Funct."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/j.ijbiomac.2016.10.101","article-title":"Microwave-assisted synthesis, structure and anti-tumor activity of selenized Artemisia sphaerocephala polysaccharide","volume":"95","author":"Wang","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.enzmictec.2008.12.003","article-title":"Biosynthesis of selenium-containing polysaccharides with antioxidant activity in liquid culture of Hericium erinaceum","volume":"44","author":"Malinowska","year":"2009","journal-title":"Enzyme Microb. Technol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"30153","DOI":"10.3402\/fnr.v60.30153","article-title":"Production of intracellular selenium-enriched polysaccharides from thin stillage by Cordyceps sinensis and its bioactivities","volume":"60","author":"Yang","year":"2016","journal-title":"Food Nutr. Res."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.fct.2013.08.082","article-title":"Antidiabetic activity of mycelia selenium-polysaccharide from Catathelasma ventricosum in STZ-induced diabetic mice","volume":"62","author":"Liu","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.carbpol.2012.03.016","article-title":"Chemical modification and antioxidant activities of polysaccharide from mushroom Inonotus obliquus","volume":"89","author":"Ma","year":"2012","journal-title":"Carbohydr. Polym."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s00253-004-1787-z","article-title":"Medicinal mushroom modulators of molecular targets as cancer therapeutics","volume":"67","author":"Zaidman","year":"2005","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.carbpol.2010.12.058","article-title":"Production, preliminary characterization and antitumor activity in vitro of polysaccharides from the mycelium of Pholiota dinghuensis Bi","volume":"84","author":"Gan","year":"2011","journal-title":"Carbohydr. Polym."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1016\/S0008-6215(03)00198-8","article-title":"Antitumor activities of heteropolysaccharides of Poria cocos mycelia from different strains and culture media","volume":"338","author":"Jin","year":"2003","journal-title":"Carbohydr. Res."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0960-8524(03)00041-5","article-title":"Bioeffects of selenite on the growth of Spirulina platensis and its biotransformation","volume":"89","author":"Li","year":"2003","journal-title":"Bioresour. Technol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1016\/j.biortech.2008.10.037","article-title":"Preparation, characterization and immunomodulatory activity of selenium-enriched exopolysaccharide produced by bacterium Enterobacter cloacae z0206","volume":"100","author":"Xu","year":"2009","journal-title":"Bioresour. Technol."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"5733","DOI":"10.2147\/IJN.S140939","article-title":"Inhibitory activity of selenium nanoparticles functionalized with oseltamivir on H1N1 influenza virus","volume":"12","author":"Li","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jinorgbio.2016.11.023","article-title":"Quercetin loading CdSe\/Zns nanoparticles as efficient antibacterial and anticancer materials","volume":"167","author":"Yang","year":"2017","journal-title":"J. Inorg. Biochem."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"3205","DOI":"10.1002\/jbm.a.34262","article-title":"Nanostructured selenium for preventing biofilm formation on polycarbonate medical devices","volume":"100","author":"Wang","year":"2012","journal-title":"J. Biomed. Mater. Res. A"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1111\/1751-7915.12700","article-title":"Antimicrobial activity of biogenically produced spherical se-nanomaterials embedded in organic material against Pseudomonas aeruginosa and Staphylococcus aureus strains on hydroxyapatite-coated surfaces","volume":"10","author":"Piacenza","year":"2017","journal-title":"Microb. Biotechnol."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1111\/1751-7915.12374","article-title":"Biogenic selenium nanoparticles: Characterization, antimicrobial activity and effects on human dendritic cells and fibroblasts","volume":"9","author":"Cremonini","year":"2016","journal-title":"Microb. Biotechnol."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.colsurfb.2015.12.056","article-title":"Selenium-substituted hydroxyapatite nanoparticles and their in vivo antitumor effect on hepatocellular carcinoma","volume":"140","author":"Wang","year":"2016","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"8671","DOI":"10.2147\/IJN.S144615","article-title":"Selenium-coated nanostructured lipid carriers used for oral delivery of berberine to accomplish a synergic hypoglycemic effect","volume":"12","author":"Yin","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.cbi.2014.09.017","article-title":"Selenium nanoparticles involve hsp-70 and sirt1 in preventing the progression of type 1 diabetic nephropathy","volume":"223","author":"Kumar","year":"2014","journal-title":"Chem. Biol. Interact."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1002\/jbm.b.33448","article-title":"In vitro and in vivo antioxidant, cytotoxic, and anti-chronic inflammatory arthritic effect of selenium nanoparticles","volume":"104","author":"Malhotra","year":"2016","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.jtemb.2015.05.005","article-title":"Biomedical potential of actinobacterially synthesized selenium nanoparticles with special reference to anti-biofilm, anti-oxidant, wound healing, cytotoxic and anti-viral activities","volume":"32","author":"Ramya","year":"2015","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jtemb.2016.09.003","article-title":"Biosynthesis of selenium nanoparticles using enterococcus faecalis and evaluation of their antibacterial activities","volume":"39","author":"Shoeibi","year":"2017","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1007\/s00449-015-1413-8","article-title":"Green synthesis and structural characterization of selenium nanoparticles and assessment of their antimicrobial property","volume":"38","author":"Srivastava","year":"2015","journal-title":"Bioprocess Biosyst. Eng."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/2008-2231-21-33","article-title":"Selenium nanoparticle-enriched lactobacillus brevis causes more efficient immune responses in vivo and reduces the liver metastasis in metastatic form of mouse breast cancer","volume":"21","author":"Yazdi","year":"2013","journal-title":"Daru"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.colsurfb.2015.05.024","article-title":"45s5bioglass\u00ae-based scaffolds coated with selenium nanoparticles or with poly(lactide-co-glycolide)\/selenium particles: Processing, evaluation and antibacterial activity","volume":"132","author":"Boccaccini","year":"2015","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1016\/j.freeradbiomed.2007.02.013","article-title":"Elemental selenium at nano size possesses lower toxicity without compromising the fundamental effect on selenoenzymes: Comparison with selenomethionine in mice","volume":"42","author":"Wang","year":"2007","journal-title":"Free Radic. Biol. Med."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.2147\/IJN.S109822","article-title":"Multifunctional selenium nanoparticles as carriers of HSP70 siRNA to induce apoptosis of HepG2 cells","volume":"11","author":"Li","year":"2016","journal-title":"Int. J. Nanomed."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.livsci.2011.08.005","article-title":"Improved fetal hair follicle development by maternal supplement of selenium at nano size (Nano-Se)","volume":"142","author":"Wu","year":"2011","journal-title":"Livest. Sci."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.anireprosci.2009.10.003","article-title":"Effect of elemental nano-selenium on semen quality, glutathione peroxidase activity, and testis ultrastructure in male Boer goats","volume":"118","author":"Shi","year":"2010","journal-title":"Anim. Reprod. Sci."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1155\/2013\/493524","article-title":"Optimization of synthesis of seleno-sargassum fusiforme (harv.) setch. Polysaccharide by response surface methodology, its characterization, and antioxidant activity","volume":"2013","author":"Ji","year":"2013","journal-title":"J. Chem."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.carbpol.2017.06.050","article-title":"The characterization, selenylation and antidiabetic activity of mycelial polysaccharides from Catathelasma ventricosum","volume":"174","author":"Liu","year":"2017","journal-title":"Carbohydr. Polym."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1021\/acs.jafc.6b04788","article-title":"Selenylation of polysaccharide from the sweet potato and evaluation of antioxidant, antitumor, and antidiabetic activities","volume":"65","author":"Yuan","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ijbiomac.2017.01.039","article-title":"Selenizing Hericium erinaceus polysaccharides induces dendritic cells maturation through MAPK and NF-\u03baB signaling pathways","volume":"97","author":"Qin","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.carbpol.2016.06.090","article-title":"Synthesis of selenium-containing Artemisia sphaerocephala polysaccharides: Solution conformation and anti-tumor activities in vitro","volume":"152","author":"Wang","year":"2016","journal-title":"Carbohydr. Polym."},{"key":"ref_186","first-page":"47","article-title":"Selenium biofortification biotechnologies of wheat grain in south-eastern part of Romania for a better human health","volume":"24","author":"Oancea","year":"2014","journal-title":"Studia Univ. Vasile Goldis Arad Seria Stiintele Vietii"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/bs.acr.2017.07.002","article-title":"Chapter eight: Selenium and epigenetics in cancer: Focus on DNA methylation","volume":"Volume 136","author":"Tew","year":"2017","journal-title":"Advances in Cancer Research"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1351\/PAC-REP-10-06-02","article-title":"Isotopic compositions of the elements 2009 (IUPAC technical report)","volume":"83","author":"Berglund","year":"2011","journal-title":"Pure Appl. Chem."},{"key":"ref_189","first-page":"129","article-title":"Determination of selenium in dietary supplements by ETAAS and HG-AAS: A comparative study","volume":"23","author":"Valiente","year":"2002","journal-title":"At. Spectrosc."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/S0039-9140(97)00172-0","article-title":"Microwave assisted reduction of Se(VI) to Se(IV) and determination by HG\/FI-ICP\/MS for inorganic selenium speciation","volume":"45","author":"Donard","year":"1998","journal-title":"Talanta"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/lom3.10164","article-title":"A practical method for the determination of total selenium in environmental samples using isotope dilution-hydride generation-inductively coupled plasma-mass spectrometry","volume":"15","author":"Kleckner","year":"2017","journal-title":"Limnol. Oceanogr. Methods"},{"key":"ref_192","first-page":"79","article-title":"Determination of as and se in seawater by flow injection vapor generation ETV-ICP-MS","volume":"20","author":"Lam","year":"1999","journal-title":"At. Spectrosc."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jpba.2013.09.016","article-title":"Determination of macro and trace elements in multivitamin dietary supplements by high-resolution continuum source graphite furnace atomic absorption spectrometry with slurry sampling","volume":"88","author":"Krawczyk","year":"2014","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.trac.2017.12.005","article-title":"The role of selenium in mercury toxicity\u2014Current analytical techniques and future trends in analysis of selenium and mercury interactions in biological matrices","volume":"104","author":"Gajdosechova","year":"2017","journal-title":"Trends Anal. Chem."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.sab.2017.02.004","article-title":"Investigation of biotransformation of selenium in plants using spectrometric methods","volume":"130","author":"Konopka","year":"2017","journal-title":"Spectrochim. Acta Part B At. Spectrosc."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jtemb.2014.10.004","article-title":"Determination of selenium and its compounds in marine organisms","volume":"29","author":"Bryszewska","year":"2015","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/S0946-672X(99)80065-0","article-title":"Direct determination of selenium and other trace elements in serum samples by ICP-MS","volume":"12","author":"Forrer","year":"1999","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.foodchem.2011.10.076","article-title":"Elemental analysis of nutritional preparations by inductively coupled plasma mass and optical emission spectrometry","volume":"132","author":"Pouzar","year":"2012","journal-title":"Food Chem."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"3327","DOI":"10.1016\/j.fct.2010.08.032","article-title":"Determination of selenium content in aqueous extract of medicinal plants used as herbal supplement for cancer patients","volume":"48","author":"Kolachi","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1177\/104063870501700405","article-title":"Comparison of selenium determination in liver samples by atomic absorption spectroscopy and inductively coupled plasma\u2013mass spectrometry","volume":"17","author":"Miksa","year":"2005","journal-title":"J. Vet. Diagn. Investig."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/S0584-8547(97)00050-5","article-title":"Comparison of chemical modifiers for the determination of selenium by electrothermal atomic-absorption spectrometry","volume":"52","author":"Bulska","year":"1997","journal-title":"Spectrochim. Acta Part B At. Spectrosc."},{"key":"ref_202","first-page":"1","article-title":"Determination of selenium in human blood serum by electrothermal atomic absorption spectrometry","volume":"2011","author":"Stafilov","year":"2011","journal-title":"Chem. Sci. J."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1016\/j.talanta.2011.06.015","article-title":"Method development and optimization for the determination of selenium in bean and soil samples using hydride generation electrothermal atomic absorption spectrometry","volume":"85","author":"Shaltout","year":"2011","journal-title":"Talanta"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.microc.2018.04.009","article-title":"Effect of variable ultraviolet wavelength and intensity on photochemical vapor generation of trace selenium detected by atomic fluorescence spectrometry","volume":"140","author":"Zou","year":"2018","journal-title":"Microchem. J."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.sab.2010.07.001","article-title":"Analytical determination of selenium in medical samples, staple food and dietary supplements by means of total reflection x-ray fluorescence spectroscopy","volume":"65","author":"Stosnach","year":"2010","journal-title":"Spectrochim. Acta Part B At. Spectrosc."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1351\/pac200072081453","article-title":"Guidelines for terms related to chemical speciation and fractionation of elements. Definitions, structural aspects, and methodological approaches (IUPAC recommendations 2000)","volume":"72","author":"Ariese","year":"2000","journal-title":"Pure Appl. Chem."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"8759","DOI":"10.1074\/jbc.M610078200","article-title":"Extracellular production of hydrogen selenide accounts for thiol-assisted toxicity of selenite against saccharomyces cerevisiae","volume":"282","author":"Tarze","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0300-483X(90)90037-H","article-title":"Comparative embryotoxicity of selenite and selenate: Uptake in murine embryonal and fetal tissues and effects on blastocysts and embryonic cells in vitro","volume":"63","author":"Danielsson","year":"1990","journal-title":"Toxicology"},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1007\/BF01141346","article-title":"Comparative toxicity of selenite and selenate to the amphipod Hyalella azteca","volume":"24","author":"Brasher","year":"1993","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"ref_210","doi-asserted-by":"crossref","unstructured":"Boehler, C.J., Raines, A.M., and Sunde, R.A. (2013). Deletion of thioredoxin reductase and effects of selenite and selenate toxicity in caenorhabditis elegans. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0071525"},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s10646-007-0140-6","article-title":"Toxicity of selenate and selenite to the potworm Enchytraeus albidus (Annelida: Enchytraeidae): A laboratory test","volume":"16","author":"Somogyi","year":"2007","journal-title":"Ecotoxicology"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.trac.2017.07.012","article-title":"A systematic review and meta-analysis of voltammetric and optical techniques for inorganic selenium determination in water","volume":"95","author":"Devi","year":"2017","journal-title":"Trends Analyt. Chem."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.jhazmat.2017.10.034","article-title":"Biotransformation and detoxification of selenite by microbial biogenesis of selenium-sulfur nanoparticles","volume":"344","author":"Vogel","year":"2018","journal-title":"J. Hazard. Mater."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.fcr.2017.06.008","article-title":"Difference of selenium uptake and distribution in the plant and selenium form in the grains of rice with foliar spray of selenite or selenate at different stages","volume":"211","author":"Deng","year":"2017","journal-title":"Field Crop. Res."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1007\/s12161-012-9365-y","article-title":"Determination of inorganic selenium species in dietary supplements by hyphenated analytical system HPLC-HG-AAS","volume":"5","author":"Kozak","year":"2012","journal-title":"Food Anal. Methods"},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.microc.2015.10.004","article-title":"Uv-photochemical vapor generation with quartz furnace atomic absorption spectrometry for simple and sensitive determination of selenium in dietary supplements","volume":"124","year":"2016","journal-title":"Microchem. J."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"4828","DOI":"10.1016\/j.jece.2017.09.021","article-title":"Acid switched efficient, cost effective, selective separation and determination of selenium(iv)","volume":"5","author":"Barache","year":"2017","journal-title":"J. Environ. Chem. Eng."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1021\/es0613714","article-title":"Selenium volatiles as proxy to the metabolic pathways of selenium in genetically modified Brassica juncea","volume":"41","author":"Kubachka","year":"2007","journal-title":"Environ. Sci. Technol."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0021-9673(04)01417-7","article-title":"Investigation of the elemental composition and chemical association of several elements in fulvic acids dietary supplements by size-exclusion chromatography UV inductively coupled plasma mass spectrometric","volume":"1054","author":"Grant","year":"2004","journal-title":"J. Chromatogr. A"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.envexpbot.2016.01.006","article-title":"Selenium uptake, transformation and inter-element interactions by selected wildlife plant species after foliar selenate application","volume":"125","author":"Mestek","year":"2016","journal-title":"Environ. Exp. Bot."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.aca.2018.01.068","article-title":"Comparison of analytical methods using enzymatic activity, immunoaffinity and selenium-specific mass spectrometric detection for the quantitation of glutathione peroxidase 1","volume":"1011","author":"Sonet","year":"2018","journal-title":"Anal. Chim. Acta"},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1021\/ac3033799","article-title":"Characterization of selenium incorporation into wheat proteins by two-dimensional gel electrophoresis\u2013laser ablation ICP MS followed by capillary HPLC\u2013ICP MS and electrospray linear trap quadrupole orbitrap MS","volume":"85","author":"Bianga","year":"2013","journal-title":"Anal. Chem."},{"key":"ref_223","unstructured":"Chavatte, L. (2018). Imaging of selenium by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) in 2-d electrophoresis gels and biological tissues. Selenoproteins: Methods and Protocols, Springer New York."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.aca.2004.11.068","article-title":"Determination of selenium species in infant formulas and dietetic supplements using liquid chromatography\u2013hydride generation atomic fluorescence spectrometry","volume":"535","author":"Campillo","year":"2005","journal-title":"Anal. Chim. Acta"},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1039\/C5JA00276A","article-title":"Determination of semet and se(iv) in biofortified yeast by ion-pair reversed phase liquid chromatography-hydride generation-microwave induced nitrogen plasma atomic emission spectrometry (HPLC-HG-MP-AES)","volume":"31","author":"Barrientos","year":"2016","journal-title":"J. Anal. At. Spectrom."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.foodchem.2012.10.046","article-title":"Review: On published data and methods for selenium in mushrooms","volume":"138","author":"Falandysz","year":"2013","journal-title":"Food Chem."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.ijbiomac.2018.05.078","article-title":"The characteristics and antioxidation of oudemansiella radicata selenium polysaccharides on lipopolysaccharide-induced endo-toxemic mice","volume":"116","author":"Gao","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"2744","DOI":"10.1039\/C8FO00027A","article-title":"Structural characterization and antitumor activity of a novel se-polysaccharide from selenium-enriched cordyceps gunnii","volume":"9","author":"Sun","year":"2018","journal-title":"Food Funct."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.carbpol.2015.02.029","article-title":"Synthesis, characterization, antioxidant activity and neuroprotective effects of selenium polysaccharide from radix hedysari","volume":"125","author":"Wei","year":"2015","journal-title":"Carbohydr. Polym."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.talanta.2017.06.013","article-title":"Proteins in microbial synthesis of selenium nanoparticles","volume":"174","author":"Tugarova","year":"2017","journal-title":"Talanta"},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1128\/AEM.67.2.769-773.2001","article-title":"Mobilization of selenite by ralstonia metallidurans CH34","volume":"67","author":"Roux","year":"2001","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"S304","DOI":"10.1155\/2009\/109608","article-title":"Mixed surfactant template method for preparation of nanometer selenium","volume":"6","author":"Li","year":"2009","journal-title":"E-J. Chem."},{"key":"ref_233","doi-asserted-by":"crossref","unstructured":"Dwivedi, S., AlKhedhairy, A.A., Ahamed, M., and Musarrat, J. (2013). Biomimetic synthesis of selenium nanospheres by bacterial strain js-11 and its role as a biosensor for nanotoxicity assessment: A novel se-bioassay. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0057404"},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.nano.2016.10.009","article-title":"High-throughput bioaccumulation, biotransformation, and production of silver and selenium nanoparticles using genetically engineered pichia pastoris","volume":"13","author":"Elahian","year":"2017","journal-title":"Nanomedicine"},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"37155","DOI":"10.1038\/srep37155","article-title":"Production of selenium nanoparticles in pseudomonas putida KT2440","volume":"6","author":"Chaves","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jhazmat.2016.02.035","article-title":"Selenite biotransformation and detoxification by stenotrophomonas maltophilia SeITE02: Novel clues on the route to bacterial biogenesis of selenium nanoparticles","volume":"324","author":"Lampis","year":"2017","journal-title":"J. Hazard. Mater."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.foodres.2014.01.040","article-title":"Flow field-flow fractionation for particle size characterization of selenium nanoparticles incubated in gastrointestinal conditions","volume":"57","author":"Somchue","year":"2014","journal-title":"Food Res. Int."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.sab.2017.03.019","article-title":"Asymmetrical flow field-flow fractionation coupled to inductively coupled plasma mass spectrometry for sizing senps for packaging applications","volume":"132","author":"Vera","year":"2017","journal-title":"Spectrochim. Acta Part B At. Spectrosc."},{"key":"ref_239","first-page":"1","article-title":"Chapter 1: Introduction to the analysis and risk of nanomaterials in environmental and food samples","volume":"Volume 59","year":"2012","journal-title":"Comprehensive Analytical Chemistry"},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"9361","DOI":"10.1021\/ac201952t","article-title":"Determining transport efficiency for the purpose of counting and sizing nanoparticles via single particle inductively coupled plasma mass spectrometry","volume":"83","author":"Pace","year":"2011","journal-title":"Anal. Chem."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"5051","DOI":"10.1007\/s00216-016-9638-1","article-title":"Single-particle-ICP-MS advances","volume":"408","author":"Winchester","year":"2016","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"10291","DOI":"10.1021\/es502422v","article-title":"Nanoparticle size detection limits by single particle icp-ms for 40 elements","volume":"48","author":"Lee","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/S0584-8547(02)00069-1","article-title":"Reaction cells and collision cells for ICP-MS: A tutorial review","volume":"57","author":"Tanner","year":"2002","journal-title":"Spectrochim. Acta Part B At. Spectrosc."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0039-9140(94)80106-1","article-title":"A mathematical correction method for spectral interferences on selenium in inductively coupled plasma mass spectrometry","volume":"41","author":"Goossens","year":"1994","journal-title":"Talanta"},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.jtemb.2018.02.005","article-title":"Selenium and selenium species in feeds and muscle tissue of Atlantic salmon","volume":"47","author":"Sele","year":"2018","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.lwt.2018.04.048","article-title":"Development of a method for producing selenium-enriched radish sprouts","volume":"95","author":"Trolove","year":"2018","journal-title":"LWT"},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.aquaculture.2017.10.040","article-title":"Toxicity and biochemical transformation of selenium species in rotifer (Brachionus Plicatilis) enrichments","volume":"484","author":"Ponce","year":"2018","journal-title":"Aquaculture"},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.foodchem.2013.01.116","article-title":"In vitro bioavailability of total selenium and selenium species from seafood","volume":"139","year":"2013","journal-title":"Food Chem."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jtemb.2016.11.015","article-title":"Selenium speciation profiles in biofortified sangiovese wine","volume":"43","author":"Fontanella","year":"2017","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.lwt.2015.12.028","article-title":"Analogy in selenium enrichment and selenium speciation between selenized yeast Saccharomyces cerevisiae and Hericium erinaceus (lion\u2019s mane mushroom)","volume":"68","author":"Ouerdane","year":"2016","journal-title":"LWT-Food Sci. Technol."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.chemosphere.2018.02.007","article-title":"Effect of selenium-enriched organic material amendment on selenium fraction transformation and bioavailability in soil","volume":"199","author":"Wang","year":"2018","journal-title":"Chemosphere"},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.micpath.2017.12.042","article-title":"Mechanism of bio molecule stabilized selenium nanoparticles against oxidation process and Clostridium botulinum","volume":"115","author":"Tareq","year":"2018","journal-title":"Microb. Pathogenesis"},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.meatsci.2017.03.014","article-title":"Dietary linseed oil supplemented with organic selenium improved the fatty acid nutritional profile, muscular selenium deposition, water retention, and tenderness of fresh pork","volume":"131","author":"Jiang","year":"2017","journal-title":"Meat Sci."},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.chemosphere.2017.08.158","article-title":"Natural variation of selenium in brazil nuts and soils from the amazon region","volume":"188","author":"Wadt","year":"2017","journal-title":"Chemosphere"},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.sjbs.2015.08.007","article-title":"The extraction of different proteins in selenium enriched peanuts and their antioxidant properties","volume":"23","author":"Zhao","year":"2016","journal-title":"Saudi J. Biol. Sci."},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.scienta.2017.07.014","article-title":"Uptake and partitioning of selenium in basil (Ocimum Basilicum L.) plants grown in hydroponics","volume":"225","author":"Puccinelli","year":"2017","journal-title":"Sci. Hortic. (Amsterdam)"},{"key":"ref_257","unstructured":"Thompson, B., and Amoroso, L. (2010). Nationwide supplementation of sodium selenate to commercial fertilizers: History and 25-year results from the finnish selenium monitoring programme. Combating Micronutrient Deficiencies: Food-Based Approaches, FAO & CAB Intenational."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.anifeedsci.2015.10.009","article-title":"Effects of selenium yeast level in diet on carcass and meat quality, tissue selenium distribution and glutathione peroxidase activity in ducks","volume":"210","year":"2015","journal-title":"Anim. Feed Sci. Technol."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.microc.2016.11.007","article-title":"The role of analytical techniques in the determination of metals and metalloids in dietary supplements: A review","volume":"136","author":"Smichowski","year":"2018","journal-title":"Microchem. J."},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.foodchem.2017.08.068","article-title":"Quantification of selenomethionine in plasma using UPLC\u2013MS\/MS after the oral administration of selenium-enriched yeast to rats","volume":"241","author":"Zhang","year":"2018","journal-title":"Food Chem."},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jhazmat.2016.12.061","article-title":"Microbial selenium sulfide reduction for selenium recovery from wastewater","volume":"329","author":"Hageman","year":"2017","journal-title":"J. Hazard. Mater."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/10\/10\/1466\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T15:24:31Z","timestamp":1760196271000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/10\/10\/1466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,9]]},"references-count":261,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2018,10]]}},"alternative-id":["nu10101466"],"URL":"https:\/\/doi.org\/10.3390\/nu10101466","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,9]]}}}