{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T04:24:10Z","timestamp":1783571050514,"version":"3.55.0"},"reference-count":44,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2018,10,15]],"date-time":"2018-10-15T00:00:00Z","timestamp":1539561600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The development of nutraceutical ingredients has risen as a nutritional solution for health prevention. This study evaluated the effects of Oleactiv\u00ae, an ingredient developed for the prevention of atherogenesis, in hypercholesterolemic hamsters. Oleactiv\u00ae is a polyphenol-rich ingredient obtained from artichoke, olive and grape extracts as part of fruit and vegetables commonly consumed within the Mediterranean diet. A total of 21 Golden Syrian hamsters were divided into three groups. The standard group (STD) was fed a normolipidemic diet for 12 weeks, while the control group (CTRL) and Oleactiv\u00ae goup (OLE) were fed a high-fat diet. After sacrifice, the aortic fatty streak area (AFSA), plasmatic total cholesterol (TC), high-density lipoproteins (HDL-C), non-HDL-C and triglycerides (TG), were assessed. The cholesterol efflux capacity (CEC) of hamster plasma was quantified using a radiolabeled technique in murine macrophages J774. OLE administration induced a significant reduction of AFSA (\u221269%, p &lt; 0.0001). Hamsters of the OLE group showed a significant decrease of both non-HDL-C (\u2212173 mmol\/L, p &lt; 0.05) and TG (\u2212154 mmol\/L, p &lt; 0.05). Interestingly, OLE induced a significant increase of total CEC (+17,33%, p &lt; 0,05). Oleactiv\u00ae supplementation prevented atheroma development and had positive effects on the lipid profile of hypercholesterolemic hamsters. The increased CEC underlines the anti-atherosclerotic mechanism at the root of the atheroma reduction observed.<\/jats:p>","DOI":"10.3390\/nu10101511","type":"journal-article","created":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T02:52:53Z","timestamp":1539658373000},"page":"1511","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Anti-Atherosclerotic Effect of a Polyphenol-Rich Ingredient, Oleactiv\u00ae, in a Hypercholesterolemia-Induced Golden Syrian Hamster Model"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3922-8438","authenticated-orcid":false,"given":"Cindy","family":"Romain","sequence":"first","affiliation":[{"name":"Fytexia SAS, Innovation and Scientific Affairs, 34350 Vendres, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Piemontese","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze degli Alimenti e del Farmaco, Universit\u00e0 degli Studi di Parma, 43124 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Battista","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze degli Alimenti e del Farmaco, Universit\u00e0 degli Studi di Parma, 43124 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Bernini","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze degli Alimenti e del Farmaco, Universit\u00e0 degli Studi di Parma, 43124 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Ossoli","sequence":"additional","affiliation":[{"name":"Centro E. Grossi Paoletti, Dipartimento di Scienze Farmacologiche e Biomolecolari, Universit\u00e0 degli Studi di Milano, 20133 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianna","family":"Strazzella","sequence":"additional","affiliation":[{"name":"Centro E. Grossi Paoletti, Dipartimento di Scienze Farmacologiche e Biomolecolari, Universit\u00e0 degli Studi di Milano, 20133 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6050-0870","authenticated-orcid":false,"given":"Sylvie","family":"Gaillet","sequence":"additional","affiliation":[{"name":"Nutrition & M\u00e9tabolisme, UMR 204 NUTRIPASS, Pr\u00e9vention des Malnutritions & des Pathologies Associ\u00e9es, Universit\u00e9 Montpellier Sud de France, 34394 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Max","family":"Rouanet","sequence":"additional","affiliation":[{"name":"Nutrition & M\u00e9tabolisme, UMR 204 NUTRIPASS, Pr\u00e9vention des Malnutritions & des Pathologies Associ\u00e9es, Universit\u00e9 Montpellier Sud de France, 34394 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6368-250X","authenticated-orcid":false,"given":"Julien","family":"Cases","sequence":"additional","affiliation":[{"name":"Fytexia SAS, Innovation and Scientific Affairs, 34350 Vendres, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2701-6021","authenticated-orcid":false,"given":"Ilaria","family":"Zanotti","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze degli Alimenti e del Farmaco, Universit\u00e0 degli Studi di Parma, 43124 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,10,15]]},"reference":[{"key":"ref_1","unstructured":"(2018, June 29). 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