{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T21:39:44Z","timestamp":1775252384598,"version":"3.50.1"},"reference-count":35,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T00:00:00Z","timestamp":1539734400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Kuwait University Research","award":["WF02\/13"],"award-info":[{"award-number":["WF02\/13"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Few studies have investigated the association between Acne vulgaris (AV) and vitamin D level. In this study we aimed to investigate the association between 25-hydroxyvitamin D (25-OH-VitD) level and AV in a country with plenty of sunshine. A cross-sectional study was conducted on 714 adolescents who were randomly selected from public schools using multistage cluster random sampling with probability proportional to size. 25-OH-VitD levels were measured using liquid chromatography-tandem mass spectrometry (LC-MS\/MS). The Global Acne Grading System (GAGS) was used to assess the severity of AV. Data on potential confounders were collected from the parents through a self-administered questionnaire, and from the adolescents using a face-to-face interview. Of 714 participants, 351 (41.16%) were males. The mean (standard deviation (SD)) age was 12.28 (0.81) years. AV was observed in 479 (67.1%) adolescents. There was no significant association between 25-OH-VitD level and clinically assessed AV before or after adjusting for potential confounders. This was consistent whether 25-OH-VitD was fitted as a continuous variable or categorized using acceptable cutoff points or tertiles. In this study vitamin D status was not associated with AV, therefore our data do not support vitamin D supplementation either to treat or to prevent AV.<\/jats:p>","DOI":"10.3390\/nu10101525","type":"journal-article","created":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T10:22:54Z","timestamp":1539771774000},"page":"1525","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Plasma 25-Hydroxy Vitamin D is not Associated with Acne Vulgaris"],"prefix":"10.3390","volume":"10","author":[{"given":"Abdullah","family":"Al-Taiar","sequence":"first","affiliation":[{"name":"Department Community Medicine and Behavioural Sciences, Faculty of Medicine, Kuwait University, Box 24923, Safat 13110, Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mona","family":"AlKhabbaz","sequence":"additional","affiliation":[{"name":"Quality and Accreditation Directorate, Ministry of Health, Box 5, State 13001, Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdur","family":"Rahman","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition; College of Life Sciences, Kuwait University, Box 5969, Safat 13060, Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reem","family":"Al-Sabah","sequence":"additional","affiliation":[{"name":"Department Community Medicine and Behavioural Sciences, Faculty of Medicine, Kuwait University, Box 24923, Safat 13110, Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lemia","family":"Shaban","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition; College of Life Sciences, Kuwait University, Box 5969, Safat 13060, Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1261-788X","authenticated-orcid":false,"given":"Saeed","family":"Akhtar","sequence":"additional","affiliation":[{"name":"Department Community Medicine and Behavioural Sciences, Faculty of Medicine, Kuwait University, Box 24923, Safat 13110, Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,10,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/bjd.13462","article-title":"A global perspective on the epidemiology of acne","volume":"172","author":"Tan","year":"2015","journal-title":"Br. 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