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The importance of essential fatty acids (EFAs) has been recognized in the fields of cardiac science and cardiac medicine, with the significant effects of various fatty acids having been confirmed by experimental studies. Polyunsaturated fatty acids are considered to be important versatile mediators for improving and maintaining human health over the entire lifespan, however, only the cardiac effect has been extensively documented. Recently, it has been shown that omega-3 fatty acids may play a beneficial role in several human pathologies, such as obesity and diabetes mellitus type 2, and are also associated with a reduced incidence of stroke and atherosclerosis, and decreased incidence of cardiovascular diseases. A reasonable diet and wise supplementation of omega-3 EFAs are essential in the prevention and treatment of cardiovascular diseases prevention and treatment.<\/jats:p>","DOI":"10.3390\/nu10101561","type":"journal-article","created":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T08:43:36Z","timestamp":1540284216000},"page":"1561","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":322,"title":["Polyunsaturated Fatty Acids and Their Potential Therapeutic Role in Cardiovascular System Disorders\u2014A Review"],"prefix":"10.3390","volume":"10","author":[{"given":"Ewa","family":"Soko\u0142a-Wysocza\u0144ska","sequence":"first","affiliation":[{"name":"The Lumina Cordis Foundation, Szymanowskiego Street 2\/a, 51-609 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Wysocza\u0144ski","sequence":"additional","affiliation":[{"name":"FLC Pharma Ltd., Wroclaw Technology Park Muchoborska Street 18, 54-424 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolanta","family":"Wagner","sequence":"additional","affiliation":[{"name":"FLC Pharma Ltd., Wroclaw Technology Park Muchoborska Street 18, 54-424 Wroclaw, Poland"},{"name":"Department of Bioorganic Chemistry, Faculty of Chemistry, University of Technology, Wybrzeze Wyspianskiego Street 27, 50-370 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7548-8918","authenticated-orcid":false,"given":"Katarzyna","family":"Czy\u017c","sequence":"additional","affiliation":[{"name":"Institute of Animal Breeding, Faculty of Biology and Animal Sciences, Wroclaw University of Environmental and Life Sciences, Chelmonskiego Street 38c, 50-001 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Bodkowski","sequence":"additional","affiliation":[{"name":"Institute of Animal Breeding, Faculty of Biology and Animal Sciences, Wroclaw University of Environmental and Life Sciences, Chelmonskiego Street 38c, 50-001 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanis\u0142aw","family":"Lochy\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Bioorganic Chemistry, Faculty of Chemistry, University of Technology, Wybrzeze Wyspianskiego Street 27, 50-370 Wroclaw, Poland"},{"name":"Institute of Cosmetology, Wroclaw College of Physiotherapy, Kosciuszki 4 Street, 50-038 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo\u017cena","family":"Patkowska-Soko\u0142a","sequence":"additional","affiliation":[{"name":"Institute of Animal Breeding, Faculty of Biology and Animal Sciences, Wroclaw University of Environmental and Life Sciences, Chelmonskiego Street 38c, 50-001 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,10,21]]},"reference":[{"key":"ref_1","first-page":"257","article-title":"Evaluation of the anti-proliferative activity of natural lipid preparations against tumor cell lines","volume":"13","author":"Bodkowski","year":"2014","journal-title":"J. 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