{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T06:08:44Z","timestamp":1769753324989,"version":"3.49.0"},"reference-count":36,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2018,10,29]],"date-time":"2018-10-29T00:00:00Z","timestamp":1540771200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["Apq1 2013\/2 110.620\/2014"],"award-info":[{"award-number":["Apq1 2013\/2 110.620\/2014"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Changes in lipid metabolism occur during the development and progression non-alcoholic fatty liver disease (NAFLD). However, the fatty acid (FA) profile in red blood cells (RBC) from patients with liver fibrosis remains unexplored. Thus, the goal of this study was to evaluate the fatty acid profile in RBC, dietary lipid intake and insulin resistance indicators in patients with NAFLD, according to the degree of hepatic fibrosis. Using elastography, patients were classified with (n = 52) and without (n = 37) advanced liver fibrosis. The fatty acid profile in RBC was analyzed using gas chromatography and the lipid intake was evaluated through a 24-h dietary recall. Subjects with advanced liver fibrosis had higher levels of palmitic, stearic and oleic acid and total monounsaturated fatty acid (MUFA) and insulin (p &lt; 0.05), and lower levels of elongase very long chain fatty acids protein-6 and the delta-5-desaturase enzymatic activity (p &lt; 0.05). These results suggest a lack of regulation of enzymes related to FA metabolism in patients with advanced fibrosis.<\/jats:p>","DOI":"10.3390\/nu10111586","type":"journal-article","created":{"date-parts":[[2018,10,29]],"date-time":"2018-10-29T11:10:41Z","timestamp":1540811441000},"page":"1586","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Advanced Liver Fibrosis Is Independently Associated with Palmitic Acid and Insulin Levels in Patients with Non-Alcoholic Fatty Liver Disease"],"prefix":"10.3390","volume":"10","author":[{"given":"K\u00e1tia","family":"Cansan\u00e7\u00e3o","sequence":"first","affiliation":[{"name":"Institute of Nutrition Josu\u00e9 de Castro of Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21.941-902, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luana","family":"Silva Monteiro","sequence":"additional","affiliation":[{"name":"Nutrition Course, Federal University of Rio de Janeiro (Campus UFRJ-Maca\u00e9), Maca\u00e9, Rio de Janeiro 27.930-560, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Carvalho Leite","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University Hospital Clementino Fraga Filho, School of Medicine of UFRJ, Rio de Janeiro 21.941-902, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"D\u00e1valos","sequence":"additional","affiliation":[{"name":"Laboratory of Epigenetics of Lipid Metabolism, Madrid Institute for Advanced Studies (IMDEA)-Food, CEI UAM+CSIC, 28049 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Tavares do Carmo","sequence":"additional","affiliation":[{"name":"Institute of Nutrition Josu\u00e9 de Castro of Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21.941-902, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilza","family":"Arantes Ferreira Peres","sequence":"additional","affiliation":[{"name":"Institute of Nutrition Josu\u00e9 de Castro of Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21.941-902, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,10,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1159\/000336669","article-title":"Nonalcoholic fatty liver disease\/steatohepatitis: Epidemiology, pathogenesis, clinical presentation and treatment","volume":"30","author":"Stimac","year":"2012","journal-title":"Dig Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1053\/j.gastro.2008.03.003","article-title":"Mechanisms of Hepatic Fibrogenesis","volume":"134","author":"Friedman","year":"2008","journal-title":"Gastroenterology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/MED.0b013e3283293015","article-title":"Nonalcoholic fatty liver disease in type 2 diabetes mellitus","volume":"16","author":"Cusi","year":"2009","journal-title":"Curr. 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