{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T10:44:04Z","timestamp":1784198644222,"version":"3.55.0"},"reference-count":64,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2018,11,3]],"date-time":"2018-11-03T00:00:00Z","timestamp":1541203200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010198","name":"Ministerio de Econom\u00eda, Industria y Competitividad, Gobierno de Espa\u00f1a","doi-asserted-by":"publisher","award":["AGL2013-42757-R and AGL2017-87884-R"],"award-info":[{"award-number":["AGL2013-42757-R and AGL2017-87884-R"]}],"id":[{"id":"10.13039\/501100010198","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Factors such as lactation stage and premature and small-for-gestational conditions could lead to great inter-individual variability in the carotenoid content of human milk. The aim was to analyze the carotenoid content in colostrum and mature milk of preterm (PT) and full-term (FT) mothers to establish whether they are significantly different and, if so, the stage of lactation when the differences are established. Samples of blood, colostrum, and mature milk were collected from Spanish donating mothers who gave birth to PT or FT infants. Carotenoids from serum and milk samples were analyzed by HPLC-atmospheric pressure chemical ionization (APCI)-MS. Quantitatively, colostrum from PT mothers presented lower total carotenoid content when compared to that from FT mothers. The only exception was lutein, where levels were not different. The transition from colostrum to mature milk makes observed differences in the carotenoid content disappear, since there were no variances between PT and FT groups for both individual and total carotenoid content. The premature birth condition affects the quantitative carotenoid composition of the colostrum but has no effect on the lutein content. This fact could be related to the significant role of this xanthophyll in the development of infant retina and feasibly to cognitive function.<\/jats:p>","DOI":"10.3390\/nu10111654","type":"journal-article","created":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T10:43:45Z","timestamp":1541414625000},"page":"1654","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Carotenoid Content in Human Colostrum is Associated to Preterm\/Full-Term Birth Condition"],"prefix":"10.3390","volume":"10","author":[{"given":"Ana A. O.","family":"Xavier","sequence":"first","affiliation":[{"name":"Department of Food Phytochemistry, Instituto de la Grasa (CSIC), Campus Universitario, Building 46, 41013 Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"D\u00edaz-Salido","sequence":"additional","affiliation":[{"name":"Unidad de Neonatolog\u00eda, Hospital Virgen del Roc\u00edo, 41013 Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Arenilla-V\u00e9lez","sequence":"additional","affiliation":[{"name":"Unidad de Neonatolog\u00eda, Hospital Virgen del Roc\u00edo, 41013 Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2323-5721","authenticated-orcid":false,"given":"Josefa","family":"Aguayo-Maldonado","sequence":"additional","affiliation":[{"name":"Unidad de Neonatolog\u00eda, Hospital Virgen del Roc\u00edo, 41013 Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Garrido-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Food Phytochemistry, Instituto de la Grasa (CSIC), Campus Universitario, Building 46, 41013 Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Fontecha","sequence":"additional","affiliation":[{"name":"Institute of Food Science Research (CSIC-UAM), 28049 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7919-0614","authenticated-orcid":false,"given":"Alicia","family":"S\u00e1nchez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Laboratorio de Espectrometr\u00eda de Masas, Instituto de la Grasa (CSIC), 41013 Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6914-8378","authenticated-orcid":false,"given":"Antonio","family":"P\u00e9rez-G\u00e1lvez","sequence":"additional","affiliation":[{"name":"Department of Food Phytochemistry, Instituto de la Grasa (CSIC), Campus Universitario, Building 46, 41013 Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,11,3]]},"reference":[{"key":"ref_1","unstructured":"Leon-Cava, N., Lutter, C., Ross, J., and Martin, L. 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