{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T22:49:22Z","timestamp":1762642162873,"version":"build-2065373602"},"reference-count":26,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003668","name":"Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries","doi-asserted-by":"publisher","award":["314044-3"],"award-info":[{"award-number":["314044-3"]}],"id":[{"id":"10.13039\/501100003668","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Metabolic syndrome is characterized by a combination of several metabolic disorders, including obesity, hyperglycemia, and hyperlipidemia. A simultaneous occurrence is one of the most crucial features of metabolic syndrome; therefore, we selected an animal model in which this would be reflected. We fed C57BL\/6N mice a high-fat diet for 23 weeks to develop metabolic syndrome and examined the efficacy of Rubus occidentalis (RO) for hyperglycemia and hypercholesterolemia. Oral administration of RO for 16 weeks improved hyperglycemia as indicated by significantly decreased fasting glucose levels and a glucose tolerance test. Improvements were also observed in hypercholesterolemia, in which significant decreases in serum total cholesterol, non-high-density lipoprotein (non-HDL) cholesterol, apolipoprotein A-1, and apolipoprotein B levels were observed. The time comparison of major biomarkers, observed at the initiation and termination of the experimental period, consistently supported the beneficial effects of RO on each metabolic phenotype. In addition, RO treatment attenuated the excessive fat accumulation in hepatic and adipose tissue by decreasing the size and number of lipid droplets. These results suggested that RO simultaneously exerted antihyperglycemic and antihyperlipidemic effects in mice with diet-induced metabolic syndrome.<\/jats:p>","DOI":"10.3390\/nu10121846","type":"journal-article","created":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T06:02:09Z","timestamp":1543816929000},"page":"1846","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Multifaceted Effect of Rubus Occidentalis on Hyperglycemia and Hypercholesterolemia in Mice with Diet-Induced Metabolic Diseases"],"prefix":"10.3390","volume":"10","author":[{"given":"Jiyeon","family":"Kim","sequence":"first","affiliation":[{"name":"College of Pharmacy, Sahmyook University, Seoul 01795, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7101-7115","authenticated-orcid":false,"given":"Jinho","family":"An","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Sahmyook University, Seoul 01795, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heetae","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Sahmyook University, Seoul 01795, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyungjae","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Sahmyook University, Seoul 01795, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su Jung","family":"Lee","sequence":"additional","affiliation":[{"name":"Berry &amp; Biofood Research Institute, Jeonbuk 585-943, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye Ran","family":"Choi","sequence":"additional","affiliation":[{"name":"Berry &amp; Biofood Research Institute, Jeonbuk 585-943, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Wung","family":"Kwon","sequence":"additional","affiliation":[{"name":"Berry &amp; Biofood Research Institute, Jeonbuk 585-943, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2147-0170","authenticated-orcid":false,"given":"Tae-Bum","family":"Lee","sequence":"additional","affiliation":[{"name":"Institute of natural cosmetic industry for namwon, Jeollabuk-do 55801, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youngcheon","family":"Song","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Sahmyook University, Seoul 01795, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyunseok","family":"Kong","sequence":"additional","affiliation":[{"name":"College of Animal Biotechnology &amp; Resource, Sahmyook University, Seoul 01795, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,12,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3389\/fendo.2013.00052","article-title":"Mechanisms of obesity-induced inflammation and insulin resistance: Insights into the emerging role of nutritional strategies","volume":"4","author":"McArdle","year":"2013","journal-title":"Front. 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