{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T11:35:41Z","timestamp":1779363341797,"version":"3.51.4"},"reference-count":24,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T00:00:00Z","timestamp":1543968000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["SIR2014"],"award-info":[{"award-number":["SIR2014"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Resveratrol, because of its low solubility in water and its high membrane permeability, is collocated in the second class of the biopharmaceutical classification system, with limited bioavailability due to its dissolution rate. Solid dispersion of resveratrol supported on Magnesium DiHydroxide (Resv@MDH) was evaluated to improve solubility and increase bioavailability of resveratrol. Fluorimetric microscopy analysis displays three types of microparticles with similar size: Type 1 that emitted preferably fluorescence at 445 nm with bandwidth of 50 nm, type 2 that emitted preferably fluorescence at 605 nm with bandwidth of 70 nm and type 3 that is non-fluorescent. Micronized pure resveratrol displays only microparticles type 1 whereas type 3 are associated to pure magnesium dihydroxide. Dissolution test in simulated gastric environment resveratrol derived from Resv@MDH in comparison to resveratrol alone displayed better solubility. A 3-fold increase of resveratrol bioavailability was observed after oral administration of 50 mg\/kg of resveratrol from Resv@MDH in rabbits. We hypothesize that type 2 microparticles represent magnesium dihydroxide microparticles with a resveratrol shell and that they are responsible for the improved resveratrol solubility and bioavailability of Resv@MDH.<\/jats:p>","DOI":"10.3390\/nu10121925","type":"journal-article","created":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T12:22:00Z","timestamp":1544012520000},"page":"1925","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Solid Dispersion of Resveratrol Supported on Magnesium DiHydroxide (Resv@MDH) Microparticles Improves Oral Bioavailability"],"prefix":"10.3390","volume":"10","author":[{"given":"Roberto","family":"Spogli","sequence":"first","affiliation":[{"name":"Prolabin &amp; Tefarm, Spin-Off Un. of University of Perugia, Via Dell\u2019Acciaio 9, Ponte Felcino, 06134 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4065-8734","authenticated-orcid":false,"given":"Maria","family":"Bastianini","sequence":"additional","affiliation":[{"name":"Prolabin &amp; Tefarm, Spin-Off Un. of University of Perugia, Via Dell\u2019Acciaio 9, Ponte Felcino, 06134 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Ragonese","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Biology and Biotechnologies, University of Perugia, Via Elce di Sotto 8, 06123 Perugia, Italy"},{"name":"Department of Experimental Medicine, Perugia Medical School, University of Perugia, Piazza Lucio Severi 1, 06132 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rossana Giulietta","family":"Iannitti","sequence":"additional","affiliation":[{"name":"S&amp;R Farmaceutici S.p.A Bastia Umbra, 08063 Perugia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Monarca","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Biology and Biotechnologies, University of Perugia, Via Elce di Sotto 8, 06123 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Bastioli","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Biology and Biotechnologies, University of Perugia, Via Elce di Sotto 8, 06123 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina","family":"Nakashidze","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Natural Science and Health Care, Batumi Shota Rustaveli State University, 6010 Batumi, Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"Brecchia","sequence":"additional","affiliation":[{"name":"Department of Veterinary Science, University of Perugia, Via San Costanzo 4, 06126 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8500-7970","authenticated-orcid":false,"given":"Laura","family":"Menchetti","sequence":"additional","affiliation":[{"name":"Department of Veterinary Science, University of Perugia, Via San Costanzo 4, 06126 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1562-4495","authenticated-orcid":false,"given":"Michela","family":"Codini","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, University of Perugia, Via A. Fabretti 48, 06123 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3114-8812","authenticated-orcid":false,"given":"Cataldo","family":"Arcuri","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, Perugia Medical School, University of Perugia, Piazza Lucio Severi 1, 06132 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loretta","family":"Mancinelli","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Biology and Biotechnologies, University of Perugia, Via Elce di Sotto 8, 06123 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Fioretti","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Biology and Biotechnologies, University of Perugia, Via Elce di Sotto 8, 06123 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,12,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/nrd2060","article-title":"Therapeutic potential of resveratrol: The in vivo evidence","volume":"5","author":"Baur","year":"2006","journal-title":"Nat. Rev. Drug. Discov."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1002\/mnfr.201100143","article-title":"Resveratrol and healt\u2014A comprehensive review of human clinical trials","volume":"55","author":"Smoliga","year":"2011","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_3","first-page":"1403","article-title":"In Vitro Safety\/Protection Assessment of Resveratrol and Pterostilbene in a Human Hepatoma Cell Line (HepG2)","volume":"10","author":"Lombardi","year":"2015","journal-title":"Nat. Prod. Commun."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.cmet.2011.10.002","article-title":"Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans","volume":"14","author":"Timmers","year":"2011","journal-title":"Cell Metab."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"5942","DOI":"10.1158\/1078-0432.CCR-10-1486","article-title":"Resveratrol: Challenges in translation to the clinic\u2014A critical discussion","volume":"16","author":"Subramanian","year":"2010","journal-title":"Clin. Cancer Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1158\/1055-9965.EPI-07-0022","article-title":"Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent","volume":"16","author":"Boocock","year":"2007","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1002\/mnfr.200800177","article-title":"Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers","volume":"53","author":"Almeida","year":"2009","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1023\/A:1016212804288","article-title":"A theoretical basis for a biopharmaceutic drug classification: The correlation of in vitro drug product dissolution and in vivo bioavailability","volume":"12","author":"Amidon","year":"1995","journal-title":"Pharm. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0939-6411(00)00091-6","article-title":"Modern bioavailability, bioequivalence and biopharmaceutics classification system. New scientific approaches to international regulatory standards","volume":"50","author":"Amidon","year":"2000","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jconrel.2011.09.083","article-title":"Administration of resveratrol: What formulation solutions to bioavailability limitations?","volume":"158","author":"Amri","year":"2012","journal-title":"J. Control Release"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/j.biochi.2013.01.008","article-title":"Optimization of trans-Resveratrol bioavailability for human therapy","volume":"95","author":"Amiot","year":"2013","journal-title":"Biochimie"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1007\/s11095-008-9677-1","article-title":"The impact of aqueous solubility and dose on the pharmacokinetic profiles of resveratrol","volume":"25","author":"Das","year":"2008","journal-title":"Pharm. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1007\/s11095-006-9060-z","article-title":"Increased transport of resveratrol across monolayers of the human intestinal Caco-2 cells is mediated by inhibition and saturation of metabolites","volume":"23","author":"Hagenauer","year":"2006","journal-title":"Pharm. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1517\/17425255.3.4.469","article-title":"Impact of physiological, physicochemical and biopharmaceutical factors in absorption and metabolism mechanisms on the drug oral bioavailability of rats and humans","volume":"3","author":"Hurst","year":"2007","journal-title":"Expert. Opin. Drug. Metab. Toxicol."},{"key":"ref_15","first-page":"1673","article-title":"Does the combination of resveratrol with Al (III) and Zn (II) improve its antioxidant activity?","volume":"6","author":"Dias","year":"2011","journal-title":"Nat. Prod. Commun."},{"key":"ref_16","first-page":"445","article-title":"HPLCIdentification of Copper (II)-Trans-ResveratrolComplexes in ethanolicAqueousSolution","volume":"55","author":"Flieger","year":"2017","journal-title":"J. Chromatogr. Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jssc.2005.09.040","article-title":"Synthesis, characterisation and anion exchange properties of copper, magnesium, zinc and nickel hydroxy nitrate","volume":"179","author":"Biswicka","year":"2006","journal-title":"J. Solid State Chem."},{"key":"ref_18","first-page":"461","article-title":"A Novel Self-Microemulsifying System for the Simultaneous Delivery and Enhanced Oral Absorption of Curcumin and Resveratrol","volume":"83","author":"Jaisamut","year":"2017","journal-title":"Planta Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"6570","DOI":"10.3390\/molecules15096570","article-title":"Determination of quercitin and resveratrol in whole blood-implication for bioavalaibility studies","volume":"15","author":"Biasutto","year":"2010","journal-title":"Molecules"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.theriogenology.2017.10.046","article-title":"Effects of local lipopolysaccharide administration on the expression of Toll-like receptor 4 and pro-inflammatory cytokines in uterus and oviduct of rabbit does","volume":"107","author":"Menchetti","year":"2018","journal-title":"Theriogenology"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijpharm.2006.07.011","article-title":"A century of dissolution research: From Noyes and Whitney to the Biopharmaceutics Classification System","volume":"321","author":"Dokoumetzidis","year":"2006","journal-title":"Int. J. Pharm."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1002\/jps.21650","article-title":"Supersaturating drug delivery systems: The answer to solubility-limited oral bioavailability?","volume":"98","author":"Brouwers","year":"2009","journal-title":"J. Pharm. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/bs.acr.2017.11.006","article-title":"Evaluation of Resveratrol in Cancer Patients and Experimental Models","volume":"137","author":"Valentovic","year":"2018","journal-title":"Adv Cancer Res."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Yang, H.C., Wang, J.Y., Bu, X.Y., Yang, B., Wang, B.Q., Hu, S., Yan, Z.Y., Gao, Y.S., Han, S.Y., and Qu, M.Q. (2018). Resveratrol restores sensitivity of glioma cells to temozolamide through inhibiting the activation of Wnt signaling pathway. J. Cell Physiol.","DOI":"10.1002\/jcp.27409"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/10\/12\/1925\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T15:31:20Z","timestamp":1760196680000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/10\/12\/1925"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,5]]},"references-count":24,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2018,12]]}},"alternative-id":["nu10121925"],"URL":"https:\/\/doi.org\/10.3390\/nu10121925","relation":{"has-preprint":[{"id-type":"doi","id":"10.20944\/preprints201810.0584.v1","asserted-by":"object"}]},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,5]]}}}