{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:49:28Z","timestamp":1772758168727,"version":"3.50.1"},"reference-count":33,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T00:00:00Z","timestamp":1545091200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HD 034568 and UG3OD023286"],"award-info":[{"award-number":["R01 HD 034568 and UG3OD023286"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Screening for gestational diabetes mellitus (GDM) during pregnancy is cumbersome. Measurement of plasma fructosamine may help simplify the first step of detecting GDM. We aimed to assess the predictive value of mid-pregnancy fructosamine for GDM, and its association with postpartum glycemic indices. Among 1488 women from Project Viva (mean \u00b1 SD: 32.1 \u00b1 5.0 years old; pre-pregnancy body mass index 24.7 \u00b1 5.3 kg\/m2), we measured second trimester fructosamine and assessed gestational glucose tolerance with a 50 g glucose challenge test (GCT) followed, if abnormal, by a 100 g oral glucose tolerance test (OGTT). Approximately 3 years postpartum (median 3.2 years; SD 0.4 years), we measured maternal glycated hemoglobin (n = 450) and estimated insulin resistance (HOMA-IR; n = 132) from fasting blood samples. Higher glucose levels 1 h post 50 g GCT were associated with higher fructosamine levels (Pearson\u2019s r = 0.06; p = 0.02). However, fructosamine \u2265222 \u00b5mol\/L (median) had a sensitivity of 54.8% and specificity of 48.6% to detect GDM (area under the receiver operating characteristic curve = 0.52); other fructosamine thresholds did not show better predictive characteristics. Fructosamine was also weakly associated with 3-year postpartum glycated hemoglobin (per 1 SD increment: adjusted \u03b2 = 0.03 95% CI [0.00, 0.05] %) and HOMA-IR (per 1 SD increment: adjusted % difference 15.7, 95% CI [3.7, 29.0] %). Second trimester fructosamine is a poor predictor of gestational glucose tolerance and postpartum glycemic indices.<\/jats:p>","DOI":"10.3390\/nu10122003","type":"journal-article","created":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T03:12:30Z","timestamp":1545102750000},"page":"2003","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Mid-Pregnancy Fructosamine Measurement\u2014Predictive Value for Gestational Diabetes and Association with Postpartum Glycemic Indices"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4918-7534","authenticated-orcid":false,"given":"V\u00e9ronique","family":"Gingras","sequence":"first","affiliation":[{"name":"Division of Chronic Disease Research across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheryl L.","family":"Rifas-Shiman","sequence":"additional","affiliation":[{"name":"Division of Chronic Disease Research across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8212-4354","authenticated-orcid":false,"given":"Karen M.","family":"Switkowski","sequence":"additional","affiliation":[{"name":"Division of Chronic Disease Research across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2513-3339","authenticated-orcid":false,"given":"Emily","family":"Oken","sequence":"additional","affiliation":[{"name":"Division of Chronic Disease Research across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA"},{"name":"Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-France","family":"Hivert","sequence":"additional","affiliation":[{"name":"Division of Chronic Disease Research across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA"},{"name":"Diabetes Unit, Massachusetts General Hospital, Boston, MA 02214, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,12,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"American Diabetes Association (2018). 13. Management of diabetes in pregnancy: Standards of medical care in diabetes-2018. Diabetes Care, 41, S137\u2013S143.","DOI":"10.2337\/dc18-S013"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"HAPO Study Cooperative Research Group (2008). Hyperglycemia and adverse pregnancy outcomes. N. Engl. J. Med., 358, 1991\u20132002.","DOI":"10.1056\/NEJMoa0707943"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"International Association of Diabetes and Pregnancy Study Groups Consensus Panel (2010). International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy. Diabetes Care, 33, 676\u2013682.","DOI":"10.2337\/dc09-1848"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"American Diabetes Association (2018). 2. Classification and diagnosis of diabetes: Standards of medical care in diabetes-2018. Diabetes Care, 41, S13\u2013S27.","DOI":"10.2337\/dc18-S002"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Committee on Practice Bulletins\u2014Obstetrics (2018). Acog practice bulletin no. 190: Gestational diabetes mellitus. Obstet. Gynecol., 131, e49\u2013e64.","DOI":"10.1097\/AOG.0000000000002501"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e111","DOI":"10.2337\/dc18-0556","article-title":"The sensitivity and specificity of the glucose challenge test in a universal two-step screening strategy for gestational diabetes mellitus using the 2013 world health organization criteria","volume":"41","author":"Benhalima","year":"2018","journal-title":"Diabetes Care"},{"key":"ref_7","first-page":"515","article-title":"The reproducibility of the 50-g, 1-hour glucose screen for diabetes in pregnancy","volume":"82","author":"Parra","year":"1993","journal-title":"Obstet. Gynecol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/j.1471-0528.2012.03423.x","article-title":"Glucose challenge test for detecting gestational diabetes mellitus: A systematic review","volume":"119","author":"Ardilouze","year":"2012","journal-title":"BJOG"},{"key":"ref_9","unstructured":"World health organization (2018, August 07). Use of glycated haemoglobin (hba1c) in the diagnosis of diabetes mellitus. Available online: http:\/\/www.Who.Int\/diabetes\/publications\/diagnosis_diabetes2011\/en\/."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.2337\/diacare.27.5.1200","article-title":"Hba1c levels are significantly lower in early and late pregnancy","volume":"27","author":"Nielsen","year":"2004","journal-title":"Diabetes Care"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1093\/clinchem\/33.12.2153","article-title":"Fructosamine: Structure, analysis, and clinical usefulness","volume":"33","author":"Armbruster","year":"1987","journal-title":"Clin. Chem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1159\/000318705","article-title":"Gestational diabetes: An evaluation of serum fructosamine as a screening test in a high-risk population","volume":"71","author":"Agarwal","year":"2011","journal-title":"Gynecol. Obstet. Invest."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0020-7292(91)90534-C","article-title":"Fructosamine as a screening-test for gestational diabetes mellitus: A reappraisal","volume":"34","author":"Nasrat","year":"1991","journal-title":"Int. J. Gynaecol. Obstet."},{"key":"ref_14","first-page":"151","article-title":"Markers of glycemic control and neonatal morbidity in high-risk insulin-resistant pregnancies","volume":"33","author":"Cahill","year":"2016","journal-title":"Am. J. Perinatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1111\/dme.12482","article-title":"Prediction of gestational diabetes in obese pregnant women from the UK pregnancies better eating and activity (upbeat) pilot trial","volume":"31","author":"Maitland","year":"2014","journal-title":"Diabet. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/ije\/dyu008","article-title":"Cohort profile: Project viva","volume":"44","author":"Oken","year":"2015","journal-title":"Int. J. Epidemiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1093\/clinchem\/34.12.2545","article-title":"Stability of serum fructosamine during storage","volume":"34","author":"Koskinen","year":"1988","journal-title":"Clin. Chem."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1373\/clinchem.2012.188367","article-title":"Associations of alternative markers of glycemia with hemoglobin a(1c) and fasting glucose","volume":"58","author":"Juraschek","year":"2012","journal-title":"Clin. Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.2337\/dc12-1896","article-title":"Serum fructosamine and glycated albumin and risk of mortality and clinical outcomes in hemodialysis patients","volume":"36","author":"Shafi","year":"2013","journal-title":"Diabetes Care"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/ajh.2008.326","article-title":"Intrauterine exposure to gestational diabetes, child adiposity, and blood pressure","volume":"22","author":"Wright","year":"2009","journal-title":"Am. J. Hypertens."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Oken, E., Kleinman, K.P., Rich-Edwards, J., and Gillman, M.W. (2003). A nearly continuous measure of birth weight for gestational age using a United States national reference. BMC Pediatr., 3.","DOI":"10.1186\/1471-2431-3-6"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/S0140-6736(83)90982-0","article-title":"Fructosamine in diabetic pregnancy","volume":"2","author":"Roberts","year":"1983","journal-title":"Lancet"},{"key":"ref_24","first-page":"242","article-title":"Relationship between fetal growth and maternal fructosamine in diabetic pregnancy","volume":"70","author":"Roberts","year":"1987","journal-title":"Obstet. Gynecol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1055\/s-2007-1009154","article-title":"The role of serum fructosamine as a screening test for gestational diabetes mellitus","volume":"21","author":"Vermes","year":"1989","journal-title":"Horm. Metab. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1097\/00006250-199011000-00009","article-title":"Fructosamine compared with a glucose load as a screening test for gestational diabetes","volume":"76","author":"Roberts","year":"1990","journal-title":"Obstet. Gynecol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s004040050237","article-title":"Serum fructosamine and fructosamine-albumin ratio as screening tests for gestational diabetes mellitus","volume":"262","author":"Bor","year":"1999","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ejogrb.2017.12.036","article-title":"Efficacy of maternal and biological parameters at the time of diagnosis of gestational diabetes mellitus in predicting neonatal morbidity","volume":"221","author":"Ducarme","year":"2018","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1007\/s00125-017-4380-6","article-title":"Metabolic profiling of gestational diabetes in obese women during pregnancy","volume":"60","author":"White","year":"2017","journal-title":"Diabetologia"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1007\/s11892-014-0548-3","article-title":"Beyond hba1c and glucose: The role of nontraditional glycemic markers in diabetes diagnosis, prognosis, and management","volume":"14","author":"Parrinello","year":"2014","journal-title":"Curr. Diab. Rep."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S2213-8587(13)70199-2","article-title":"Fructosamine and glycated albumin for risk stratification and prediction of incident diabetes and microvascular complications: A prospective cohort analysis of the atherosclerosis risk in communities (aric) study","volume":"2","author":"Selvin","year":"2014","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Malmstr\u00f6m, H., Walldius, G., Grill, V., Jungner, I., Gudbj\u00f6rnsdottir, S., and Hammar, N. (2014). Fructosamine is a useful indicator of hyperglycaemia and glucose control in clinical and epidemiological studies--cross-sectional and longitudinal experience from the AMORIS cohort. PLoS ONE, 29.","DOI":"10.1371\/journal.pone.0111463"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1177\/1932296814567227","article-title":"Advantages and pitfalls of fructosamine and glycated albumin in the diagnosis and treatment of diabetes","volume":"9","author":"Danese","year":"2015","journal-title":"J. Diabetes Sci. Technol."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/10\/12\/2003\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T15:34:39Z","timestamp":1760196879000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/10\/12\/2003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,18]]},"references-count":33,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2018,12]]}},"alternative-id":["nu10122003"],"URL":"https:\/\/doi.org\/10.3390\/nu10122003","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,18]]}}}