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Moreover, according to the World Health Organization, moderate-to-profound hearing loss affects about 466 million people worldwide. Its incidence varies in each population segment, affecting approximately 10% of children and increasing to 30% of the population over 65 years. However, hearing loss receives still very limited research funding and public awareness. This sensory impairment is caused by genetic and environmental factors, and among the latter, the nutritional status has acquired relevance due its association to hearing loss detected in recent epidemiological studies. Several experimental models have proved that the onset and progression of hearing loss are closely linked to the availability of nutrients and their metabolism. Here, we have reviewed studies focused on nutrient effects on auditory function. These studies support the potential of nutritional therapy for the protection against hearing loss progression, which is especially relevant to the aging process and related quality of life.<\/jats:p>","DOI":"10.3390\/nu11010035","type":"journal-article","created":{"date-parts":[[2018,12,24]],"date-time":"2018-12-24T10:37:49Z","timestamp":1545647869000},"page":"35","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Interplay between Nutrition and Hearing Loss: State of Art"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2836-4642","authenticated-orcid":false,"given":"Ana M.","family":"Puga","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical and Health Sciences, Faculty of Pharmacy, CEU San Pablo University, 28668 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4714-9051","authenticated-orcid":false,"given":"Mar\u00eda A.","family":"Pajares","sequence":"additional","affiliation":[{"name":"Department of Structural and Chemical Biology, Centro de Investigaciones Biol\u00f3gicas (CSIC), 28040 Madrid, Spain"},{"name":"Molecular Hepatology Group, Hospital La Paz Institute for Health Research (IdiPAZ), 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregorio","family":"Varela-Moreiras","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Health Sciences, Faculty of Pharmacy, CEU San Pablo University, 28668 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4401-1233","authenticated-orcid":false,"given":"Teresa","family":"Partearroyo","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Health Sciences, Faculty of Pharmacy, CEU San Pablo University, 28668 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,12,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1146\/annurev-genet-102108-134135","article-title":"Hearing loss: Mechanisms revealed by genetics and cell biology","volume":"43","author":"Dror","year":"2009","journal-title":"Annu. 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