{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T20:53:16Z","timestamp":1767905596611,"version":"3.49.0"},"reference-count":43,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2019,1,3]],"date-time":"2019-01-03T00:00:00Z","timestamp":1546473600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014566","name":"Fondazione Celiachia","doi-asserted-by":"publisher","award":["008_FC_2015"],"award-info":[{"award-number":["008_FC_2015"]}],"id":[{"id":"10.13039\/501100014566","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Regione Campania Le patologie della nutrizione e del metabolismo dell'adulto","award":["06.06.2012"],"award-info":[{"award-number":["06.06.2012"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Coeliac disease (CeD) is an immune-mediated inflammatory enteropathy triggered by the ingestion of gluten in genetically susceptible individuals. Gastrointestinal (GI) hormone response related to appetite and glucose metabolism is still under-investigated in patients with CeD. This study aimed at shedding light on the appetite sensations, glycaemia and hormone response induced by a complex meal in patients with coeliac disease. Twenty-two women with CeD, nine at the diagnosis (CeDD) and thirteen under a gluten-free diet (CeDGF), and ten healthy subjects (HS) were enrolled in a single day intervention study. All subjects consumed a test meal, recorded their appetite sensations, and blood was collected over three hours after meal consumption. The study found a lower decrease in hunger in CeDD compared to CeDGF and HS after meal intake. Data showed no difference of fullness and satiety between the groups. CeDD had lower insulin and glucose-dependent insulinotropic polypeptide (GIP) than CeDGF and HS. Both CeDD and CeDGF experienced a lower post-prandial response of glucose than HS. Data suggested that patients with CeD have an impaired glucose absorption after more than 12 months of gluten-free diet. Postprandial GIP may play a significant role in appetite cues and insulin response to a complex meal.<\/jats:p>","DOI":"10.3390\/nu11010082","type":"journal-article","created":{"date-parts":[[2019,1,3]],"date-time":"2019-01-03T11:11:56Z","timestamp":1546513916000},"page":"82","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Appetite and Gastrointestinal Hormone Response to a Gluten-Free Meal in Patients with Coeliac Disease"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6608-5209","authenticated-orcid":false,"given":"Paola","family":"Vitaglione","sequence":"first","affiliation":[{"name":"Department of Agricultural Sciences, University of Naples \u201cFederico II\u201d, 80055 Portici, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1133-1502","authenticated-orcid":false,"given":"Fabiana","family":"Zingone","sequence":"additional","affiliation":[{"name":"Department of Surgery, Oncology, and Gastroenterology, University of Padua, 35100 Padua, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolina","family":"Virgilio","sequence":"additional","affiliation":[{"name":"Department of Agricultural Sciences, University of Naples \u201cFederico II\u201d, 80055 Portici, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7426-1145","authenticated-orcid":false,"given":"Carolina","family":"Ciacci","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery, and Dentistry, \u201cScuola Medica Salernitana\u201d University of Salerno, 84084 Fisciano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,1,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1136\/gutjnl-2013-306578","article-title":"Diagnosis and management of adult coeliac disease: Guidelines from the British society of gastroenterology","volume":"63","author":"Ludvigsson","year":"2014","journal-title":"Gut"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1111\/j.1572-0241.1998.00403.x","article-title":"Esophageal impairment in adult celiac disease with steatorrhea","volume":"93","author":"Iovino","year":"1998","journal-title":"Am. 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