{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T04:17:31Z","timestamp":1772425051155,"version":"3.50.1"},"reference-count":54,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2019,1,6]],"date-time":"2019-01-06T00:00:00Z","timestamp":1546732800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007586","name":"Aix-Marseille Universit\u00e9","doi-asserted-by":"publisher","award":["no grant number"],"award-info":[{"award-number":["no grant number"]}],"id":[{"id":"10.13039\/100007586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"publisher","award":["no grant number"],"award-info":[{"award-number":["no grant number"]}],"id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"publisher"}]},{"name":"France Life Imaging","award":["ANR-11-INBS-0006"],"award-info":[{"award-number":["ANR-11-INBS-0006"]}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-14-CE17-0016-COFLORES"],"award-info":[{"award-number":["ANR-14-CE17-0016-COFLORES"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["FRM DBS20140930772"],"award-info":[{"award-number":["FRM DBS20140930772"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Type 2 diabetic women have a high risk of mortality via myocardial infarction even with anti-diabetic treatments. Resveratrol (RSV) is a natural polyphenol, well-known for its antioxidant property, which has also shown interesting positive effects on mitochondrial function. Therefore, we aim to investigate the potential protective effect of 1 mg\/kg\/day of RSV on high energy compounds, during myocardial ischemia-reperfusion in type 2 diabetic female Goto-Kakizaki (GK) rats. For this purpose, we used 31P magnetic resonance spectroscopy in isolated perfused heart experiments, with a simultaneous measurement of myocardial function and coronary flow. RSV enhanced adenosine triphosphate (ATP) and phosphocreatine (PCr) contents in type 2 diabetic hearts during reperfusion, in combination with better functional recovery. Complementary biochemical analyses showed that RSV increased creatine, total adenine nucleotide heart contents and citrate synthase activity, which could be involved in better mitochondrial functioning. Moreover, improved coronary flow during reperfusion by RSV was associated with increased eNOS, SIRT1, and P-Akt protein expression in GK rat hearts. In conclusion, RSV induced cardioprotection against ischemia-reperfusion injury in type 2 diabetic female rats via increased high energy compound contents and expression of protein involved in NO pathway. Thus, RSV presents high potential to protect the heart of type 2 diabetic women from myocardial infarction.<\/jats:p>","DOI":"10.3390\/nu11010105","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T03:06:06Z","timestamp":1547003166000},"page":"105","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Protective Effect of Resveratrol against Ischemia-Reperfusion Injury via Enhanced High Energy Compounds and eNOS-SIRT1 Expression in Type 2 Diabetic Female Rat Heart"],"prefix":"10.3390","volume":"11","author":[{"given":"Natacha","family":"Fourny","sequence":"first","affiliation":[{"name":"Aix-Marseille University, CNRS, Centre de R\u00e9sonance Magn\u00e9tique Biologique et M\u00e9dicale (CRMBM), Facult\u00e9 de M\u00e9decine, 27 Boulevard Jean Moulin, 13385 Marseille, CEDEX 05, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carole","family":"Lan","sequence":"additional","affiliation":[{"name":"Aix-Marseille University, CNRS, Centre de R\u00e9sonance Magn\u00e9tique Biologique et M\u00e9dicale (CRMBM), Facult\u00e9 de M\u00e9decine, 27 Boulevard Jean Moulin, 13385 Marseille, CEDEX 05, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"S\u00e9r\u00e9e","sequence":"additional","affiliation":[{"name":"Aix-Marseille University, INSERM, INRA, Centre de Recherche en Cardiovasculaire et Nutrition (C2VN), Facult\u00e9 de M\u00e9decine, 27 Boulevard Jean Moulin, 13385 Marseille, CEDEX 05, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monique","family":"Bernard","sequence":"additional","affiliation":[{"name":"Aix-Marseille University, CNRS, Centre de R\u00e9sonance Magn\u00e9tique Biologique et M\u00e9dicale (CRMBM), Facult\u00e9 de M\u00e9decine, 27 Boulevard Jean Moulin, 13385 Marseille, CEDEX 05, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martine","family":"Desrois","sequence":"additional","affiliation":[{"name":"Aix-Marseille University, CNRS, Centre de R\u00e9sonance Magn\u00e9tique Biologique et M\u00e9dicale (CRMBM), Facult\u00e9 de M\u00e9decine, 27 Boulevard Jean Moulin, 13385 Marseille, CEDEX 05, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,1,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1007\/s00125-014-3260-6","article-title":"Diabetes as risk factor for incident coronary heart disease in women compared with men: A systematic review and meta-analysis of 64 cohorts including 858,507 individuals and 28,203 coronary events","volume":"57","author":"Peters","year":"2014","journal-title":"Diabetologia"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1161\/CIR.0000000000000343","article-title":"Sex Differences in the Cardiovascular Consequences of Diabetes Mellitus: A Scientific Statement From the American Heart Association","volume":"132","author":"Regensteiner","year":"2015","journal-title":"Circulation"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0002-9149(74)90089-7","article-title":"Role of diabetes in congestive heart failure: The Framingham study","volume":"34","author":"Kannel","year":"1974","journal-title":"Am. 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