{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T19:09:57Z","timestamp":1778094597286,"version":"3.51.4"},"reference-count":40,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T00:00:00Z","timestamp":1546905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Trade, Industry &amp; Energy(MOTIE, Korea)","award":["10080691"],"award-info":[{"award-number":["10080691"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Sensorineural hearing loss (SNHL) is one of the most common causes of disability, affecting over 466 million people worldwide. However, prevention or therapy of SNHL has not been widely studied. Avocado oil has shown many health benefits but it has not yet been studied in regards to SNHL. Therefore, we aimed to investigate the efficacy of avocado oil on SNHL in vitro and in vivo and elucidate its mode of action. For the present study, we used enhanced functional avocado oil extract (DKB122). DKB122 led to recovery of otic hair cells in zebrafish after neomycin-induced otic cell damage. Also, DKB122 improved auditory sensory transmission function in a mouse model of noise induced-hearing loss and protected sensory hair cells in the cochlea. In addition, RNA sequencing was performed to elucidate the mechanism involved. KEGG pathway enrichment analysis of differentially expressed genes showed that DKB122 protected House Ear Institute-Organ of Corti 1 (HEI-OC1) cells against neomycin-related alterations in gene expression due to oxidative stress, cytokine production and protein synthesis.<\/jats:p>","DOI":"10.3390\/nu11010113","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T03:06:06Z","timestamp":1547003166000},"page":"113","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Avocado Oil Extract Modulates Auditory Hair Cell Function through the Regulation of Amino Acid Biosynthesis Genes"],"prefix":"10.3390","volume":"11","author":[{"given":"Youn Hee","family":"Nam","sequence":"first","affiliation":[{"name":"Department of Oriental Medicine Biotechnology, College of Life Sciences and Graduate School of Biotechnology, Kyung Hee University, Global Campus, Gyeonggi 17104, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Oriental Medicine Biotechnology, College of Life Sciences and Graduate School of Biotechnology, Kyung Hee University, Global Campus, Gyeonggi 17104, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seo Yeon","family":"Jeong","sequence":"additional","affiliation":[{"name":"Gachon Institute of Pharmaceutical Sciences, College of Pharmacy, Gachon University, Incheon 21936, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thu Nguyen Minh","family":"Pham","sequence":"additional","affiliation":[{"name":"Gachon Institute of Pharmaceutical Sciences, College of Pharmacy, Gachon University, Incheon 21936, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanlapa","family":"Nuankaew","sequence":"additional","affiliation":[{"name":"Department of Oriental Medicine Biotechnology, College of Life Sciences and Graduate School of Biotechnology, Kyung Hee University, Global Campus, Gyeonggi 17104, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Oriental Medicine Biotechnology, College of Life Sciences and Graduate School of Biotechnology, Kyung Hee University, Global Campus, Gyeonggi 17104, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4938-9179","authenticated-orcid":false,"given":"Rodrigo","family":"Casta\u00f1eda","sequence":"additional","affiliation":[{"name":"Department of Oriental Medicine Biotechnology, College of Life Sciences and Graduate School of Biotechnology, Kyung Hee University, Global Campus, Gyeonggi 17104, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seo Yule","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Oriental Medicine Biotechnology, College of Life Sciences and Graduate School of Biotechnology, Kyung Hee University, Global Campus, Gyeonggi 17104, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Seon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Oriental Medicine Biotechnology, College of Life Sciences and Graduate School of Biotechnology, Kyung Hee University, Global Campus, Gyeonggi 17104, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kye Wan","family":"Lee","sequence":"additional","affiliation":[{"name":"R&amp;D Center, Dongkook Pharm. Co., Ltd., Gyeonggi 16229, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Suk","family":"Lee","sequence":"additional","affiliation":[{"name":"R&amp;D Center, Dongkook Pharm. Co., Ltd., Gyeonggi 16229, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Do Hoon","family":"Kim","sequence":"additional","affiliation":[{"name":"R&amp;D Center, Dongkook Pharm. Co., Ltd., Gyeonggi 16229, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu Hwa","family":"Park","sequence":"additional","affiliation":[{"name":"R&amp;D Center, Dongkook Pharm. Co., Ltd., Gyeonggi 16229, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon 21983, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In Seok","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul 03722, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Se-Young","family":"Choung","sequence":"additional","affiliation":[{"name":"Department of Preventive Pharmacy and Toxicology, College of Pharmacy, Kyung Hee University, Seoul 02453, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin Na","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Oriental Medicine Biotechnology, College of Life Sciences and Graduate School of Biotechnology, Kyung Hee University, Global Campus, Gyeonggi 17104, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2258-8354","authenticated-orcid":false,"given":"Kwang Won","family":"Jeong","sequence":"additional","affiliation":[{"name":"Gachon Institute of Pharmaceutical Sciences, College of Pharmacy, Gachon University, Incheon 21936, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4161-6798","authenticated-orcid":false,"given":"Tong Ho","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Oriental Medicine Biotechnology, College of Life Sciences and Graduate School of Biotechnology, Kyung Hee University, Global Campus, Gyeonggi 17104, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,1,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1016\/S0140-6736(13)61613-X","article-title":"Auditory and non-auditory effects of noise on health","volume":"383","author":"Basner","year":"2014","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1055\/s-0036-1586162","article-title":"Sudden Sensorineural Hearing Loss and Autoimmune Systemic Diseases","volume":"21","author":"Rossini","year":"2017","journal-title":"Int. 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