{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T03:06:15Z","timestamp":1788923175240,"version":"build-2803163510"},"reference-count":46,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2019,1,21]],"date-time":"2019-01-21T00:00:00Z","timestamp":1548028800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The aim of the present investigation was to test the hypothesis that quercetin (Q) may prevent the strength loss and neuromuscular impairment associated with eccentric exercise-induced muscle damage (EEIMD). Twelve young men (26.1 \u00b1 3.1 years) ingested either Q (1000 mg\/day) or placebo (PLA) for 14 days using a randomized, double-blind, crossover study design. Participants completed a comprehensive neuromuscular (NM) evaluation before, during and after an eccentric protocol able to induce a severe muscle damage (10 sets of 10 maximal lengthening contractions). The NM evaluation comprised maximal voluntary isometric contraction (MVIC) and force\u2013velocity relationship assessments with simultaneous recording of electromyographic signals (EMG) from the elbow flexor muscles. Soreness, resting arm angle, arm circumference, plasma creatine kinase (CK) and lactate dehydrogenase (LDH) were also assessed. Q supplementation significantly increased the isometric strength recorded during MVIC compared to baseline (+4.7%, p &lt; 0.05). Moreover, the torque and muscle fiber conduction velocity (MFCV) decay recorded during the eccentric exercise was significant lower in Q compared to PLA. Immediately after the EEIMD, isometric strength, the force\u2013velocity relationship and MFCV were significantly lower when participants were given PLA rather than Q. Fourteen days of Q supplementation seems able to attenuate the severity of muscle weakness caused by eccentric-induced myofibrillar disruption and sarcolemmal action potential propagation impairment.<\/jats:p>","DOI":"10.3390\/nu11010205","type":"journal-article","created":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T03:08:22Z","timestamp":1548126502000},"page":"205","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["The Effects of Quercetin Supplementation on Eccentric Exercise-Induced Muscle Damage"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6017-1683","authenticated-orcid":false,"given":"Ilenia","family":"Bazzucchi","sequence":"first","affiliation":[{"name":"Laboratory of Exercise Physiology\u2014Department of Movement, Human and Health Sciences, Universit\u00e0 degli Studi di Roma \u201cForo Italico\u201d, Piazza Lauro De Bosis 6, 00135 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Patrizio","sequence":"additional","affiliation":[{"name":"Laboratory of Exercise Physiology\u2014Department of Movement, Human and Health Sciences, Universit\u00e0 degli Studi di Roma \u201cForo Italico\u201d, Piazza Lauro De Bosis 6, 00135 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8900-8839","authenticated-orcid":false,"given":"Roberta","family":"Ceci","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry of Movement\u2014Department of Movement, Human and Health Sciences, Universit\u00e0 degli Studi di Roma \u201cForo Italico\u201d, Piazza Lauro De Bosis 6, 00135 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1664-9387","authenticated-orcid":false,"given":"Guglielmo","family":"Duranti","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry of Movement\u2014Department of Movement, Human and Health Sciences, Universit\u00e0 degli Studi di Roma \u201cForo Italico\u201d, Piazza Lauro De Bosis 6, 00135 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Sgr\u00f2","sequence":"additional","affiliation":[{"name":"Endocrinology Unit\u2014Department of Movement, Human and Health Sciences, Universit\u00e0 degli Studi di Roma \u201cForo Italico\u201d, Piazza Lauro De Bosis 6, 00135 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Sabatini","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry of Movement\u2014Department of Movement, Human and Health Sciences, Universit\u00e0 degli Studi di Roma \u201cForo Italico\u201d, Piazza Lauro De Bosis 6, 00135 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Di Luigi","sequence":"additional","affiliation":[{"name":"Endocrinology Unit\u2014Department of Movement, Human and Health Sciences, Universit\u00e0 degli Studi di Roma \u201cForo Italico\u201d, Piazza Lauro De Bosis 6, 00135 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Sacchetti","sequence":"additional","affiliation":[{"name":"Laboratory of Exercise Physiology\u2014Department of Movement, Human and Health Sciences, Universit\u00e0 degli Studi di Roma \u201cForo Italico\u201d, Piazza Lauro De Bosis 6, 00135 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7228-9064","authenticated-orcid":false,"given":"Francesco","family":"Felici","sequence":"additional","affiliation":[{"name":"Laboratory of Exercise Physiology\u2014Department of Movement, Human and Health Sciences, Universit\u00e0 degli Studi di Roma \u201cForo Italico\u201d, Piazza Lauro De Bosis 6, 00135 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,1,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/j.1469-7793.2001.00333.x","article-title":"Muscle damage from eccentric exercise: Mechanism, mechanical signs, adaptations and clinical applications","volume":"537","author":"Proske","year":"2001","journal-title":"J. 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