{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T16:30:20Z","timestamp":1770222620382,"version":"3.49.0"},"reference-count":65,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2019,1,21]],"date-time":"2019-01-21T00:00:00Z","timestamp":1548028800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>This study aimed to evaluate the effect of Lactobacillus reuteri DSM 17938 (DSM) on ethanol-induced gastric injury, and if its possible mechanism of action is related to inhibiting the transient receptor potential vanilloid type 1 (TRPV1). We evaluated the effect of supplementing 108 CFU\u2022g body wt\u22121\u2022day\u22121 of DSM on ethanol-induced gastric injury. DSM significantly reduced the ulcer area (1.940 \u00b1 1.121 mm2) with 3 days of pretreatment. The effects of DSM supplementation were reversed by Resiniferatoxin (RTX), TRPV1 agonist (3 nmol\/kg p.o.). Substance P (SP) (1 \u03bcmol\/L per 20 g) plus 50% ethanol resulted in hemorrhagic lesions, and DSM supplementation did not reverse the lesion area induced by administering SP. TRPV1 staining intensity was lower, SP, malondialdehyde (MDA) and nitrite levels were reduced, and restored normal levels of antioxidant parameters (glutathione and superoxide dismutase) in the gastric mucosa in mice treated with DSM. In conclusion, DSM exhibited gastroprotective activity through decreased expression of TRPV1 receptor and decreasing SP levels, with a consequent reduction of oxidative stress.<\/jats:p>","DOI":"10.3390\/nu11010208","type":"journal-article","created":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T03:08:22Z","timestamp":1548126502000},"page":"208","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Lactobacillus reuteri DSM 17938 Protects against Gastric Damage Induced by Ethanol Administration in Mice: Role of TRPV1\/Substance P Axis"],"prefix":"10.3390","volume":"11","author":[{"given":"Ana P.","family":"Oliveira","sequence":"first","affiliation":[{"name":"Laboratory of Pharmacology of Inflammation and Gastrointestinal Disorders (Lafidg), Federal University of Piau\u00ed, Av. S\u00e3o Sebasti\u00e3o, n\u00ba 2819, CEP 64202-02, Parna\u00edba, PI, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luan K. M.","family":"Souza","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology of Inflammation and Gastrointestinal Disorders (Lafidg), Federal University of Piau\u00ed, Av. S\u00e3o Sebasti\u00e3o, n\u00ba 2819, CEP 64202-02, Parna\u00edba, PI, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thiago S. L.","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology of Inflammation and Gastrointestinal Disorders (Lafidg), Federal University of Piau\u00ed, Av. S\u00e3o Sebasti\u00e3o, n\u00ba 2819, CEP 64202-02, Parna\u00edba, PI, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone de","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology of Inflammation and Gastrointestinal Disorders (Lafidg), Federal University of Piau\u00ed, Av. S\u00e3o Sebasti\u00e3o, n\u00ba 2819, CEP 64202-02, Parna\u00edba, PI, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerolayne M.","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology of Inflammation and Gastrointestinal Disorders (Lafidg), Federal University of Piau\u00ed, Av. S\u00e3o Sebasti\u00e3o, n\u00ba 2819, CEP 64202-02, Parna\u00edba, PI, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisca Beatriz M.","family":"Sousa","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology of Inflammation and Gastrointestinal Disorders (Lafidg), Federal University of Piau\u00ed, Av. S\u00e3o Sebasti\u00e3o, n\u00ba 2819, CEP 64202-02, Parna\u00edba, PI, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renan O.","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Federal University of Cear\u00e1, CEP 60430-270, Fortaleza, Cear\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dvison M.","family":"Pac\u00edfico","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Morphofunctional Sciences, Department of Morphology, Faculty of Medicine, Federal University Cear\u00e1, CEP 60430-170, Fortaleza-CE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Concei\u00e7\u00e3o S.","family":"Martins","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Morphofunctional Sciences, Department of Morphology, Faculty of Medicine, Federal University Cear\u00e1, CEP 60430-170, Fortaleza-CE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerly Anne de C.","family":"Brito","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Morphofunctional Sciences, Department of Morphology, Faculty of Medicine, Federal University Cear\u00e1, CEP 60430-170, Fortaleza-CE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcellus H.L.P.","family":"Souza","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Federal University of Cear\u00e1, CEP 60430-270, Fortaleza, Cear\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7234-3382","authenticated-orcid":false,"given":"Jand Venes R.","family":"Medeiros","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology of Inflammation and Gastrointestinal Disorders (Lafidg), Federal University of Piau\u00ed, Av. 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