{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T23:20:25Z","timestamp":1778109625721,"version":"3.51.4"},"reference-count":77,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T00:00:00Z","timestamp":1549929600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Casen Recordati SL","award":["Contract 01\/2015"],"award-info":[{"award-number":["Contract 01\/2015"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Acute otitis media (AOM) is one of the most common bacterial infections in children. Empiric antibiotherapy leads to increasing antimicrobial resistance rates among otopathogens and may impair the correct development of the microbiota in early life. In this context, probiotics seem to be an attractive approach for preventing recurrent AOM (rAOM) through the restoration of the middle ear and nasopharyngeal microbiota. The aim of this study was the selection of a probiotic strain (Lactobacillus salivarius PS7), specifically tailored for its antagonism against otopathogens. Since L. salivarius PS7 was safe and displayed a strong antimicrobial activity against otopathogens, its efficacy in preventing rAOM was assessed in a trial involving 61 children suffering from rAOM. Children consumed daily ~1 \u00d7 109 CFU of L. salivarius PS7, and the number of AOM episodes were registered and compared with that observed in the previous 6 and 12 months. The microbiota of samples collected from the external auditory canal samples was quantitatively and qualitatively assessed. The number of AOM episodes during the intervention period decreased significantly (84%) when compared to that reported during the 6 months period before the probiotic intervention. In conclusion, L. salivarius PS7 is a promising strain for the prevention of rAOM in infants and children.<\/jats:p>","DOI":"10.3390\/nu11020376","type":"journal-article","created":{"date-parts":[[2019,2,13]],"date-time":"2019-02-13T02:49:44Z","timestamp":1550026184000},"page":"376","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Prevention of Recurrent Acute Otitis Media in Children Through the Use of Lactobacillus salivarius PS7, a Target-Specific Probiotic Strain"],"prefix":"10.3390","volume":"11","author":[{"given":"Nivia","family":"C\u00e1rdenas","sequence":"first","affiliation":[{"name":"Department of Nutrition and Food Science, Complutense University of Madrid, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia","family":"Mart\u00edn","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Science, Complutense University of Madrid, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebeca","family":"Arroyo","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Science, Complutense University of Madrid, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Centro de Salud Bermeo, Tonpoi Kalea, s\/n, 48370 Bermeo, Bizkaia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Carrera","sequence":"additional","affiliation":[{"name":"Centro de Salud Silvano, Av. de Machupichu, 58, 28043 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Badiola","sequence":"additional","affiliation":[{"name":"Laboratorios Casen Recordati S.L., V\u00eda de las Dos Castillas, 33, 28224 Pozuelo de Alarc\u00f3n, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Science, Complutense University of Madrid, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1285-9686","authenticated-orcid":false,"given":"Juan M.","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Science, Complutense University of Madrid, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,2,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"G2","DOI":"10.1016\/j.vaccine.2008.11.005","article-title":"The burden of otitis media","volume":"26","author":"Rovers","year":"2008","journal-title":"Vaccine"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Venekamp, R.P., Sanders, S.L., Glasziou, P.P., Del Mar, C.B., and Rovers, M.M. 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