{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T20:24:49Z","timestamp":1790367889551,"version":"4.1.0"},"reference-count":26,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2019,3,6]],"date-time":"2019-03-06T00:00:00Z","timestamp":1551830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004442","name":"Narodowym Centrum Nauki","doi-asserted-by":"publisher","award":["2015\/17\/D\/NZ7\/00792"],"award-info":[{"award-number":["2015\/17\/D\/NZ7\/00792"]}],"id":[{"id":"10.13039\/501100004442","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Ampicillin (AMP) is frequently administered parenterally in critically ill patients with meningitis or endocarditis. Many of them require parallel infusion of total parenteral nutrition (TPN) admixtures. The aim of the study was to determine the physicochemical stability of AMP in TPN admixtures. Methods: AMP was added to two formulations of TPN admixtures differing in the lipid emulsion (Lipofundin\u00ae MCT\/LCT 20% or LIPIDem\u00ae). Samples were stored at 4 \u00b1 1 \u00b0C with light protection, and at 25 \u00b1 1 \u00b0C with and without light protection to assess the impact of temperature and light on formulation stability. Every 24 h the pH, zeta potential, mean droplet diameter (MDD) of a lipid emulsion, and AMP concentration using HPLC method were determined. The assessment of stability and compatibility of TPN admixtures with vitamins and trace elements was carried out immediately after preparation and after 24 h of storage. Results: The addition of AMP as well as vitamins and trace elements to the TPN admixtures did not affect their physical stability. An increase in the pH value of approx. 0.6 and reduction of zeta potential were observed. The MDD of the lipid emulsions was below the limit of 500 nm (dynamic light scattering (DLS) method) and no fat droplets greater than 525 nm were observed (light diffraction (LD) method). The content of AMP after the first 24 h was within the acceptable limit of 90% for TPN admixtures stored at 4 \u00b1 1 \u00b0C and 25 \u00b1 1 \u00b0C with light protection. Conclusions: The results showed that co-administration of AMP in the same bag with TPN admixture at the tested dose is possible when used ex tempore and with light protection.<\/jats:p>","DOI":"10.3390\/nu11030559","type":"journal-article","created":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T10:52:22Z","timestamp":1551955942000},"page":"559","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Effect of Lipid Emulsion on Stability of Ampicillin in Total Parenteral Nutrition"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5106-5937","authenticated-orcid":false,"given":"Maciej","family":"Stawny","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Poznan University of Medical Sciences, 6 Grunwaldzka, 60-780 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Gosty\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Poznan University of Medical Sciences, 6 Grunwaldzka, 60-780 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5986-7544","authenticated-orcid":false,"given":"Katarzyna","family":"Dettlaff","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Poznan University of Medical Sciences, 6 Grunwaldzka, 60-780 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Jeli\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Poznan University of Medical Sciences, 6 Grunwaldzka, 60-780 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8646-4636","authenticated-orcid":false,"given":"Eliza","family":"G\u0142\u00f3wka","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Poznan University of Medical Sciences, 6 Grunwaldzka, 60-780 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Ogrodowczyk","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Poznan University of Medical Sciences, 6 Grunwaldzka, 60-780 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,3,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1111\/jphp.12647","article-title":"Physical compatibility of total parenteral nutrition and drugs in Y-site administration to children from neonates to adolescents","volume":"69","author":"Staven","year":"2016","journal-title":"J. Pharm. Pharm."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s12937-016-0149-x","article-title":"Development and evaluation of a test program for Y-site compatibility testing of total parenteral nutrition and intravenous drugs","volume":"15","author":"Staven","year":"2015","journal-title":"Nutr. J."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Garcia, J., Garg, A., Song, Y., Fotios, A., Andersen, C., and Garg, S. (2018). Compatibility of intravenous ibuprofen with lipids and parenteral nutrition, for use as a continuous infusion. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0190577"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Mediavilla, M.M., Molina, A., Navarro, L., Grau, L., Pujol, M.D., Cardenete, J., Cardona, D., and Riera, P. (2018). Physicochemical Compatibility of Amiodarone with Parenteral Nutrition. JPEN J. Parenter. Enter. Nutr.","DOI":"10.1002\/jpen.1419"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1002\/ncp.10013","article-title":"Physicochemical Stability and Sterility of Standard Parenteral Nutrition Solutions and Simulated Y-Site Admixtures for Neonates","volume":"33","author":"Riera","year":"2018","journal-title":"Nutr. Clin. Pract."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1097\/CCM.0b013e3181e8adcc","article-title":"Systematic review of physical and chemical compatibility of commonly used medications administered by continuous infusion in intensive care units","volume":"38","author":"Kanji","year":"2010","journal-title":"Crit. Care Med."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Cardona, D., Nadal, M., Estelrich, J., and Mangues, M.A. (2013). Review of drug stability in parenteral nutrition admixtures. e-SPEN J., 8.","DOI":"10.1016\/j.clnme.2013.06.001"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Stawny, M., Olijarczyk, R., Jaroszkiewicz, E., and Jeli\u0144ska, A. (2013). Pharmaceutical point of view on parenteral nutrition. Sci. World J., 2013.","DOI":"10.1155\/2013\/415310"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"M\u00fchlebach, S. (2009). Basics in clinical nutrition: Drugs and nutritional admixtures. e-SPEN, 4.","DOI":"10.1016\/j.eclnm.2009.01.008"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1177\/0148607116667060","article-title":"Management of Parenteral Nutrition in Hospitalized Adult Patients","volume":"41","author":"Mundi","year":"2017","journal-title":"J. Parenter. Enter. Nutr."},{"key":"ref_11","unstructured":"(2009). USP <729> Globule Size Distribution in Lipid Injectable Emulsions, United States Pharmacopeial Convention. The United States Pharmacopeia 33\/National Formulary 28."},{"key":"ref_12","unstructured":"Council of Europe (2017). European Pharmacopoeia, Council of Europe. [9th ed.]."},{"key":"ref_13","unstructured":"ISO 13099-1 (2012). Colloidal Systems Methods for Zeta Potential Determination Part 1: Electroacoustic and Electrokinetic Phenomena, ISO. International Organization of Standards."},{"key":"ref_14","unstructured":"ISO 13099-2, I. (2012). Colloidal Systems Methods for Zeta Potential Determination Part 2: Optical Methods, ISO. International Organization of Standards."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1093\/ajhp\/52.6.623","article-title":"Physicochemical stability of total nutrient admixtures","volume":"52","author":"Driscoll","year":"1995","journal-title":"Am. J. Heal. Pharm."},{"key":"ref_16","first-page":"309","article-title":"Physical Assessments of Lipid Injectable Emulsions Via Microscopy: A Comparison to Methods Proposed in United States Pharmacopeia Chapter 729","volume":"10","author":"Driscoll","year":"2006","journal-title":"Int. J. Pharm. Compd."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1007\/s11095-006-9092-4","article-title":"Lipid injectable emulsions: Pharmacopeial and safety issues","volume":"23","author":"Driscoll","year":"2006","journal-title":"Pharm. Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"67S","DOI":"10.1177\/0148607115595976","article-title":"PFAT5 and the Evolution of Lipid Admixture Stability","volume":"39","author":"Klang","year":"2015","journal-title":"J. Parenter. Enter. Nutr. JPEN"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1016\/j.nut.2008.06.003","article-title":"Container effects on the physicochemical properties of parenteral lipid emulsions","volume":"24","author":"Gonyon","year":"2008","journal-title":"Nutrition"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0169-409X(95)00116-O","article-title":"Stability of lipid emulsions for drug delivery","volume":"20","author":"Washington","year":"1996","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0378-5173(90)90271-5","article-title":"The electrokinetic properties of phospholipid stabilized fat emulsions. IV. The effect of glucose and of pH","volume":"64","author":"Washington","year":"1990","journal-title":"Int. J. Pharm."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0378-5173(90)90281-8","article-title":"The electrokinetic properties of phospholipid-stabilized fat emulsions. II. Droplet mobility in mixed electrolytes","volume":"58","author":"Washington","year":"1990","journal-title":"Int. J. Pharm."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.colsurfb.2009.03.016","article-title":"Comparison of the physicochemical properties of MCT-containing fat emulsions in total nutrient admixtures","volume":"72","author":"Balogh","year":"2009","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_24","first-page":"53","article-title":"Y-Site Compatibility of Medications with Parenteral Nutrition","volume":"12","author":"Robinson","year":"2007","journal-title":"J. Pediatr. Pharm."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1177\/0148607185009002220","article-title":"Piggyback Compatibility of Antibiotics with Pediatric Parenteral Nutrition Solutions","volume":"9","author":"Watson","year":"1985","journal-title":"J. Parenter. Enter. Nutr."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1177\/014860719902300267","article-title":"Compatibility of medications with 3-in-1 parenteral nutrition admixtures","volume":"23","author":"Trissel","year":"1999","journal-title":"J. Parenter. Enter. 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