{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:44:44Z","timestamp":1790181884844,"version":"4.1.0"},"reference-count":83,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2019,3,14]],"date-time":"2019-03-14T00:00:00Z","timestamp":1552521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008340","name":"Elsass Fonden","doi-asserted-by":"publisher","award":["18-2-0638"],"award-info":[{"award-number":["18-2-0638"]}],"id":[{"id":"10.13039\/501100008340","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Brain-derived neurotrophic factor (BDNF) is a mediator of exercise and nutrition-induced neural plasticity. In children with cerebral palsy (CP), neuromuscular deficits and mobility impairment have a negative impact on their physical activity level and nutritional status, but whether these children have reduced BDNF concentrations is unknown. Therefore, the aim of the present study was to investigate the plasma BDNF concentration, nutritional status, and physical activity level in children with mild to severe CP. Blood sampling, dietary registration, and questionnaires were completed for children with mild CP (gross motor function classification system (GMFCS) I\u2013II, n = 31, age 10.6 \u00b1 0.6 years), severe CP (GMFCS IV\u2013V, n = 14, age 10.9 \u00b1 1.1 years) and typically developed (TD) children (n = 22, age 10.9 \u00b1 0.6 years). Children with severe CP had ~40% lower plasma BDNF concentration than TD children (p &lt; 0.05). Furthermore, children with severe CP had lower daily physical activity level than TD children (p &lt; 0.01), and a daily intake of energy, n-3 fatty acids, and dietary fibers that was only ~50% of TD (p &gt; 0.001). Reduced plasma BDNF concentrations were observed in children with severe CP. This may be of significance for optimal neural growth and plasticity. This was observed together with low physical activity levels and a suboptimal intake of energy, n-3 fatty acids, and dietary fibers.<\/jats:p>","DOI":"10.3390\/nu11030620","type":"journal-article","created":{"date-parts":[[2019,3,15]],"date-time":"2019-03-15T04:12:09Z","timestamp":1552623129000},"page":"620","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Suboptimal Nutrition and Low Physical Activity Are Observed Together with Reduced Plasma Brain-Derived Neurotrophic Factor (BDNF) Concentration in Children with Severe Cerebral Palsy (CP)"],"prefix":"10.3390","volume":"11","author":[{"given":"Solvejg L.","family":"Hansen","sequence":"first","affiliation":[{"name":"Molecular Physiology Section, Department of Nutrition, Exercise and Sports, University of Copenhagen, 2100 Copenhagen \u00d8, Denmark"},{"name":"Department of Neuroscience, University of Copenhagen, 2200 Copenhagen N, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Lorentzen","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, University of Copenhagen, 2200 Copenhagen N, Denmark"},{"name":"Elsass Institute, 2920 Charlottenlund, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin T.","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Molecular Physiology Section, Department of Nutrition, Exercise and Sports, University of Copenhagen, 2100 Copenhagen \u00d8, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederikke L.","family":"Hendrich","sequence":"additional","affiliation":[{"name":"Molecular Physiology Section, Department of Nutrition, Exercise and Sports, University of Copenhagen, 2100 Copenhagen \u00d8, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Jorsal","sequence":"additional","affiliation":[{"name":"Geelsg\u00e5rdskolen, Region Hovedstaden, 2830 Virum, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Pingel","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, University of Copenhagen, 2200 Copenhagen N, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens B.","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, University of Copenhagen, 2200 Copenhagen N, Denmark"},{"name":"Elsass Institute, 2920 Charlottenlund, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bente","family":"Kiens","sequence":"additional","affiliation":[{"name":"Molecular Physiology Section, Department of Nutrition, Exercise and Sports, University of Copenhagen, 2100 Copenhagen \u00d8, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,3,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3389\/fpubh.2014.00104","article-title":"Psychosocial perspectives and the issue of prevention in childhood obesity","volume":"2","author":"Stein","year":"2014","journal-title":"Front Public Health"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1080\/02701367.2011.10599785","article-title":"The effects of physical activity and physical fitness on children\u2019s achievement and cognitive outcomes: A meta-analysis","volume":"82","author":"Fedewa","year":"2011","journal-title":"Res. 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