{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T21:32:14Z","timestamp":1770327134952,"version":"3.49.0"},"reference-count":36,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T00:00:00Z","timestamp":1556064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Nestle Foundation","award":["81CR"],"award-info":[{"award-number":["81CR"]}]},{"DOI":"10.13039\/501100001655","name":"DAAD","doi-asserted-by":"publisher","award":["PhD Scholarship"],"award-info":[{"award-number":["PhD Scholarship"]}],"id":[{"id":"10.13039\/501100001655","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Iron absorption was impaired in the presence of sub-clinical inflammation (SCI) and might hamper the effect of iron supplementation. The purpose of the study was to identify the influence of SCI on iron supplementation. A randomized, double-blinded, placebo-controlled experimental study was conducted among anaemic adolescent schoolgirls in Ayeyarwady region, Myanmar. A total of 402 schoolgirls were recruited from six schools screened from 1269 girls who were assigned into one of four groups: Folate group (2.5 mg of folate), Vitamin A group (15,000 IU of vitamin), Iron folate group (60 mg elemental iron and folate) and Iron, and vitamin A and folate group. Supplementation was done once a week for 12 weeks. Iron, vitamin A and inflammation were measured at the baseline, middle and endline. Changes in serum ferritin and body iron were significantly higher in the IFA and IFA + vitA among those without SCI. There was interaction between vitamin A and SCI on Hb changes. Analysis of GLM repeated measure showed interactions between treatment and SCI for hemoglobin and serum transferrin receptor. Those treated with vitamin A had better outcomes when there was SCI. Inflammation accompanied a negative effect on iron supplementation and vitamin A improved efficacy of iron supplementation in the presence of SCI.<\/jats:p>","DOI":"10.3390\/nu11040918","type":"journal-article","created":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T03:02:59Z","timestamp":1556161379000},"page":"918","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Is Iron Supplementation Influenced by Sub-Clinical Inflammation?: A Randomized Controlled Trial Among Adolescent Schoolgirls in Myanmar"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6417-2942","authenticated-orcid":false,"given":"Min","family":"Kyaw Htet","sequence":"first","affiliation":[{"name":"South East Asian Ministers of Education Organization, Regional Center for Food and Nutrition (SEAMEO RECFON) Pusat Kajian Gizi Regional, Universitas Indonesia, Jakarta 10430, Indonesia"},{"name":"Township Health Department, Ministry of Health Myanmar, Hakha 03011, Chin State, Myanmar"},{"name":"Sydney School of Public Health, Sydney Medical School, The University of Sydney, Sydney NSW 2006, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umi","family":"Fahmida","sequence":"additional","affiliation":[{"name":"South East Asian Ministers of Education Organization, Regional Center for Food and Nutrition (SEAMEO RECFON) Pusat Kajian Gizi Regional, Universitas Indonesia, Jakarta 10430, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Drupadi","family":"Dillon","sequence":"additional","affiliation":[{"name":"South East Asian Ministers of Education Organization, Regional Center for Food and Nutrition (SEAMEO RECFON) Pusat Kajian Gizi Regional, Universitas Indonesia, Jakarta 10430, Indonesia"},{"name":"Faculty of Medicine, University of Indonesia, Jakarta 10430, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arwin","family":"Akib","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Indonesia, Jakarta 10430, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Budi","family":"Utomo","sequence":"additional","affiliation":[{"name":"Faculty of Public Health, University of Indonesia, Depok 16424, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Thurnham","sequence":"additional","affiliation":[{"name":"Northern Ireland Centre for Food and Health, School of Biomedical Science, University of Ulster, Coleraine BT52 1SA, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,4,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1017\/S1368980008002401","article-title":"Worldwide prevalence of anaemia, WHO Vitamin and Mineral Nutrition Information System, 1993\u20132005","volume":"12","author":"McLean","year":"2008","journal-title":"Public Health Nutr."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0140-6736(07)61235-5","article-title":"Nutritional iron deficiency","volume":"370","author":"Zimmermann","year":"2007","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1177\/156482651203300302","article-title":"Iron-fortified wheat flour and iron deficiency among women","volume":"33","author":"Grimm","year":"2012","journal-title":"Food Nutr. 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