{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T08:59:43Z","timestamp":1790240383084,"version":"4.1.0"},"reference-count":59,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T00:00:00Z","timestamp":1556755200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Over recent decades, many clinical trials on curcumin supplementation have been conducted on various autoimmune diseases including osteoarthritis, type 2 diabetes, and ulcerative colitis patients. This review attempts to summarize the highlights from these clinical trials. The efficacy of curcumin either alone or in conjunction with existing treatment was evaluated. Sixteen clinical trials have been conducted in osteoarthritis, 14 of which yielded significant improvements in multiple disease parameters. Eight trials have been conducted in type 2 diabetes, all yielding significant improvement in clinical or laboratory outcomes. Three trials were in ulcerative colitis, two of which yielded significant improvement in at least one clinical outcome. Additionally, two clinical trials on rheumatoid arthritis, one clinical trial on lupus nephritis, and two clinical trials on multiple sclerosis resulted in inconclusive results. Longer duration, larger cohort size, and multiple dosage arm trials are warranted to establish the long term benefits of curcumin supplementation. Multiple mechanisms of action of curcumin on these diseases have been researched, including the modulation of the eicosanoid pathway towards a more anti-inflammatory pathway, and the modulation of serum lipid levels towards a favorable profile. Overall, curcumin supplementation emerges as an effective therapeutic agent with minimal-to-no side effects, which can be added in conjunction to current standard of care.<\/jats:p>","DOI":"10.3390\/nu11051004","type":"journal-article","created":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T03:15:22Z","timestamp":1556766922000},"page":"1004","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["Curcumin in Autoimmune and Rheumatic Diseases"],"prefix":"10.3390","volume":"11","author":[{"given":"Melissa","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, University of Houston, 3517 Cullen Blvd, Room 2004, Houston, TX 77204, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5423-0002","authenticated-orcid":false,"given":"Umair","family":"Akbar","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of Houston, 3517 Cullen Blvd, Room 2004, Houston, TX 77204, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandra","family":"Mohan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of Houston, 3517 Cullen Blvd, Room 2004, Houston, TX 77204, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,5,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1016\/j.ejca.2005.05.009","article-title":"Curcumin: The story so far","volume":"41","author":"Sharma","year":"2005","journal-title":"Eur. J. Cancer"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1196\/annals.1352.010","article-title":"Curcumin: Getting back to the roots","volume":"1056","author":"Shishodia","year":"2005","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.tips.2008.11.002","article-title":"Pharmacological basis for the role of curcumin in chronic diseases: An age-old spice with modern targets","volume":"30","author":"Aggarwal","year":"2009","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S0140-6736(00)98193-5","article-title":"Turmeric (curcumin) in biliary diseases","volume":"229","author":"Oppenheimer","year":"1927","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"4095","DOI":"10.2147\/DDDT.S175763","article-title":"curcumin alleviates rheumatoid arthritis-induced inflammation and synovial hyperplasia by targeting mTOr pathway in rats","volume":"12","author":"Dai","year":"2018","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.biotechadv.2014.04.004","article-title":"Curcumin, a component of golden spice: From bedside to bench and back","volume":"32","author":"Prasad","year":"2014","journal-title":"Biotechnol. Adv."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1208\/s12248-012-9432-8","article-title":"Therapeutic roles of curcumin: Lessons learned from clinical trials","volume":"15","author":"Gupta","year":"2013","journal-title":"AAPS J."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Hsu, C.H., and Cheng, A.L. (2007). Clinical studies with curcumin. The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease, Springer.","DOI":"10.1007\/978-0-387-46401-5_21"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Haroyan, A., Mukuchyan, V., Mkrtchyan, N., Minasyan, N., Gasparyan, S., Sargsyan, A., and Hovhannisyan, A. (2018). Efficacy and safety of curcumin and its combination with boswellic acid in osteoarthritis: A comparative, randomized, double-blind, placebo-controlled study. BMC Complement. Altern. Med., 18.","DOI":"10.1186\/s12906-017-2062-z"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s10787-016-0289-9","article-title":"Curcuma longa extract reduces inflammatory and oxidative stress biomarkers in osteoarthritis of knee: A four-month, double-blind, randomized, placebo-controlled trial","volume":"24","author":"Srivastava","year":"2016","journal-title":"Inflammopharmacology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3109\/19390211.2015.1008611","article-title":"Mitigation of systemic oxidative stress by curcuminoids in osteoarthritis: Results of a randomized controlled trial","volume":"13","author":"Panahi","year":"2016","journal-title":"J. Diet. Suppl."},{"key":"ref_12","first-page":"321","article-title":"The efficacy and safety of a combination of glucosamine hydrochloride, chondroitin sulfate and bio-curcumin with exercise in the treatment of knee osteoarthritis: A randomized, double-blind, placebo-controlled study","volume":"52","author":"Sterzi","year":"2016","journal-title":"Eur. J. Phys. Rehabil. Med."},{"key":"ref_13","first-page":"521","article-title":"Impact of supplementation with curcuminoids on systemic inflammation in patients with knee osteoarthritis: Findings from a randomized double-blind placebo-controlled trial","volume":"65","author":"Rahimnia","year":"2015","journal-title":"Drug Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1002\/ptr.5174","article-title":"Curcuminoid treatment for knee osteoarthritis: A randomized double-blind placebo-controlled trial","volume":"28","author":"Panahi","year":"2014","journal-title":"Phytother. Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1007\/s00776-014-0633-0","article-title":"Short-term effects of highly-bioavailable curcumin for treating knee osteoarthritis: A randomized, double-blind, placebo-controlled prospective study","volume":"19","author":"Nakagawa","year":"2014","journal-title":"J. Orthopaedic Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"451","DOI":"10.2147\/CIA.S58535","article-title":"Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: A multicenter study","volume":"9","author":"Kuptniratsaikul","year":"2014","journal-title":"Clin. Interventions Aging"},{"key":"ref_17","first-page":"3959","article-title":"Meriva (R)+ Glucosamine versus Condroitin+ Glucosamine in patients with knee osteoarthritis: An observational study","volume":"18","author":"Belcaro","year":"2014","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s10787-012-0163-3","article-title":"Safety and efficacy of Curcuma longa extract in the treatment of painful knee osteoarthritis: A randomized placebo-controlled trial","volume":"21","author":"Madhu","year":"2013","journal-title":"Inflammopharmacology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.3892\/mmr.2013.1661","article-title":"Clinical evaluation of a formulation containing Curcuma longa and Boswellia serrata extracts in the management of knee osteoarthritis","volume":"8","author":"Kizhakkedath","year":"2013","journal-title":"Mol. Med. Rep."},{"key":"ref_20","first-page":"S51","article-title":"The efficacy of Curcuma Longa L. extract as an adjuvant therapy in primary knee osteoarthritis: A randomized control trial","volume":"95","author":"Pinsornsak","year":"2012","journal-title":"J. Med. Assoc. Thai."},{"key":"ref_21","first-page":"337","article-title":"Efficacy and safety of Meriva (R), a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patients","volume":"15","author":"Belcaro","year":"2010","journal-title":"Altern. Med. Rev."},{"key":"ref_22","first-page":"55","article-title":"Product-evaluation registry of Meriva\u00ae, a curcumin-phosphatidylcholine complex, for the complementary management of osteoarthritis","volume":"52","author":"Belcaro","year":"2010","journal-title":"Panminerva Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1089\/acm.2008.0186","article-title":"Efficacy and safety of Curcuma domestica extracts in patients with knee osteoarthritis","volume":"15","author":"Kuptniratsaikul","year":"2009","journal-title":"J. Altern. Complement. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1089\/107628002761574635","article-title":"Boswellia\u2013curcumin preparation for treating knee osteoarthritis: A clinical evaluation","volume":"8","author":"Badria","year":"2002","journal-title":"Altern. Complement. Therapies"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"13","DOI":"10.2165\/00003495-199600525-00004","article-title":"The mechanisms of action of NSAIDs in analgesia","volume":"52","author":"Cashman","year":"1996","journal-title":"Drugs"},{"key":"ref_26","first-page":"176","article-title":"Glucosamine for osteoarthritis: Part I, review of the clinical evidence","volume":"87","author":"Biggee","year":"2004","journal-title":"Rhode Island Med. J."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.jnutbio.2013.09.013","article-title":"Reduction of atherogenic risk in patients with type 2 diabetes by curcuminoid extract: A randomized controlled trial","volume":"25","author":"Chuengsamarn","year":"2014","journal-title":"J. Nutr. Biochem."},{"key":"ref_28","first-page":"902","article-title":"Curcuminoids Target Decreasing Serum Adipocyte-fatty Acid Binding Protein Levels in Their Glucose-lowering Effect in Patients with Type 2 Diabetes","volume":"27","author":"Na","year":"2014","journal-title":"Biomed. Enveion. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1002\/mnfr.201200131","article-title":"Curcuminoids exert glucose-lowering effect in type 2 diabetes by decreasing serum free fatty acids: A double-blind, placebo-controlled trial","volume":"57","author":"Na","year":"2013","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.2337\/dc12-0116","article-title":"Curcumin extract for prevention of type 2 diabetes","volume":"35","author":"Chuengsamarn","year":"2012","journal-title":"Diabetes Care"},{"key":"ref_31","first-page":"11","article-title":"Meriva\u00ae, a lecithinized curcumin delivery system, in diabetic microangiopathy and retinopathy","volume":"54","author":"Steigerwalt","year":"2012","journal-title":"Panminerva Med."},{"key":"ref_32","first-page":"43","article-title":"Potential role of curcumin phytosome (Meriva) in controlling the evolution of diabetic microangiopathy. A pilot study","volume":"53","author":"Appendino","year":"2011","journal-title":"Panminerva Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"365","DOI":"10.3109\/00365599.2011.585622","article-title":"Oral supplementation of turmeric attenuates proteinuria, transforming growth factor-\u03b2 and interleukin-8 levels in patients with overt type 2 diabetic nephropathy: A randomized, double-blind and placebo-controlled study","volume":"45","author":"Khajehdehi","year":"2011","journal-title":"Scand. J. Urol. Nephrol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"243","DOI":"10.2165\/00126839-200809040-00004","article-title":"Effect of NCB-02, atorvastatin and placebo on endothelial function, oxidative stress and inflammatory markers in patients with type 2 diabetes mellitus","volume":"9","author":"Usharani","year":"2008","journal-title":"Drugs R D"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1161\/01.CIR.0000141735.13202.B6","article-title":"Combined adipocyte-macrophage fatty acid-binding protein deficiency improves metabolism, atherosclerosis, and survival in apolipoprotein E-deficient mice","volume":"110","author":"Boord","year":"2004","journal-title":"Circulation"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"147","DOI":"10.4292\/wjgpt.v8.i2.147","article-title":"Low dose oral curcumin is not effective in induction of remission in mild to moderate ulcerative colitis: Results from a randomized double blind placebo controlled trial","volume":"8","author":"Kedia","year":"2017","journal-title":"World J. Gastrointestinal Pharmacol. Ther."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1016\/j.cgh.2015.02.019","article-title":"Curcumin in combination with mesalamine induces remission in patients with mild-to-moderate ulcerative colitis in a randomized controlled trial","volume":"13","author":"Lang","year":"2015","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/j.cgh.2006.08.008","article-title":"Curcumin maintenance therapy for ulcerative colitis: Randomized, multicenter, double-blind, placebo-controlled trial","volume":"4","author":"Hanai","year":"2006","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1002\/ptr.4639","article-title":"A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis","volume":"26","author":"Chandran","year":"2012","journal-title":"Phytother. Res."},{"key":"ref_40","first-page":"632","article-title":"Preliminary study on antirheumatic activity of curcumin (diferuloyl methane)","volume":"138","author":"Dcodhar","year":"1980","journal-title":"Indian J. Med. Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1053\/j.jrn.2011.03.002","article-title":"Oral supplementation of turmeric decreases proteinuria, hematuria, and systolic blood pressure in patients suffering from relapsing or refractory lupus nephritis: A randomized and placebo-controlled study","volume":"22","author":"Khajehdehi","year":"2012","journal-title":"J. Renal Nutr."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"5222","DOI":"10.1002\/jcp.26301","article-title":"Nanocurcumin restores aberrant miRNA expression profile in multiple sclerosis, randomized, double-blind, placebo-controlled trial","volume":"233","author":"Dolati","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.intimp.2018.05.018","article-title":"Changes in Th17 cells function after nanocurcumin use to treat multiple sclerosis","volume":"61","author":"Dolati","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"21243","DOI":"10.1074\/jbc.RA117.000123","article-title":"The anti-inflammatory activity of curcumin is mediated by its oxidative metabolites","volume":"292","author":"Edwards","year":"2017","journal-title":"J. Biol. Chem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1093\/carcin\/bgh165","article-title":"Modulation of arachidonic acid metabolism by curcumin and related \u03b2-diketone derivatives: Effects on cytosolic phospholipase A 2, cyclooxygenases and 5-lipoxygenase","volume":"25","author":"Hong","year":"2004","journal-title":"Carcinogenesis"},{"key":"ref_46","first-page":"9247","article-title":"COX-2 inhibitors: A lesson in unexpected problems","volume":"23","author":"Drazen","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/os.12412","article-title":"Curcumin Inhibits Proliferation of Synovial Cells by Downregulating Expression of Matrix Metalloproteinase-3 in Osteoarthritis","volume":"11","author":"Zeng","year":"2019","journal-title":"Orthopaedic Surg."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1080\/08860220701540326","article-title":"Antihyperlipidemic effect of curcumin and tetrahydrocurcumin in experimental type 2 diabetic rats","volume":"29","author":"Pari","year":"2007","journal-title":"Renal Fail."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"3549","DOI":"10.1210\/en.2008-0262","article-title":"Dietary curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesity","volume":"149","author":"Weisberg","year":"2008","journal-title":"Endocrinology"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.intimp.2010.08.014","article-title":"Immunomodulatory and therapeutic activity of curcumin","volume":"11","author":"Srivastava","year":"2011","journal-title":"Int. Immunopharmacol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.canlet.2004.09.041","article-title":"Chemopreventive and therapeutic effects of curcumin","volume":"223","author":"Duvoix","year":"2005","journal-title":"Cancer Lett."},{"key":"ref_52","first-page":"363","article-title":"Anticancer potential of curcumin: Preclinical and clinical studies","volume":"23","author":"Aggarwal","year":"2003","journal-title":"Anticancer Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/pros.1074","article-title":"Therapeutic potential of curcumin in human prostate cancer. III. Curcumin inhibits proliferation, induces apoptosis, and inhibits angiogenesis of LNCaP prostate cancer cells in vivo","volume":"47","author":"Dorai","year":"2001","journal-title":"Prostate"},{"key":"ref_54","first-page":"3868","article-title":"Dietary curcumin inhibits chemotherapy-induced apoptosis in models of human breast cancer","volume":"62","author":"Somasundaram","year":"2002","journal-title":"Cancer Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0925-4439(96)00032-4","article-title":"Curcumin, an antioxidant and anti-tumor promoter, induces apoptosis in human leukemia cells","volume":"1317","author":"Kuo","year":"1996","journal-title":"Biochim. Biophys. Acta BBA Mol. Basis Dis."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Cole, G.M., Teter, B., and Frautschy, S.A. (2007). Neuroprotective Effects of Curcumin. The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease, Springer.","DOI":"10.1007\/978-0-387-46401-5_8"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"367","DOI":"10.3233\/JAD-2004-6403","article-title":"Curcumin interaction with copper and iron suggests one possible mechanism of action in Alzheimer\u2019s disease animal models","volume":"6","author":"Baum","year":"2004","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.jamda.2016.12.071","article-title":"Clinical use of curcumin in depression: A meta-analysis","volume":"18","author":"Ng","year":"2017","journal-title":"J. Am. Med. Directors Assoc."},{"key":"ref_59","first-page":"2","article-title":"Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: The golden pigment from golden spice","volume":"46","author":"Prasad","year":"2014","journal-title":"Cancer Res. Treat. Off. J. Korean Cancer Assoc."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/11\/5\/1004\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T12:48:43Z","timestamp":1760186923000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/11\/5\/1004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,2]]},"references-count":59,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2019,5]]}},"alternative-id":["nu11051004"],"URL":"https:\/\/doi.org\/10.3390\/nu11051004","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,2]]}}}