{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:35:13Z","timestamp":1790328913978,"version":"4.1.0"},"reference-count":33,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T00:00:00Z","timestamp":1557446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Anti-M\u00fcllerian hormone (AMH) is considered to be one of the most significant indicators of women\u2019s fertility. Many studies have shown that vitamin D may modify human reproductive functions; however, the results are conflicting. The composition of follicular fluid (FF) creates the biochemical environment of the oocyte and affects its quality, which later determines the embryo quality. In this study, we aimed to revise with advanced statistical techniques the relationship between AMH and vitamin D in FF. Methods: The study was designed as a prospective single-center study in infertile patients with AMH \u2265 0.7 ng\/mL who underwent controlled ovarian hyperstimulation for in vitro fertilization. AMH and vitamin D levels in FF were measured. Next, the standard and advanced statistical (including segmented regression) techniques were applied. Results: We observed a negative linear correlation between levels of AMH in serum and FF and total vitamin D concentrations up to approximately 30 ng\/mL; with a statistically significant relationship in FF. Beyond that concentration, the trend was positive but statistically insignificant. Conclusions: As an existing \u201cchange-point problem\u201d was noticed, we suggest segmentation in the relationship between vitamin D and AMH during infertility treatment.<\/jats:p>","DOI":"10.3390\/nu11051053","type":"journal-article","created":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T03:57:07Z","timestamp":1557719827000},"page":"1053","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Vitamin D and Anti-M\u00fcllerian Hormone Levels in Infertility Treatment: The Change-Point Problem"],"prefix":"10.3390","volume":"11","author":[{"given":"Anna","family":"Bednarska-Czerwi\u0144ska","sequence":"first","affiliation":[{"name":"GynCentrum Clinic, \u017belazna 1, 40-851 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3754-5453","authenticated-orcid":false,"given":"Katarzyna","family":"Olszak-W\u0105sik","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Obstetrics and Oncological Gynecology, Silesian Medical University, Batorego 15, 41-902 Bytom, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Olejek","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Obstetrics and Oncological Gynecology, Silesian Medical University, Batorego 15, 41-902 Bytom, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u0142","family":"Czerwi\u0144ski","sequence":"additional","affiliation":[{"name":"GynCentrum Clinic, \u017belazna 1, 40-851 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5278-989X","authenticated-orcid":false,"given":"Andrzej","family":"Tukiendorf","sequence":"additional","affiliation":[{"name":"Department of Public Health, Wroc\u0142aw Medical University, Bartla 5, 51-618 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,5,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1093\/humrep\/deh819","article-title":"Anti-M\u00fcllerian hormone concentrations in maternal serum during pregnancy","volume":"20","author":"Giulini","year":"2005","journal-title":"Hum. 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