{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:55:12Z","timestamp":1792083312895,"version":"4.4.0"},"reference-count":209,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2019,5,11]],"date-time":"2019-05-11T00:00:00Z","timestamp":1557532800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Glutathione (GSH) is a critical endogenous antioxidant found in all eukaryotic cells. Higher GSH concentrations protect against cellular damage, tissue degeneration, and disease progression in various models, so there is considerable interest in developing interventions that augment GSH biosynthesis. Oral GSH supplementation is not the most efficient option due to the enzymatic degradation of ingested GSH within the intestine by \u03b3-glutamyltransferase, but supplementation of its component amino acids\u2014cysteine, glycine, and glutamate\u2014enhances tissue GSH synthesis. Furthermore, supplementation with some non-precursor amino acids and micronutrients appears to influence the redox status of GSH and related antioxidants, such as vitamins C and E, lowering systemic oxidative stress and slowing the rate of tissue deterioration. In this review, the effects of oral supplementation of amino acids and micronutrients on GSH metabolism are evaluated. And since specific dietary patterns and diets are being prescribed as first-line therapeutics for conditions such as hypertension and diabetes, the impact of overall diets on GSH homeostasis is also assessed.<\/jats:p>","DOI":"10.3390\/nu11051056","type":"journal-article","created":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T05:35:39Z","timestamp":1557725739000},"page":"1056","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":118,"title":["Impact of Supplementary Amino Acids, Micronutrients, and Overall Diet on Glutathione Homeostasis"],"prefix":"10.3390","volume":"11","author":[{"given":"Rebecca L.","family":"Gould","sequence":"first","affiliation":[{"name":"Department of Foods and Nutrition, University of Georgia, Athens, GA 30602, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Pazdro","sequence":"additional","affiliation":[{"name":"Department of Foods and Nutrition, University of Georgia, Athens, GA 30602, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,5,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mam.2008.08.006","article-title":"Glutathione: Overview of its protective roles, measurement, and biosynthesis","volume":"30","author":"Forman","year":"2009","journal-title":"Mol. Asp. Med."},{"key":"ref_2","first-page":"8","article-title":"Glutathione!","volume":"13","author":"Pizzorno","year":"2014","journal-title":"Integr. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.cbi.2006.03.001","article-title":"Mitochondrial glutathione transport: Physiological, pathological and toxicological implications","volume":"163","author":"Lash","year":"2006","journal-title":"Chem. Biol. Interact."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.mam.2008.08.004","article-title":"Plasma membrane glutathione transporters and their roles in cell physiology and pathophysiology","volume":"30","author":"Ballatori","year":"2009","journal-title":"Mol. Asp. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/736837","article-title":"Glutathione Homeostasis and Functions: Potential Targets for Medical Interventions","volume":"2012","author":"Lushchak","year":"2012","journal-title":"J. Amino Acids"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1126\/science.1523409","article-title":"Oxidized redox state of glutathione in the endoplasmic reticulum","volume":"257","author":"Hwang","year":"1992","journal-title":"Science"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.freeradbiomed.2013.07.036","article-title":"The thioredoxin antioxidant system","volume":"66","author":"Lu","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"19376","DOI":"10.3390\/molecules191219376","article-title":"Potential Role of Sulfur-Containing Antioxidant Systems in Highly Oxidative Environments","volume":"19","author":"Mukwevho","year":"2014","journal-title":"Molecules"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.exger.2010.08.002","article-title":"Vitamin E and C supplementation reduces oxidative stress, improves antioxidant enzymes and positive muscle work in chronically loaded muscles of aged rats","volume":"45","author":"Ryan","year":"2010","journal-title":"Exp. Gerontol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1139\/y93-109","article-title":"Partners in defense, vitamin E and vitamin C","volume":"71","author":"Chan","year":"1993","journal-title":"Can. J. Physiol. Pharm."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1080\/13813450701661198","article-title":"The central role of glutathione in the pathophysiology of human diseases","volume":"113","author":"Franco","year":"2007","journal-title":"Arch. Physiol. Biochem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1080\/07315724.1986.10720121","article-title":"Intracellular cysteine and glutathione delivery systems","volume":"5","author":"Meister","year":"1986","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.semcdb.2012.03.017","article-title":"Glutathione synthesis and its role in redox signaling","volume":"23","author":"Zhang","year":"2012","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/sj.embor.7400645","article-title":"The role of glutathione in disulphide bond formation and endoplasmic-reticulum-generated oxidative stress","volume":"7","author":"Chakravarthi","year":"2006","journal-title":"EMBO Rep."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.mam.2008.05.005","article-title":"Regulation of glutathione synthesis","volume":"30","author":"Lu","year":"2009","journal-title":"Mol. Asp. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1097\/00075197-200101000-00012","article-title":"Glutathione in disease","volume":"4","author":"Reid","year":"2001","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0753-3322(03)00043-X","article-title":"The importance of glutathione in human disease","volume":"57","author":"Townsend","year":"2003","journal-title":"BioMed Pharm."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1093\/jn\/134.3.489","article-title":"Glutathione metabolism and its implications for health","volume":"134","author":"Wu","year":"2004","journal-title":"J. Nutr."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.3390\/molecules15031242","article-title":"Prodrug Approach for Increasing Cellular Glutathione Levels","volume":"15","author":"Cacciatore","year":"2010","journal-title":"Molecules"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/j.1399-5448.2011.00806.x","article-title":"All glutathione forms are depleted in blood of obese and type 1 diabetic children","volume":"13","author":"Pastore","year":"2012","journal-title":"Pediatr. Diabetes"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"6","DOI":"10.5409\/wjcp.v3.i1.6","article-title":"Evaluation of oxidant-antioxidant status in overweight and morbidly obese Saudi children","volume":"3","author":"Albuali","year":"2014","journal-title":"World J. Clin. Pediatr."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1002\/mds.22401","article-title":"Randomized, double-blind, pilot evaluation of intravenous glutathione in Parkinson\u2019s disease","volume":"24","author":"Hauser","year":"2009","journal-title":"Mov. Disord."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"16002","DOI":"10.1038\/npjparkd.2016.2","article-title":"Central nervous system uptake of intranasal glutathione in Parkinson\u2019s disease","volume":"2","author":"Mischley","year":"2016","journal-title":"npj Parkinsons Dis."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1089\/acm.2010.0716","article-title":"Effects of oral glutathione supplementation on systemic oxidative stress biomarkers in human volunteers","volume":"17","author":"Allen","year":"2011","journal-title":"J. Altern. Complement. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1079\/BJN19970147","article-title":"Effect of orally administered glutathione on glutathione levels in some organs of rats: Role of specific transporters","volume":"78","author":"Favilli","year":"1997","journal-title":"Br. J. Nutr."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00394-014-0706-z","article-title":"Randomized controlled trial of oral glutathione supplementation on body stores of glutathione","volume":"54","author":"Richie","year":"2015","journal-title":"Eur. J. Nutr."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.redox.2015.07.012","article-title":"Effects of N-acetylcysteine, oral glutathione (GSH) and a novel sublingual form of GSH on oxidative stress markers: A comparative crossover study","volume":"6","author":"Schmitt","year":"2015","journal-title":"Redox Biol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/ecam\/nem040","article-title":"The treatment of pulmonary diseases and respiratory-related conditions with inhaled (nebulized or aerosolized) glutathione","volume":"5","author":"Prousky","year":"2008","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"CR677","DOI":"10.12659\/MSM.882125","article-title":"A clinical trial of glutathione supplementation in autism spectrum disorders","volume":"17","author":"Kern","year":"2011","journal-title":"Med. Sci. Monit."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Honda, Y., Kessoku, T., Sumida, Y., Kobayashi, T., Kato, T., Ogawa, Y., Tomeno, W., Imajo, K., Fujita, K., and Yoneda, M. (2017). Efficacy of glutathione for the treatment of nonalcoholic fatty liver disease: An open-label, single-arm, multicenter, pilot study. BMC Gastroenterol., 17.","DOI":"10.1186\/s12876-017-0652-3"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/BF02284971","article-title":"The systemic availability of oral glutathione","volume":"43","author":"Witschi","year":"1992","journal-title":"Eur. J. Clin. Pharm."},{"key":"ref_32","first-page":"G530","article-title":"Fate of dietary glutathione: Disposition in the gastrointestinal tract","volume":"259","author":"Hagen","year":"1990","journal-title":"Am. J. Physiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/B978-0-12-420117-0.00003-7","article-title":"Gamma-glutamyl transpeptidase: Redox regulation and drug resistance","volume":"122","author":"Hanigan","year":"2014","journal-title":"Adv. Cancer Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.trsl.2006.12.010","article-title":"Comparative efficacies of 2 cysteine prodrugs and a glutathione delivery agent in a colitis model","volume":"150","author":"Oz","year":"2007","journal-title":"Transl. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0899-9007(02)00774-8","article-title":"Impact of oral l-glutamine on glutathione, glutamine, and glutamate blood levels in volunteers","volume":"18","author":"Valencia","year":"2002","journal-title":"Nutrition"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1089\/ars.2011.4391","article-title":"The cystine\/glutamate antiporter system x(c)(-) in health and disease: From molecular mechanisms to novel therapeutic opportunities","volume":"18","author":"Lewerenz","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/intimm\/4.1.7","article-title":"T4+ cell numbers are correlated with plasma glutamate and cystine levels: Association of hyperglutamataemia with immunodeficiency in diseases with different aetiologies","volume":"4","author":"Eck","year":"1992","journal-title":"Int. Immunol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.nut.2011.10.014","article-title":"Plasma glutathione of HIV+ patients responded positively and differently to dietary supplementation with cysteine or glutamine","volume":"28","author":"Moreto","year":"2012","journal-title":"Nutrition"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e1319","DOI":"10.1097\/MD.0000000000001319","article-title":"Glutamine Supplementation in Intensive Care Patients: A Meta-Analysis of Randomized Clinical Trials","volume":"94","author":"Oldani","year":"2015","journal-title":"Medicine"},{"key":"ref_40","first-page":"70","article-title":"Effect of oral glutamine administration on oxidative stress, morbidity and mortality in critically ill surgical patients","volume":"26","author":"Kumar","year":"2007","journal-title":"Indian J. Gastroenterol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1182\/blood.V116.21.1636.1636","article-title":"Metabolic Fate of Oral Glutamine Supplementation within Plasma and Erythrocytes of Patients with Sickle Cell Disease: Preliminary Pharmacokinetics Results","volume":"116","author":"Morris","year":"2010","journal-title":"Blood"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.eclnm.2007.03.004","article-title":"Influence of oral glutamine and glucose on markers of oxidative stress in a paraquat rat model","volume":"2","author":"Sand","year":"2007","journal-title":"e-Spen Eur. e-J. Clin. Nutr. Metab."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/S0022-4804(03)00083-0","article-title":"Effect of glutamine on glutathione, IGF-I, and TGF-\u03b21","volume":"111","author":"Johnson","year":"2003","journal-title":"J. Surg. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1177\/0148607198022004224","article-title":"Glutamine Enhances Gut Glutathione Production","volume":"22","author":"Cao","year":"1998","journal-title":"JPEN J. Parenter. Enter. Nutr."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.3748\/wjg.v13.i20.2833","article-title":"Effects of glutamine supplementation on gut barrier, glutathione content and acute phase response in malnourished rats during inflammatory shock","volume":"13","author":"Belmonte","year":"2007","journal-title":"World J. Gastroenterol."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Badole, S.L., Jangam, G.B., Chaudhari, S.M., Ghule, A.E., and Zanwar, A.A. (2014). L-Glutamine Supplementation Prevents the Development of Experimental Diabetic Cardiomyopathy in Streptozotocin-Nicotinamide Induced Diabetic Rats. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0092697"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1139\/apnm-2016-0049","article-title":"l-glutamine and l-alanine supplementation increase glutamine-glutathione axis and muscle HSP-27 in rats trained using a progressive high-intensity resistance exercise","volume":"41","author":"Leite","year":"2016","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.nut.2008.09.014","article-title":"Effects of oral supplementation with glutamine and alanyl-glutamine on glutamine, glutamate, and glutathione status in trained rats and subjected to long-duration exercise","volume":"25","author":"Cruzat","year":"2009","journal-title":"Nutrition"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.nut.2013.10.019","article-title":"Oral free and dipeptide forms of glutamine supplementation attenuate oxidative stress and inflammation induced by endotoxemia","volume":"30","author":"Cruzat","year":"2014","journal-title":"Nutrition"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1177\/0148607112460682","article-title":"Side effects of long-term glutamine supplementation","volume":"37","author":"Holecek","year":"2013","journal-title":"JPEN J. Parenter. Enter. Nutr."},{"key":"ref_51","first-page":"81","article-title":"Dietary Glycine Is Rate-Limiting for Glutathione Synthesis and May Have Broad Potential for Health Protection","volume":"18","author":"McCarty","year":"2018","journal-title":"Ochsner J."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1007\/s00726-014-1758-3","article-title":"Glycine is a nutritionally essential amino acid for maximal growth of milk-fed young pigs","volume":"46","author":"Wang","year":"2014","journal-title":"Amino Acids"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1042\/CS20130164","article-title":"Glycine restores glutathione and protects against oxidative stress in vascular tissue from sucrose-fed rats","volume":"126","year":"2014","journal-title":"Clin. Sci."},{"key":"ref_54","first-page":"1","article-title":"Glycine Increases Insulin Sensitivity and Glutathione Biosynthesis and Protects against Oxidative Stress in a Model of Sucrose-Induced Insulin Resistance","volume":"2018","author":"Franco","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1210\/jc.2013-2376","article-title":"Effect of increasing glutathione with cysteine and glycine supplementation on mitochondrial fuel oxidation, insulin sensitivity, and body composition in older HIV-infected patients","volume":"99","author":"Nguyen","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"McBean, G.J. (2017). Cysteine, Glutathione, and Thiol Redox Balance in Astrocytes. Antioxidants, 6.","DOI":"10.3390\/antiox6030062"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/BF00234911","article-title":"Cytotoxic effects of acidic and sulphur containing amino acids on the infant mouse central nervous system","volume":"14","author":"Olney","year":"1971","journal-title":"Exp. Brain Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/0003-9861(57)90217-5","article-title":"Quantitative nutritional studies with water-soluble, chemically defined diets. II. Nitrogen balance and metabolism","volume":"72","author":"Birnbaum","year":"1957","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/227609b0","article-title":"Brain damage in infant mice following oral intake of glutamate, aspartate or cysteine","volume":"227","author":"Olney","year":"1970","journal-title":"Nature"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0091-3057(75)90160-4","article-title":"Brain damage and associated behavioral deficits following the administration of L-cysteine to infant rats","volume":"3","author":"Shapre","year":"1975","journal-title":"Pharm. Biochem. Behav."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0076-6879(87)43059-0","article-title":"Intracellular delivery of cysteine","volume":"143","author":"Anderson","year":"1987","journal-title":"Methods Enzym."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0378-4274(93)90140-S","article-title":"Toxicity evaluations of l-cysteine and Procysteine\u2122, a cysteine prodrug, given once intravenously to neonatal rats","volume":"69","author":"White","year":"1993","journal-title":"Toxicol. Lett."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1126\/science.6342137","article-title":"Mutagenicity of glutathione and cysteine in the Ames test","volume":"220","author":"Glatt","year":"1983","journal-title":"Science"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"3725","DOI":"10.1016\/0006-2952(85)90237-0","article-title":"Mutagenicity of cysteine and penicillamine and its enantiomeric selectivity","volume":"34","author":"Glatt","year":"1985","journal-title":"Biochem. Pharm."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1177\/0148607114546375","article-title":"Effect of High-Dose Cysteine Supplementation on Erythrocyte Glutathione: A Double-Blinded, Randomized Placebo-Controlled Pilot Study in Critically Ill Neonates","volume":"40","author":"Calkins","year":"2016","journal-title":"JPEN J. Parenter. Enter. Nutr."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"15089","DOI":"10.1073\/pnas.2436385100","article-title":"The atherogenic effect of excess methionine intake","volume":"100","author":"Troen","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"144","DOI":"10.4162\/nrp.2015.9.2.144","article-title":"Effects of excessive dietary methionine on oxidative stress and dyslipidemia in chronic ethanol-treated rats","volume":"9","author":"Kim","year":"2015","journal-title":"Nutr. Res. Pract."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.coph.2007.04.005","article-title":"N-Acetylcysteine\u2014A safe antidote for cysteine\/glutathione deficiency","volume":"7","author":"Atkuri","year":"2007","journal-title":"Curr. Opin. Pharm."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1021\/jm9909600","article-title":"Population, acid-base, and redox properties of N-acetylcysteine conformers","volume":"43","author":"Noszal","year":"2000","journal-title":"J. Med. Chem."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S1054-3589(08)60985-0","article-title":"N-acetylcysteine: Pharmacological considerations and experimental and clinical applications","volume":"38","author":"Cotgreave","year":"1997","journal-title":"Adv. Pharm."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"5606","DOI":"10.1073\/pnas.76.11.5606","article-title":"Glutathione: Interorgan translocation, turnover, and metabolism","volume":"76","author":"Griffith","year":"1979","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1136\/thx.46.1.39","article-title":"Cysteine and glutathione concentrations in plasma and bronchoalveolar lavage fluid after treatment with N-acetylcysteine","volume":"46","author":"Bridgeman","year":"1991","journal-title":"Thorax"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1046\/j.1365-2362.2000.00736.x","article-title":"N-acetylcysteine replenishes glutathione in HIV infection","volume":"30","author":"Zaretsky","year":"2000","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.freeradbiomed.2017.12.007","article-title":"N-acetylcysteine supplementation increases exercise performance and reduces oxidative stress only in individuals with low levels of glutathione","volume":"115","author":"Paschalis","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1093\/gerona\/gly034","article-title":"Improved Cardiovascular Function in Old Mice After N-Acetyl Cysteine and Glycine Supplemented Diet: Inflammation and Mitochondrial Factors","volume":"73","author":"Cieslik","year":"2018","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1182\/blood.V90.1.1","article-title":"Homocysteine and Thrombotic Disease","volume":"90","author":"Angelo","year":"1997","journal-title":"Blood"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"407","DOI":"10.3109\/00365528909093067","article-title":"Effects of oral S-adenosyl-l-methionine on hepatic glutathione in patients with liver disease","volume":"24","author":"Vendemiale","year":"1989","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0741-8329(02)00230-6","article-title":"S-Adenosyl-l-methionine and alcoholic liver disease in animal models: Implications for early intervention in human beings","volume":"27","author":"Lieber","year":"2002","journal-title":"Alcohol"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.3748\/wjg.v16.i11.1366","article-title":"Hepatoprotective effects of S-adenosyl-l-methionine against alcohol- and cytochrome P450 2E1-induced liver injury","volume":"16","author":"Cederbaum","year":"2010","journal-title":"World J. Gastroenterol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S0955-2863(03)00116-5","article-title":"S-adenosylmethionine (SAMe) protects against acute alcohol induced hepatotoxicity in mice","volume":"14","author":"Song","year":"2003","journal-title":"J. Nutr. Biochem."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1159\/000008555","article-title":"Augmentation of Mitochondrial Reduced Glutathione by S-Adenosyl-l-Methionine Administration in Ischemia-Reperfusion Injury of the Rat Steatotic Liver Induced by Choline-Methionine-Deficient Diet","volume":"30","author":"Kaneshiro","year":"1998","journal-title":"Eur. Surg. Res."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1016\/S0016-5085(98)70034-4","article-title":"Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor","volume":"115","author":"Colell","year":"1998","journal-title":"Gastroenterology"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"164","DOI":"10.15430\/JCP.2016.21.3.164","article-title":"Effects of S-Adenosylmethionine and Its Combinations with Taurine and\/or Betaine on Glutathione Homeostasis in Ethanol-induced Acute Hepatotoxicity","volume":"21","year":"2016","journal-title":"J. Cancer Prev."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0741-8329(02)00229-X","article-title":"S-Adenosyl-l-methionine and mitochondrial reduced glutathione depletion in alcoholic liver disease","volume":"27","author":"Colell","year":"2002","journal-title":"Alcohol"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/hep.1840110203","article-title":"S-Adenosyl-l-methionine attenuates alcohol-induced liver injury in the baboon","volume":"11","author":"Lieber","year":"1990","journal-title":"Hepatology"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/S0168-8278(99)80274-8","article-title":"Role of S-adenosyl-l-methionine in the treatment of liver diseases","volume":"30","author":"Lieber","year":"1999","journal-title":"J. Hepatol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1089\/acm.2008.0402","article-title":"Dietary Supplement S-Adenosyl-l-Methionine (AdoMet) Effects on Plasma Homocysteine Levels in Healthy Human Subjects: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial","volume":"15","author":"Thompson","year":"2009","journal-title":"J. Altern. Complement. Med."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/hep.510310219","article-title":"The glutathione precursor L-2-oxothiazolidine-4-carboxylic acid protects against liver injury due to chronic enteral ethanol exposure in the rat","volume":"31","author":"Iimuro","year":"2000","journal-title":"Hepatology"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.1096\/fasebj.6.12.1521740","article-title":"Elevation of lung glutathione by oral supplementation of L-2-oxothiazolidine-4-carboxylate protects against oxygen toxicity in protein-energy malnourished rats","volume":"6","author":"Taylor","year":"1992","journal-title":"FASEB J."},{"key":"ref_90","first-page":"851","article-title":"L-2-oxothiazolidine-4-carboxylate, a cysteine precursor, stimulates growth and normalizes tissue glutathione concentrations in rats fed a sulfur amino acid-deficient diet","volume":"125","author":"Jain","year":"1995","journal-title":"J. Nutr."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1016\/S0891-5849(03)00181-3","article-title":"L-2-oxothiazolidine-4-carboxylate supplementation in murine gamma-GT deficiency","volume":"34","author":"Held","year":"2003","journal-title":"Free Radic. Biol. Med."},{"key":"ref_92","first-page":"73","article-title":"L-2-oxothiazolidine-4-carboxylic acid attenuates oxidative stress and inflammation in retinal pigment epithelium","volume":"20","author":"Promsote","year":"2014","journal-title":"Mol. Vis."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/S0271-5317(02)00462-1","article-title":"Effects of dietary protein and L-2-oxothiazolidine-4-carboxylate on rat brain glutathione concentration","volume":"22","author":"Zhang","year":"2002","journal-title":"Nutr. Res."},{"key":"ref_94","first-page":"331","article-title":"L-2-oxothiazolidine-4-carboxylic acid, a cysteine prodrug: Pharmacokinetics and effects on thiols in plasma and lymphocytes in human","volume":"257","author":"Porta","year":"1991","journal-title":"J. Pharm. Exp. Ther."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1177\/089686080202200301","article-title":"L-2-oxothiazolidine-4-carboxylate: An agent that modulates lipopolysaccharide-induced peritonitis in rats","volume":"22","author":"Korybalska","year":"2002","journal-title":"Perit. Dial. Int."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1093\/jn\/128.4.671","article-title":"Selective elevation of glutathione levels in target tissues with L-2-oxothiazolidine-4-carboxylate (OTC) protects against hyperoxia-induced lung damage in protein-energy malnourished rats: Implications for a new treatment strategy","volume":"128","author":"Levy","year":"1998","journal-title":"J. Nutr."},{"key":"ref_97","first-page":"9","article-title":"Effect of L-2-oxothiazolidine-4-carboxylate administration on glutathione and cysteine concentrations in guinea pig liver and kidney","volume":"19","author":"Nishina","year":"1987","journal-title":"Physiol. Chem. Phys. Med. NMR"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1016\/j.bbagen.2012.09.008","article-title":"Glutathione synthesis","volume":"1830","author":"Lu","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.bbadis.2017.11.009","article-title":"Serine prevented high-fat diet-induced oxidative stress by activating AMPK and epigenetically modulating the expression of glutathione synthesis-related genes","volume":"1864","author":"Zhou","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Zhou, X., He, L., Wu, C., Zhang, Y., Wu, X., and Yin, Y. (2017). Serine alleviates oxidative stress via supporting glutathione synthesis and methionine cycle in mice. Mol. Nutr. Food Res., 61.","DOI":"10.1002\/mnfr.201700262"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1159\/000491967","article-title":"Effects of Dietary Serine Supplementation on Intestinal Integrity, Inflammation and Oxidative Status in Early-Weaned Piglets","volume":"48","author":"Zhou","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"260","DOI":"10.3945\/jn.114.199711","article-title":"L-Serine Supplementation Attenuates Alcoholic Fatty Liver by Enhancing Homocysteine Metabolism in Mice and Rats","volume":"145","author":"Sim","year":"2014","journal-title":"J. Nutr."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"476","DOI":"10.3389\/fendo.2018.00476","article-title":"Long-Term l-Serine Administration Reduces Food Intake and Improves Oxidative Stress and Sirt1\/NF\u03baB Signaling in the Hypothalamus of Aging Mice","volume":"9","author":"Zhou","year":"2018","journal-title":"Front. Endocrinol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.bbadis.2005.04.003","article-title":"Supplementation with N-acetylcysteine and taurine failed to restore glutathione content in liver of streptozotocin-induced diabetics rats but protected from oxidative stress","volume":"1741","author":"Patriarca","year":"2005","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/978-1-4899-0117-0_13","article-title":"Effect of taurine supplementation on the lipid peroxide formation and the activities of glutathione-related enzymes in the liver and islet of type I and II diabetic model mice","volume":"442","author":"Lim","year":"1998","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1016\/j.fct.2009.04.030","article-title":"Effect of taurine supplementation on cytochrome P450 2E1 and oxidative stress in the liver and kidneys of rats with streptozotocin-induced diabetes","volume":"47","author":"Yao","year":"2009","journal-title":"Food Chem. Toxicol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1159\/000048587","article-title":"Protection effects of Taurine supplementation against cisplatin-induced nephrotoxicity in rats","volume":"48","author":"Saad","year":"2002","journal-title":"Chemotherapy"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1096\/fj.201700586R","article-title":"Taurine treatment prevents derangement of the hepatic gamma-glutamyl cycle and methylglyoxal metabolism in a mouse model of classical homocystinuria: Regulatory crosstalk between thiol and sulfinic acid metabolism","volume":"32","author":"Maclean","year":"2018","journal-title":"FASEB J."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/cbf.1198","article-title":"The effect of taurine supplementation on oxidative stress in experimental hypothyroidism","volume":"24","author":"Dirican","year":"2006","journal-title":"Cell Biochem. Funct."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1161\/01.CIR.0000124229.40424.80","article-title":"Taurine Supplementation Reduces Oxidative Stress and Improves Cardiovascular Function in an Iron-Overload Murine Model","volume":"109","author":"Oudit","year":"2004","journal-title":"Circulation"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"219","DOI":"10.3923\/pjbs.2011.219.225","article-title":"Effects of Taurine on Glutathione Peroxidase, Glutathione Reductase and Reduced Glutathione Levels in Rats","volume":"14","author":"Anand","year":"2011","journal-title":"Pak. J. Biol. Sci."},{"key":"ref_112","first-page":"680","article-title":"Effect of dietary taurine supplementation on GSH and NAD(P)-redox status, lipid peroxidation, and energy metabolism in diabetic precataractous lens","volume":"40","author":"Obrosova","year":"1999","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1271\/bbb.66.1755","article-title":"Improving effect of dietary taurine supplementation on the oxidative stress and lipid levels in the plasma, liver and aorta of rabbits fed on a high-cholesterol diet","volume":"66","author":"Balkan","year":"2002","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"45","DOI":"10.7324\/JAPS.2016.601006","article-title":"Protective and therapeutic impact of taurine on some biochemical, immunological and histological parameters in diabetic rats","volume":"6","author":"Foda","year":"2016","journal-title":"J. Appl. Pharm. Sci."},{"key":"ref_115","first-page":"101","article-title":"Effects of taurine supplementation following eccentric exercise in young adults","volume":"39","author":"Tromm","year":"2013","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"26","DOI":"10.4162\/nrp.2016.10.1.26","article-title":"Vitamin A supplementation modifies the antioxidant system in rats","volume":"10","author":"Cha","year":"2016","journal-title":"Nutr. Res. Pract."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Petiz, L.L., Girardi, C.S., Bortolin, R.C., Kunzler, A., Gasparotto, J., Rabelo, T.K., Matt\u00e9, C., Moreira, J.C.F., and Gelain, D.P. (2017). Vitamin A Oral Supplementation Induces Oxidative Stress and Suppresses IL-10 and HSP70 in Skeletal Muscle of Trained Rats. Nutrients, 9.","DOI":"10.3390\/nu9040353"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1038\/ejcn.2014.114","article-title":"Vitamin D and L-cysteine levels correlate positively with GSH and negatively with insulin resistance levels in the blood of type 2 diabetic patients","volume":"68","author":"Jain","year":"2014","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1111\/cen.12449","article-title":"Vitamin D status is independently associated with plasma glutathione and cysteine thiol\/disulphide redox status in adults","volume":"81","author":"Alvarez","year":"2014","journal-title":"Clin. Endocrinol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"799.12","DOI":"10.1096\/fasebj.31.1_supplement.799.12","article-title":"Positive association between reduced GSH and inadequacy\/deficiency of 25-hydroxy-vitamin D in obese children","volume":"31","author":"Jain","year":"2017","journal-title":"FASEB J."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1007\/s00198-005-1881-9","article-title":"The effect of vitamin K2 on bone metabolism in aged female rats","volume":"16","author":"Sakamoto","year":"2005","journal-title":"Osteoporos. Int."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/0955-2863(93)90078-B","article-title":"Interaction between vitamin E and glutathione in rat brain\u2014Effect of acute alcohol administration","volume":"4","author":"Marcus","year":"1993","journal-title":"J. Nutr. Biochem."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Bucioli, S.A., de Abreu, L.C., Valenti, V.E., Leone, C., and Vannucchi, H. (2011). Effects of vitamin E supplementation on renal non-enzymatic antioxidants in young rats submitted to exhaustive exercise stress. BMC Complement. Altern. Med., 11.","DOI":"10.1186\/1472-6882-11-133"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/0304-4165(77)90154-4","article-title":"The influence of dietary selenium and vitamin E on glutathione peroxidase and glutathione in the rat","volume":"497","author":"Scott","year":"1977","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"770","DOI":"10.3181\/00379727-151-39304","article-title":"Vitamin E supplementation and glutathione peroxidase activity","volume":"151","author":"Yang","year":"1976","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"ref_126","first-page":"140","article-title":"Effect of vitamin E on the oxidative state of glutathione in plasma","volume":"8","author":"Costagliola","year":"1990","journal-title":"Clin. Physiol. Biochem."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/0026-0495(85)90019-8","article-title":"Vitamin E and red blood cell glutathione","volume":"34","author":"Costagliola","year":"1985","journal-title":"Metabolism"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1159\/000012815","article-title":"Effect of glycemic control and vitamin E supplementation on total glutathione content in non-insulin-dependent diabetes mellitus","volume":"44","author":"Sharma","year":"2000","journal-title":"Ann. Nutr. Metab."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.2337\/diacare.23.9.1389","article-title":"Vitamin E supplementation restores glutathione and malondialdehyde to normal concentrations in erythrocytes of type 1 diabetic children","volume":"23","author":"Jain","year":"2000","journal-title":"Diabetes Care"},{"key":"ref_130","first-page":"177","article-title":"Effect of vitamin E supplementation on diabetes induced oxidative stress in experimental diabetes in rats","volume":"43","author":"Garg","year":"2005","journal-title":"Indian J. Exp. Biol."},{"key":"ref_131","first-page":"146","article-title":"Vitamin E status, glutathione peroxidase activity and the effect of vitamin E supplementation in children with thalassemia","volume":"76","author":"Suthutvoravut","year":"1993","journal-title":"J. Med. Assoc. Thail."},{"key":"ref_132","first-page":"1","article-title":"Antioxidants Supplementation in Elderly Cardiovascular Patients","volume":"2013","author":"Vila","year":"2013","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"25702","DOI":"10.3402\/fnr.v59.25702","article-title":"Role of vitamin B6 status on antioxidant defenses, glutathione, and related enzyme activities in mice with homocysteine-induced oxidative stress","volume":"59","author":"Hsu","year":"2015","journal-title":"Food Nutr. Res."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/S0891-5849(00)00462-7","article-title":"Pyridoxine and pyridoxamine inhibits superoxide radicals and prevents lipid peroxidation, protein glycosylation, and (Na+ + K+)-ATPase activity reduction in high glucose-treated human erythrocytes","volume":"30","author":"Jain","year":"2001","journal-title":"Free Radic. Biol. Med."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1016\/j.biocel.2004.01.028","article-title":"Vitamin C or Vitamin B6 supplementation prevent the oxidative stress and decrease of prostacyclin generation in homocysteinemic rats","volume":"36","author":"Mahfouz","year":"2004","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/j.1742-7843.2005.pto_97109.x","article-title":"Pyridoxine attenuates chromium-induced oxidative stress in rat kidney","volume":"97","author":"Anand","year":"2005","journal-title":"Basic Clin. Pharm. Toxicol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/jat.1077","article-title":"Protective effect of vitamin B6 in chromium-induced oxidative stress in liver","volume":"25","author":"Anand","year":"2005","journal-title":"J. Appl. Toxicol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/351598","article-title":"Vitamin B6 Supplementation Improves Oxidative Stress and Enhances Serum Paraoxonase\/Arylesterase Activities in Streptozotocin-Induced Diabetic Rats","volume":"2014","author":"Tas","year":"2014","journal-title":"Sci. World J."},{"key":"ref_139","first-page":"1","article-title":"Vitamin B-6 Supplementation Could Mediate Antioxidant Capacity by Reducing Plasma Homocysteine Concentration in Patients with Hepatocellular Carcinoma after Tumor Resection","volume":"2016","author":"Cheng","year":"2016","journal-title":"BioMed Res. Int."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1159\/000333790","article-title":"Effects of exercise and B vitamins on homocysteine and glutathione in Parkinson\u2019s disease: A randomized trial","volume":"10","author":"Lamberg","year":"2012","journal-title":"Neurodegener. Dis."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1681\/ASN.V1061287","article-title":"Effects of High-Dose Folic Acid and Pyridoxine on Plasma and Erythrocyte Sulfur Amino Acids in Hemodialysis Patients","volume":"10","author":"Suliman","year":"1999","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0891-5849(94)90019-1","article-title":"The redox couple between glutathione and ascorbic acid: A chemical and physiological perspective","volume":"17","author":"Winkler","year":"1994","journal-title":"Free Radic. Biol. Med."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"9397","DOI":"10.1016\/S0021-9258(17)36891-6","article-title":"Glutathione-ascorbic acid antioxidant system in animals","volume":"269","author":"Meister","year":"1994","journal-title":"J. Biol. Chem."},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Pasquier, C., Olivier, R.Y., Auclair, C., and Packer, L. (1994). The Antioxidant Effects of Glutathione and Ascorbic Acid. Oxidative Stress, Cell Activation and Viral Infection, Birkh\u00e4user.","DOI":"10.1007\/978-3-0348-7424-3"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"198","DOI":"10.3746\/pnf.2015.20.3.198","article-title":"Low Nourishment of Vitamin C Induces Glutathione Depletion and Oxidative Stress in Healthy Young Adults","volume":"20","author":"Waly","year":"2015","journal-title":"Prev. Nutr. Food Sci."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/BF02867720","article-title":"Effect of methionine and vitamin C supplementation on pulmonary glutathione-s-transferase and glutathione levels in ageing rats","volume":"8","author":"Lal","year":"1993","journal-title":"Indian J. Clin. Biochem."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0271-5317(84)80039-1","article-title":"An increase in glutathione peroxidase activity induced by high supplementation of vitamin C in rats","volume":"4","author":"Chen","year":"1984","journal-title":"Nutr. Res."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"411","DOI":"10.3177\/jnsv.40.411","article-title":"Effect of vitamin C on antioxidants, lipid peroxidation, and GSH system in the normal guinea pig heart","volume":"40","author":"Rojas","year":"1994","journal-title":"J. Nutr. Sci. Vitam."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1093\/ajcn\/58.1.103","article-title":"Vitamin C elevates red blood cell glutathione in healthy adults","volume":"58","author":"Johnston","year":"1993","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1093\/ajcn\/77.1.189","article-title":"Vitamin C augments lymphocyte glutathione in subjects with ascorbate deficiency","volume":"77","author":"Lenton","year":"2003","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"436","DOI":"10.3177\/jnsv.56.436","article-title":"Effect of Vitamin E and C Supplements on Antioxidant Defense System in Cardiovascular Disease Patients in Zahedan, Southeast Iran","volume":"56","author":"Karajibani","year":"2010","journal-title":"J. Nutr. Sci. Vitam."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.contraception.2011.11.006","article-title":"Effect of vitamin E and C supplements on lipid peroxidation and GSH-dependent antioxidant enzyme status in the blood of women consuming oral contraceptives","volume":"86","author":"Zal","year":"2012","journal-title":"Contraception"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1207\/S15327914NC4602_04","article-title":"Selenium supplementation enhances low selenium levels and stimulates glutathione peroxidase activity in peripheral blood and distal colon mucosa in past and present carriers of colon adenomas","volume":"46","author":"Seufert","year":"2003","journal-title":"Nutr. Cancer"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1089\/ars.2010.3586","article-title":"Glutathione peroxidase-1 in health and disease: From molecular mechanisms to therapeutic opportunities","volume":"15","author":"Lubos","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jtemb.2004.01.001","article-title":"Effects of dietary selenium on glutathione peroxidase and thioredoxin reductase activity and recovery from cardiac ischemia-reperfusion","volume":"18","author":"Venardos","year":"2004","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1093\/jn\/104.4.444","article-title":"Response of glutathione peroxidase to dietary selenium in rats","volume":"104","author":"Chow","year":"1974","journal-title":"J. Nutr."},{"key":"ref_157","first-page":"2670","article-title":"Effect of Dietary Selenium on the Interaction between 2-Acetylaminofluorene and Rat Liver DNA in vivo","volume":"40","author":"Wortzman","year":"1980","journal-title":"Cancer Res."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1093\/ajcn\/48.2.316","article-title":"Selenium and vitamin E supplementation: Activities of glutathione peroxidase in human tissues","volume":"48","author":"Thomson","year":"1988","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"e17945","DOI":"10.5812\/numonthly.17945","article-title":"Effect of selenium supplementation on glutathione peroxidase enzyme activity in patients with chronic kidney disease: A randomized clinical trial","volume":"6","author":"Sedighi","year":"2014","journal-title":"Nephrourol. Mon."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1385\/BTER:97:1:15","article-title":"Selenium supplementation on plasma glutathione peroxidase activity in patients with end-stage chronic renal failure","volume":"97","author":"Zachara","year":"2004","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0946-672X(01)80034-1","article-title":"Selenium and glutathione levels, and glutathione peroxidase activities in blood components of uremic patients on hemodialysis supplemented with selenium and treated with erythropoietin","volume":"15","author":"Zachara","year":"2001","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/BF02990128","article-title":"Effect of Selenium Supplementation on Platelet Selenium, Glutathione Peroxidase, and Aggregation","volume":"15","author":"Wang","year":"1988","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0946-672X(11)80013-1","article-title":"Human Selenium Supplementation as Assessed by Changes in Blood Selenium Concentration and Glutathione Peroxidase Activity","volume":"9","year":"1995","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1007\/BF00441140","article-title":"Plasma glutathione peroxidase after selenium supplementation in patients with reduced selenium state","volume":"138","author":"Steiner","year":"1982","journal-title":"Eur. J. Pediatr."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1590\/1678-4685-gmb-2017-0334","article-title":"Oxidative stress assessment by glutathione peroxidase activity and glutathione levels in response to selenium supplementation in patients with Mucopolysaccharidosis I, II and VI","volume":"42","author":"Yamamoto","year":"2019","journal-title":"Genet. Mol. Biol."},{"key":"ref_166","first-page":"120","article-title":"Effects of organic selenium supplement on glutathione peroxidase activities: A meta-analysis of randomized controlled trials","volume":"41","author":"Jiang","year":"2012","journal-title":"Wei Sheng Yan Jiu"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/1520-670X(2000)13:3<299::AID-JTRA7>3.0.CO;2-P","article-title":"Effect of selenium supplementation on the influence of cadmium on glutathione and glutathione peroxidase system in mouse liver","volume":"13","author":"Jamba","year":"2000","journal-title":"J. Trace Elem. Med."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1136\/ard.51.9.1044","article-title":"Glutathione redox cycle enzymes and selenium in severe rheumatoid arthritis: Lack of antioxidative response to selenium supplementation in polymorphonuclear leucocytes","volume":"51","author":"Tarp","year":"1992","journal-title":"Ann. Rheum. Dis."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/ajcn\/48.1.139","article-title":"Selenium supplementation in healthy Belgian adults: Response in platelet glutathione peroxidase activity and other blood indices","volume":"48","author":"Vertongen","year":"1988","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1093\/jn\/112.3.488","article-title":"Role of magnesium in glutathione metabolism of rat erythrocytes","volume":"112","author":"Hsu","year":"1982","journal-title":"J. Nutr."},{"key":"ref_171","first-page":"21","article-title":"Oral Magnesium Potentiates Glutathione Activity in Experimental Diabetic Rats","volume":"5","author":"Ige","year":"2016","journal-title":"Int. J. Diabetes Res."},{"key":"ref_172","first-page":"49","article-title":"Red cell magnesium and glutathione peroxidase in infertile women--effects of oral supplementation with magnesium and selenium","volume":"7","author":"Howard","year":"1994","journal-title":"Magnes. Res."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s00011-007-7077-3","article-title":"Effects of magnesium supplementation on the glutathione redox system in atopic asthmatic children","volume":"57","author":"Bede","year":"2008","journal-title":"Inflamm. Res."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"222","DOI":"10.3945\/ajcn.114.098616","article-title":"Magnesium supplementation affects metabolic status and pregnancy outcomes in gestational diabetes: A randomized, double-blind, placebo-controlled trial","volume":"102","author":"Bahmani","year":"2015","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"9139","DOI":"10.3390\/nu7115459","article-title":"Definition of the Mediterranean Diet; a Literature Review","volume":"7","author":"Davis","year":"2015","journal-title":"Nutrients"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"3065S","DOI":"10.1093\/jn\/131.11.3065S","article-title":"The Mediterranean Diets: What Is So Special about the Diet of Greece? The Scientific Evidence","volume":"131","author":"Simopoulos","year":"2001","journal-title":"J. Nutr."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.3945\/ajcn.2008.26528","article-title":"Association between adherence to the Mediterranean diet and oxidative stress","volume":"88","author":"Dai","year":"2008","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1089\/ars.2016.6839","article-title":"Is There an Interplay Between Adherence to Mediterranean Diet, Antioxidant Status, and Vascular Disease in Atrial Fibrillation Patients?","volume":"25","author":"Pastori","year":"2016","journal-title":"Antioxid. Redox Signal."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.celrep.2018.08.078","article-title":"Consumption of Mediterranean versus Western Diet Leads to Distinct Mammary Gland Microbiome Populations","volume":"25","author":"Shively","year":"2018","journal-title":"Cell Rep."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1093\/jn\/nxx045","article-title":"Higher Mediterranean Diet Quality Scores and Lower Body Mass Index Are Associated with a Less-Oxidized Plasma Glutathione and Cysteine Redox Status in Adults","volume":"148","author":"Bettermann","year":"2018","journal-title":"J. Nutr."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1172\/JCI21625","article-title":"Increased oxidative stress in obesity and its impact on metabolic syndrome","volume":"114","author":"Furukawa","year":"2004","journal-title":"J. Clin. Investig."},{"key":"ref_182","unstructured":"Challa, H.J., and Uppaluri, K.R. (2018). DASH Diet (Dietary Approaches to Stop Hypertension). StatPearls [Internet], StatPearls Publishing."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.nut.2012.11.020","article-title":"A randomized controlled clinical trial investigating the effect of DASH diet on insulin resistance, inflammation, and oxidative stress in gestational diabetes","volume":"29","author":"Asemi","year":"2013","journal-title":"Nutrition"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1067\/mlc.2000.105977","article-title":"Blood glutathione decreases in chronic diseases","volume":"135","author":"Lang","year":"2000","journal-title":"J. Lab. Clin. Med."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1111\/liv.12990","article-title":"The effects of DASH diet on weight loss and metabolic status in adults with non-alcoholic fatty liver disease: A randomized clinical trial","volume":"36","author":"Telkabadi","year":"2016","journal-title":"Liver Int."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.nut.2014.03.008","article-title":"Effects of DASH diet on lipid profiles and biomarkers of oxidative stress in overweight and obese women with polycystic ovary syndrome: A randomized clinical trial","volume":"30","author":"Asemi","year":"2014","journal-title":"Nutrition"},{"key":"ref_187","first-page":"528","article-title":"Alternative nutrition and glutathione levels","volume":"138","author":"Simoncic","year":"1999","journal-title":"Casopis Lekaru Ceskych"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/BF02867387","article-title":"Oxidant and antioxidant status in vegetarians and fish eaters","volume":"18","author":"Poornima","year":"2003","journal-title":"Indian J. Clin. Biochem."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1093\/ajcn\/62.6.1221","article-title":"Antioxidant status in long-term adherents to a strict uncooked vegan diet","volume":"62","author":"Rauma","year":"1995","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1017\/S0029665115004334","article-title":"The long-term health of vegetarians and vegans","volume":"75","author":"Appleby","year":"2016","journal-title":"Proc. Nutr. Soc."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/j.1464-5491.2010.03209.x","article-title":"Vegetarian diet improves insulin resistance and oxidative stress markers more than conventional diet in subjects with Type 2 diabetes","volume":"28","author":"Kahleova","year":"2011","journal-title":"Diabet. Med."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1161\/01.STR.0000138022.86509.2d","article-title":"Relationship between plasma glutathione levels and cardiovascular disease in a defined population: The Hisayama study","volume":"35","author":"Shimizu","year":"2004","journal-title":"Stroke"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1038\/sj.ejcn.1602615","article-title":"Influence of habitual diet on antioxidant status: A study in a population of vegetarians and omnivores","volume":"61","author":"Haldar","year":"2007","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"155","DOI":"10.4162\/nrp.2012.6.2.155","article-title":"Long-term vegetarians have low oxidative stress, body fat, and cholesterol levels","volume":"6","author":"Kim","year":"2012","journal-title":"Nutr. Res. Pract."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"838","DOI":"10.3389\/fimmu.2017.00838","article-title":"The Impact of Western Diet and Nutrients on the Microbiota and Immune Response at Mucosal Interfaces","volume":"8","author":"Statovci","year":"2017","journal-title":"Front. Immunol."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"218","DOI":"10.3325\/cmj.2014.55.218","article-title":"Impact of ovariectomy, high fat diet, and lifestyle modifications on oxidative\/antioxidative status in the rat liver","volume":"55","author":"Heffer","year":"2014","journal-title":"Croat. Med. J."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.freeradbiomed.2016.03.032","article-title":"A Western diet induced NAFLD in LDLR(-\/)(-) mice is associated with reduced hepatic glutathione synthesis","volume":"96","author":"Li","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.3945\/jn.108.104125","article-title":"Western-style diets induce oxidative stress and dysregulate immune responses in the colon in a mouse model of sporadic colon cancer","volume":"139","author":"Erdelyi","year":"2009","journal-title":"J. Nutr."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/1475-2891-12-144","article-title":"Dietary protein and plasma total homocysteine, cysteine concentrations in coronary angiographic subjects","volume":"12","author":"Xiao","year":"2013","journal-title":"Nutr. J."},{"key":"ref_200","doi-asserted-by":"crossref","unstructured":"Olsen, T., Ovrebo, B., Turner, C., Bastani, N.E., Refsum, H., and Vinknes, K.J. (2018). Combining Dietary Sulfur Amino Acid Restriction with Polyunsaturated Fatty Acid Intake in Humans: A Randomized Controlled Pilot Trial. Nutrients, 10.","DOI":"10.3390\/nu10121822"},{"key":"ref_201","first-page":"97","article-title":"Health effects of changes in the structure of dietary macronutrients intake in western societies","volume":"66","author":"Okreglicka","year":"2015","journal-title":"Roczniki Pa\u0144stwowego Zak\u0142adu Higieny"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"17549","DOI":"10.3402\/fnr.v56i0.17549","article-title":"High hydrostatic pressure pre-treatment of whey proteins enhances whey protein hydrolysate inhibition of oxidative stress and IL-8 secretion in intestinal epithelial cells","volume":"56","author":"Piccolomini","year":"2012","journal-title":"Food Nutr. Res."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S1569-1993(03)00097-3","article-title":"Improved glutathione status in young adult patients with cystic fibrosis supplemented with whey protein","volume":"2","author":"Grey","year":"2003","journal-title":"J. Cyst. Fibros"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1007\/s11064-010-0217-0","article-title":"Liposomal-glutathione provides maintenance of intracellular glutathione and neuroprotection in mesencephalic neuronal cells","volume":"35","author":"Zeevalk","year":"2010","journal-title":"Neurochem. Res."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1089\/jir.2014.0210","article-title":"Liposomal Glutathione Supplementation Restores TH1 Cytokine Response to Mycobacterium tuberculosis Infection in HIV-Infected Individuals","volume":"35","author":"Ly","year":"2015","journal-title":"J. Interferon Cytokine Res."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1097\/FJC.0b013e31827c0f02","article-title":"Oral pretreatment with liposomal glutathione attenuates reperfusion injury in rabbit isolated hearts","volume":"61","author":"Lauver","year":"2013","journal-title":"J. Cardiovasc. Pharm."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"3159","DOI":"10.1038\/nprot.2006.378","article-title":"Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method","volume":"1","author":"Rahman","year":"2006","journal-title":"Nat. Protoc."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.ab.2010.08.012","article-title":"Validation of high-performance liquid chromatographyboron-doped diamond detection for assessing hepatic glutathione redox status","volume":"407","author":"Park","year":"2010","journal-title":"Anal. Biochem."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0378-4347(01)00081-0","article-title":"Simultaneous determination of reduced and oxidized glutathione in peripheral blood mononuclear cells by liquid chromatography-electrospray mass spectrometry","volume":"757","author":"Camera","year":"2001","journal-title":"J. Chromatogr. B Biomed. Sci. Appl."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/11\/5\/1056\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T12:51:04Z","timestamp":1760187064000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/11\/5\/1056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,11]]},"references-count":209,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2019,5]]}},"alternative-id":["nu11051056"],"URL":"https:\/\/doi.org\/10.3390\/nu11051056","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,11]]}}}