{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T06:18:56Z","timestamp":1790489936068,"version":"4.1.0"},"reference-count":75,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T00:00:00Z","timestamp":1557878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011947","name":"Abbott Nutrition","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/100011947","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Preventing muscle wasting in certain chronic diseases including cancer is an ongoing challenge. Studies have shown that polyphenols derived from fruits and vegetables shows promise in reducing muscle loss in cellular and animal models of muscle wasting. We hypothesized that polyphenols derived from plums (Prunus domestica) could have anabolic and anti-catabolic benefits on skeletal muscle. The effects of a polyphenol-enriched plum extract (PE60) were evaluated in vitro on C2C12 and Colon-26 cancer cells. Data were analyzed using a one-way ANOVA and we found that treatment of myocytes with plum extract increased the cell size by ~3-fold (p &lt; 0.05) and stimulated myoblast differentiation by ~2-fold (p &lt; 0.05). Plum extract induced total protein synthesis by ~50% (p &lt; 0.05), reduced serum deprivation-induced total protein degradation by ~30% (p &lt; 0.05), and increased expression of Insulin-Like Growth Factor-1 (IGF-1) by ~2-fold (p &lt; 0.05). Plum extract also reduced tumor necrosis factor \u03b1 (TNF\u03b1)-induced nuclear factor \u03baB (NF\u03baB) activation by 80% (p &lt; 0.05) in A549\/NF-\u03baB-luc cells. In addition, plum extract inhibited the growth of Colon-26 cancer cells, and attenuated cytotoxicity in C2C12 myoblasts induced by soluble factors released from Colon-26 cells. In conclusion, our data suggests that plum extract may have pluripotent health benefits on muscle, due to its demonstrated ability to promote myogenesis, stimulate muscle protein synthesis, and inhibit protein degradation. It also appears to protect muscle cell from tumor-induced cytotoxicity.<\/jats:p>","DOI":"10.3390\/nu11051077","type":"journal-article","created":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T11:37:40Z","timestamp":1557920260000},"page":"1077","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Polyphenol-Enriched Plum Extract Enhances Myotubule Formation and Anabolism while Attenuating Colon Cancer-induced Cellular Damage in C2C12 Cells"],"prefix":"10.3390","volume":"11","author":[{"given":"Faten A.","family":"Alsolmei","sequence":"first","affiliation":[{"name":"Food Chemistry and Nutrition Science Research Laboratory, Agricultural Research Station, College of Agriculture, Petersburg, VA 23806, USA"},{"name":"Department of Biology, College of Natural and Health Sciences, Virginia State University, Petersburg, VA 23806, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiwen","family":"Li","sequence":"additional","affiliation":[{"name":"Food Chemistry and Nutrition Science Research Laboratory, Agricultural Research Station, College of Agriculture, Petersburg, VA 23806, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzette L.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Abbott-Nutrition Division, Research and Development, 3300 Stelzer Road, Columbus, OH 43219, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Padmavathy","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Valley Children\u2019s Hospital, Madera, CA 93636, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul W.","family":"Johns","sequence":"additional","affiliation":[{"name":"Abbott-Nutrition Division, Research and Development, 3300 Stelzer Road, Columbus, OH 43219, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafat A.","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Food Chemistry and Nutrition Science Research Laboratory, Agricultural Research Station, College of Agriculture, Petersburg, VA 23806, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,5,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/0002-9343(80)90254-5","article-title":"Protein calorie under-nutrition in hospitalized cancer patients","volume":"68","author":"Nixon","year":"1980","journal-title":"Am. 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