{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T17:19:49Z","timestamp":1769275189080,"version":"3.49.0"},"reference-count":48,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T00:00:00Z","timestamp":1558915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI18\/00921"],"award-info":[{"award-number":["PI18\/00921"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI15\/00285"],"award-info":[{"award-number":["PI15\/00285"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008666","name":"Fundaci\u00f3 la Marat\u00f3 de TV3","doi-asserted-by":"publisher","award":["Jorge Joven"],"award-info":[{"award-number":["Jorge Joven"]}],"id":[{"id":"10.13039\/100008666","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ag\u00e8ncia de Gesti\u00f3 d\u2019Ajuts Universitaris i de Recerca","award":["2017SGR436"],"award-info":[{"award-number":["2017SGR436"]}]},{"DOI":"10.13039\/501100007512","name":"Universitat Rovira i Virgili","doi-asserted-by":"publisher","award":["Mart\u00ed i Franqu\u00e8s 2016PMF-POST-02"],"award-info":[{"award-number":["Mart\u00ed i Franqu\u00e8s 2016PMF-POST-02"]}],"id":[{"id":"10.13039\/501100007512","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Foundation for Research and Development of the Department of Internal Medicine of the Franciscus Gasthuis","award":["Castro-Cabezas"],"award-info":[{"award-number":["Castro-Cabezas"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Postprandial lipemia can lead to an accumulation of atherogenic lipoproteins in the circulation associated with systemic low-grade inflammation and an increased risk of cardiovascular disease. Lifestyle and pharmacological treatments are usually prescribed for prevention. Vitamin D3 (cholecalciferol), as an anti-atherogenic agent, is being taken into consideration due to its potential beneficial effects in lipid metabolism and its anti-inflammatory potency. To assess the effects of vitamin D3 in the postprandial lipid profile in obese, vitamin D-deficient women, a non-targeted lipidomics approach using liquid chromatography coupled to a quadrupole time-of flight mass spectrometer was used to identify and quantitate a wide-range of circulating lipid species, including diglycerides, lysophosphatidylcholines, phosphatidylcholines, phosphatidylethanolamines, sphingomyelins and triglycerides. The most important changes were found in plasmatic sphingomyelin levels, which experience a decrease after vitamin D3 intake. Our results suggest a turnover of sphingomyelins, probably due to an increased activity of neutral sphingomyelinases, and, therefore, with implications in the clearance of chylomicrons, LDL and VLDL, decreasing postprandial inflammation and macrophage adherence to endothelia, potentially improving cardiovascular disease risk.<\/jats:p>","DOI":"10.3390\/nu11051194","type":"journal-article","created":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T11:19:27Z","timestamp":1558955967000},"page":"1194","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Effect of Vitamin D3 on the Postprandial Lipid Profile in Obese Patients: A Non-Targeted Lipidomics Study"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0147-1712","authenticated-orcid":false,"given":"Salvador","family":"Fern\u00e1ndez-Arroyo","sequence":"first","affiliation":[{"name":"Universitat Rovira i Virgili, Departament de Medicina i Cirurgia, Unitat de Recerca Biom\u00e8dica, C\/de l\u2019Escorxador S\/N, 43003 Tarragona, Spain"},{"name":"Campus of International Excellence Southern Catalonia, 43003 Tarragona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0954-295X","authenticated-orcid":false,"given":"Anna","family":"Hern\u00e1ndez-Aguilera","sequence":"additional","affiliation":[{"name":"Institut d\u2019investigaci\u00f3 Sanit\u00e0ria Pere Virgili, C\/de l\u2019Escorxador S\/N, 43003 Tarragona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marijke A.","family":"de Vries","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Center for Diabetes and Vascular Medicine, Franciscus Gasthuis &amp; Vietland, 3045 PM Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3935-1233","authenticated-orcid":false,"given":"Benjamin","family":"Burggraaf","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Center for Diabetes and Vascular Medicine, Franciscus Gasthuis &amp; Vietland, 3045 PM Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen","family":"van der Zwan","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, Franciscus Gasthuis &amp; Vietland, 3045 PM Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadine","family":"Pouw","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, Franciscus Gasthuis &amp; Vietland, 3045 PM Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Joven","sequence":"additional","affiliation":[{"name":"Universitat Rovira i Virgili, Departament de Medicina i Cirurgia, Unitat de Recerca Biom\u00e8dica, C\/de l\u2019Escorxador S\/N, 43003 Tarragona, Spain"},{"name":"Campus of International Excellence Southern Catalonia, 43003 Tarragona, Spain"},{"name":"Institut d\u2019investigaci\u00f3 Sanit\u00e0ria Pere Virgili, C\/de l\u2019Escorxador S\/N, 43003 Tarragona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Castro Cabezas","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Center for Diabetes and Vascular Medicine, Franciscus Gasthuis &amp; Vietland, 3045 PM Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,5,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.atherosclerosis.2015.10.025","article-title":"In vivo evidence for chylomicrons as mediators of postprandial inflammation","volume":"243","author":"Klop","year":"2015","journal-title":"Atherosclerosis"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/978-3-319-07320-0_12","article-title":"Postprandial inflammation: Targeting glucose and lipids","volume":"824","author":"Klop","year":"2014","journal-title":"Adv. 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