{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:56:12Z","timestamp":1790034972460,"version":"4.0.1"},"reference-count":104,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T00:00:00Z","timestamp":1559174400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Cardiovascular disease is a leading cause of death around the world. Overall diet quality and dietary behaviors are core contributors to metabolic health. While therapeutic targets have traditionally focused on levels of lipoprotein cholesterol when evaluating cardiovascular risk, current perspectives on high-density lipoprotein (HDL) have shifted to evaluating the functionality of this lipoprotein particle. Effects of diet on cardiovascular health are mediated through multiple pathways, but the impact on HDL composition and function deserves greater attention. Potential areas of investigation involve changes in particle characteristics, distribution, microRNA cargo, and other functional changes such as improvements to cholesterol efflux capacity. Various dietary patterns like the Mediterranean diet and Dietary Approaches to Stop Hypertension (DASH) diet have beneficial effects on cardiovascular health and may prevent cardiovascular events. These healthful dietary patterns tend to be rich in plant-based foods, with cardiovascular benefits likely resulting from synergistic effects of the individual dietary components. The purpose of this review is to summarize current perspectives on selected functions of HDL particles and how various dietary patterns affect cardiovascular health biomarkers, with a focus on HDL functionality.<\/jats:p>","DOI":"10.3390\/nu11061231","type":"journal-article","created":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T11:07:44Z","timestamp":1559214464000},"page":"1231","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Relationship Between HDL Functional Characteristics and Cardiovascular Health and Potential Impact of Dietary Patterns: A Narrative Review"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8586-2886","authenticated-orcid":false,"given":"Allison S.","family":"Bardagjy","sequence":"first","affiliation":[{"name":"Department of Nutrition and Graduate Group in Nutritional Biology, University of California, Davis, CA 95616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francene M.","family":"Steinberg","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Graduate Group in Nutritional Biology, University of California, Davis, CA 95616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,5,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e67","DOI":"10.1161\/CIR.0000000000000558","article-title":"Heart Disease and Stroke Statistics-2018 Update: A Report from the American Heart Association","volume":"137","author":"Benjamin","year":"2018","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nature10146","article-title":"Progress and challenges in translating the biology of atherosclerosis","volume":"473","author":"Libby","year":"2011","journal-title":"Nature"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1161\/CIRCULATIONAHA.106.676890","article-title":"Subendothelial lipoprotein retention as the initiating process in atherosclerosis: Update and therapeutic implications","volume":"116","author":"Tabas","year":"2007","journal-title":"Circulation"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1161\/CIRCULATIONAHA.109.192703","article-title":"Defining and setting national goals for cardiovascular health promotion and disease reduction: The American Heart Association\u2019s strategic Impact Goal through 2020 and beyond","volume":"121","author":"Hong","year":"2010","journal-title":"Circulation"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1161\/CIRCULATIONAHA.111.081083","article-title":"Ideal cardiovascular health predicts lower risks of myocardial infarction, stroke, and vascular death across whites, blacks, and hispanics: The northern Manhattan study","volume":"125","author":"Dong","year":"2012","journal-title":"Circulation"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1016\/j.jacc.2010.11.041","article-title":"Community prevalence of ideal cardiovascular health, by the American Heart Association definition, and relationship with cardiovascular disease incidence","volume":"57","author":"Folsom","year":"2011","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.jacc.2006.09.032","article-title":"Metabolic syndrome and risk of incident cardiovascular events and death: A systematic review and meta-analysis of longitudinal studies","volume":"49","author":"Gami","year":"2007","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1124\/pr.58.3.1","article-title":"Functionally defective high-density lipoprotein: A new therapeutic target at the crossroads of dyslipidemia, inflammation, and atherosclerosis","volume":"58","author":"Kontush","year":"2006","journal-title":"Pharmacol. Rev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/nrcardio.2015.124","article-title":"Dysfunctional HDL and atherosclerotic cardiovascular disease","volume":"13","author":"Rosenson","year":"2016","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1093\/cvr\/cvu164","article-title":"Spotlight on HDL biology: New insights in metabolism, function, and translation","volume":"103","author":"Rader","year":"2014","journal-title":"Cardiovasc. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1161\/ATVBAHA.117.307025","article-title":"From High-Density Lipoprotein Cholesterol to Measurements of Function: Prospects for the Development of Tests for High-Density Lipoprotein Functionality in Cardiovascular Disease","volume":"38","author":"Sacks","year":"2018","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1161\/01.RES.0000170946.56981.5c","article-title":"New insights into the regulation of HDL metabolism and reverse cholesterol transport","volume":"96","author":"Lewis","year":"2005","journal-title":"Circ. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.ecl.2014.08.001","article-title":"Beginning to understand high-density lipoproteins","volume":"43","author":"Badimon","year":"2014","journal-title":"Endocrinol. Metab. Clin. N. Am."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1097\/MOL.0000000000000446","article-title":"Time to ditch HDL-C as a measure of HDL function?","volume":"28","author":"Ronsein","year":"2017","journal-title":"Curr. Opin. Lipidol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.jacl.2013.08.001","article-title":"High-density lipoproteins: A consensus statement from the National Lipid Association","volume":"7","author":"Toth","year":"2013","journal-title":"J. Clin. Lipidol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1161\/CIRCRESAHA.117.311978","article-title":"Trials and Tribulations of CETP Inhibitors","volume":"122","author":"Tall","year":"2018","journal-title":"Circ. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.1161\/CIRCULATIONAHA.116.025678","article-title":"Cholesterol Efflux Capacity, High-Density Lipoprotein Particle Number, and Incident Cardiovascular Events: An Analysis from the JUPITER Trial (Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin)","volume":"135","author":"Khera","year":"2017","journal-title":"Circulation"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1001\/jama.299.21.2524","article-title":"Association of loss-of-function mutations in the ABCA1 gene with high-density lipoprotein cholesterol levels and risk of ischemic heart disease","volume":"299","author":"Nordestgaard","year":"2008","journal-title":"JAMA"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1093\/eurheartj\/ehp145","article-title":"The T111I variant in the endothelial lipase gene and risk of coronary heart disease in three independent populations","volume":"30","author":"Jensen","year":"2009","journal-title":"Eur. Heart J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1038\/nm.2937","article-title":"The not-so-simple HDL story: Is it time to revise the HDL cholesterol hypothesis?","volume":"18","author":"Rader","year":"2012","journal-title":"Nat. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1373\/clinchem.2010.155333","article-title":"HDL measures, particle heterogeneity, proposed nomenclature, and relation to atherosclerotic cardiovascular events","volume":"57","author":"Rosenson","year":"2011","journal-title":"Clin. Chem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"24020","DOI":"10.1074\/jbc.R114.583658","article-title":"Molecular mechanisms of cellular cholesterol efflux","volume":"289","author":"Phillips","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/eurheartj\/ehp399","article-title":"Cholesteryl ester transfer protein: At the heart of the action of lipid-modulating therapy with statins, fibrates, niacin, and cholesteryl ester transfer protein inhibitors","volume":"31","author":"Chapman","year":"2010","journal-title":"Eur. Heart J."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s11883-011-0171-6","article-title":"Lecithin cholesterol acyltransferase: An anti- or pro-atherogenic factor?","volume":"13","author":"Rousset","year":"2011","journal-title":"Curr. Atheroscler. Rep."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1194\/jlr.R027011","article-title":"New molecular insights into CETP structure and function: A review","volume":"53","author":"Charles","year":"2012","journal-title":"J. Lipid Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1007\/s11883-011-0177-0","article-title":"Experimental models for the investigation of high-density lipoprotein-mediated cholesterol efflux","volume":"13","author":"Giannarelli","year":"2011","journal-title":"Curr. Atheroscler. Rep."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1056\/NEJMoa1001689","article-title":"Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis","volume":"364","author":"Khera","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1056\/NEJMoa1409065","article-title":"HDL cholesterol efflux capacity and incident cardiovascular events","volume":"371","author":"Rohatgi","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1161\/ATVBAHA.115.305504","article-title":"High-Density Lipoprotein (HDL) Phospholipid Content and Cholesterol Efflux Capacity Are Reduced in Patients with Very High HDL Cholesterol and Coronary Disease","volume":"35","author":"Agarwala","year":"2015","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.atherosclerosis.2015.08.027","article-title":"HDL: Quality or quantity?","volume":"243","year":"2015","journal-title":"Atherosclerosis"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1194\/jlr.M075648","article-title":"Influence of HDL particles on cell-cholesterol efflux under various pathological conditions","volume":"58","author":"Asztalos","year":"2017","journal-title":"J. Lipid Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s11883-006-0065-1","article-title":"Oxidized low-density lipoprotein biomarkers in atherosclerosis","volume":"8","author":"Tsimikas","year":"2006","journal-title":"Curr. Atheroscler. Rep."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1194\/jlr.P030601","article-title":"Dietary cholesterol increases paraoxonase 1 enzyme activity","volume":"53","author":"Kim","year":"2012","journal-title":"J. Lipid Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.jacc.2006.03.057","article-title":"Is plasma oxidized low-density lipoprotein, measured with the widely used antibody 4E6, an independent predictor of coronary heart disease among, U.S. men and women?","volume":"48","author":"Wu","year":"2006","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1161\/hc0102.102847","article-title":"Increased plasma C-reactive protein in familial hypoalphalipoproteinemia: A proinflammatory condition?","volume":"105","author":"Sampietro","year":"2002","journal-title":"Circulation"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.beem.2014.01.003","article-title":"Strategies for vascular disease prevention: The role of lipids and related markers including apolipoproteins, low-density lipoproteins (LDL)-particle size, high sensitivity C-reactive protein (hs-CRP), lipoprotein-associated phospholipase A2 (Lp-PLA(2)) and lipoprotein(a) (Lp(a))","volume":"28","author":"Dallmeier","year":"2014","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1161\/01.CIR.0000142055.53122.FA","article-title":"Circulating mononuclear cells in the obese are in a proinflammatory state","volume":"110","author":"Ghanim","year":"2004","journal-title":"Circulation"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1056\/NEJMoa1107477","article-title":"C-reactive protein, fibrinogen, and cardiovascular disease prediction","volume":"367","author":"Kaptoge","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1194\/jlr.R400017-JLR200","article-title":"Thematic review series: The immune system and atherogenesis. Lipoprotein-associated inflammatory proteins: Markers or mediators of cardiovascular disease?","volume":"46","author":"Chait","year":"2005","journal-title":"J. Lipid Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/S0022-2275(20)39863-1","article-title":"Serum amyloid A (SAA): Influence on HDL-mediated cellular cholesterol efflux","volume":"36","author":"Banka","year":"1995","journal-title":"J. Lipid Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.bbrc.2016.04.092","article-title":"Heparin interactions with apoA1 and SAA in inflammation-associated HDL","volume":"474","author":"Digre","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/89986","article-title":"High-density lipoprotein binding to scavenger receptor-BI activates endothelial nitric oxide synthase","volume":"7","author":"Yuhanna","year":"2001","journal-title":"Nat. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1172\/JCI200421072","article-title":"HDL action on the vascular wall: Is the answer NO?","volume":"113","author":"Shaul","year":"2004","journal-title":"J. Clin. Investig."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.1161\/01.CIR.0000070934.69310.1A","article-title":"Restoration of endothelial function by increasing high-density lipoprotein in subjects with isolated low high-density lipoprotein","volume":"107","author":"Bisoendial","year":"2003","journal-title":"Circulation"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1161\/01.RES.0000199272.59432.5b","article-title":"High-density lipoprotein promotes endothelial cell migration and reendothelialization via scavenger receptor-B type I","volume":"98","author":"Seetharam","year":"2006","journal-title":"Circ. Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1007\/s11936-010-0075-8","article-title":"Thrombi of different pathologies: Implications for diagnosis and treatment","volume":"12","author":"Bayon","year":"2010","journal-title":"Curr. Treat. Options Cardiovasc. Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1161\/CIRCULATIONAHA.109.870709","article-title":"Reconstituted high-density lipoprotein attenuates platelet function in individuals with type 2 diabetes mellitus by promoting cholesterol efflux","volume":"120","author":"Calkin","year":"2009","journal-title":"Circulation"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1172\/JCI5006","article-title":"High-density lipoprotein enhancement of anticoagulant activities of plasma protein S and activated protein C","volume":"103","author":"Griffin","year":"1999","journal-title":"J. Clin. Investig."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1161\/01.RES.0000225982.01988.93","article-title":"Endothelial and antithrombotic actions of HDL","volume":"98","author":"Mineo","year":"2006","journal-title":"Circ. Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1161\/CIRCULATIONAHA.105.607135","article-title":"High-density lipoproteins and their constituent, sphingosine-1-phosphate, directly protect the heart against ischemia\/reperfusion injury in vivo via the S1P3 lysophospholipid receptor","volume":"114","author":"Theilmeier","year":"2006","journal-title":"Circulation"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1161\/CIRCULATIONAHA.115.012427","article-title":"Sphingosine-1-Phosphate Receptor Agonist Fingolimod Increases Myocardial Salvage and Decreases Adverse Postinfarction Left Ventricular Remodeling in a Porcine Model of Ischemia\/Reperfusion","volume":"133","author":"Vahl","year":"2016","journal-title":"Circulation"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1161\/CIRCULATIONAHA.108.843219","article-title":"High-density lipoprotein modulates glucose metabolism in patients with type 2 diabetes mellitus","volume":"119","author":"Drew","year":"2009","journal-title":"Circulation"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1007\/s00125-007-0752-7","article-title":"Apolipoprotein A-I stimulates AMP-activated protein kinase and improves glucose metabolism","volume":"50","author":"Han","year":"2007","journal-title":"Diabetologia"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nrendo.2011.235","article-title":"The emerging role of HDL in glucose metabolism","volume":"8","author":"Drew","year":"2012","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/ncb2210","article-title":"MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins","volume":"13","author":"Vickers","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Niculescu, L.S., Simionescu, N., Sanda, G.M., Carnuta, M.G., Stancu, C.S., Popescu, A.C., Popescu, M.R., Vlad, A., Dimulescu, D.R., and Simionescu, M. (2015). MiR-486 and miR-92a Identified in Circulating HDL Discriminate between Stable and Vulnerable Coronary Artery Disease Patients. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0140958"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"3292","DOI":"10.1038\/ncomms4292","article-title":"HDL-transferred microRNA-223 regulates ICAM-1 expression in endothelial cells","volume":"5","author":"Tabet","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1161\/CIRCULATIONAHA.115.018585","article-title":"Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review","volume":"133","author":"Mozaffarian","year":"2016","journal-title":"Circulation"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2870","DOI":"10.1161\/CIRCULATIONAHA.110.968735","article-title":"Components of a cardioprotective diet: New insights","volume":"123","author":"Mozaffarian","year":"2011","journal-title":"Circulation"},{"key":"ref_60","unstructured":"Dietary Guidelines Advisory Committee (2015). Scientific Report of the 2015 Dietary Guidelines Advisory Committee."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1161\/CIRCULATIONAHA.116.023712","article-title":"Mediterranean Diet Improves High-Density Lipoprotein Function in High-Cardiovascular-Risk Individuals: A Randomized Controlled Trial","volume":"135","author":"Hernaez","year":"2017","journal-title":"Circulation"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"e34","DOI":"10.1056\/NEJMoa1800389","article-title":"Primary Prevention of Cardiovascular Disease with a Mediterranean Diet Supplemented with Extra-Virgin Olive Oil or Nuts","volume":"378","author":"Estruch","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1146\/annurev-food-032217-020802","article-title":"Advances in Understanding the Molecular Basis of the Mediterranean Diet Effect","volume":"9","author":"Corella","year":"2018","journal-title":"Annu. Rev. Food Sci. Technol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1001\/jama.292.12.1440","article-title":"Effect of a mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: A randomized trial","volume":"292","author":"Esposito","year":"2004","journal-title":"JAMA"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.3945\/ajcn.116.146803","article-title":"A Mediterranean diet lowers blood pressure and improves endothelial function: Results from the MedLey randomized intervention trial","volume":"105","author":"Davis","year":"2017","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"263","DOI":"10.3945\/ajcn.2008.27290","article-title":"Close adherence to a Mediterranean diet improves endothelial function in subjects with abdominal obesity","volume":"90","author":"Rallidis","year":"2009","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.clnesp.2016.11.002","article-title":"Short-term effects of Mediterranean-type diet intervention on soluble cellular adhesion molecules in subjects with abdominal obesity","volume":"17","author":"Rallidis","year":"2017","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1096\/fj.09-148452","article-title":"In vivo nutrigenomic effects of virgin olive oil polyphenols within the frame of the Mediterranean diet: A randomized controlled trial","volume":"24","author":"Konstantinidou","year":"2010","journal-title":"FASEB J."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1001\/archinte.167.11.1195","article-title":"Effect of a traditional Mediterranean diet on lipoprotein oxidation: A randomized controlled trial","volume":"167","author":"Fito","year":"2007","journal-title":"Arch. Intern. Med."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.atherosclerosis.2013.08.014","article-title":"Mediterranean diet supplemented with nuts reduces waist circumference and shifts lipoprotein subfractions to a less atherogenic pattern in subjects at high cardiovascular risk","volume":"230","author":"Damasceno","year":"2013","journal-title":"Atherosclerosis"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.3945\/jn.115.229476","article-title":"Long-Term Immunomodulatory Effects of a Mediterranean Diet in Adults at High Risk of Cardiovascular Disease in the PREvencion con DIeta MEDiterranea (PREDIMED) Randomized Controlled Trial","volume":"146","author":"Casas","year":"2016","journal-title":"J. Nutr."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s00394-015-1060-5","article-title":"A Mediterranean diet supplemented with extra virgin olive oil or nuts improves endothelial markers involved in blood pressure control in hypertensive women","volume":"56","author":"Storniolo","year":"2017","journal-title":"Eur. J. Nutr."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7326\/0003-4819-145-1-200607040-00004","article-title":"Effects of a Mediterranean-style diet on cardiovascular risk factors: A randomized trial","volume":"145","author":"Estruch","year":"2006","journal-title":"Ann. Intern. Med."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.3945\/jn.117.248419","article-title":"A Mediterranean Diet Reduces F2-Isoprostanes and Triglycerides among Older Australian Men and Women after 6 Months","volume":"147","author":"Davis","year":"2017","journal-title":"J. Nutr."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/s11745-013-3780-8","article-title":"Egg consumption modulates HDL lipid composition and increases the cholesterol-accepting capacity of serum in metabolic syndrome","volume":"48","author":"Andersen","year":"2013","journal-title":"Lipids"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.atherosclerosis.2009.10.002","article-title":"HDL superphospholipidation enhances key steps in reverse cholesterol transport","volume":"209","author":"Tchoua","year":"2010","journal-title":"Atherosclerosis"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"e1800847","DOI":"10.1002\/mnfr.201800847","article-title":"Increased Consumption of Virgin Olive Oil, Nuts, Legumes, Whole Grains, and Fish Promotes HDL Functions in Humans","volume":"63","author":"Hernaez","year":"2019","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1700445","DOI":"10.1002\/mnfr.201700445","article-title":"Determinants of HDL Cholesterol Efflux Capacity after Virgin Olive Oil Ingestion: Interrelationships with Fluidity of HDL Monolayer","volume":"61","author":"Rubio","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jnutbio.2012.03.015","article-title":"Lycopene intervention reduces inflammation and improves HDL functionality in moderately overweight middle-aged individuals","volume":"24","author":"McEneny","year":"2013","journal-title":"J. Nutr. Biochem."},{"key":"ref_80","unstructured":"Sawrey-Kubicek, L., Zhu, C., Bardagjy, A.S., Rhodes, C.H., Sacchi, R., Randolph, J.M., Steinberg, F.M., and Zivkovic, A.M. (2019). Egg consumption without weight loss or carbohydrate restriction increases the cholesterol efflux capacity of high-density lipoproteins in overweight, postmenopausal women. Am. J. Clin. Nutr., in press."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.3945\/jn.116.245126","article-title":"Inclusion of Almonds in a Cholesterol-Lowering Diet Improves Plasma HDL Subspecies and Cholesterol Efflux to Serum in Normal-Weight Individuals with Elevated LDL Cholesterol","volume":"147","author":"Berryman","year":"2017","journal-title":"J. Nutr."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"788","DOI":"10.3945\/jn.112.170993","article-title":"Acute consumption of walnuts and walnut components differentially affect postprandial lipemia, endothelial function, oxidative stress, and cholesterol efflux in humans with mild hypercholesterolemia","volume":"143","author":"Berryman","year":"2013","journal-title":"J. Nutr."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1056\/NEJM199704173361601","article-title":"A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group","volume":"336","author":"Appel","year":"1997","journal-title":"N. Engl. J. Med."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1007\/s11883-006-0020-1","article-title":"The effects of macronutrients on blood pressure and lipids: An overview of the DASH and OmniHeart trials","volume":"8","author":"Miller","year":"2006","journal-title":"Curr. Atheroscler. Rep."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1001\/jama.294.19.2455","article-title":"Effects of protein, monounsaturated fat, and carbohydrate intake on blood pressure and serum lipids: Results of the OmniHeart randomized trial","volume":"294","author":"Appel","year":"2005","journal-title":"JAMA"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"302","DOI":"10.3945\/ajcn.115.111757","article-title":"Dietary Approaches to Stop Hypertension diet retains effectiveness to reduce blood pressure when lean pork is substituted for chicken and fish as the predominant source of protein","volume":"102","author":"Sayer","year":"2015","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S0007114514003341","article-title":"Effects of the Dietary Approach to Stop Hypertension (DASH) diet on cardiovascular risk factors: A systematic review and meta-analysis","volume":"113","author":"Siervo","year":"2015","journal-title":"Br. J. Nutr."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"341","DOI":"10.3945\/ajcn.115.123281","article-title":"Comparison of the DASH (Dietary Approaches to Stop Hypertension) diet and a higher-fat DASH diet on blood pressure and lipids and lipoproteins: A randomized controlled trial","volume":"103","author":"Chiu","year":"2016","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1093\/ajcn\/74.1.80","article-title":"Effects on blood lipids of a blood pressure-lowering diet: The Dietary Approaches to Stop Hypertension (DASH) Trial","volume":"74","author":"Obarzanek","year":"2001","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3945\/ajcn.111.016261","article-title":"Beef in an Optimal Lean Diet study: Effects on lipids, lipoproteins, and apolipoproteins","volume":"95","author":"Roussell","year":"2012","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Chiavaroli, L., Viguiliouk, E., Nishi, S.K., and Blanco Mejia, S. (2019). DASH Dietary Pattern and Cardiometabolic Outcomes: An Umbrella Review of Systematic Reviews and Meta-Analyses. Nutrients, 11.","DOI":"10.3390\/nu11020338"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"472396","DOI":"10.1155\/2012\/472396","article-title":"Blood Pressure-Lowering Mechanisms of the DASH Dietary Pattern","volume":"2012","author":"Lin","year":"2012","journal-title":"J. Nutr. Metab."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1001\/archinternmed.2009.470","article-title":"Effects of the DASH diet alone and in combination with exercise and weight loss on blood pressure and cardiovascular biomarkers in men and women with high blood pressure: The ENCORE study","volume":"170","author":"Blumenthal","year":"2010","journal-title":"Arch. Intern. Med."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.3945\/jn.110.136739","article-title":"The Dietary Approaches to Stop Hypertension eating plan affects C-reactive protein, coagulation abnormalities, and hepatic function tests among type 2 diabetic patients","volume":"141","author":"Azadbakht","year":"2011","journal-title":"J. Nutr."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1161\/01.HYP.0000053450.19998.11","article-title":"DASH diet lowers blood pressure and lipid-induced oxidative stress in obesity","volume":"41","author":"Lopes","year":"2003","journal-title":"Hypertension"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s11883-019-0770-1","article-title":"Dietary Patterns and Cardiovascular Disease: Insights and Challenges for Considering Food Groups and Nutrient Sources","volume":"21","author":"Tapsell","year":"2019","journal-title":"Curr. Atheroscler. Rep."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1017\/S0007114515003177","article-title":"Dietary patterns and CVD: A systematic review and meta-analysis of observational studies","volume":"114","author":"Sanchez","year":"2015","journal-title":"Br. J. Nutr."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.numecd.2008.06.005","article-title":"Dietary patterns and 5-year incidence of cardiovascular disease: A multivariate analysis of the ATTICA study","volume":"19","author":"Panagiotakos","year":"2009","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"647","DOI":"10.3945\/ajcn.2009.27597","article-title":"Dietary patterns and incident cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis","volume":"90","author":"Nettleton","year":"2009","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1093\/ajcn\/nqy151","article-title":"Food groups and intermediate disease markers: A systematic review and network meta-analysis of randomized trials","volume":"108","author":"Schwingshackl","year":"2018","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s11883-019-0779-5","article-title":"Plant-Based Diets for Cardiovascular Disease Prevention: All Plant Foods Are Not Created Equal","volume":"21","author":"Hemler","year":"2019","journal-title":"Curr. Atheroscler. Rep."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"3640","DOI":"10.1080\/10408398.2016.1138447","article-title":"Vegetarian, vegan diets and multiple health outcomes: A systematic review with meta-analysis of observational studies","volume":"57","author":"Dinu","year":"2017","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"E460","DOI":"10.1152\/ajpendo.00127.2018","article-title":"Impact of a one-year lifestyle modification program on cholesterol efflux capacities in men with abdominal obesity and dyslipidemia","volume":"315","author":"Boyer","year":"2018","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.3945\/jn.113.175273","article-title":"Changes in both global diet quality and physical activity level synergistically reduce visceral adiposity in men with features of metabolic syndrome","volume":"143","author":"Nazare","year":"2013","journal-title":"J. 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