{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T04:03:13Z","timestamp":1789790593889,"version":"4.0.1"},"reference-count":78,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T00:00:00Z","timestamp":1561680000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Oral diabetes-specific nutritional supplements (ONS-D) induce favourable postprandial responses in subjects with type 2 diabetes (DM2), but they have not been correlated yet with incretin release and subjective appetite (SA). This randomised, double-blind, cross-over study compared postprandial effects of ONS-D with isomaltulose and sucromalt versus standard formula (ET) on glycaemic index (GI), insulin, glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide 1 (GLP-1) and SA in 16 individuals with DM2. After overnight fasting, subjects consumed a portion of supplements containing 25 g of carbohydrates or reference food. Blood samples were collected at baseline and at 30, 60, 90, 120, 150 and 180 min; and SA sensations were assessed by a visual analogue scale on separate days. Glycaemic index values were low for ONS-D and intermediate for ET (p &lt; 0.001). The insulin area under the curve (AUC0\u2013180 min) (p &lt; 0.02) and GIP AUC (p &lt; 0.02) were lower after ONS-D and higher GLP-1 AUC when compared with ET (p &lt; 0.05). Subjective appetite AUC was greater after ET than ONS-D (p &lt; 0.05). Interactions between hormones, hunger, fullness and GI were found, but not within the ratings of SA; isomaltulose and sucromalt may have influenced these factors.<\/jats:p>","DOI":"10.3390\/nu11071477","type":"journal-article","created":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T11:20:26Z","timestamp":1561720826000},"page":"1477","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Effect of Oral Nutritional Supplements with Sucromalt and Isomaltulose versus Standard Formula on Glycaemic Index, Entero-Insular Axis Peptides and Subjective Appetite in Patients with Type 2 Diabetes: A Randomised Cross-Over Study"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7860-5112","authenticated-orcid":false,"given":"Lisse","family":"Angarita D\u00e1vila","sequence":"first","affiliation":[{"name":"Escuela de Nutrici\u00f3n y Diet\u00e9tica, Facultad de Medicina, Universidad Andres Bello, Sede Concepci\u00f3n 4260000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1880-8887","authenticated-orcid":false,"given":"Valmore","family":"Berm\u00fadez","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Salud, Universidad Sim\u00f3n Bol\u00edvar, Barranquilla 080003, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Aparicio","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Endocrino-Metab\u00f3licas \u201cDr. F\u00e9lix G\u00f3mez\u201d, Escuela de Medicina. Facultad de Medicina, Universidad del Zulia, Maracaibo 4001, Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"C\u00e9spedes","sequence":"additional","affiliation":[{"name":"Departamento de Medicina F\u00edsica y Rehabilitaci\u00f3n, Hospital \u201c12 de Octubre\u201d, Madrid 28041, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma.","family":"Escobar","sequence":"additional","affiliation":[{"name":"Escuela de Nutrici\u00f3n y Diet\u00e9tica, Facultad de Medicina, Universidad Andres Bello, Sede Concepci\u00f3n 4260000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Dur\u00e1n-Ag\u00fcero","sequence":"additional","affiliation":[{"name":"Escuela de Nutrici\u00f3n y Diet\u00e9tica, Facultad de Ciencias para el Cuidado de la Salud, Universidad San Sebasti\u00e1n, Santiago 7500000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana","family":"Cisternas","sequence":"additional","affiliation":[{"name":"Escuela de Salud, Universidad Tecnol\u00f3gica de Chile, INACAP, Sede Concepci\u00f3n, Talcahuano 4260000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"de Assis Costa","sequence":"additional","affiliation":[{"name":"Faculty of Medicine\/UniFAGOC, Ub\u00e1 36506-022, Minas Gerais, Brazil"},{"name":"Universidade do Estado de Minas Gerais (UEMG), Barbacena 36202-284, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Rojas-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Escuela de Nutrici\u00f3n y Diet\u00e9tica, Facultad de Medicina, Universidad Andres Bello, Santiago 8370321, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Reyna","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Endocrino-Metab\u00f3licas \u201cDr. F\u00e9lix G\u00f3mez\u201d, Escuela de Medicina. 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