{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:53:18Z","timestamp":1791917598966,"version":"4.3.4"},"reference-count":176,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2019,6,29]],"date-time":"2019-06-29T00:00:00Z","timestamp":1561766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["F4605"],"award-info":[{"award-number":["F4605"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Cow\u2019s milk is one of the most important and basic nutrients introduced early in life in our diet but can induce IgE-associated allergy. IgE-associated allergy to cow\u2019s milk can cause severe allergic manifestations in the gut, skin and even in the respiratory tract and may lead to life-threatening anaphylactic shock due to the stability of certain cow\u2019s milk allergens. Here, we provide an overview about the allergen molecules in cow\u2019s milk and the advantages of the molecular diagnosis of IgE sensitization to cow\u2019s milk by serology. In addition, we review current strategies for prevention and treatment of cow\u2019s milk allergy and discuss how they could be improved in the future by innovative molecular approaches that are based on defined recombinant allergens, recombinant hypoallergenic allergen derivatives and synthetic peptides.<\/jats:p>","DOI":"10.3390\/nu11071492","type":"journal-article","created":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T03:23:59Z","timestamp":1561951439000},"page":"1492","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Molecular Approaches for Diagnosis, Therapy and Prevention of Cow\u2019s Milk Allergy"],"prefix":"10.3390","volume":"11","author":[{"given":"Birgit","family":"Linhart","sequence":"first","affiliation":[{"name":"Department of Pathophysiology and Allergy Research, Medical University of Vienna, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphaela","family":"Freidl","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Allergy Research, Medical University of Vienna, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Elisyutina","sequence":"additional","affiliation":[{"name":"NRC Institute of Immunology FMBA of Russia, 115478 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Musa","family":"Khaitov","sequence":"additional","affiliation":[{"name":"NRC Institute of Immunology FMBA of Russia, 115478 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1930-5424","authenticated-orcid":false,"given":"Alexander","family":"Karaulov","sequence":"additional","affiliation":[{"name":"Laboratory of Immunopathology, Department of Clinical Immunology and Allergy, Sechenov First Moscow State Medical University, 119435 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf","family":"Valenta","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Allergy Research, Medical University of Vienna, 1090 Vienna, Austria"},{"name":"NRC Institute of Immunology FMBA of Russia, 115478 Moscow, Russia"},{"name":"Laboratory of Immunopathology, Department of Clinical Immunology and Allergy, Sechenov First Moscow State Medical University, 119435 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,6,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1053\/j.gastro.2015.02.006","article-title":"Food allergies: The basics","volume":"148","author":"Valenta","year":"2015","journal-title":"Gastroenterology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1097\/WOX.0b013e3181defeb9","article-title":"World Allergy Organization (WAO) Diagnosis and Rationale for Action against Cow\u2019s Milk Allergy (DRACMA) Guidelines","volume":"3","author":"Fiocchi","year":"2010","journal-title":"World Allergy Organ. 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