{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T03:13:25Z","timestamp":1791947605599,"version":"4.3.4"},"reference-count":53,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T00:00:00Z","timestamp":1562544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Southern Queensland Research and Innovation Division","award":["SRF09"],"award-info":[{"award-number":["SRF09"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Nanoparticle formulations improve bioavailability and so may allow low-dose formulations of food-derived compounds such as curcumin to attenuate chronic systemic disease despite intrinsically low oral bioavailability. The current study induced metabolic syndrome in male Wistar rats aged eight\u2013nine weeks using a high-carbohydrate, high-fat diet (H) with corn starch diet (C) as control. Using a reversal protocol, rats were given curcumin as either nanoparticles encapsulated in poly(lactic\u2013co\u2013glycolic acid) (5 mg\/kg\/day, HCNP) or as an unformulated low dose or high-dose suspension in water (low-dose, 5 mg\/kg\/day, HC5; high-dose, 100 mg\/kg\/day, HC100) or blank nanoparticles (HBNP) for the final eight weeks of the 16 week study. We analysed cardiovascular parameters including systolic blood pressure and left ventricular diastolic stiffness along with histopathology, liver parameters including plasma liver enzymes, histopathology and metabolic parameters, including glucose tolerance, blood lipid profile and body composition, and plasma curcumin concentrations. HC100 and HCNP but not HBNP normalised systolic blood pressure (C = 120 \u00b1 4; H = 143 \u00b1 5; HBNP = 141 \u00b1 3; HC5 = 143 \u00b1 4; HC100 = 126 \u00b1 4; HCNP = 128 \u00b1 4 mmHg), left ventricular diastolic stiffness and liver fat deposition. No other improvements were induced in HC100 or HCNP or other intervention groups (HC5 and HBNP). We conclude that 5 mg\/kg\/day curcumin nanoparticles in H rats showed similar improvements in cardiovascular function as 100 mg\/kg\/day unformulated curcumin correlating with similar plasma curcumin concentrations.<\/jats:p>","DOI":"10.3390\/nu11071542","type":"journal-article","created":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T11:02:37Z","timestamp":1562583757000},"page":"1542","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Low-Dose Curcumin Nanoparticles Normalise Blood Pressure in Male Wistar Rats with Diet-Induced Metabolic Syndrome"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2164-0819","authenticated-orcid":false,"given":"Ryan","family":"du Preez","sequence":"first","affiliation":[{"name":"Functional Foods Research Group, University of Southern Queensland, Toowoomba, QLD 4350, Australia"},{"name":"School of Health and Wellbeing, University of Southern Queensland, Toowoomba, QLD 4350, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Pahl","sequence":"additional","affiliation":[{"name":"Functional Foods Research Group, University of Southern Queensland, Toowoomba, QLD 4350, Australia"},{"name":"School of Health and Wellbeing, University of Southern Queensland, Toowoomba, QLD 4350, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meenakshi","family":"Arora","sequence":"additional","affiliation":[{"name":"Texas A&amp;M Rangel College of Pharmacy, Texas A&amp;M University\u2013College Station, TX 77843, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. N. V.","family":"Ravi Kumar","sequence":"additional","affiliation":[{"name":"Texas A&amp;M Rangel College of Pharmacy, Texas A&amp;M University\u2013College Station, TX 77843, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7837-991X","authenticated-orcid":false,"given":"Lindsay","family":"Brown","sequence":"additional","affiliation":[{"name":"Functional Foods Research Group, University of Southern Queensland, Toowoomba, QLD 4350, Australia"},{"name":"School of Health and Wellbeing, University of Southern Queensland, Toowoomba, QLD 4350, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5464-3376","authenticated-orcid":false,"given":"Sunil K.","family":"Panchal","sequence":"additional","affiliation":[{"name":"Functional Foods Research Group, University of Southern Queensland, Toowoomba, QLD 4350, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,7,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Hewlings, S.J., and Kalman, D.S. (2017). Curcumin: A review of its\u2019 effects on human health. Foods, 6.","DOI":"10.3390\/foods6100092"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Sundar Dhilip Kumar, S., Houreld, N.N., and Abrahamse, H. (2018). Therapeutic potential and recent advances of curcumin in the treatment of aging-associated diseases. Molecules, 23.","DOI":"10.3390\/molecules23040835"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/biof.1041","article-title":"Molecular mechanisms of curcumin action: Gene expression","volume":"39","author":"Shishodia","year":"2013","journal-title":"Biofactors"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1021\/acs.jmedchem.6b00975","article-title":"The essential medicinal chemistry of curcumin","volume":"60","author":"Nelson","year":"2017","journal-title":"J. Med. Chem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.ejmech.2018.12.016","article-title":"The therapeutic potential of curcumin: A review of clinical trials","volume":"163","author":"Salehi","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.3389\/fpls.2016.01507","article-title":"Development of prediction model and experimental validation in predicting the curcumin content of turmeric (Curcuma longa L.)","volume":"7","author":"Akbar","year":"2016","journal-title":"Front. Plant Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jchromb.2007.03.010","article-title":"Oral bioavailability of curcumin in rat and the herbal analysis from Curcuma longa by LC-MS\/MS","volume":"853","author":"Yang","year":"2007","journal-title":"J. Chromatogr. B"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.jnutbio.2013.10.002","article-title":"Application of nanotechnology in improving bioavailability and bioactivity of diet-derived phytochemicals","volume":"25","author":"Wang","year":"2014","journal-title":"J. Nutr. Biochem."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4143\/crt.2014.46.1.2","article-title":"Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: The golden pigment from golden spice","volume":"46","author":"Prasad","year":"2014","journal-title":"Cancer Res. Treat."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"6027","DOI":"10.2147\/IJN.S132434","article-title":"Liposomal curcumin and its application in cancer","volume":"12","author":"Feng","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1007\/s00394-016-1376-9","article-title":"Analysis of different innovative formulations of curcumin for improved relative oral bioavailability in human subjects","volume":"57","author":"Purpura","year":"2018","journal-title":"Eur. J. Nutr."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.ejps.2009.02.019","article-title":"Nanoparticle encapsulation improves oral bioavailability of curcumin by at least 9-fold when compared to curcumin administered with piperine as absorption enhancer","volume":"37","author":"Shaikh","year":"2009","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"694","DOI":"10.3109\/1061186X.2016.1157883","article-title":"Oral bioavailability of curcumin: Problems and advancements","volume":"24","author":"Liu","year":"2016","journal-title":"J. Drug Target."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/obr.12229","article-title":"Metabolic syndrome: A closer look at the growing epidemic and its associated pathologies","volume":"16","year":"2015","journal-title":"Obes. Rev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"160287","DOI":"10.5888\/pcd14.160287","article-title":"Metabolic syndrome prevalence by race\/ethnicity and sex in the United States, National Health and Nutrition Examination Survey, 1988\u20132012","volume":"14","author":"Moore","year":"2017","journal-title":"Prev. Chronic Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1111\/obr.12313","article-title":"Functional foods as potential therapeutic options for metabolic syndrome","volume":"16","author":"Brown","year":"2015","journal-title":"Obes. Rev."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1111\/bph.13816","article-title":"Nano-curcumin safely prevents streptozotocin-induced inflammation and apoptosis in pancreatic beta cells for effective management of Type 1 diabetes mellitus","volume":"174","author":"Ganugula","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.colsurfb.2012.06.024","article-title":"Pharmacokinetics of curcumin-loaded PLGA and PLGA\u2013PEG blend nanoparticles after oral administration in rats","volume":"101","author":"Khalil","year":"2013","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Grama, C.N., Suryanarayana, P., Patil, M.A., Raghu, G., Balakrishna, N., Kumar, M.N., and Reddy, G.B. (2013). Efficacy of biodegradable curcumin nanoparticles in delaying cataract in diabetic rat model. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0078217"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1615\/CritRevTherDrugCarrierSyst.v21.i5.20","article-title":"PLGA nanoparticles in drug delivery: The state of the art","volume":"21","author":"Bala","year":"2004","journal-title":"Crit. Rev. Ther. Drug Carr. Syst."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Vallianou, N., Stratigou, T., Christodoulatos, G.S., and Dalamaga, M. (2019). Understanding the role of the gut microbiome and microbial metabolites in obesity and obesity-associated metabolic disorders: Current evidence and perspectives. Curr. Obes. Rep.","DOI":"10.1007\/s13679-019-00352-2"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.3389\/fmicb.2017.02146","article-title":"Balancing herbal medicine and functional food for prevention and treatment of cardiometabolic diseases through modulating gut microbiota","volume":"8","author":"Lyu","year":"2017","journal-title":"Front. Microbiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1097\/FJC.0b013e3181feb90a","article-title":"High-carbohydrate high-fat diet-induced metabolic syndrome and cardiovascular remodeling in rats","volume":"57","author":"Panchal","year":"2011","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"46457","DOI":"10.1038\/srep46457","article-title":"Saturated fatty acids induce development of both metabolic syndrome and osteoarthritis in rats","volume":"7","author":"Sekar","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Wanyonyi, S., du Preez, R., Brown, L., Paul, N.A., and Panchal, S.K. (2017). Kappaphycus alvarezii as a food supplement prevents diet-induced metabolic syndrome in rats. Nutrients, 9.","DOI":"10.3390\/nu9111261"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.cbi.2015.12.012","article-title":"Curcumin prevents inflammatory response, oxidative stress and insulin resistance in high fructose fed male Wistar rats: Potential role of serine kinases","volume":"244","author":"Maithilikarpagaselvi","year":"2016","journal-title":"Chem. Biol. Interact."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1007\/s00018-008-7452-4","article-title":"Curcumin: From ancient medicine to current clinical trials","volume":"65","author":"Hatcher","year":"2008","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1002\/ptr.5779","article-title":"Effects of curcumin on serum vitamin E concentrations in individuals with metabolic syndrome","volume":"31","author":"Mohammadi","year":"2017","journal-title":"Phytother. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.2147\/IJN.S32630","article-title":"Effects of polymer molecular weight on relative oral bioavailability of curcumin","volume":"7","author":"Tsai","year":"2012","journal-title":"Int. J. Nanomed."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4155\/tde.14.91","article-title":"PLGA: A unique polymer for drug delivery","volume":"6","author":"Kapoor","year":"2015","journal-title":"Ther. Deliv."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.2174\/1381612823666170222122822","article-title":"Curcumin and endothelial function: Evidence and mechanisms of protective effects","volume":"23","author":"Karimian","year":"2017","journal-title":"Curr. Pharm. Des."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"7348372","DOI":"10.1155\/2017\/7348372","article-title":"Uncoupling Protein 2: A key player and a potential therapeutic target in vascular diseases","volume":"2017","author":"Pierelli","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"187","DOI":"10.18632\/aging.101149","article-title":"Curcumin supplementation improves vascular endothelial function in healthy middle-aged and older adults by increasing nitric oxide bioavailability and reducing oxidative stress","volume":"9","author":"Strahler","year":"2017","journal-title":"Aging"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1080\/10408398.2017.1396201","article-title":"Lipid-modifying activity of curcuminoids: A systematic review and meta-analysis of randomized controlled trials","volume":"59","author":"Pirro","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1080\/07315724.2017.1392263","article-title":"Effect of curcumin on anthropometric measures: A systematic review on randomized clinical trials","volume":"37","author":"Hariri","year":"2018","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1002\/oby.22110","article-title":"Dietary curcumin intervention targets mouse white adipose tissue inflammation and brown adipose tissue UCP1 expression","volume":"26","author":"Song","year":"2018","journal-title":"Obesity"},{"key":"ref_37","first-page":"11503","article-title":"Curcumin prevents the non-alcoholic fatty hepatitis via mitochondria protection and apoptosis reduction","volume":"8","author":"Wang","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1700731","DOI":"10.1002\/mnfr.201700731","article-title":"Highly dispersible and bioavailable curcumin but not native curcumin induces brown-like adipocyte formation in mice","volume":"62","author":"Nishikawa","year":"2018","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"E201","DOI":"10.1152\/ajpendo.00285.2017","article-title":"Curcumin and other dietary polyphenols: Potential mechanisms of metabolic actions and therapy for diabetes and obesity","volume":"314","author":"Jin","year":"2018","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1039\/C7FO01242J","article-title":"Curcumin as a functional food-derived factor: Degradation products, metabolites, bioactivity, and future perspectives","volume":"9","author":"Tsuda","year":"2018","journal-title":"Food Funct."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.phrs.2018.06.007","article-title":"The clinical efficacy of curcumin-containing nutraceuticals: An overview of systematic reviews","volume":"134","author":"Pagano","year":"2018","journal-title":"Pharmacol. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jnutbio.2015.09.006","article-title":"Curcumin induces brown fat-like phenotype in 3T3-L1 and primary white adipocytes","volume":"27","author":"Lone","year":"2016","journal-title":"J. Nutr. Biochem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"919","DOI":"10.3945\/jn.108.100966","article-title":"Curcumin inhibits adipogenesis in 3T3-L1 adipocytes and angiogenesis and obesity in C57\/BL mice","volume":"139","author":"Ejaz","year":"2009","journal-title":"J. Nutr."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1097\/MIB.0000000000000522","article-title":"The role of curcumin in modulating colonic microbiota during colitis and colon cancer prevention","volume":"21","author":"McFadden","year":"2015","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1361780","DOI":"10.1080\/16546628.2017.1361780","article-title":"Regulative effects of curcumin spice administration on gut microbiota and its pharmacological implications","volume":"61","author":"Shen","year":"2017","journal-title":"Food Nutr. Res."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Shen, L., and Ji, H.-F. (2018). Bidirectional interactions between dietary curcumin and gut microbiota. Crit. Rev. Food Sci. Nutr.","DOI":"10.1080\/10408398.2018.1478388"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.micpath.2018.08.036","article-title":"Gut microbiome: Microflora association with obesity and obesity-related comorbidities","volume":"124","author":"Lone","year":"2018","journal-title":"Microb. Pathog."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1080\/10408398.2018.1433629","article-title":"Influence of functional food components on gut health","volume":"59","author":"Wan","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/advances\/nmx011","article-title":"The problem of curcumin and its bioavailability: Could its gastrointestinal influence contribute to its overall health-enhancing effects?","volume":"9","author":"Lopresti","year":"2018","journal-title":"Adv. Nutr."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"C438","DOI":"10.1152\/ajpcell.00235.2016","article-title":"Curcumin improves intestinal barrier function: Modulation of intracellular signaling, and organization of tight junctions","volume":"312","author":"Wang","year":"2017","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Ghosh, S.S., Bie, J., Wang, J., and Ghosh, S. (2014). Oral supplementation with non-absorbable antibiotics or curcumin attenuates Western diet-induced atherosclerosis and glucose intolerance in LDLR\u2212\/\u2212 mice\u2013Role of intestinal permeability and macrophage activation. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0108577"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1289\/ehp.96104400","article-title":"Scaling basic toxicokinetic parameters from rat to man","volume":"104","author":"Bachmann","year":"1996","journal-title":"Environ. Health Perspect."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","article-title":"Dose translation from animal to human studies revisited","volume":"22","author":"Nihal","year":"2008","journal-title":"FASEB J."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/11\/7\/1542\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:03:33Z","timestamp":1760187813000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/11\/7\/1542"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,8]]},"references-count":53,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2019,7]]}},"alternative-id":["nu11071542"],"URL":"https:\/\/doi.org\/10.3390\/nu11071542","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,8]]}}}