{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:21:45Z","timestamp":1780471305627,"version":"3.54.1"},"reference-count":97,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T00:00:00Z","timestamp":1564531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["SAF2016-75508"],"award-info":[{"award-number":["SAF2016-75508"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"name":"AGAUR, Catalonia","award":["2017-SGR-106"],"award-info":[{"award-number":["2017-SGR-106"]}]},{"name":"CERCA Programme\/Generalitat de Catalunya","award":["--"],"award-info":[{"award-number":["--"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Oxidative damage is involved in the pathophysiology of age-related ailments, including Alzheimer\u2019s disease (AD). Studies have shown that the brain tissue and also lymphocytes from AD patients present increased oxidative stress compared to healthy controls (HCs). Here, we use lymphoblastoid cell lines (LCLs) from AD patients and HCs to investigate the role of resveratrol (RV) and selenium (Se) in the reduction of reactive oxygen species (ROS) generated after an oxidative injury. We also studied whether these compounds elicited expression changes in genes involved in the antioxidant cell response and other aging-related mechanisms. AD LCLs showed higher ROS levels than those from HCs in response to H2O2 and FeSO4 oxidative insults. RV triggered a protective response against ROS under control and oxidizing conditions, whereas Se exerted antioxidant effects only in AD LCLs under oxidizing conditions. RV increased the expression of genes encoding known antioxidants (catalase, copper chaperone for superoxide dismutase 1, glutathione S-transferase zeta 1) and anti-aging factors (sirtuin 1 and sirtuin 3) in both AD and HC LCLs. Our findings support RV as a candidate for inducing resilience and protection against AD, and reinforce the value of LCLs as a feasible peripheral cell model for understanding the protective mechanisms of nutraceuticals against oxidative stress in aging and AD.<\/jats:p>","DOI":"10.3390\/nu11081764","type":"journal-article","created":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T11:37:07Z","timestamp":1564573027000},"page":"1764","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":93,"title":["Role of Resveratrol and Selenium on Oxidative Stress and Expression of Antioxidant and Anti-Aging Genes in Immortalized Lymphocytes from Alzheimer\u2019s Disease Patients"],"prefix":"10.3390","volume":"11","author":[{"given":"Marta","family":"Cos\u00edn-Tom\u00e0s","sequence":"first","affiliation":[{"name":"Institut d\u2019Investigacions Biom\u00e8diques de Barcelona (IIBB), Consejo Superior de Investigaciones Cient\u00edficas (CSIC), 08036 Barcelona, Spain"},{"name":"Department of Human Genetics, Research Institute of the McGill University Health Centre, Montreal, QC H3A 0C7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00falia","family":"Senserrich","sequence":"additional","affiliation":[{"name":"Institut d\u2019Investigacions Biom\u00e8diques de Barcelona (IIBB), Consejo Superior de Investigaciones Cient\u00edficas (CSIC), 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Arum\u00ed-Planas","sequence":"additional","affiliation":[{"name":"Institut d\u2019Investigacions Biom\u00e8diques de Barcelona (IIBB), Consejo Superior de Investigaciones Cient\u00edficas (CSIC), 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Alqu\u00e9zar","sequence":"additional","affiliation":[{"name":"Department of Molecular Biomedicine, Centro de Investigaciones Biol\u00f3gicas, CSIC, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3095-4254","authenticated-orcid":false,"given":"Merc\u00e8","family":"Pall\u00e0s","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy and Food Sciences, Institut de Neuroci\u00e8ncies, Universitat de Barcelona, 08028 Barcelona, Spain"},{"name":"CIBER de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, 28031 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3416-9440","authenticated-orcid":false,"given":"\u00c1ngeles","family":"Mart\u00edn-Requero","sequence":"additional","affiliation":[{"name":"Department of Molecular Biomedicine, Centro de Investigaciones Biol\u00f3gicas, CSIC, 28040 Madrid, Spain"},{"name":"CIBER de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, 28031 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9367-8483","authenticated-orcid":false,"given":"Cristina","family":"Su\u00f1ol","sequence":"additional","affiliation":[{"name":"Institut d\u2019Investigacions Biom\u00e8diques de Barcelona (IIBB), Consejo Superior de Investigaciones Cient\u00edficas (CSIC), 08036 Barcelona, Spain"},{"name":"CIBER de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), Instituto de Salud Carlos III, 28031 Madrid, Spain"},{"name":"Institut d\u2019Investigaci\u00f3 Biom\u00e8dica August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perla","family":"Kaliman","sequence":"additional","affiliation":[{"name":"Institut d\u2019Investigacions Biom\u00e8diques de Barcelona (IIBB), Consejo Superior de Investigaciones Cient\u00edficas (CSIC), 08036 Barcelona, Spain"},{"name":"Faculty of Health Sciences, Universitat Oberta de Catalunya, 08018 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coral","family":"Sanfeliu","sequence":"additional","affiliation":[{"name":"Institut d\u2019Investigacions Biom\u00e8diques de Barcelona (IIBB), Consejo Superior de Investigaciones Cient\u00edficas (CSIC), 08036 Barcelona, Spain"},{"name":"CIBER de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), Instituto de Salud Carlos III, 28031 Madrid, Spain"},{"name":"Institut d\u2019Investigaci\u00f3 Biom\u00e8dica August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,7,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1017\/S135561771700100X","article-title":"Alzheimer\u2019s Disease: Past, Present, and Future","volume":"23","author":"Bondi","year":"2017","journal-title":"J. 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