{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T03:29:39Z","timestamp":1772767779591,"version":"3.50.1"},"reference-count":177,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2019,8,31]],"date-time":"2019-08-31T00:00:00Z","timestamp":1567209600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011011","name":"Junta de Andaluc\u00eda","doi-asserted-by":"publisher","award":["P12-CTS-1507"],"award-info":[{"award-number":["P12-CTS-1507"]}],"id":[{"id":"10.13039\/501100011011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010198","name":"Ministerio de Econom\u00eda, Industria y Competitividad, Gobierno de Espa\u00f1a","doi-asserted-by":"publisher","award":["BIO2014-56092-R"],"award-info":[{"award-number":["BIO2014-56092-R"]}],"id":[{"id":"10.13039\/501100010198","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Diet-based chemoprevention of cancer has emerged as an interesting approach to evade the disease or even target its early phases, reducing its incidence or slowing down tumor progression. In its basis in the essential role of angiogenesis for tumor growth and metastasis, angioprevention proposes the use of inhibitors of angiogenesis in cancer prevention. The anti-angiogenic potential exhibited by many natural compounds contained in many Mediterranean diet constituents makes this dietary pattern especially interesting as a source of chemopreventive agents, defined within the angioprevention strategy. In this review, we focus on natural bioactive compounds derived from the main foods included in the Mediterranean diet that display anti-angiogenic activity, as well as their possible use as angiopreventive agents.<\/jats:p>","DOI":"10.3390\/nu11092036","type":"journal-article","created":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T03:16:12Z","timestamp":1567394172000},"page":"2036","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["The Mediterranean Diet, a Rich Source of Angiopreventive Compounds in Cancer"],"prefix":"10.3390","volume":"11","author":[{"given":"Beatriz","family":"Mart\u00ednez-Poveda","sequence":"first","affiliation":[{"name":"Department of Molecular Biology and Biochemistry, Faculty of Sciences, University of M\u00e1laga, Andaluc\u00eda Tech, 29071 M\u00e1laga, Spain"},{"name":"IBIMA (Biomedical Research Institute of M\u00e1laga), 29071 M\u00e1laga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Antonio","family":"Torres-Vargas","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Biochemistry, Faculty of Sciences, University of M\u00e1laga, Andaluc\u00eda Tech, 29071 M\u00e1laga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda del Carmen","family":"Oca\u00f1a","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Biochemistry, Faculty of Sciences, University of M\u00e1laga, Andaluc\u00eda Tech, 29071 M\u00e1laga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Garc\u00eda-Caballero","sequence":"additional","affiliation":[{"name":"Laboratory of Angiogenesis and Vascular Metabolism, VIB Center for Cancer Biology, VIB, 3000 Leuven, Belgium"},{"name":"Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, Leuven Cancer Institute, KU Leuven, 3000 Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7275-6462","authenticated-orcid":false,"given":"Miguel \u00c1ngel","family":"Medina","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Biochemistry, Faculty of Sciences, University of M\u00e1laga, Andaluc\u00eda Tech, 29071 M\u00e1laga, Spain"},{"name":"IBIMA (Biomedical Research Institute of M\u00e1laga), 29071 M\u00e1laga, Spain"},{"name":"CIBER of Rare Diseases, Group U741 (CB06\/07\/0046), 29071 M\u00e1laga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6419-8867","authenticated-orcid":false,"given":"Ana R.","family":"Quesada","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Biochemistry, Faculty of Sciences, University of M\u00e1laga, Andaluc\u00eda Tech, 29071 M\u00e1laga, Spain"},{"name":"IBIMA (Biomedical Research Institute of M\u00e1laga), 29071 M\u00e1laga, Spain"},{"name":"CIBER of Rare Diseases, Group U741 (CB06\/07\/0046), 29071 M\u00e1laga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,8,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/nature04478","article-title":"Angiogenesis in life, disease and medicine","volume":"438","author":"Carmeliet","year":"2005","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.cell.2011.08.039","article-title":"Basis and therapeutic aspects of angiogenesis","volume":"146","author":"Potente","year":"2011","journal-title":"Cell"},{"key":"ref_3","first-page":"2224","article-title":"\u00c1ngel Angiogenesis and signal transduction in endothelial cells","volume":"61","author":"Quesada","year":"2004","journal-title":"Cell. 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